Team 6: Hemostasis, Thrombo-Inflammation and Neurovascular Repair

Team leaders: Marie-Christine BOUTON & Nathalie KUBIS

Team 6 comprises 6 interconnected groups, each with a specific research theme and a dedicated group leader:

The team 6 projects are focused on hemostasis, thrombosis and vascular injury, but are also involved in developing therapeutic strategies for cerebral ischemia at the acute and at the chronic phase, as well as in ICU patients. We combine biochemical and cellular approaches, in vivo experimental models and clinical researches for translational application.

Recently, we have demonstrated that:

  • Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
  • GPVI is a platelet receptor with a central role in the repairing functions of platelets
  • There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
  • Immunomodulation and cell therapy might help to improve post-stroke functional recovery
  • Neutrophil extracellular traps interfere with thrombolysis

We have also developed:

  • New imaging modalities for intracranial vascular studies
  • Innovative endovascular approaches for the treatment of intracranial vascular malformations

Our major common research themes are:

  •  Coagulation disorders (haemophilia, thrombophilia…)
  •  Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation)
  •  Vascular and cerebral injury (stroke, aneurysms)
  •  Cerebral plasticity
  • The search for prognostic markers of functional outcome in stroke and neuro-ICU patients
Family name
First name
Position
Tel
Email
AJZENBERGNadinePUPH101.40.25.85.21nadine.ajzenberg@aphp.fr
ALLARDJulienM2jfx.allard@gmail.com
AROCASVéroniqueCR01.40.25.75.32veronique.arocas@inserm.fr
BILLIALDPhilippePRphilippe.billiald@u-psud.fr
BLANCRaphaelPHrblanc29@gmail.com
BONNINPhilippeMCUPHHCphilippe.bonnin@aphp.fr
BOULAFTALIYacineCR01.40.25.86.15yacine.boulaftali@inserm.fr
BOURRIENNEMarie-CharlotteDoctorantmarie.bourrienne@inserm.fr
BOUTIGNYAlexandrePHUalexandre.boutigny@gmail.com
BOUTONMarie-ChristineDR201.40.25.75.32marie-christine.bouton@inserm.fr
DADDIKaouterM1kawtar.daddi@gmail.com
DE RAUCOURTEmmanuellePHemmanuelle.de-raucourt@aphp.fr
DESILLESJean-PhilippePHU01.40.25.86.01jpdesilles@gmail.com
DU PASQUIERAdaM2ada.dup@outlook.fr
DUPONTSébastienIRsebastien.dupont@inserm.fr
FAILLEDorothéeMCUPH01.40.25.85.21dorothee.faille@aphp.fr
FARKHCarineM2carine.farkh@inserm.fr
GRESPierreStagiaire
HO-TIN-NOEBenoitDR201.40.25.86.03benoit.ho-tin-noe@inserm.fr
ILANKARASAAbarnaStagiaire
JANDROT-PERRUSMartineDREM01.40.25.75.31martine.jandrot-perrus@inserm.fr
KUBISNathaliePUPH101.49.95.80.88nathalie.kubis@aphp.fr
LAGEATElodieM1
LE CHAPELAINOphélieDoctorantophelie.lechapelain@gmail.com
LEBASHéloisePOST-DOCheloise.lebas@inserm.fr
LOYAUStéphaneIE01.40.25.75.33stephane.loyau@inserm.fr
LOZERONPierreMCUPH1pierre.lozeron@aphp.fr
MADJENECélinaDoctorant01.40.25.75.33celina.madjene@inserm.fr
MAHRIAminaM2amina.mahri@inserm.fr
MARTOSRaphaelDoctorantraphael.martos@inserm.fr
MAUPUClemenceDoctorantclemence.maupu@inserm.fr
MAVOUNASabrinaDoctorantsabrina.mavouna@inserm.fr
MAZIGHIMikaelPUPH01.40.25.70.33mikael.mazighi@aphp.fr
MONBERNARDPierrepierre.monbernard@inserm.fr
OLLIVIERVéroniqueIR01.40.25.86.03veronique.ollivier@inserm.fr
PASCALEloiseContrat à durée déterminée (catégorie B)eloise.pascal@inserm.fr
PERROTAstridM2astride.perrot@ip-paris.fr
PIOTINMichelPHUmpiotin@for.paris
RICHARDBenjaminMCF01.40.25.86.15benjamin.richard@inserm.fr
SALFATIJonasAIjonas.salfati@inserm.fr
SOLO NOMENJANAHARYMialitianaAI01.40.25.86.01mialitiana.solo-nomenjanahary@inserm.fr
