Event Information:
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Team 3: Biomedical engineering - tissue engineering and immersive technologies
Group leaders: Teresa SIMON YARZA & Patrick NATAF
Team 3 is made up of the previous team 3 from which the new team 4 has emerged with an activity focused on nanotechnology and imaging. The new team 3 is a multidisciplinary team in which chemists, physico-chemists, biologists, engineers, pharmacists, clinicians and surgeons, collaborate to develop innovative research projects, tissue engineering products and medical devices, and the transfer in industry and clinic. Thus, the team possesses the knowledge and know how to act at all the steps of the development from the research product to the patient. A recent example of this is the 2022 “Proof of Concept In Vivo” project SUVAR funded by INSERM Transfert. Based on the results of the thesis by L. Gernez to chemically modify the lumen of PVA small vascular grafts, which led to the writing of a patent, a project was built up together with surgeons in the team to further evaluate the clinical potential of this system. Another example is the clinical transfer of polysaccharide beads for tissue regeneration that led to > 25 publications, several PhD defenses, four patents by the team, and the license to Siltiss company that obtain in 2022 the agreement by the French agency for health (ANSM) to lunch clinical trial.
In particular, the main themes of research that are developed in the team are:
• Theme 1: Multiscale functional materials for tissue engineering
• Theme 2: Immersive technologies applied to medical device development and medicinePublications
2460799 Z48AKWG7 2024 items 1 infection-and-immunity 0 default asc year 729 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JAMA 330:2343.2460799 Z48AKWG7 2022 items 1 infection-and-immunity 0 default asc year 729 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JAMA 327:442.2460799 Z48AKWG7 2021 items 1 infection-and-immunity 0 default asc year 729 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Adv Healthcare Materials 10:2001237.2460799 Z48AKWG7 2020 items 1 infection-and-immunity 0 default asc year 729 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Adv Biosys 4:1900284.2460799 Z48AKWG7 2019 items 1 infection-and-immunity 0 default asc year 729 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European J of Heart Fail 21:1619–1627.2460799 Z48AKWG7 2018 items 1 infection-and-immunity 0 default asc year 729 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N Engl J Med 379:2297–2306.1.Nahon P, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Zucman D, Di Martino V, Sutton A, Roudot-Thoraval F, Audureau E, Nahon P, Marcellin P, Guyader D, Pol S, Fontaine H, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Leroy V, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Dharancy S, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Hillaire S, Di Martino V. 2018. Incidence of Hepatocellular Carcinoma After Direct Antiviral Therapy for HCV in Patients With Cirrhosis Included in Surveillance Programs. 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Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study. Gastroenterology 155:431-442.e10.1.Atlan M, Simon-Yarza T, Ino JM, Hunsinger V, Corté L, Ou P, Aid-Launais R, Chaouat M, Letourneur D. 2018. Design, characterization and in vivo performance of synthetic 2 mm-diameter vessel grafts made of PVA-gelatin blends. Sci Rep 8:7417.1.Colasuonno M, Palange AL, Aid R, Ferreira M, Mollica H, Palomba R, Emdin M, Del Sette M, Chauvierre C, Letourneur D, Decuzzi P. 2018. Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots. ACS Nano 12:12224–12237.1.Zununi Vahed S, Barzegari A, Zuluaga M, Letourneur D, Pavon-Djavid G. 2018. Myocardial infarction and gut microbiota: An incidental connection. Pharmacological Research 129:308–317.1.Fysekidis M, Cosson E, Takbou K, Sutton A, Charnaux N, Banu I, Vicaut E, Valensi P. 2018. Effects of insulin analogs as an add-on to metformin on cutaneous microcirculation in type 2 diabetic patients. Microvascular Research 116:6–14.1.Atlan M, Lellouch AG, Legagneux J, Chaouat M, Masquelet A-C, Letourneur D. 2018. A New Synthetic Model for Microvascular Anastomosis Training? A Randomized Comparative Study Between Silicone and Polyvinyl Alcohol Gelatin Tubes. Journal of Surgical Education 75:182–187.1.Lemaignen A, Armand-Lefevre L, Birgand G, Mabileau G, Lolom I, Ghodbane W, Dilly M-P, Nataf P, Lucet J-C. 2018. Thirteen-year experience with universal Staphylococcus aureus nasal decolonization prior to cardiac surgery: a quasi-experimental study. Journal of Hospital Infection 100:322–328.1.Plan Sangnier A, Preveral S, Curcio A, K. A. Silva A, Lefèvre CT, Pignol D, Lalatonne Y, Wilhelm C. 2018. Targeted thermal therapy with genetically engineered magnetite magnetosomes@RGD: Photothermia is far more efficient than magnetic hyperthermia. Journal of Controlled Release 279:271–281.1.Heuzé C, Lepage L, Loubet P, Duval X, Cimadevilla C, Verdonk C, Hyafil F, Rouzet F, Ou P, Nataf P, Vahanian A, Messika-Zeitoun D. 2018. Infective Endocarditis After Bentall Surgery. JACC: Cardiovascular Imaging 11:1535–1537.1.Joy J, Pereira J, Aid-Launais R, Pavon-Djavid G, Ray AR, Letourneur D, Meddahi-Pellé A, Gupta B. 2018. Gelatin — Oxidized carboxymethyl cellulose blend based tubular electrospun scaffold for vascular tissue engineering. International Journal of Biological Macromolecules 107:1922–1935.1.Fricain JC, Aid R, Lanouar S, Maurel DB, Le Nihouannen D, Delmond S, Letourneur D, Amedee Vilamitjana J, Catros S. 2018. In-vitro and in-vivo design and validation of an injectable polysaccharide-hydroxyapatite composite material for sinus floor augmentation. Dental Materials 34:1024–1035.1.Jolivet S, Lescure F-X, Armand-Lefevre L, Raffoul R, Dilly M-P, Ghodbane W, Nataf P, Lucet J-C. 2018. Surgical site infection with extended-spectrum β-lactamase-producing Enterobacteriaceae after cardiac surgery: incidence and risk factors. Clinical Microbiology and Infection 24:283–288.1.Zuluaga M, Gueguen V, Letourneur D, Pavon-Djavid G. 2018. Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury. Chemico-Biological Interactions 279:145–158.1.Marinval N, Morenc M, Labour MN, Samotus A, Mzyk A, Ollivier V, Maire M, Jesse K, Bassand K, Niemiec-Cyganek A, Haddad O, Jacob MP, Chaubet F, Charnaux N, Wilczek P, Hlawaty H. 2018. Fucoidan/VEGF-based surface modification of decellularized pulmonary heart valve improves the antithrombotic and re-endothelialization potential of bioprostheses. Biomaterials 172:14–29.1.Juenet M, Aid-Launais R, Li B, Berger A, Aerts J, Ollivier V, Nicoletti A, Letourneur D, Chauvierre C. 2018. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156:204–216.1.Annonay N, Challali F, Labour M-N, Bockelée V, Garcia-Sanchez A, Tetard F, Besland M-P, Djemia P, Chaubet F. 2018. Thin films of binary amorphous Zn-Zr alloys developed by magnetron co-sputtering for the production of degradable coronary stents: A preliminary study. Bioactive Materials 3:385–388.1.Dreyfus J, Ghalem N, Garbarz E, Cimadevilla C, Nataf P, Vahanian A, Caranhac G, Messika-Zeitoun D. 2018. Timing of Referral of Patients With Severe Isolated Tricuspid Valve Regurgitation to Surgeons (from a French Nationwide Database). The American Journal of Cardiology 122:323–326.1.Eugène M, Urena M, Abtan J, Carrasco J-L, Ghodbane W, Nataf P, Vahanian A, Himbert D. 2018. Effectiveness of Rescue Percutaneous Balloon Aortic Valvuloplasty in Patients With Severe Aortic Stenosis and Acute Heart Failure. The American Journal of Cardiology 121:746–750.1.Cacoub P, Nahon P, Layese R, Blaise L, Desbois AC, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Capron D, Thiefin G, Zucman D, Di Martino V, Bagnis CI, Ziol M, Sutton A, Letouze E, Roudot-Thoraval F, Audureau E, Nahon P, Marcellin P, Guyader D, Pol S, Fontaine H, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Leroy V, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Dharancy S, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Thiefin G, Hillaire S, Di Martino V. 2018. Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients. American Heart Journal 198:4–17.1.Verdonk C, Cimadevilla C, Lepage L, Perez F, Ghodbane W, Raffoul R, Alkhoder S, Nataf P, Vahanian A, Messika-Zeitoun D. 2018. Systematic transoesophageal echocardiography after mitral valve replacement: Rates and determinants of paravalvular regurgitation. Archives of Cardiovascular Diseases 111:528–533.1.Verdonk C, Darmon A, Cimadevilla C, Lepage L, Raffoul R, Nataf P, Vahanian A, Messika-Zeitoun D. 2018. Is tricuspid annuloplasty increasing surgical mortality and morbidity during mitral valve replacement? A single-centre experience. Archives of Cardiovascular Diseases 111:480–486.1.Collignon A-M, Lesieur J, Anizan N, Azzouna RB, Poliard A, Gorin C, Letourneur D, Chaussain C, Rouzet F, Rochefort GY. 2018. Early angiogenesis detected by PET imaging with 64Cu-NODAGA-RGD is predictive of bone critical defect repair. Acta Biomaterialia 82:111–121.1.Lanouar S, Aid-Launais R, Oliveira A, Bidault L, Closs B, Labour M-N, Letourneur D. 2018. Effect of cross-linking on the physicochemical and in vitro properties of pullulan/dextran microbeads. J Mater Sci: Mater Med 29:77.1.Guerrero J, Oliveira H, Aid R, Bareille R, Siadous R, Letourneur D, Mao Y, Kohn J, Amédée J. 2018. Influence of the three‐dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3. J Tissue Eng Regen Med 12:e1936–e1949.1.Dubreil C, Sainte Catherine O, Lalatonne Y, Journé C, Ou P, Van Endert P, Motte L. 2018. Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice. Small 14:1802053.1.Giménez‐Marqués M, Bellido E, Berthelot T, Simón‐Yarza T, Hidalgo T, Simón‐Vázquez R, González‐Fernández Á, Avila J, Asensio MC, Gref R, Couvreur P, Serre C, Horcajada P. 2018. GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness. Small 14:1801900.1.Teston E, Maldiney T, Marangon I, Volatron J, Lalatonne Y, Motte L, Boisson‐Vidal C, Autret G, Clément O, Scherman D, Gazeau F, Richard C. 2018. Nanohybrids with Magnetic and Persistent Luminescence Properties for Cell Labeling, Tracking, In Vivo Real‐Time Imaging, and Magnetic Vectorization. Small 14:1800020.1.Allaire M, Nahon P, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J, Zarski J, Riachi G, Calès P, Péron J, Alric L, Bourlière M, Mathurin P, Blanc J, Abergel A, Serfaty L, Mallat A, Grangé J, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen‐Khac E, Bernard‐Chabert B, Zucman D, Di Martino V, Sutton A, Letouzé E, Audureau E, Roudot‐Thoraval F, for the ANRS CO12 CirVir Group. 2018. 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Angewandte Chemie 130:10734–10738.2460799 Z48AKWG7 2017 items 1 infection-and-immunity 0 default asc year 729 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