Team 1: Cardiovascular Immunobiology

Group leaders: Giuseppina CALIGIURI & Antonino NICOLETTI

The research in this team is devoted to study the multiple mechanisms through which the immune system

interacts with diseased vessels and we design new vascular-protective immunointervention strategies. Our research program relies on specific skills and tools: experimental animal models, tissue biobank, (immuno-)histology, and up-to-date flow cytometry core.

 

In the recent years, we have:

  • Identified the CD31 as a molecule of pacification of the blood-vessel interface and have brought the proof of concept of its therapeutic potential;
  • Deciphered local immune responses around atherothrombotic vessels and defined novel pathogenic immune pathways in the advanced stages of atherothrombotic disease;
  • Targeted the neutrophils and their molecular effectors in stroke.

Our current major research focuses are: 

  • To suppress adverse vascular effects of reperfusion in brain, heart, intestine, and lungs;
  • To evaluate new immune-related pathways and immunointervention strategies;
  • To investigate the causal link between atherothrombosis and periodontal diseases;
  • To evaluate the role of CD31 in transplantation;
  • To discover new cellular and molecular pathways leading to aortic valve calcification.

Since 2012, we have filed 6 patents:

  • Caligiuri G, Nicoletti A. 2012. “Use of CD31 peptides in the treatment of atherothrombosis and autoimmune disorders”. PCT/EP2009058188 / WO 2010/000741 A1.
  • Caligiuri G, Nicoletti A. 2012. “Improved CD31 peptides”. PCT/EP2013/062806 / WO2013190014 A1.
  • Caligiuri G, Nicoletti A. 2015. “Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways”. PCT/EPT2009/58220 / WO 2010/000756 A1.
  • Caligiuri G, Nicoletti A. 2015. “Detection of platelet-derived shed CD31”. PCT/EP2013/055489 / WO2013152919 A1.
  • Caligiuri G, Nicoletti A, Le Guludec D, Bay S. 2016. “CD31shed as a molecular target for imaging of inflammation”. EP16305516.
  • Caligiuri G, Nicoletti A, Michel JB. 2016. “CD31shed agonists for use in the prevention and/or treatment of reperfusion injury”. EP16305311.
Family name
First name
Position
Tel
Email
ARANGALAGEDimitriMCUPH01.40.25.75.58dimitri.arangalage@aphp.fr
AZNARBastienM1bastien.aznar@live.fr
BRAUDGaétanM1gaetan.braud01@gmail.com
CALIGIURIGiuseppinaDR101.40.25.75.56giuseppina.caligiuri@inserm.fr
CAROFFGildazPHjildaz.caroff@gmail.com
CLEMENTMarcPOST-DOCmarc.clement@inserm.fr
CORCOSOlivierPHU01.40.87.56.66olivier.corcos@gmail.com
DELBOSCSandrineCR01.40.25.75.56sandrine.delbosc@inserm.fr
DESCHAMPSLydiaPH01.40.25.80.03lydia.deschamps@aphp.fr
DORENTRichardPHrichard.dorent@aphp.fr
DOUTEMelodieDoctorantmelodie.doute@inserm.fr
DUBOIS-MIGNONTaniaM2t.dubois.mignon@gmail.com
EVENGuillaumeAutre_Ch01.40.25.75.58guillaume@tridekone.com
FAGNENPaulineM2pauline.fagnen@aphp.fr
FRANCKGregoryCR01.40.25.75.57gregory.franck@inserm.fr
GASTONAnh-ThuTCH01.40.25.75.58athugaston@yahoo.fr
HADDOUSabrinaIE01.40.25.75.55sabrina.haddou@inserm.fr
LASCHET-KHALLOUJamilaIR01.40.25.75.58jamila.laschet@inserm.fr
LE BORGNEMarieMCF01.40.25.75.51marie.le-borgne-moynier@inserm.fr
MANGINGabriellePOST-DOCgabrielle.mangin@inserm.fr
MISSONIERCharlotteStagiaire
NICOLETTIAntoninoPR101.40.25.75.56antonino.nicoletti@inserm.fr
PARAMarylouDoctorantmarylou.para@aphp.fr
SANNIERAurelieMCUPH01.40.25.75.21aurelie.sannier@aphp.fr
SBIHIZinebPOST-DOC01.40.25.75.51sb.zineb@gmail.com
SENEMAUDJeanDoctorantjeansenemaud@yahoo.fr
SITBONSamuelM2as.sitbon@gmail.com
SKARBEKCharlesPOST-DOC01.40.25.75.57charles.skarbek@inserm.fr
SPELLELaurentPUPH01.40.25.86.00laurent@spelle.fr
SUCGaspardDoctorantgaspard.suc@aphp.fr
TRANTrangAutre_Ch01.40.25.75.57t.tran@tridekone.com
TRAN DINHAlexyMCUPH01.40.25.75.24alexy.trandinh@gmail.com
ZOUHRYIlyassDoctorantzouhry.ilyass@gmail.com
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Sannier A, Stroumza N, Atlan M, Even G, Guedj K, Sénémaud J, Coscas R, Caligiuri G, Nicoletti A. 2021. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc 53:746–749.
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Kikoïne J, Urena M, Chong Nguyen C, Fischer Q, Carrasco JL, Brochet E, Ducrocq G, Vahanian A, Iung B, Himbert D. 2021. Predictors and clinical impact of thrombosis after transcatheter mitral valve implantation using balloon-expandable bioprostheses. EuroIntervention 16:1455–1462.
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Gerschenfeld G, Smadja D, Turc G, Olindo S, Laborne FX, Yger M, Caroff J, Gonçalves B, Seners P, Cantier M, l’Hermitte Y, Aghasaryan M, Alecu C, Marnat G, Ben Hassen W, Kalsoum E, Clarençon F, Piotin M, Spelle L, Denier C, Sibon I, Alamowitch S, Chausson N. 2021. Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy. Neurology 97:e2173–e2184.
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Eugène M, Duchnowski P, Prendergast B, Wendler O, Laroche C, Monin JL, Jobic Y, Popescu BA, Bax JJ, Vahanian A, Iung B. 2021. Contemporary Management of Severe Symptomatic Aortic Stenosis. J Am Coll Cardiol 78:2131–2143.
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Elmaleh Y, De Tymowski C, Zappella N, Jean-Baptiste S, Tran-Dinh A, Tanaka S, Yung S, Lortat-Jacob B, Mal H, Castier Y, Atchade E, Montravers P. 2021. Blood transfusion of the donor is associated with stage 3 primary graft dysfunction after lung transplantation. Clin Transplant 35:e14407.
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Diaz-Rodriguez S, Rasser C, Mesnier J, Chevallier P, Gallet R, Choqueux C, Even G, Sayah N, Chaubet F, Nicoletti A, Ghaleh B, Feldman LJ, Mantovani D, Caligiuri G. 2021. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J 42:1760–1769.
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