Team 1: Cardiovascular Immunobiology

Group leaders: Giuseppina CALIGIURI & Antonino NICOLETTI

The research in this team is devoted to study the multiple mechanisms through which the immune system

interacts with diseased vessels and we design new vascular-protective immunointervention strategies. Our research program relies on specific skills and tools: experimental animal models, tissue biobank, (immuno-)histology, and up-to-date flow cytometry core.

 

In the recent years, we have:

  • Identified the CD31 as a molecule of pacification of the blood-vessel interface and have brought the proof of concept of its therapeutic potential;
  • Deciphered local immune responses around atherothrombotic vessels and defined novel pathogenic immune pathways in the advanced stages of atherothrombotic disease;
  • Targeted the neutrophils and their molecular effectors in stroke.

Our current major research focuses are: 

  • To suppress adverse vascular effects of reperfusion in brain, heart, intestine, and lungs;
  • To evaluate new immune-related pathways and immunointervention strategies;
  • To investigate the causal link between atherothrombosis and periodontal diseases;
  • To evaluate the role of CD31 in transplantation;
  • To discover new cellular and molecular pathways leading to aortic valve calcification.

Since 2012, we have filed 6 patents:

  • Caligiuri G, Nicoletti A. 2012. “Use of CD31 peptides in the treatment of atherothrombosis and autoimmune disorders”. PCT/EP2009058188 / WO 2010/000741 A1.
  • Caligiuri G, Nicoletti A. 2012. “Improved CD31 peptides”. PCT/EP2013/062806 / WO2013190014 A1.
  • Caligiuri G, Nicoletti A. 2015. “Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways”. PCT/EPT2009/58220 / WO 2010/000756 A1.
  • Caligiuri G, Nicoletti A. 2015. “Detection of platelet-derived shed CD31”. PCT/EP2013/055489 / WO2013152919 A1.
  • Caligiuri G, Nicoletti A, Le Guludec D, Bay S. 2016. “CD31shed as a molecular target for imaging of inflammation”. EP16305516.
  • Caligiuri G, Nicoletti A, Michel JB. 2016. “CD31shed agonists for use in the prevention and/or treatment of reperfusion injury”. EP16305311.
Family name
First name
Position
Tel
Email
ARANGALAGEDimitriMCUPH01.40.25.75.58dimitri.arangalage@aphp.fr
CALIGIURIGiuseppinaDR201.40.25.75.56giuseppina.caligiuri@inserm.fr
CAROFFGildazPHjildaz.caroff@gmail.com
CLEMENTMarcPOST-DOCmarc.clement@inserm.fr
CORCOSOlivierPHU01.40.87.56.66olivier.corcos@gmail.com
DELBOSCSandrineCR01.40.25.75.56sandrine.delbosc@inserm.fr
DESCHAMPSLydiaPH01.40.25.80.03lydia.deschamps@aphp.fr
DESCHILDRECatherineAI01.40.25.86.09catherine.deschildre@inserm.fr
DORENTRichardPHrichard.dorent@aphp.fr
DOUTEMelodieDoctorantmelodie.doute@inserm.fr
EVENGuillaumeAutre_Ch01.40.25.75.58guillaume@tridekone.com
FRANCKGregoryCR01.40.25.75.57gregory.franck@inserm.fr
GASTONAnh-ThuTCH01.40.25.75.58athugaston@yahoo.fr
GETTINGSMélanieIRmelanie.gettings@inserm.fr
GUEDJKevinPOST-DOC01.40.25.75.51kevin.guedj@inserm.fr
HOUTIAInesAI01.40.25.75.57ines.houtia@inserm.fr
LASCHET-KHALLOUJamilaIR01.40.25.75.58jamila.laschet@inserm.fr
LE BORGNEMarieMCF01.40.25.75.51marie.le-borgne-moynier@inserm.fr
MANGINGabriellePOST-DOCgabrielle.mangin@inserm.fr
NICOLETTIAntoninoPR101.40.25.75.56antonino.nicoletti@inserm.fr
PARAMarylouDoctorantmarylou.para@aphp.fr
QUENETTEFannyIE01.40.25.75.51fanny.quenette@inserm.fr
SANNIERAurelieMCUPH01.40.25.75.21aurelie.sannier@aphp.fr
SENEMAUDJeanDoctorantjeansenemaud@yahoo.fr
SPELLELaurentPUPH01.40.25.86.00laurent@spelle.fr
TRANTrangAutre_EC01.40.25.75.57t.tran@tridekone.com
TRAN DINHAlexyMCUPH01.40.25.75.24alexy.trandinh@gmail.com
VAHANIANAlecPUPHEMalec.vahanian@aphp.fr
VORBEJulieDoctorant01.40.25.75.57julie.vorbe@inserm.fr
ZOUHRYIlyassCCAzouhry.ilyass@gmail.com
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Mihalea C, Caroff J, Ikka L, Benachour N, Da Ros V, Abdelkhalek H, Iacobucci M, Marenco de la Torre JJ, Pagiola I, Yasuda T, Popa BV, Ples H, Pescariu S, Moret J, Spelle L. 2019. Y-stenting with braided stents for wide-neck intracranial bifurcation aneurysms. A single-center initial experience. Journal of Neuroradiology Journal De Neuroradiologie.
