Team 5: Atherothrombotic Disease in Heart and Brain

Group leader: Gabriel STEG

ClinicalresearchTeam 5 “Translational research on cardio- and cerebrovascular disease” started with an innovative collaboration of cardiologists and neurologists (formerly within the “clinical research on atherothrombosis” team) implemented by basic science researchers, coming from the former team on “Vascular Remodelling”. Our projects are focussed on 1/ international clinical trials assessing medical strategies and new therapies in coronary artery disease and cerebrovascular disease, particularly acute coronary syndromes and stroke, and 2/ on translational research aiming to uncover new biological markers of atherothrombosis in humans as a basis for new diagnostic/theranostic tools, but also for developing new therapeutic tools (in particular HDL-based therapies).

There is a dire need for therapies to help address the cardiovascular consequences of the diabetes and obesity epidemic. While important, this is not limited to the development of more potent and safer agents to prevent thrombosis, stabilize or prevent atherosclerosis, or treat hyperglycemia. The potential hazards (on cardiovascular mortality) of aggressive management of hyperglycemia have emphasized the need to fully assess the cardiovascular impact of antidiabetic drugs. Recent clinical trials also underlined the importance of rigorous evaluation of the clinical effectiveness of routine therapeutic strategies. Future treatments will need to demonstrate safety and cost-effectiveness in addition to efficacy. Our aim is to focus on new, effective, safe, affordable and easily implementable therapeutic strategies for atherothrombosis and diabetes.

Link to the Group on “Eicosanoids & Vascular Pharmacology”

Family name
First name
Position
Tel
Email
ABERGELHélèneIR01.57.27.53.57helene.abergel@aphp.fr
ABTANJérémieDoctorantjeremie.abtan@aphp.fr
AMARENCOPierrePUPH01.40.25.87.25pierre.amarenco@aphp.fr
BADJIHichem AhmedDoctorant01.40.25.75.29hichem.badji@inserm.fr
BOUFFARDCatherineTECHcatherine.bouffard@aphp.fr
BOUHADOUNAmelDoctorant01.40.25.75.29amelbouhadoun@gmail.com
CIMADEVILLAClairePHclaire.cimadevilla@aphp.fr
DUCROCQGregoryPUPHgregory.ducrocq@aphp.fr
ELBEZYedidAutre_ECyedid.elbez@aphp.fr
FARNOUDRezaIR01.57.27.53.52reza.farnoud@bch.aphp.fr
FELDMANLaurentPUPH01.40.25.66.01laurent.feldman@aphp.fr
FUENTESAxelleCDDBaxelle.fuentes@gmail.com
JULIARDJean-MichelPH01.40.25.85.21jean-michel.juliard@aphp.fr
LAVALLEEPhilippaMCUPH01.40.25.70.33philippalavallee@yahoo.fr
LONGROISDanPUPH01.40.25.74.27dan.longrois@aphp.fr
MERHEBGaelleStag M2gaelle.merheb@etu.u-paris.fr
MESEGUER GANCEDOElenaPH01.40.25.74.90elena.meseguer@aphp.fr
NGUYENCarolineCCA01.40.25.83.53caroline.nguyen@aphp.fr
NORELXavierIR01.40.25.75.29xnorel@hotmail.com
RENSONLouisStag M2louis.renson@aphp.fr
SIMONTabassomePUPHtabassome.simon@sat.aphp.fr
SORBETSEmmanuelPHemmanuel.sorbets@aphp.fr
SPIELERJean-FrançoisMCF01.40.25.87.28jean-francois.spieler@aphp.fr
STEGPhilippe GabrielPUPH01.40.25.73.25gabriel.steg@aphp.fr
TOUBOULPierre-JeanPUPH01.40.25.87.25pjtw@noos.fr

Publications

1.
Weizman O, Tea V, Marijon E, Eltchaninoff H, Manzo-Silberman S, Leclercq F, Albert F, Bataille V, Drouet E, Naccache N, Puymirat E, Ferrières J, Schiele F, Simon T, Danchin N. 2023. Very long-term outcomes after acute myocardial infarction in young men and women: Insights from the FAST-MI program. Arch Cardiovasc Dis 116:324–334.
