Team 6: Hemostasis, Thrombo-Inflammation and Neurovascular Repair

Team leaders: Marie-Christine BOUTON & Nathalie KUBIS

Team 6 comprises 6 interconnected groups, each with a specific research theme and a dedicated group leader:

The team 6 projects are focused on hemostasis, thrombosis and vascular injury, but are also involved in developing therapeutic strategies for cerebral ischemia at the acute and at the chronic phase, as well as in ICU patients. We combine biochemical and cellular approaches, in vivo experimental models and clinical researches for translational application.

Recently, we have demonstrated that:

  • Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
  • GPVI is a platelet receptor with a central role in the repairing functions of platelets
  • There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
  • Immunomodulation and cell therapy might help to improve post-stroke functional recovery
  • Neutrophil extracellular traps interfere with thrombolysis

We have also developed:

  • New imaging modalities for intracranial vascular studies
  • Innovative endovascular approaches for the treatment of intracranial vascular malformations

Our major common research themes are:

  •  Coagulation disorders (haemophilia, thrombophilia…)
  •  Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation)
  •  Vascular and cerebral injury (stroke, aneurysms)
  •  Cerebral plasticity
  • The search for prognostic markers of functional outcome in stroke and neuro-ICU patients
Family name
First name
Position
Tel
Email
AJZENBERGNadinePUPH101.40.25.85.21nadine.ajzenberg@aphp.fr
AKHENAKSelena
AROCASVéroniqueCR01.40.25.75.32veronique.arocas@inserm.fr
BLANCRaphaelPHrblanc29@gmail.com
BONNINPhilippeMCUPHHCphilippe.bonnin@aphp.fr
BOULAFTALIYacineCR01.40.25.86.15yacine.boulaftali@inserm.fr
BOURRIENNEMarie-CharlotteDoctorantmarie.bourrienne@inserm.fr
BOUTIGNYAlexandrePHUalexandre.boutigny@gmail.com
BOUTONMarie-ChristineDR201.40.25.75.32marie-christine.bouton@inserm.fr
DE RAUCOURTEmmanuellePHemmanuelle.de-raucourt@aphp.fr
DESILLESJean-PhilippePHU01.40.25.86.01jpdesilles@gmail.com
DI MEGLIOLucasDoctorant01.40.25.86.01lucas.dimeglio@gmail.com
DUPONTSébastienIRsebastien.dupont@inserm.fr
EMMELINYannTCHyann.emmelin@inserm.fr
FAILLEDorothéeMCUPH01.40.25.85.21dorothee.faille@aphp.fr
HO-TIN-NOEBenoitDR201.40.25.86.03benoit.ho-tin-noe@inserm.fr
JANDROT-PERRUSMartineDREM01.40.25.75.31martine.jandrot-perrus@inserm.fr
KUBISNathaliePUPH101.49.95.80.88nathalie.kubis@aphp.fr
LAUGÉAbigailabigail.lauge@gmail.com
LE CHAPELAINOphélieDoctorantophelie.lechapelain@gmail.com
LEBASHéloisePOST-DOCheloise.lebas@inserm.fr
LOYAUStéphaneIE01.40.25.75.33stephane.loyau@inserm.fr
LOZERONPierreMCUPH1pierre.lozeron@aphp.fr
MADJENECélinaDoctorant01.40.25.75.33celina.madjene@inserm.fr
MARTOSRaphaelDoctorantraphael.martos@inserm.fr
MAUPUClemenceDoctoranteclemence.maupu@inserm.fr
MAVOUNASabrina
MAZIGHIMikaelPUPH01.40.25.70.33mikael.mazighi@aphp.fr
OLLIVIERVéroniqueIR01.40.25.86.03veronique.ollivier@inserm.fr
PIOTINMichelPHUmpiotin@for.paris
RICHARDBenjaminMCF01.40.25.86.15benjamin.richard@inserm.fr
ROMÉRO DE AVILALolitaromerodeavila.lolita@gmail.com
SALFATIJonasAIjonas.salfati@inserm.fr
SOLO NOMENJANAHARYMialitianaAI01.40.25.86.01mialitiana.solo-nomenjanahary@inserm.fr
SONNEVILLERomainPUPH01.40.25.61.39romain.sonneville@aphp.fr
VENISSELaurenceAI01.40.25.75.33laurence.venisse@inserm.fr
YAHIAOUIKatiaDoctorantkatia.yahiaoui@inserm.fr
ZALGHOUTSaraDoctorantsara.zalghout@inserm.fr
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Jabbour P, Sweid A, Tjoumakaris S, Piotin M, Brinjikji W, Bekelis K, Raz E, Sourour N, Nimjee SM, Lopes DK, Hassan AE, Pandey AS, Gonzalez LF, Hanel RA, Siddiqui AH, Hasan D, Lavine SD, Bendok BR. 2020. In Reply: May Cooler Heads Prevail During a Pandemic: Stroke in COVID-19 Patients or COVID-19 in Stroke Patients? Neurosurgery https://doi.org/10.1093/neuros/nyaa384.