Team 6: Hemostasis, Thrombo-Inflammation and Neurovascular Repair

Team leaders: Marie-Christine BOUTON & Nathalie KUBIS

Team 6 comprises 6 interconnected groups, each with a specific research theme and a dedicated group leader:

The team 6 projects are focused on hemostasis, thrombosis and vascular injury, but are also involved in developing therapeutic strategies for cerebral ischemia at the acute and at the chronic phase, as well as in ICU patients. We combine biochemical and cellular approaches, in vivo experimental models and clinical researches for translational application.

Recently, we have demonstrated that:

  • Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
  • GPVI is a platelet receptor with a central role in the repairing functions of platelets
  • There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
  • Immunomodulation and cell therapy might help to improve post-stroke functional recovery
  • Neutrophil extracellular traps interfere with thrombolysis

We have also developed:

  • New imaging modalities for intracranial vascular studies
  • Innovative endovascular approaches for the treatment of intracranial vascular malformations

Our major common research themes are:

  •  Coagulation disorders (haemophilia, thrombophilia…)
  •  Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation)
  •  Vascular and cerebral injury (stroke, aneurysms)
  •  Cerebral plasticity
  • The search for prognostic markers of functional outcome in stroke and neuro-ICU patients
Family name
First name
Position
Tel
Email
AJZENBERGNadinePUPH101.40.25.85.21nadine.ajzenberg@aphp.fr
AROCASVéroniqueCR01.40.25.75.32veronique.arocas@inserm.fr
BLANCRaphaelPHrblanc29@gmail.com
BONNINPhilippeMCUPHHCphilippe.bonnin@aphp.fr
BOULAFTALIYacineCR01.40.25.86.15yacine.boulaftali@inserm.fr
BOURRIENNEMarie-CharlotteDoctorantmarie.bourienne@inserm.fr
BOUTIGNYAlexandrePHUalexandre.boutigny@gmail.com
BOUTONMarie-ChristineDR201.40.25.75.32marie-christine.bouton@inserm.fr
DE RAUCOURTEmmanuellePHemmanuelle.de-raucourt@aphp.fr
DESILLESJean-PhilippePHU01.40.25.86.01jpdesilles@gmail.com
DI MEGLIOLucasDoctorant01.40.25.86.01lucas.dimeglio@gmail.com
DUPONTSébastienIRsebastien.dupont@inserm.fr
EMMELINYannTCHyann.emmelin@inserm.fr
FAILLEDorothéeMCUPH01.40.25.85.21dorothee.faille@aphp.fr
HO-TIN-NOEBenoitCR01.40.25.86.03benoit.ho-tin-noe@inserm.fr
JADOUISoumayaDoctorantjadoui.soumaya@hotmail.fr
JANDROT-PERRUSMartineDREM01.40.25.75.31martine.jandrot-perrus@inserm.fr
KUBISNathaliePUPH101.49.95.80.88nathalie.kubis@aphp.fr
LE CHAPELAINOphélieDoctorantophelie.lechapelain@gmail.com
LEBASHéloisePOST-DOCheloise.lebas@inserm.fr
LOYAUStéphaneIE01.40.25.75.33stephane.loyau@inserm.fr
LOZERONPierreMCUPH1pierre.lozeron@aphp.fr
MADJENECélinaDoctorant01.40.25.75.33celina.madjene@inserm.fr
MARTOSRaphaelDoctorantraphael.martos@inserm.fr
MAUPUClemenceDoctorantemaupu.clemence@gmail.com
MAZIGHIMikaelPUPH01.40.25.70.33mikael.mazighi@aphp.fr
NOBRECatlineTCHcatline.nobre@inserm.fr
OLLIVIERVéroniqueIE01.40.25.86.03veronique.ollivier@inserm.fr
PIOTINMichelPHUmpiotin@for.paris
RICHARDBenjaminMCF01.40.25.86.15benjamin.richard@inserm.fr
SOLO NOMENJANAHARYMialitianaAI01.40.25.86.01mialitiana.solo-nomenjanahary@inserm.fr
SONNEVILLERomainPUPH01.40.25.61.39romain.sonneville@aphp.fr
VENISSELaurenceAI01.40.25.75.33laurence.venisse@inserm.fr
YAHIAOUIKatiaDoctorantkatia_yahiaoui@hotmail.fr
ZALGHOUTSaraDoctorantsarazalghout95@gmail.com
1.
Weisenburger-Lile D, Blanc R, Kyheng M, Desilles J-P, Labreuche J, Piotin M, Mazighi M, Consoli A, Lapergue B, Gory B, on behalf of the Endovascular Treatment in Ischemic Stroke Investigators. 2019. Direct Admission versus Secondary Transfer for Acute Stroke Patients Treated with Intravenous Thrombolysis and Thrombectomy: Insights from the Endovascular Treatment in Ischemic Stroke Registry. Cerebrovascular Diseases (Basel, Switzerland) 1–9.