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Mesnier J, Suc G, Sayah N, Abtan J, Steg PG. 2023. Relevance of medical information obtained from ChatGPT: Are large language models friends or foes? Arch Cardiovasc Dis 116:485–486.
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Tank A, Johnston SC, Jain R, Amarenco P, Mellström C, Rikner K, Denison H, Ladenvall P, Knutsson M, Himmelmann A, Evans SR, James S, Molina CA, Wang Y, Ouwens M. 2023. Cost-effectiveness of ticagrelor plus aspirin versus aspirin in acute ischaemic stroke or transient ischaemic attack: an economic evaluation of the THALES trial. BMJ Neurol Open 5:e000478.
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Khoury R, Dupin C, Nguyen C, Halut M, Mordant P, Khalil A. 2023. Unusual Case of High-Flow Left Heart Failure: Physiopathology, Multimodality Imaging, and Endovascular Management. Circ Cardiovasc Imaging 16:e014219.
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Mohammadi KA, Brackin T, Schwartz GG, Steg PG, Szarek M, Manvelian G, Pordy R, Fazio S, Geba GP. 2023. Effect of proprotein convertase subtilisin/kexin type 9 inhibition on cancer events: A pooled, post hoc, competing risk analysis of alirocumab clinical  trials. Cancer Med 12:16859–16868.
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Belhassen M, Hanon O, Steg PG, Mahé I, Née M, Jacoud F, Dalon F, Cotté F-E, Guitard-Dehoux D, Marant-Micallef C, Van Ganse E, Danchin N. 2023. Apixaban versus other anticoagulants in patients with nonvalvular fibrillation: a comparison of all-cause and event-related costs in real-life setting in France. Eur J Health Econ 24:867–875.
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Puymirat E, Soulat G, Fayol A, Mousseaux E, Montalescot G, Cayla G, Steg PG, Berard L, Rousseau A, Drouet É, Simon T, Danchin N. 2023. Rationale and design of the direct oral anticoagulants for prevention of left ventricular thrombus after anterior acute myocardial infarction (APERITIF) trial. Am Heart J 266:98–105.
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Goodman SG, Steg PG, Poulouin Y, Bhatt DL, Bittner VA, Diaz R, Garon G, Harrington RA, Jukema JW, Manvelian G, Stipek W, Szarek M, White HD, Schwartz GG. 2023. Long-Term Efficacy, Safety, and Tolerability of Alirocumab in 8242 Patients Eligible for 3 to 5 Years of Placebo-Controlled Observation in the ODYSSEY  OUTCOMES Trial. J Am Heart Assoc 12:e029216.
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Oqab Z, Kunadian V, Wood DA, Storey RF, Rao SV, Mehran R, Pinilla-Echeverri N, Mani T, Boone RH, Kassam S, Bossard M, Mansour S, Ball W, Sibbald M, Valettas N, Moreno R, Steg PG, Cairns JA, Mehta SR. 2023. Complete Revascularization Versus Culprit-Lesion-Only PCI in STEMI Patients With Diabetes and Multivessel Coronary Artery Disease: Results From the COMPLETE  Trial. Circ Cardiovasc Interv 16:e012867.
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Bouzid D, Kapfer T, Marot S, Ing V, Ferré VM, Chauvin A, Le Goff J, Ellouze S, Salmona M, Hermand C, Bourg A, Schnuriger A, Fémy F, Van Tinh MN, Brichler S, Veyer D, Le Borgne P, Fafi-Kremer S, L’Honneur AS, Augustin C, Simon T, Cachanado M, Freund Y. 2023. Outcomes of Omicron sub-lineages BA.1.1 and BA.2 infection compared with the sub-lineage BA.1 infection in emergency departments’ patients. Clin Microbiol Infect 29:551–553.
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Desroche L-M, Mandry D, Ducrocq G, Durand-Zaleski I, Alfaiate T, Millischer D, Milleron O, Huttin O, Valla M, Belle L, Lavie-Badie Y, Farah B, Diakov C, Logeart D, Safar B, Burdet C, Jondeau G. 2023. Multicentre medicoeconomic evaluation of cardiac magnetic resonance imaging for predicting coronary artery disease in left ventricular dysfunction: The CAMAREC  study design. Arch Cardiovasc Dis 116:366–372.