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Makhezer N, Ben Khemis M, Liu D, Khichane Y, Marzaioli V, Tlili A, Mojallali M, Pintard C, Letteron P, Hurtado-Nedelec M, El-Benna J, Marie J-C, Sannier A, Pelletier A-L, Dang PM-C. 2019. NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions. Mucosal Immunology 12:117–131.
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Jasseron C, Legeai C, Jacquelinet C, Nubret-Le Coniat K, Flécher E, Cantrelle C, Audry B, Bastien O, Dorent R. 2019. Optimization of heart allocation: The transplant risk score. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 19:1507–1517.
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Ivanes F, Cantrelle C, Genet T, Le Feuvre C, Legeai C, Jasseron C, Pipien I, Epailly E, Bastien O, Angoulvant D, Dorent R. 2019. Performing diagnostic coronary angiography to evaluate high-risk cardiac donors: A French nationwide cohort study. International Journal of Cardiology 277:71–78.
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Franck G, Even G, Gautier A, Salinas M, Loste A, Procopio E, Gaston A-T, Morvan M, Dupont S, Deschildre C, Berissi S, Laschet J, Nataf P, Nicoletti A, Michel J-B, Caligiuri G. 2019. Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis. European Heart Journal 40:928–937.
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Farah J, Rouchaud A, Henry T, Regen C, Mihalea C, Moret J, Spelle L. 2019. Dose reference levels and clinical determinants in stroke neuroradiology interventions. European Radiology 29:645–653.
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Garcia R, Bouleti C, Sirol M, Logeart D, Monnot C, Ardidie-Robouant C, Caligiuri G, Mercadier J-J, Germain S. 2019. VEGF-A plasma levels are associated with microvascular obstruction in patients with ST-segment elevation myocardial infarction. International Journal of Cardiology.
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Delattre C, Velazquez D, Roques C, Pavon-Djavid G, Ollivier V, Lokajczyk A, Avramoglou T, Gueguen V, Louedec L, Caligiuri G, Jandrot-Perrus M, Boisson-Vidal C, Letourneur D, Meddahi-Pelle A. 2019. In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent. BioImpacts: BI 9:25–36.
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Da Ros V, Cortese J, Chassin O, Rouchaud A, Sarov M, Caroff J, Mihalea C, Minosse S, Taifas I, Scaggiante J, Greco L, Ikka L, Ben Achour N, Di Giuliano F, Ozanne A, Legris N, Diomedi M, Sallustio F, Floris R, Denier C, Spelle L. 2019. Thrombectomy or intravenous thrombolysis in patients with NIHSS of 5 or less? Journal of Neuroradiology Journal De Neuroradiologie.
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Clavel P, Hebert S, Saleme S, Mounayer C, Rouchaud A, Marin B. 2019. Cumulative incidence of restenosis in the endovascular treatment of extracranial carotid artery stenosis: a meta-analysis. Journal of Neurointerventional Surgery.
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Ben Hassen W, Malley C, Boulouis G, Clarençon F, Bartolini B, Bourcier R, Rodriguez Régent C, Bricout N, Labeyrie MA, Gentric JC, Rouchaud A, Soize S, Saleme S, Raoult H, Gallas S, Eugène F, Anxionnat R, Herbreteau D, Bracard S, Naggara O. 2019. Inter- and intraobserver reliability for angiographic leptomeningeal collateral flow assessment by the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) scale. Journal of Neurointerventional Surgery 11:338–341.
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Ben Abdallah I, El Batti S, Huguet A, Corcos O, Castier Y. 2019. Conservative Therapy vs. Extensive Stenting in Superior Mesenteric Artery Dissection: the Right Balance remains to Be Found. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery 57:603.
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Baroudjian B, Arangalage D, Cuzzubbo S, Hervier B, Lebbé C, Lorillon G, Tazi A, Zalcman G, Bouattour M, Lioté F, Gautier J-F, Brosseau S, Lourenco N, Delyon J, group P. 2019. Management of immune-related adverse events resulting from immune checkpoint blockade. Expert Review of Anticancer Therapy 19:209–222.
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Caligiuri G. 2019. Mechanotransduction, immunoregulation and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovascular Research.