SONNEVILLERomainPUPH01.40.25.61.39romain.sonneville@aphp.fr
VENISSELaurenceAI01.40.25.75.33laurence.venisse@inserm.fr
YAHIAOUIKatiaDoctorantkatia.yahiaoui@inserm.fr
ZALGHOUTSaraDoctorantsara.zalghout@inserm.fr
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Aldea S, Alkhairy A, Le Guérinel C, Piotin M. 2022. Microsurgical Ligation of a Dural Arteriovenous Fistula of the Petrous Apex-A 2-Dimensional Operative Video. World Neurosurg 160:67.
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Douarinou M, Gory B, Consoli A, Lapergue B, Kyheng M, Labreuche J, Anadani M, Blanc R, Marnat G, Bourcier R, Sibon I, Eugène F, Vannier S, Audibert G, Mione G, Richard S. 2022. Impact of Strategy on Clinical Outcome in Large Vessel Occlusion Stroke Successfully Reperfused: ETIS Registry Results. Stroke 53:e1–e4.
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Anadani M, Maïer B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Gory B, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M. 2022. Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial. Stroke 53:719–727.
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Delvoye F, Loyau S, Labreuche J, Taylor G, Maier B, Piotin M, Blanc R, Escalard S, Di Meglio L, Ben Maacha M, Redjem H, Smajda S, Ciccio G, Hébert S, Sabben C, Jandrot-Perrus M, Maertens De Noordhout A, Mazighi M, Ho-Tin-Noé B, Desilles JP. 2022. Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients. Platelets 33:285–290.
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Desilles JP, Solo Nomenjanahary M, Consoli A, Ollivier V, Faille D, Bourrienne MC, Hamdani M, Dupont S, Di Meglio L, Escalard S, Maier B, Blanc R, Piotin M, Lapergue B, Ajzenberg N, Vasse M, Mazighi M, Ho-Tin-Noé B. 2022. Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke. J Thromb Haemost https://doi.org/10.1111/jth.15646.
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Levy B, Girerd N, Amour J, Besnier E, Nesseler N, Helms J, Delmas C, Sonneville R, Guidon C, Rozec B, David H, Bougon D, Chaouch O, Walid O, Hervé D, Belin N, Gaide-Chevronnay L, Rossignol P, Kimmoun A, Duarte K, Slutsky AS, Brodie D, Fellahi JL, Ouattara A, Combes A. 2022. Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial. Jama 327:442–453.
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Grand T, Dargazanli C, Papagiannaki C, Bruggeman A, Maurer C, Gascou G, Fauche C, Bourcier R, Tessier G, Blanc R, Machaa MB, Marnat G, Barreau X, Ognard J, Gentric JC, Barbier C, Gory B, Rodriguez C, Boulouis G, Eugène F, Thouant P, Ricolfi F, Janot K, Herbreteau D, Eker OF, Cappucci M, Dobrocky T, Möhlenbruch M, Demerath T, Psychogios M, Fischer S, Cianfoni A, Majoie C, Emmer B, Marquering H, Valter R, Lenck S, Premat K, Cortese J, Dormont D, Sourour NA, Shotar E, Samson Y, Clarençon F. 2022. Benefit of Mechanical Thrombectomy in Acute Ischemic Stroke Related to Calcified Cerebral Embolus. J Neuroradiol https://doi.org/10.1016/j.neurad.2022.02.006.
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Turc G, Tsivgoulis G, Audebert HJ, Boogaarts H, Bhogal P, De Marchis GM, Fonseca AC, Khatri P, Mazighi M, Pérez de la Ossa N, Schellinger PD, Strbian D, Toni D, White P, Whiteley W, Zini A, van Zwam W, Fiehler J. 2022. European Stroke Organisation (ESO)-European Society for Minimally Invasive Neurological Therapy (ESMINT) expedited recommendation on indication for intravenous thrombolysis before mechanical thrombectomy in patients with acute ischemic stroke and anterior circulation large vessel occlusion. J Neurointerv Surg 14:209.