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Bensoussan Y, Martinez E, Van Der Woerd B, Johns M, Nguyen C, Watts S, O’Dell K. 2023. The Effect of Subglottic Steroid injection on Blood Glucose in a Cohort of Patients With Subglottic Stenosis. Laryngoscope 133:1590–1594.
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Carrière M, Prudentos J-B, Lecigne A, Laran A, Nguyen CT, Destruhaut F, Naveau A. 2023. Digital optimization of teeth setup in an edentulous patient with partial glossectomy: A case report. J Prosthodont 32:461–468.
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Suc G, Himbert D, Brochet E, Ducrocq G, Vahanian A, Urena M. 2023. Direct Transcatheter Mitral Valve-in-Ring Replacement to Treat a Failing Alfieri Valve Repair. JACC Cardiovasc Interv 16:1292–1294.
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Lacombe K, Hueso T, Porcher R, Mekinian A, Chiarabini T, Georgin-Lavialle S, Ader F, Saison J, Martin-Blondel G, De Castro N, Bonnet F, Cazanave C, Francois A, Morel P, Hermine O, Pourcher V, Michel M, Lescure X, Soussi N, Brun P, Pommeret F, Sellier P, Rousset S, Piroth L, Michot J-M, Baron G, de Lamballerie X, Mariette X, Tharaux P-L, Resche-Rigon M, Ravaud P, Simon T, Tiberghien P. 2023. Use of covid-19 convalescent plasma to treat patients admitted to hospital for covid-19 with or without underlying immunodeficiency: open label, randomised  clinical trial. BMJ Med 2:e000427.
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Pellenc Q, Renard R, Gaudemer A, Amarenco P, Lavallée P. 2023. Bypass grafting to the third segment of the vertebral artery for symptomatic extensive vertebrobasilar atherosclerotic disease. J Vasc Surg Cases Innov Tech 9:101260.
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Sitbon S, Ou P, Nguyen C, Ehmer C, Garbarz E, Brochet E, Fuchs A, Aubry P, Abtan J. 2023. Four-Dimensional Flow Magnetic Resonance Imaging Features of a Platypnea-Orthodeoxia Syndrome Caused by a Patent Foramen Ovale. Circ Cardiovasc Imaging 16:601–603.
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Steg PG, Kikoïne J. 2023. Do We Need Ischemia Testing to Monitor Asymptomatic Patients With Chronic Coronary Syndromes? Circulation 147:5–7.
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Henriksen BT, Krogseth M, Andersen RD, Davies MN, Nguyen CT, Mathiesen L, Andersson Y. 2023. Clinical pharmacist intervention to improve medication safety for hip fracture patients through secondary and primary care settings: a nonrandomised controlled  trial. J Orthop Surg Res 18:434.
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Abtan J, Bhatt DL, Elbez Y, Ducrocq G, Goto S, Smith SCJ, Ohman EM, Eagle KA, Fox K, Harrington RA, Leiter LA, Mehta SR, Simon T, Petrov I, Sinnaeve PR, Pais P, Lev E, Bueno H, Wilson P, Steg PG. 2023. External applicability of the Effect of ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) trial: An analysis of patients with  diabetes and coronary artery disease in the REduction of Atherothrombosis for  Continued Health (REACH) registry. Int J Cardiol 370:51–57.
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Coisne A, Scotti A, Taramasso M, Granada JF, Ludwig S, Rodés-Cabau J, Lurz P, Hausleiter J, Fam N, Kodali SK, Pozzoli A, Alessandrini H, Biasco L, Brochet E, Denti P, Estevez-Loureiro R, Frerker C, Ho EC, Monivas V, Nickenig G, Praz F, Puri R, Sievert H, Tang GHL, Andreas M, Von Bardeleben RS, Rommel K-P, Muntané-Carol G, Gavazzoni M, Braun D, Lubos E, Kalbacher D, Connelly KA, Juliard J-M, Harr C, Pedrazzini G, Philippon F, Schofer J, Thiele H, Unterhuber M, Himbert D, Alcázar MU, Wild MG, Jorde U, Windecker S, Maisano F, Leon MB, Hahn RT, Latib A. 2023. Prognostic Value of Tricuspid Valve Gradient After Transcatheter Edge-to-Edge Repair: Insights From the TriValve Registry. JACC Cardiovasc Interv S1936-8798(23)00452–1.