1.
Zlatanova I, Pinto C, Bonnin P, Mathieu JRR, Bakker W, Vilar J, Lemitre M, Voehringer D, Vaulont S, Peyssonnaux C, Silvestre J-S. 2019. Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury. Circulation 139:1530–1547.
1.
Zhu F, Labreuche J, Haussen DC, Piotin M, Steglich-Arnholm H, Taschner C, Papanagiotou P, Lapergue B, Dorn F, Cognard C, Killer M, Psychogios MN, Spiotta A, Mazighi M, Bracard S, Turjman F, Richard S, Gory B, Investigators T. 2019. Hemorrhagic Transformation After Thrombectomy for Tandem Occlusions. Stroke 50:516–519.
1.
Seners P, Caroff J, Chausson N, Turc G, Denier C, Piotin M, Aghasaryan M, Alecu C, Chassin O, Lapergue B, Naggara O, Ferrigno M, Arquizan C, Cho T-H, Narata A-P, Richard S, Bricout N, Mazighi M, Costalat V, Gory B, Debiais S, Consoli A, Bracard S, Oppenheim C, Mas J-L, Smadja D, Spelle L, Baron J-C. 2019. Recanalization before Thrombectomy in Tenecteplase vs. Alteplase-Treated Drip-and-Ship Patients. Journal of Stroke 21:105–107.
1.
Voors-Pette C, Lebozec K, Dogterom P, Jullien L, Billiald P, Ferlan P, Renaud L, Favre-Bulle O, Avenard G, Machacek M, Plétan Y, Jandrot-Perrus M. 2019. Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab. Arteriosclerosis, Thrombosis, and Vascular Biology 39:956–964.
1.
Turc G, Bhogal P, Fischer U, Khatri P, Lobotesis K, Mazighi M, Schellinger PD, Toni D, de Vries J, White P, Fiehler J. 2019. European Stroke Organisation (ESO) - European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischemic Stroke. Journal of Neurointerventional Surgery.
1.
Seners P, Delepierre J, Turc G, Henon H, Piotin M, Arquizan C, Cho T-H, Lapergue B, Cottier J-P, Richard S, Legrand L, Bricout N, Mazighi M, Dargazanli C, Nighoghossian N, Consoli A, Debiais S, Bracard S, Naggara O, Leclerc X, Obadia M, Costalat V, Berthezène Y, Tisserand M, Narata A-P, Gory B, Mas J-L, Oppenheim C, Baron J-C, Collaborators P-R. 2019. Thrombus Length Predicts Lack of Post-Thrombolysis Early Recanalization in Minor Stroke With Large Vessel Occlusion. Stroke 50:761–764.
1.
Rosso C, Blanc R, Ly J, Samson Y, Lehéricy S, Gory B, Marnat G, Mazighi M, Consoli A, Labreuche J, Saleme S, Costalat V, Bracard S, Desal H, Piotin M, Lapergue B, Trial A, Investigators P-S. 2019. Impact of infarct location on functional outcome following endovascular therapy for stroke. Journal of Neurology, Neurosurgery, and Psychiatry 90:313–319.
1.
Pillois X, Guy A, Choquet É, James C, Tuffigo M, Viallard J-F, Garcia C, Bordet J-C, Jandrot-Perrus M, Payrastre B, Fiore M. 2019. First description of an IgM monoclonal antibody causing αIIb β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia. Journal of thrombosis and haemostasis: JTH 17:795–802.
1.
Panni P, Gory B, Xie Y, Consoli A, Desilles J-P, Mazighi M, Labreuche J, Piotin M, Turjman F, Eker OF, Bracard S, Anxionnat R, Richard S, Hossu G, Blanc R, Lapergue B, Investigators E. 2019. Acute Stroke With Large Ischemic Core Treated by Thrombectomy. Stroke 50:1164–1171.
1.
Pons S, Sonneville R, Bouadma L, Styfalova L, Ruckly S, Neuville M, Radjou A, Lebut J, Dilly M-P, Mourvillier B, Dorent R, Nataf P, Wolff M, Timsit J-F. 2019. Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation. Annals of Intensive Care 9:17.
1.
Oddo M, Bracard S, Cariou A, Chanques G, Citerio G, Clerckx B, Godeau B, Godier A, Horn J, Jaber S, Jung B, Kuteifan K, Leone M, Mailles A, Mazighi M, Mégarbane B, Outin H, Puybasset L, Sharshar T, Sandroni C, Sonneville R, Weiss N, Taccone FS. 2019. Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care. Annals of Intensive Care 9:47.
1.
Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Härdtner C, Koentges C, Kienle K, Ollivier V, Schell M, Dorner L, Wippel C, Stallmann D, Normann C, Bugger H, Walther P, Wolf D, Ahrens I, Lämmermann T, Ho-Tin-Noé B, Ley K, Bode C, Hilgendorf I, Duerschmied D. 2019. Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Circulation 139:918–931.
1.
Mangin G, Poittevin M, Charriaut-Marlangue C, Giannesini C, Merkoulova-Rainon T, Kubis N. 2019. Glatiramer acetate reduces infarct volume in diabetic mice with cerebral ischemia and prevents long-term memory loss. Brain, Behavior, and Immunity.
1.
Mangin G, Kubis N. 2019. Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story. Stem Cell Reviews 15:176–193.
1.
Lejealle C, Paradis V, Bruno O, de Raucourt E, Francoz C, Soubrane O, Lebrec D, Bedossa P, Valla D, Mal H, Vilgrain V, Durand F, Rautou P-E. 2019. Evidence for an Association Between Intrahepatic Vascular Changes and the Development of Hepatopulmonary Syndrome. Chest 155:123–136.
1.
Khoury N, Dargazanli C, Guenego A, Zuber K, Ekmen A, Charbonnier G, Hebert S, Capron J, Sabben C, Morvan E, Boisseau W, Maier B, Premat K, Clarençon F, Smajda S, Redjem H, Chalumeau V, Boulouis G, Chetrit A, Lecler A, Koskas P, Duron L, Ciccio G, Ducroux C, Escalard S, Desilles JP, Hamdani M, Lapergue B, Mazighi M, Ben Maacha M, Brikci-Nigassa N, Blanc R, Piotin M, Fahed R. 2019. Visual assessment of diffusion weighted imaging infarct volume lacks accuracy and reliability. Journal of Neurointerventional Surgery.
1.
Jandrot-Perrus M, Hermans C, Mezzano D. 2019. Platelet glycoprotein VI genetic quantitative and qualitative defects. Platelets 1–6.
1.
Ismail M, Armoiry X, Tau N, Zhu F, Sadeh-Gonik U, Piotin M, Blanc R, Mazighi M, Bracard S, Anxionnat R, Schmitt E, Mione G, Humbertjean L, Lacour J-C, Richard S, Barbier C, Lapergue B, Gory B. 2019. Mothership versus drip and ship for thrombectomy in patients who had an acute stroke: a systematic review and meta-analysis. Journal of Neurointerventional Surgery 11:14–19.
1.
Guy A, Gourdou-Latyszenok V, Le Lay N, Peghaire C, Kilani B, Dias JV, Duplaa C, Renault M-A, Denis C, Villeval JL, Boulaftali Y, Jandrot-Perrus M, Couffinhal T, James C. 2019. Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression. Haematologica 104:70–81.
1.
Guillaume M, Lapergue B, Gory B, Labreuche J, Consoli A, Mione G, Humbertjean L, Lacour J-C, Mazighi M, Piotin M, Blanc R, Richard S, Investigators ET in IS. 2019. Rapid Successful Reperfusion of Basilar Artery Occlusion Strokes With Pretreatment Diffusion-Weighted Imaging Posterior-Circulation ASPECTS <8 Is Associated With Good Outcome. Journal of the American Heart Association 8:e010962.
1.
Godier A, Garrigue D, Lasne D, Fontana P, Bonhomme F, Collet J-P, de Maistre E, Ickx B, Gruel Y, Mazighi M, Nguyen P, Vincentelli A, Albaladejo P, Lecompte T, Haemostasis FWG on P. 2019. Management of antiplatelet therapy for non-elective invasive procedures or bleeding complications: Proposals from the French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Thrombosis and Haemostasis (GFHT), in collaboration with the French Society for Anaesthesia and Intensive Care (SFAR). Archives of Cardiovascular Diseases 112:199–216.
1.
El Nawar R, Lapergue B, Piotin M, Gory B, Blanc R, Consoli A, Rodesch G, Mazighi M, Bourdain F, Kyheng M, Labreuche J, Pico F, Investigators E. 2019. Higher Annual Operator Volume Is Associated With Better Reperfusion Rates in Stroke Patients Treated by Mechanical Thrombectomy: The ETIS Registry. JACC Cardiovascular interventions 12:385–391.
1.
Delattre C, Velazquez D, Roques C, Pavon-Djavid G, Ollivier V, Lokajczyk A, Avramoglou T, Gueguen V, Louedec L, Caligiuri G, Jandrot-Perrus M, Boisson-Vidal C, Letourneur D, Meddahi-Pelle A. 2019. In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent. BioImpacts: BI 9:25–36.