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Anadani M, Januel AC, Finitsis S, Clarençon F, Richard S, Marnat G, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Blanc R, Lapergue B, Consoli A, Eugene F, Vannier S, Caroff J, Denier C, Boulanger M, Gauberti M, Rouchaud A, Macian Montoro F, Rosso C, Ben Hassen W, Turc G, Ozkul-Wermester O, Papagiannaki C, Albucher JF, Le Bras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, de Havenon A, Liebeskind DS, Maier B, Gory B. 2022. Effect of intravenous thrombolysis before endovascular therapy on outcome according to collateral status: insight from the ETIS Registry. J Neurointerv Surg https://doi.org/10.1136/neurintsurg-2021-018170.
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De Broucker C, Plessier A, Ollivier-Hourmand I, Dharancy S, Bureau C, Cervoni JP, Sogni P, Goria O, Corcos O, Sartoris R, Ronot M, Vilgrain V, de Raucourt E, Zekrini K, Davy H, Durand F, Payancé A, Fidouh-Houhou N, Yazdanpanah Y, Valla D, Rautou PE. 2022. Multicenter study on recent portal venous system thrombosis associated with cytomegalovirus disease. J Hepatol 76:115–122.
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Maïer B, Gory B, Lapergue B, Sibon I, Escalard S, Kyheng M, Labreuche J, de Havenon A, Petersen N, Anadani M, Gayat E, Boursin P, Ben Maacha M, Desilles JP, Blanc R, Piotin M, Halimi JM, Mazighi M. 2022. Effect of blood pressure variability in the randomized controlled BP TARGET trial. Eur J Neurol 29:771–781.
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Jaquet P, Legouy C, Le Fevre L, Grinea A, Sinnah F, Franchineau G, Patrier J, Marzouk M, Wicky PH, Alexis Geoffroy P, Arnoult F, Vledouts S, de Montmollin E, Bouadma L, Timsit JF, Sharshar T, Sonneville R. 2022. Neurologic Outcomes of Survivors of COVID-19-Associated Acute Respiratory Distress Syndrome Requiring Intubation. Crit Care Med https://doi.org/10.1097/ccm.0000000000005500.
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de Montmollin E, Dupuis C, Jaquet P, Sarton B, Sazio C, Susset V, Conrad M, Argaud L, Demeret S, Tadié JM, Barbier F, Wolff M, Timsit JF, Visseaux B, Sonneville R. 2022. Herpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact. Crit Care Med https://doi.org/10.1097/ccm.0000000000005485.
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Plessier A, Esposito-Farèse M, Baiges A, Shukla A, Pagan JCG, De Raucourt E, Ollivier-Hourmand I, Cervoni JP, De Ledinghen V, Tazi Z, Nousbaum JB, Bun R, Bureau C, Silvain C, Tournilhac O, Gerfaud-Valentin M, Durand F, Goria O, Tellez L, Albillos A, Gioia S, Riggio O, De Gottardi A, Payance A, Rautou PE, Terriou L, Charbonnier A, Elkrief L, de la Tour RP, Valla DC, Gault N, de Fontbrune FS. 2022. Paroxysmal nocturnal hemoglobinuria and vascular liver disease: Eculizumab therapy decreases mortality and thrombotic complications. Am J Hematol https://doi.org/10.1002/ajh.26474.
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Bourrienne MC, Loyau S, Benichi S, Gay J, Solo-Nomenjanahary M, Journé C, Di Meglio L, Freiherr von Seckendorff A, Desilles JP, Ho-Tin-Noé B, Ajzenberg N, Mazighi M. 2021. A Novel Mouse Model for Cerebral Venous Sinus Thrombosis. Transl Stroke Res 12:1055–1066.
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Guenego A, Dargazanli C, Weisenburger-Lile D, Gory B, Richard S, Ducroux C, Piotin M, Blanc R, Labreuche J, Lucas L, Aubertin M, Benali A, Bourcier R, Detraz L, Vannier S, Guillen M, Eugene F, Walker G, Lun R, Consoli A, Lapergue B, Fahed R. 2021. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms. World Neurosurg 149:e400–e414.