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Roule V, Beygui F, Cayla G, Range G, Motovska Z, Delarche N, Jourda F, Goube P, Guedeney P, Zeitouni M, El Kasty M, Laredo M, Dumaine R, Ducrocq G, Derimay F, Van Belle E, Manigold T, Cador R, Combaret N, Vicaut E, Montalescot G, Silvain J. 2023. P2Y(12) inhibitor loading time before elective PCI and the prevention of myocardial necrosis. Can J Cardiol S0828-282X(23)01647–1.
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Nicolau JC, Owen R, Furtado RHM, Goodman SG, Granger CB, Cohen MG, Westermann D, Yasuda S, Simon T, Hedman K, Hunt PR, Brieger DB, Pocock SJ. 2023. Long-term outcomes among stable post-acute myocardial infarction patients living in rural versus urban areas: insights from the prospective, observational TIGRIS  registry. Open Heart 10.
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Schou M, Claggett B, Miao ZM, Fernandez A, Filippatos G, Granger C, Jering K, Maggioni AP, McCausland F, Villota JN, Rouleau J-L, Mody FV, van der Meer P, Vinereanu D, McGrath M, Zhou Y, Mann DL, Solomon SD, Steg PG, Braunwald E, McMurray JJV, Pfeffer MA, Køber L. 2023. Sacubitril/valsartan compared to ramipril in high-risk post myocardial infarction patients stratified according use of mineralocorticoid receptor antagonists:  Insight from PARADISE MI trial. Eur J Heart Fail https://doi.org/10.1002/ejhf.3079.
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Teiger E, Eschalier R, Amabile N, Rioufol G, Ducrocq G, Garot P, Lepillier A, Bille J, Elbaz M, Defaye P, Audureau E, Le Corvoisier P. 2023. Left atrial appendage closure in very elderly patients in the French National Registry. Heart heartjnl-2023-322871.
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Collins HN, Johnson PI, Calderon NM, Clark PY, Gillis AD, Le AM, Nguyen D, Nguyen C, Fu L, O’Dwyer T, Harley KG. 2023. Differences in personal care product use by race/ethnicity among women in California: implications for chemical exposures. J Expo Sci Environ Epidemiol 33:292–300.
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Popovic B, Ducrocq G, Elbez Y, Bode C, Mehta SR, Pollack CV, Sabate M, Rao SV, Parkhomenko A, Feldman LJ, Sayah N, Sabatine MS, Steg PG. 2023. Clinical Significance of Culprit Vessel Occlusion in Patients With Non-ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary  Intervention. Am J Cardiol 188:95–101.
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Balagny P, Vidal-Petiot E, Renuy A, Matta J, Frija-Masson J, Steg PG, Goldberg M, Zins M, d’Ortho M-P, Wiernik E. 2023. Prevalence, treatment and determinants of obstructive sleep apnoea and its symptoms in a population-based French cohort. ERJ Open Res 9:00053–02023.
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Baber U, Spirito A, Sartori S, Angiolillo DJ, Briguori C, Cohen DJ, Collier T, Dangas G, Dudek D, Escaned J, Gibson CM, Han Y-L, Huber K, Kastrati A, Kaul U, Kornowski R, Krucoff M, Kunadian V, Vogel B, Mehta SR, Moliterno D, Sardella G, Shlofmitz RA, Sharma S, Steg PG, Pocock S, Mehran R. 2023. Clinically Driven Revascularization in High-Risk Patients Treated With Ticagrelor Monotherapy After PCI: Insights from the Randomized TWILIGHT Trial. Am J Cardiol 208:16–24.
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Durand-Zaleski I, Ducrocq G, Mimouni M, Frenkiel J, Avendano-Solá C, Gonzalez-Juanatey JR, Ferrari E, Lemesle G, Puymirat E, Berard L, Cachanado M, Arnaiz JA, Martínez-Sellés M, Silvain J, Ariza-Solé A, Calvo G, Danchin N, Paco S, Drouet E, Abergel H, Rousseau A, Simon T, Steg PG. 2023. Economic evaluation of restrictive vs. liberal transfusion strategy following acute myocardial infarction (REALITY): trial-based cost-effectiveness and  cost-utility analyses. Eur Heart J Qual Care Clin Outcomes 9:194–202.