1.
Desilles J-P, Mazighi M, Ho-Tin-Noé B. 2019. Letter by Desilles et al Regarding Article, “Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke.” Stroke 50:e98.
1.
Bohec P, Gachelin J, Ollivier V, Mutin T, Télot X, Ho-Tin-Noé B, Sanfilippo S. 2019. Acoustophoretic purification of platelets: feasibility and impact on platelet activation and function. Platelets 30:174–180.
1.
Anadani M, Spiotta A, Alawieh A, Turjman F, Piotin M, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Haussen DC, Nogueira R, Papanagiotou P, Boutchakova M, Siddiqui AH, Lapergue B, Dorn F, Cognard C, Killer-Oberpfalzer M, Mangiafico S, Ribo M, Psychogios M-N, Labeyrie M-A, Mazighi M, Biondi A, Anxionnat R, Bracard S, Richard S, Gory B, Investigators T. 2019. Effect of extracranial lesion severity on outcome of endovascular thrombectomy in patients with anterior circulation tandem occlusion: analysis of the TITAN registry. Journal of Neurointerventional Surgery.
1.
Zhu F, Lapergue B, Kyheng M, Blanc R, Labreuche J, Ben Machaa M, Duhamel A, Marnat G, Saleme S, Costalat V, Bracard S, Richard S, Desal H, Mazighi M, Consoli A, Piotin M, Gory B, Investigators AT. 2018. Similar Outcomes for Contact Aspiration and Stent Retriever Use According to the Admission Clot Burden Score in ASTER. Stroke 49:1669–1677.
1.
Widimsky P, Doehner W, Diener HC, Van Gelder IC, Halliday A, Mazighi M, Stroke EC on. 2018. The role of cardiologists in stroke prevention and treatment: position paper of the European Society of Cardiology Council on Stroke. European Heart Journal 39:1567–1573.
1.
Voicu S, Sideris G, Dillinger J-G, Yannopoulos D, Deye N, Kang C, Bonneau M, Bartos J, Kedra A, Bailliart S, Pasteur-Rousseau A, Amah G, Bonnin P, Callebert J, Henry P, Megarbane B. 2018. Synchronized Pulsatile Flow With Low Systolic Output From Veno-Arterial Extracorporeal Membrane Oxygenation Improves Myocardial Recovery After Experimental Cardiac Arrest in Pigs. Artificial Organs 42:597–604.
1.
Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A, International ECMO Network the RRN, Group the IS. 2018. Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO. An International Multicenter Retrospective Study. American Journal of Respiratory and Critical Care Medicine.
1.
Stefanini L, Lee RH, Paul DS, O’Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W. 2018. Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood 132:1951–1962.
1.
Sinnah F, Dalloz M-A, Magalhaes E, Wanono R, Neuville M, Smonig R, Radjou A, Mourvillier B, Bouadma L, Timsit J-F, d’Ortho M-P, Rouvel-Tallec A, Sonneville R. 2018. Early Electroencephalography Findings in Cardiogenic Shock Patients Treated by Venoarterial Extracorporeal Membrane Oxygenation. Critical Care Medicine 46:e389–e394.
1.
Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B. 2018. The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. Haematologica 103:e256–e258.
1.
Rautou P-E, Busse J, Kheloufi M, Vion A-C, Boulaftali Y, Stark K, Boulanger CM. 2018. Endothelial Autophagy Does Not Influence Venous Thrombosis in Mice. Thrombosis and Haemostasis 118:1113–1115.
1.
Saultier P, Szepetowski S, Canault M, Falaise C, Poggi M, Suchon P, Barlogis V, Michel G, Loyau S, Jandrot-Perrus M, Bordet J-C, Alessi M-C, Chambost H. 2018. Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation. Haematologica 103:e264–e267.
1.
Papanagiotou P, Haussen DC, Turjman F, Labreuche J, Piotin M, Kastrup A, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Nogueira RG, Boutchakova M, Siddiqui A, Lapergue B, Dorn F, Cognard C, Killer M, Mangiafico S, Ribo M, Psychogios MN, Spiotta A, Labeyrie MA, Biondi A, Mazighi M, Richard S, Anxionnat R, Bracard S, Gory B, Investigators T. 2018. Carotid Stenting With Antithrombotic Agents and Intracranial Thrombectomy Leads to the Highest Recanalization Rate in Patients With Acute Stroke With Tandem Lesions. JACC Cardiovascular interventions 11:1290–1299.