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Barral M, Pimpie C, Kaci R, Al-Dybiat I, Mirshahi M, Pocard M, Bonnin P. 2021. Assessment of Tumor Response in Mice with Ovarian Peritoneal Carcinomatosis using Doppler Ultrasound of the Superior Mesenteric Artery and Celiac Trunk. Ultrasound Med Biol 47:759–768.
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Le Moal M, Pannard A, Brient L, Richard B, Chorin M, Mineaud E, Wiegand C. 2021. Is the Cyanobacterial Bloom Composition Shifting Due to Climate Forcing or Nutrient Changes? Example of a Shallow Eutrophic Reservoir. Toxins (Basel) 13.
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Chezel J, Fischer Q, Nicaise Roland P, Abtan J, Faille D, Van Gysel D, Papo T, Ducrocq G, Sacre K. 2021. Primary antiphospholipid syndrome revealed by acute myocardial infarction in young adults: a prospective observational study. Thromb Res 198:151–153.
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Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH. 2021. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability. Thromb Haemost 121:543–546.
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Aymonnier K, Kawecki C, Arocas V, Boulaftali Y, Bouton MC. 2021. Serpins, New Therapeutic Targets for Hemophilia. Thromb Haemost 121:261–269.
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Nguyen TN, Haussen DC, Qureshi MM, Yamagami H, Fujinaka T, Mansour OY, Abdalkader M, Frankel M, Qiu Z, Taylor A, Lylyk P, Eker OF, Mechtouff L, Piotin M, Lima FO, Mont’Alverne F, Izzath W, Sakai N, Mohammaden M, Al-Bayati AR, Renieri L, Mangiafico S, Ozretic D, Chalumeau V, Ahmad S, Rashid U, Hussain SI, John S, Griffin E, Thornton J, Fiorot JA, Rivera R, Hammami N, Cervantes-Arslanian AM, Dasenbrock HH, Vu HL, Nguyen VQ, Hetts S, Bourcier R, Guile R, Walker M, Sharma M, Frei D, Jabbour P, Herial N, Al-Mufti F, Ozdemir AO, Aykac O, Gandhi D, Chugh C, Matouk C, Lavoie P, Edgell R, Beer-Furlan A, Chen M, Killer-Oberpfalzer M, Pereira VM, Nicholson P, Huded V, Ohara N, Watanabe D, Shin DH, Magalhaes PS, Kikano R, Ortega-Gutierrez S, Farooqui M, Abou-Hamden A, Amano T, Yamamoto R, Weeks A, Cora EA, Sivan-Hoffmann R, Crosa R, Möhlenbruch M, Nagel S, Al-Jehani H, Sheth SA, Lopez Rivera VS, Siegler JE, Sani AF, Puri AS, Kuhn AL, Bernava G, Machi P, Abud DG, Pontes-Neto OM, Wakhloo AK, Voetsch B, Raz E, Yaghi S, Mehta BP, Kimura N, Murakami M, Lee JS, Hong JM, Fahed R, Walker G, Hagashi E, Cordina SM, Roh HG, others. 2021. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic. Stroke Vasc Neurol 6:542–552.
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Zhu F, Ben Hassen W, Bricout N, Kerleroux B, Janot K, Gory B, Anxionnat R, Richard S, Marchal A, Blanc R, Piotin M, Consoli A, Trystram D, Rodriguez Regent C, Desilles JP, Weisenburger-Lile D, Escalard S, Herbreteau D, Ifergan H, Lima Maldonado I, Labreuche J, Henon H, Naggara O, Lapergue B, Boulouis G. 2021. Effect of Operator’s Experience on Proficiency in Mechanical Thrombectomy: A Multicenter Study. Stroke 52:2736–2742.
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Mazighi M, Thomalla G. 2021. Endovascular Therapy for Patients With Large Ischemic Strokes: Does Age Matter? Stroke 52:2229–2231.
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Maïer B, Robichon E, Bourcier R, Dargazanli C, Labreuche J, Thion LA, Leguen M, Riem R, Desilles JP, Boulouis G, Delvoye F, Hebert S, Redjem H, Smajda S, Escalard S, Blanc R, Piotin M, Lapergue B, Mazighi M. 2021. Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency. Stroke 52:2964–2967.