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Aggarwal R, Bhatt DL, Szarek M, Cannon CP, McGuire DK, Inzucchi SE, Lopes RD, Davies MJ, Banks P, Pitt B, Steg PG. 2023. Efficacy of Sotagliflozin in Adults With Type 2 Diabetes in Relation to Baseline Hemoglobin A1c. J Am Coll Cardiol 82:1842–1851.
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Thompson HR, Madsen KA, Nguyen C, Argenio K, D’Agostino E, Konty K, Day S. 2023. School-level self-reported versus objective measurements of body mass index in public high school students. Prev Med 174:107616.
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Gautier A, Picard F, Ducrocq G, Elbez Y, Fox KM, Ferrari R, Ford I, Tardif J-C, Tendera M, Steg PG. 2023. New-onset atrial fibrillation in chronic coronary syndrome: the CLARIFY registry. Eur Heart J ehad556.
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Silvain J, Lattuca B, Puymirat E, Ducrocq G, Dillinger J-G, Lhermusier T, Procopi N, Cachanado M, Drouet E, Abergel H, Danchin N, Montalescot G, Simon T, Steg PG. 2023. Impact of transfusion strategy on platelet aggregation and biomarkers in myocardial infarction patients with anemia. Eur Heart J Cardiovasc Pharmacother 9:647–657.
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Butt JH, Claggett BL, Miao ZM, Jering KS, Sim D, van der Meer P, Ntsekhe M, Amir O, Cho M-C, Carrillo-Calvillo J, Núñez JE, Cadena A, Kerkar P, Maggioni AP, Steg PG, Granger CB, Mann DL, Merkely B, Lewis EF, Solomon SD, Zhou Y, Køber L, Braunwald E, McMurray JJV, Pfeffer MA. 2023. Geographic differences in patients with acute myocardial infarction in the PARADISE-MI trial. Eur J Heart Fail 25:1228–1242.
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Delhomme C, Urena M, Chong-Nguyen C, Brochet E, Ducrocq G, Iung B, Himbert D. 2023. Emergent transcatheter mitral valve implantation: Early and mid-term outcomes. Arch Cardiovasc Dis 116:300–308.
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Lawler PR, Manvelian G, Coppi A, Damask A, Cantor MN, Ferreira MAR, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey DJ, Krebs K, Milani L, Hveem K, Damås JK, Solligård E, Stender S, Tybjærg-Hansen A, Nordestgaard BG, Hernandez-Beeftink T, Rogne T, Flores C, Villar J, Walley KR, Liu VX, Fohner AE, Lotta LA, Kyratsous CA, Sleeman MW, Scemama M, DelGizzi R, Pordy R, Horowitz JE, Baras A, Martin GS, Steg PG, Schwartz GG, Szarek M, Goodman SG. 2023. Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis. Crit Care Explor 5:e0997.
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Perrichot A, Vaittinada Ayar P, Taboulet P, Choquet C, Gay M, Casalino E, Steg PG, Curac S, Vaittinada Ayar P. 2023. Assessment of real-time electrocardiogram effects on interpretation quality by emergency physicians. BMC Med Educ 23:677.
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Das M, Ogale S, Jovanoski N, Johnson A, Nguyen C, Bhagwakar J, Lee JS. 2023. Cost-effectiveness of adjuvant atezolizumab for patients with stage II-IIIA PD-L1+ non-small-cell lung cancer. Immunotherapy 15:573–581.
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Vidal-Petiot E, Elbez Y, Mesnier J, Ducrocq G, Ford I, Tendera M, Ferrari R, Tardif J-C, Fox KM, Steg PG. 2023. Optimal or standard control of systolic and diastolic blood pressure across risk factor categories in patients with chronic coronary syndromes. Eur J Prev Cardiol 30:935–947.
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Bikdeli B, Erlinge D, Valgimigli M, Kastrati A, Han Y, Steg PG, Stables RH, Mehran R, James SK, Frigoli E, Goldstein P, Li Y, Shahzad A, Schüpke S, Mehdipoor G, Chen S, Redfors B, Crowley A, Zhou Z, Stone GW. 2023. Bivalirudin Versus Heparin During PCI in NSTEMI: Individual Patient Data Meta-Analysis of Large Randomized Trials. Circulation 148:1207–1219.