1.
Merkulova-Rainon T, Mantsounga CS, Broquères-You D, Pinto C, Vilar J, Cifuentes D, Bonnin P, Kubis N, Henrion D, Silvestre J-S, Lévy BI. 2018. Peripheral post-ischemic vascular repair is impaired in a murine model of Alzheimer’s disease. Angiogenesis 21:557–569.
1.
Lê BV, Jandrot-Perrus M, Couture C, Checkmahomed L, Venable M-C, Hamelin M-È, Boivin G. 2018. Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice. The Journal of General Virology 99:1367–1380.
1.
Mangin PH, Onselaer M-B, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP. 2018. Immobilized fibrinogen activates human platelets through glycoprotein VI. Haematologica 103:898–907.
1.
Maïer B, Turc G, Taylor G, Blanc R, Obadia M, Smajda S, Desilles J-P, Redjem H, Ciccio G, Boisseau W, Sabben C, Ben Machaa M, Hamdani M, Leguen M, Gayat E, Blacher J, Lapergue B, Piotin M, Mazighi M, Investigators ET in IS. 2018. Prognostic Significance of Pulse Pressure Variability During Mechanical Thrombectomy in Acute Ischemic Stroke Patients. Journal of the American Heart Association 7:e009378.
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Maïer B, Boursin P, Mazighi M. 2018. [Acute phase of stroke: every minute counts]. Soins; La Revue De Reference Infirmiere 63:28–31.
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Lozeron P, Tcheumeni NC, Turki S, Amiel H, Meppiel E, Masmoudi S, Roos C, Crassard I, Plaisance P, Benbetka H, Guichard J-P, Houdart E, Baudoin H, Kubis N. 2018. Contribution of EEG in transient neurological deficits. Journal of Neurology 265:89–97.
1.
Loyau S, Ho-Tin-Noé B, Bourrienne M-C, Boulaftali Y, Jandrot-Perrus M. 2018. Microfluidic Modeling of Thrombolysis. Arteriosclerosis, Thrombosis, and Vascular Biology 38:2626–2637.
1.
Lo Dico R, Tijeras-Raballand A, Bonnin P, Launay JM, Kaci R, Pimpie C, Malgras B, Dohan A, Lo Dico GM, Pocard M. 2018. Hepatectomy increases metastatic graft and growth in an immunocompetent murine model of peritoneal metastases. European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 44:784–791.
1.
Lehmann M, Schoeman RM, Krohl PJ, Wallbank AM, Samaniuk JR, Jandrot-Perrus M, Neeves KB. 2018. Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI-Dependent Manner in an In Vitro Venous Thrombosis Model. Arteriosclerosis, Thrombosis, and Vascular Biology 38:1052–1062.
1.
Le Bouc R, Clarençon F, Meseguer E, Lapergue B, Consoli A, Turc G, Naggara O, Duong DL, Servan J, Reiner P, Labeyrie MA, Fisselier M, Blanc R, Farhat W, Pires C, Zuber M, Obadia M, Mazighi M, Pico F, Mas J-L, Amarenco P, Samson Y, Consortium PS. 2018. Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity. Stroke 49:1686–1694.
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Ho-Tin-Noé B, Boulaftali Y, Camerer E. 2018. Platelets and vascular integrity: how platelets prevent bleeding in inflammation. Blood 131:277–288.
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Ho-Tin-Noé B. 2018. The multifaceted roles of platelets in inflammation and innate immunity. Platelets 29:531–532.
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Lapergue B, Labreuche J, Blanc R, Barreau X, Berge J, Consoli A, Rodesch G, Saleme S, Costalat V, Bracard S, Desal H, Duhamel A, Baffert S, Mazighi M, Gory B, Turjman F, Piotin M, Investigators AT. 2018. First-line use of contact aspiration for thrombectomy versus a stent retriever for recanalization in acute cerebral infarction: The randomized ASTER study protocol. International Journal of Stroke: Official Journal of the International Stroke Society 13:87–95.