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Seners P, Dargazanli C, Piotin M, Sablot D, Bracard S, Niclot P, Baron JC, Turc G. 2021. Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion. Stroke 52:699–702.
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Olivot JM, Albucher JF, Guenego A, Thalamas C, Mlynash M, Rousseau V, Drif A, Christensen S, Sommet A, Viguier A, Darcourt J, Calvière L, Menegon P, Raposo N, Januel AC, Bonneville F, Tourdias T, Mazighi M, Sibon I, Albers GW, Cognard C. 2021. Mismatch Profile Influences Outcome After Mechanical Thrombectomy. Stroke 52:232–240.
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Happi Ngankou E, Gory B, Marnat G, Richard S, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Maïer B, Blanc R, Lapergue B, Consoli A, Vannier S, Spelle L, Denier C, Boulanger M, Gauberti M, Saleme S, Macian F, Clarençon F, Rosso C, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Lebras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Eugène F, Finitsis S. 2021. Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry. Stroke 52:e764–e768.
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Couture M, Finitsis S, Marnat G, Richard S, Bourcier R, Constant-Dits-Beaufils P, Dargazanli C, Arquizan C, Mazighi M, Blanc R, Eugène F, Vannier S, Spelle L, Denier C, Touzé E, Barbier C, Saleme S, Macian F, Rosso C, Clarençon F, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Lebras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Lapergue B, Consoli A, Gory B, Sibon I. 2021. Impact of Prior Antiplatelet Therapy on Outcomes After Endovascular Therapy for Acute Stroke: Endovascular Treatment in Ischemic Stroke Registry Results. Stroke 52:3864–3872.
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Aubertin M, Weisenburger-Lile D, Gory B, Richard S, Blanc R, Ducroux C, Piotin M, Labreuche J, Lucas L, Dargazanli C, Benali A, Bourcier R, Detraz L, Vannier S, Guillen M, Eugene F, Walker G, Lun R, Guenego A, Consoli A, Marnat G, Maier B, Lapergue B, Fahed R. 2021. First-Pass Effect in Basilar Artery Occlusions: Insights From the Endovascular Treatment of Ischemic Stroke Registry. Stroke 52:3777–3785.
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Arling G, Mazighi M. 2021. Cost-Effectiveness of Mechanical Thrombectomy for Treatment of Stroke: From Modeling to Real-World Implementation. Stroke 52:674–676.
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Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Siddiqui A, Ribo M, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, de Havenon A, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B. 2021. Endovascular Therapy of Anterior Circulation Tandem Occlusions: Pooled Analysis From the TITAN and ETIS Registries. Stroke 52:3097–3105.
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Gendreau S, Porcher R, Thoreau B, Paule R, Maurier F, Goulenok T, Frumholtz L, Bernigaud C, Ingen-Housz-Oro S, Mekinian A, Audemard-Verger A, Gaillet A, Perard L, Samson M, Sonneville R, Arlet JB, Mirouse A, Kahn JE, Charpentier J, Hachulla É, Hummel A, Pires T, Carron PL, Durel CA, Jourde W, Puechal X, Lega JC, Sarrot-Reynauld F, Tieulie N, Diot E, Guillevin L, Terrier B. 2021. Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract. Semin Arthritis Rheum 51:436–441.
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