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Ben Abdallah I, Cerceau P, Pellenc Q, Huguet A, Corcos O, Castier Y. 2019. Laparoscopic Surgery in Chronic Mesenteric Ischemia: Release of the Superior Mesenteric Artery from the Median Arcuate Ligament Using the Transperitoneal Left Retrorenal Approach. Annals of Vascular Surgery.
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Audemard-Verger A, Pillebout E, Jamin A, Berthelot L, Aufray C, Martin B, Sannier A, Daugas E, Déchanet-Merville J, Richard Y, Monteiro R, Lucas B. 2019. Recruitment of CXCR3+ T cells into injured tissues in adult IgA vasculitis patients correlates with disease activity. Journal of Autoimmunity 99:73–80.
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Zeitouni M, Calais J, Ghodbane W, Ou P, Sannier A, Bouleti C. 2018. A Cardiac Myxoma With Intense Metabolic Activity. The Canadian Journal of Cardiology 34:92.e11-92.e12.
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Tran-Dinh A, Augustin P, Dufour G, Lasocki S, Allou N, Thabut G, Castier Y, Montravers P, Desmard M. 2018. Evaluation of Cardiac Index and Extravascular Lung Water After Single-Lung Transplantation Using the Transpulmonary Thermodilution Technique by the PiCCO2 Device. Journal of Cardiothoracic and Vascular Anesthesia 32:1731–1735.
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Roussel A, Nuzzo A, Pellenc Q, Castier Y, De Blic R, Cerceau P, Boulitrop C, Coblence M, Aguir S, Mordant P, Maggiori L, Huguet A, Sibert A, Joly F, Corcos O. 2018. Surgical revascularization of the celiac artery for persistent intestinal ischemia in short bowel syndrome. International Journal of Surgery (London, England) 49:39–44.
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Rouchaud A, Brinjikji W, Dai D, Ding Y-H, Gunderson T, Schroeder D, Spelle L, Kallmes DF, Kadirvel R. 2018. Autologous adipose-derived mesenchymal stem cells improve healing of coiled experimental saccular aneurysms: an angiographic and histopathological study. Journal of Neurointerventional Surgery 10:60–65.
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Juenet M, Aid-Launais R, Li B, Berger A, Aerts J, Ollivier V, Nicoletti A, Letourneur D, Chauvierre C. 2018. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156:204–216.
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Franck G, Mawson TL, Folco EJ, Molinaro R, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Sukhova GK, Michel J-B, Nicoletti A, Lichtman A, Wagner D, Croce KJ, Libby P. 2018. Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion. Circulation Research 123:33–42.
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Dorent R, Gandjbakhch E, Goéminne C, Ivanes F, Sebbag L, Bauer F, Epailly E, Boissonnat P, Nubret K, Amour J, Vermes E, Ou P, Guendouz S, Chevalier P, Lebreton G, Flecher E, Obadia J-F, Logeart D, de Groote P. 2018. Assessment of potential heart donors: A statement from the French heart transplant community. Archives of Cardiovascular Diseases 111:126–139.
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Couret D, Bourane S, Catan A, Nativel B, Planesse C, Dorsemans A-C, Ait-Arsa I, Cournot M, Rondeau P, Patche J, Tran-Dinh A, Lambert G, Diotel N, Meilhac O. 2018. A hemorrhagic transformation model of mechanical stroke therapy with acute hyperglycemia in mice. The Journal of Comparative Neurology 526:1006–1016.
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Chen C-C, Pouliquen E, Broisat A, Andreata F, Racapé M, Bruneval P, Kessler L, Ahmadi M, Bacot S, Saison-Delaplace C, Marcaud M, Van Huyen J-PD, Loupy A, Villard J, Demuylder-Mischler S, Berney T, Morelon E, Tsai M-K, Kolopp-Sarda M-N, Koenig A, Mathias V, Ducreux S, Ghezzi C, Dubois V, Nicoletti A, Defrance T, Thaunat O. 2018. Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection. The Journal of Clinical Investigation 128:219–232.
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Caroff J, Tamura T, King RM, Lylyk PN, Langan ET, Brooks OW, Clarençon F, Wainwright JM, Spelle L, Marosfoi M, Gounis MJ, Puri AS. 2018. Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia. Journal of Neurointerventional Surgery 10:1097–1101.
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Copin P, Ronot M, Nuzzo A, Maggiori L, Bouhnik Y, Corcos O, Vilgrain V, team S. 2018. Inter-reader agreement of CT features of acute mesenteric ischemia. European Journal of Radiology 105:87–95.