Team leaders: Marie-Christine BOUTON & Nathalie KUBIS
Team 6 comprises 6 interconnected groups, each with a specific research theme and a dedicated group leader:
The team 6 projects are focused on hemostasis, thrombosis and vascular injury, but are also involved in developing therapeutic strategies for cerebral ischemia at the acute and at the chronic phase, as well as in ICU patients. We combine biochemical and cellular approaches, in vivo experimental models and clinical researches for translational application.
Recently, we have demonstrated that:
- Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
- GPVI is a platelet receptor with a central role in the repairing functions of platelets
- There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
- Immunomodulation and cell therapy might help to improve post-stroke functional recovery
- Neutrophil extracellular traps interfere with thrombolysis
We have also developed:
- New imaging modalities for intracranial vascular studies
- Innovative endovascular approaches for the treatment of intracranial vascular malformations
Our major common research themes are:
- Coagulation disorders (haemophilia, thrombophilia…)
- Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation)
- Vascular and cerebral injury (stroke, aneurysms)
- Cerebral plasticity
- The search for prognostic markers of functional outcome in stroke and neuro-ICU patients
Family name | First name | Position | Tel | Email |
---|---|---|---|---|
AJZENBERG | Nadine | PUPH1 | 01.40.25.85.21 | nadine.ajzenberg@aphp.fr |
AROCAS | Véronique | CR | 01.40.25.75.32 | veronique.arocas@inserm.fr |
BILLIALD | Philippe | PR | philippe.billiald@u-psud.fr | |
BOULAFTALI | Yacine | CR | 01.40.25.86.15 | yacine.boulaftali@inserm.fr |
BOUTIGNY | Alexandre | PHU | alexandre.boutigny@gmail.com | |
BOUTON | Marie-Christine | DR2 | 01.40.25.75.32 | marie-christine.bouton@inserm.fr |
DADDI | Kaouter | M2 | kawtar.daddi@gmail.com | |
DE RAUCOURT | Emmanuelle | PH | emmanuelle.de-raucourt@aphp.fr | |
FAILLE | Dorothée | MCUPH | 01.40.25.85.21 | dorothee.faille@aphp.fr |
FRANÇOIS | Déborah | IR | deborahfrancois27@gmail.com | |
GRES | Pierre | M2 | pierre.gres@inserm.fr | |
JANDROT-PERRUS | Martine | DREM | 01.40.25.75.31 | martine.jandrot-perrus@inserm.fr |
KERNANET | Lambert | M2 | lkernanet@gmail.com | |
LOYAU | Stéphane | IE | 01.40.25.75.33 | stephane.loyau@inserm.fr |
MADJENE | Célina | Doctorant | 01.40.25.75.33 | celina.madjene@inserm.fr |
MAUPU | Clemence | Doctorant | clemence.maupu@inserm.fr | |
NUZZO | Alexandre | MCUPH | alexandre.nuzzo@aphp.fr | |
OLLIVIER | Véronique | IR | 01.40.25.86.03 | veronique.ollivier@inserm.fr |
RICHARD | Benjamin | MCF | 01.40.25.86.15 | benjamin.richard@inserm.fr |
SALEM | Karima | AI | karima.salem@inserm.fr | |
SALFATI | Jonas | AI | jonas.salfati@inserm.fr | |
SOLO NOMENJANAHARY | Mialitiana | AI | 01.40.25.86.01 | mialitiana.solo-nomenjanahary@inserm.fr |
TURNATURI | Carlotta | AI | carlotta.turnaturi@inserm.fr | |
YU | Junjie (Jay) | Doctorant | junjie.yu@inserm.fr |
Publications
2460799
CRH5CKDT
2022
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Nuzzo A, Czernichow S, Hertig A, Ledoux S, Poghosyan T, Quilliot D, Le Gall M, Bado A, Joly F. 2022. [Nutritionnal complications and patients follow-up after bariatric surgery]. Rev Prat 72:168–175.
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Najdawi M, Garzelli L, Nuzzo A, Huguet A, Raynaud L, Paulatto L, Panis Y, Ben Abdallah I, Castier Y, Sibert A, Vilgrain V, Corcos O, Ronot M. 2022. Endovascular revascularization of acute arterial mesenteric ischemia: report of a 3-year experience from an intestinal stroke center unit. Eur Radiol 32:5606–5615.
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Houdeville C, Leenhardt R, Souchaud M, Velut G, Carbonell N, Nion-Larmurier I, Nuzzo A, Histace A, Marteau P, Dray X. 2022. Evaluation by a Machine Learning System of Two Preparations for Small Bowel Capsule Endoscopy: The BUBS (Burst Unpleasant Bubbles with Simethicone) Study. J Clin Med 11.
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Ksouri A, Copin P, Bonvalet F, Bozi L, Cazals-Hatem D, Garzelli L, Panis Y, Weiss E, Castier Y, Bouhnik Y, Corcos O, Vilgrain V, Ronot M, Nuzzo A. 2022. Colonic involvement in acute mesenteric ischemia: prevalence, risk factors, and outcomes. Eur Radiol 32:2813–2823.
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Garzelli L, Nuzzo A, Hamon A, Ben Abdallah I, Gregory J, Raynaud L, Paulatto L, Dioguardi Burgio M, Castier Y, Panis Y, Vilgrain V, Corcos O, Ronot M. 2022. Reperfusion injury on computed tomography following endovascular revascularization of acute mesenteric ischemia: prevalence, risk factors, and patient outcome. Insights Imaging 13:194.
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Garzelli L, Felli E, Al-Taher M, Barberio M, Agnus V, Plaforet V, Bonvalet F, Baiocchini A, Nuzzo A, Paulatto L, Vilgrain V, Gallix B, Diana M, Ronot M. 2022. MRI for the Detection of Small Bowel Ischemic Injury in Arterial Acute Mesenteric Ischemia: Preclinical Study in a Porcine Model. J Magn Reson Imaging https://doi.org/10.1002/jmri.28344.
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Ben Abdallah I, Craiem D, Casciaro M, Deza D, Garzelli L, Nuzzo A, Corcos O, Ronot M, Castier Y, El Batti S. 2022. Volumetric analysis of progressive remodeling of isolated mesenteric artery dissection treated by conservative therapy. J Vasc Interv Radiol https://doi.org/10.1016/j.jvir.2022.11.009.
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Ben Abdallah I, Huguet A, Nuzzo A, Mirault T, Roussel A, El Batti S, Ronot M, Castier Y, Corcos O. 2022. Acute Isolated Mesenteric Artery Dissection: Four Year Experience From a French Intestinal Stroke Centre. Eur J Vasc Endovasc Surg 64:656–664.
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Becq A, Chandnani M, Bartley A, Nuzzo A, Bilal M, Bharadwaj S, Cohen J, Gabr M, Berzin TM, Pleskow DK, Sawhney MS. 2022. ERCP within 6 or 12 h for acute cholangitis: a propensity score-matched analysis. Surg Endosc 36:2418–2429.
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https://lvts.fr/wp-content/plugins/zotpress/
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