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Roussel M, Teissandier D, Yordanov Y, Balen F, Noizet M, Tazarourte K, Bloom B, Catoire P, Berard L, Cachanado M, Simon T, Laribi S, Freund Y. 2023. Overnight Stay in the Emergency Department and Mortality in Older Patients. JAMA Intern Med https://doi.org/10.1001/jamainternmed.2023.5961.
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Nguyen CT. 2023. An update: maternal iodine supplementation, thyroid function tests, and child neurodevelopmental outcomes. Curr Opin Endocrinol Diabetes Obes 30:265–272.
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Foucrier A, Dessalle T, Tuffet S, Federici L, Dahyot-Fizelier C, Barbier F, Pottecher J, Monsel A, Hissem T, Lefrant J-Y, Demoule A, Constantin J-M, Rousseau A, Simon T, Leone M, Bouglé A. 2023. Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated  pneumonia: an ancillary study of the iDIAPASON trial. Crit Care 27:211.
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Scotti A, Coisne A, Taramasso M, Granada JF, Ludwig S, Rodés-Cabau J, Lurz P, Hausleiter J, Fam N, Kodali SK, Rosiene J, Feinberg A, Pozzoli A, Alessandrini H, Biasco L, Brochet E, Denti P, Estévez-Loureiro R, Frerker C, Ho EC, Monivas V, Nickenig G, Praz F, Puri R, Sievert H, Tang GHL, Andreas M, Von Bardeleben RS, Rommel K-P, Muntané-Carol G, Gavazzoni M, Braun D, Koell B, Kalbacher D, Connelly KA, Juliard J-M, Harr C, Pedrazzini G, Russo G, Philippon F, Schofer J, Thiele H, Unterhuber M, Himbert D, Alcázar MU, Wild MG, Windecker S, Jorde U, Maisano F, Leon MB, Hahn RT, Latib A. 2023. Sex-related characteristics and short-term outcomes of patients undergoing transcatheter tricuspid valve intervention for tricuspid regurgitation. Eur Heart J 44:822–832.
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Amarenco P. 2023. Statin Intolerance, Bempedoic Acid, and Cardiovascular Outcomes. N Engl J Med 388:2488–2489.
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Abtan J, Ducrocq G, Elbez Y, Ferrari R, Ford I, Fox KM, Tardif J-C, Tendera M, Danchin N, Parkhomenko A, Reid CM, Gabriel Steg P. 2023. Association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease: Analysis from the CLARIFY registry. Arch Cardiovasc Dis 116:382–389.
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Bouhadoun A, Manikpurage HD, Deschildre C, Zalghout S, Dubourdeau M, Urbach V, Ho-Tin-Noe B, Deschamps L, Michel J-B, Longrois D, Norel X. 2023. DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE(2). Prostaglandins Other Lipid Mediat 165:106700.
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Baugh CW, Freund Y, Steg PG, Body R, Maron DJ, Yiadom MYAB. 2023. Strategies to mitigate emergency department crowding and its impact on cardiovascular patients. Eur Heart J Acute Cardiovasc Care 12:633–643.
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Fartoukh M, Nseir S, Mégarbane B, Cohen Y, Lafarge A, Contou D, Thille AW, Galerneau L-M, Reizine F, Cour M, Klouche K, Navellou J-C, Bitker L, Rousseau A, Tuffet S, Simon T, Voiriot G. 2023. Respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in severe SARS-CoV-2 pneumonia: a multicentre randomized controlled trial. Clin Microbiol Infect 29:734–743.
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Roustit M, Demarcq O, Laporte S, Barthélémy P, Chassany O, Cucherat M, Demotes J, Diebolt V, Espérou H, Fouret C, Galaup A, Gambotti L, Gourio C, Guérin A, Labruyère C, Paoletti X, Porcher R, Simon T, Varoqueaux N. 2022. Platform trials. Therapie https://doi.org/10.1016/j.therap.2022.12.003.
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Pico F, Labreuche J, Amarenco P. 2022. Remote Ischemic Conditioning vs Usual Care and Neurologic Function in Acute Moderate Ischemic Stroke. Jama 328:2362–2363.
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Hascoët S, Smolka G, Kilic T, Ibrahim R, Onorato EM, Calvert PA, Champagnac D, Freixa-Rofastes X, Zorinas A, Sandoval JP, Ducrocq G, Bouisset F, Fraisse A, Gerardin B. 2022. Procedural Tools and Technics for Transcatheter Paravalvular Leak Closure: Lessons from a Decade of Experience. J Clin Med 12.
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Bouhadoun A, Manikpurage HD, Deschildre C, Zalghout S, Dubourdeau M, Urbach V, Ho-Tin-Noe B, Deschamps L, Michel JB, Longrois D, Norel X. 2022. DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE(2). Prostaglandins Other Lipid Mediat 165:106700.
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White HD, Schwartz GG, Szarek M, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Goodman SG, Jukema JW, Loy M, Pagidipati N, Pordy R, Ristić AD, Zeiher AM, Wojdyla DM, Steg PG. 2022. Alirocumab after acute coronary syndrome in patients with a history of heart failure. Eur Heart J 43:1554–1565.
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Weizman O, Marijon E, Narayanan K, Boveda S, Defaye P, Martins R, Deharo JC, Laurent G, Klug D, Sadoul N, Hocini M, Mansencal N, Anselme F, Da Costa A, Maury P, Ferrières J, Schiele F, Simon T, Danchin N. 2022. Incidence, Characteristics, and Outcomes of Ventricular Fibrillation Complicating Acute Myocardial Infarction in Women Admitted Alive in the Hospital. J Am Heart Assoc 11:e025959.
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Wang Y, Pan Y, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Johnston SC. 2022. Time Course for Benefit and Risk of Ticagrelor and Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack. Neurology 99:e46–e54.
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Vergès B, Aboyans V, Angoulvant D, Boutouyrie P, Cariou B, Hyafil F, Mohammedi K, Amarenco P. 2022. Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms. Cardiovasc Diabetol 21:242.
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Tea V, Morelle JF, Gallet R, Cayla G, Lemesle G, Lhermusier T, Dillinger JG, Ducrocq G, Angouvant D, Cottin Y, Chamandi C, le Bras A, Steg PG, Montalescot G, Nelson AC, Simon T, Chatellier G, Danchin N, Puymirat E. 2022. Immediate versus staged complete myocardial revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease: A post hoc analysis of the randomized FLOWER-MI trial. Arch Cardiovasc Dis 115:496–504.
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Steg PG, Kikoïne J. 2022. Do We Need Ischemia Testing to Monitor Asymptomatic Patients With Chronic Coronary Syndromes? Circulation https://doi.org/10.1161/circulationaha.122.053565.
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Steg PG, Bhatt DL, James SK, Darlington O, Hoskin L, Simon T, Fox KM, Leiter LA, Mehta SR, Harrington RA, Himmelmann A, Ridderstråle W, Andersson M, Bueno H, De Luca L, Tank A, Mellström C, McEwan P. 2022. Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial. Eur Heart J Cardiovasc Pharmacother 8:777–785.
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Sacre K, Delaval L, Dossier A, Alexandra JF, Berleur M, Chauveheid MP, Ducrocq G, Goulenok T, van Gysel D, Rouzaud D, Papo T. 2021. New 2019 SLE EULAR/ACR classification criteria are valid for identifying patients with SLE among patients admitted for pericardial effusion. Ann Rheum Dis 80:e190.
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Puymirat E, Cayla G, Simon T, Steg PG, Montalescot G, Durand-Zaleski I, le Bras A, Gallet R, Khalife K, Morelle JF, Motreff P, Lemesle G, Dillinger JG, Lhermusier T, Silvain J, Roule V, Labèque JN, Rangé G, Ducrocq G, Cottin Y, Blanchard D, Charles Nelson A, De Bruyne B, Chatellier G, Danchin N. 2021. Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction. N Engl J Med 385:297–308.
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Picard F, Steg PG. 2021. Cardiovascular Disease Risk Reduction in Mild-Moderate Hypertriglyceridemia: Integrating Prescription of Omega-3 with Standard Treatment. Curr Atheroscler Rep 23:27.
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Picard F, Bhatt DL, Ducrocq G, Ohman EM, Goto S, Eagle KA, Wilson PWF, Smith Jr SC, Elbez Y, Steg PG. 2021. Generalizability of the REDUCE-IT trial and cardiovascular outcomes associated with hypertriglyceridemia among patients potentially eligible for icosapent ethyl therapy: An analysis of the REduction of Atherothrombosis for Continued Health (REACH) registry. Int J Cardiol 340:96–104.
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Peiffer-Smadja N, Bridier-Nahmias A, Ferré VM, Charpentier C, Garé M, Rioux C, Allemand A, Lavallée P, Ghosn J, Kramer L, Descamps D, Yazdanpanah Y, Visseaux B. 2021. Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2. Viruses 13.
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Pfeffer MA, Claggett B, Lewis EF, Granger CB, Køber L, Maggioni AP, Mann DL, McMurray JJV, Rouleau JL, Solomon SD, Steg PG, Berwanger O, Cikes M, De Pasquale CG, East C, Fernandez A, Jering K, Landmesser U, Mehran R, Merkely B, Vaghaiwalla Mody F, Petrie MC, Petrov I, Schou M, Senni M, Sim D, van der Meer P, Lefkowitz M, Zhou Y, Gong J, Braunwald E. 2021. Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction. N Engl J Med 385:1845–1855.
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Pan Y, Wangqin R, Li H, Wang Y, Meng X, Johnston SC, Simon T, Lin J, Zhao X, Liu L, Wang D, Wang Y. 2021. F2R Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA. Neurology 96:e1–e9.
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Ozen G, Aljesri K, Abdelazeem H, Norel X, Turkyılmaz G, Turkyılmaz S, Topal G. 2021. Comparative study on the effect of aspirin, TP receptor antagonist and TxA(2) synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery. Life Sci 286:120073.
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Orkin AM, Gill PJ, Ghersi D, Campbell L, Sugarman J, Emsley R, Steg PG, Weijer C, Simes J, Rombey T, Williams HC, Wittes J, Moher D, Richards DP, Kasamon Y, Getz K, Hopewell S, Dickersin K, Wu T, Ayala AP, Schulz KF, Calleja S, Boutron I, Ross JS, Golub RM, Khan KM, Mulrow C, Siegfried N, Heber J, Lee N, Kearney PR, Wanyenze RK, Hróbjartsson A, Williams R, Bhandari N, Jüni P, Chan AW. 2021. Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement. Jama 326:257–265.
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Obadia M, Lamirel C, Meseguer E, Seners P, Zuber K, Rosenheim M, Yavchitz A, Bidot S, Hage R, Sabben C, Savatovsky J, Lavallée PC, Gout O, Vignal C, Amarenco P. 2021. Vascular origin in acute transient visual disturbance: A prospective study. Eur J Neurol 28:4098–4108.
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Mesnier J, Ducrocq G, Danchin N, Ferrari R, Ford I, Tardif JC, Tendera M, Fox KM, Steg PG. 2021. International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study. Circulation 144:512–523.
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Mathieu d’Argent E, Ravel C, Rousseau A, Morcel K, Massin N, Sussfeld J, Simon T, Antoine JM, Mandelbaume J, Daraï E, Kolanska K. 2021. High-Dose Supplementation of Folic Acid in Infertile Men Improves IVF-ICSI Outcomes: A Randomized Controlled Trial (FOLFIV Trial). J Clin Med 10.
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Zijlstra LE, Schwartz GG, Steg PG, Jukema JW. 2020. Reply: Alirocumab in Polyvascular Atherosclerotic Disease. J Am Coll Cardiol 75:241.
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Zeitouni M, Giczewska A, Lopes RD, Wojdyla DM, Christersson C, Siegbahn A, De Caterina R, Steg PG, Granger CB, Wallentin L, Alexander JH. 2020. Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial. J Am Coll Cardiol 75:1145–1155.
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Yang DH, Chubb DWR, Nguyen CT. 2020. Management of an Imminent Pathological Fracture of a Fibular Neomandible Via a Minimally Invasive Approach-A Case Report. J Prosthodont 29:746–750.
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