Team 4: Cardiovascular Imaging

Group leaders: Dominique Le Guludec & François Rouzet

ImagingThe new team 4 is originated from the very large previous team 3 of U698. Members involved in preclinical and clinical imaging are now gathered in this new team. They are all from Paris 7 University and are affiliated to X. Bichat hospital. The new team is constituted by 3 PU-PH, 4 MCU-PH (one under recruitment), 2 PH (one with contrat d’interface), 3 physicians in nuclear medicine, 2 CCA. Team 4 aims the development of imaging technologies as diagnostic surrogate markers in health and disease. The purpose is to provide early detection and location of the biological process involved in tissue degeneration, and to follow in situ the therapeutic activity of new compounds targeting localized tissue specific diseases. After moving from morphological to functional approaches, the new challenge is to shift to molecular imaging, providing evidence of specific molecular, cellular and tissue localization targeting. Molecular imaging is a high standard tool for translating biological molecular knowledge into clinical applications for all fields of human tissue pathologies. Specific molecular imaging requires developing innovative ligands identified through biological and/or chemical approaches, and transversal multidisciplinary competencies and know-how: chemistry, pathophysiology, animal experimental model validation, pharmacology, imaging, biophysics, radiopharmacology, software. Imaging specialists must be closely associated to the research of such imaging ligands because the development of clinical applications is the final goal. The Unit is offering such a multidisciplinary collaboration, and national or international collaborations help us in some fields were some competencies are lacking, such as signal quantification or PET chemistry.

Since several years, we have developed a translational research going from chemistry to clinical applications of new ligands. We have built an imaging platform in both sides: at the research level, with all imaging modalities dedicated for small animal imaging (7T MRI, SPECT-CT and PET, ultrasound), as well as at the clinical level (1.5 and 3T MRI, 64 time of flight PET-CT, CZT gamma-camera), and all requirements for gamma-emitters and 68Gallium labelling. This platform is now integrated in a national network (FLI), which should help us acquiring soon a SPECT-MRI for multimodality imaging. Our group have also very close collaboration with: 1/ a highly innovative group in the field of functional MRI (R Synkus and B Van Beers, U773), with elaboration of a joint program on multimodality imaging (SPECT-MRI) in the context of the FLI network; this project is not described here but in the SFR project; 2/ IMNC laboratory, CNRS UMR 8165, Irène Buvat), which has a strong expertise on signal quantification in clinical and pre-clinical PET images.

Our project is to develop new ligands targeting biological activities within diseased cardiovascular tissues, such as inflammation, thrombus, ischemia, cell necrosis and apoptosis, fibrosis. Some non-specific agents, such as 18FDG have been evaluated, but there is still room for specific agents. Several targets have been identified; among them three represent complementary approaches: selectins (inflammation), collagen (fibrosis), and serine proteases (neoangiogenesis). We also evaluate new imaging ligands developed by industry in original cardiovascular applications and animal models. Our research includes pre-clinical evaluation on animal models developed by several teams of the unit, human ex-vivo evaluation using the large tissue collection, and clinical evaluation from early clinical stages of proof of concept to large multicentric trials.

Family name
First name
Position
Tel
Email
AIDRachidaIE01.40.25.75.40rachida.aid@inserm.fr
ANNIOGiacomoPOST-DOCanniogiacomo@gmail.com
BEN ALIKhadijaDoctorantbenali_kh@yahoo.fr
BEN AYEDFatmaM2fatma.bayed@gmail.com
CHASSAINGCarolineM2carolinechassaing@gmail.com
DARWISHOmarDoctorantomar.darwish@kcl.ac.uk
DOYEUXKayaPhysicien
GLATZMarliesPOST-DOCmarlies.glatz@gmail.com
HYAFILFabienPH01.40.25.64.75fabien.hyafil@aphp.fr
JOURNEClementAIclement.journe@inserm.fr
LAISSYJean-PierrePUPH1jean-pierre.laissy@aphp.fr
LE GULUDECDominiquePUPH101.40.25.84.13dominique.leguludec@aphp.fr
LEYGNACSébastienPhysiciensebastien.leygnac@aphp.fr
MIKAILNidaaPHUnidaa.mikail@gmail.com
OUPhallaPUPHphalla.ou@aphp.fr
PIEKARSKIEveDoctorant
ROUZETFrançoisPUPH01.40.25.64.11francois.rouzet@aphp.fr
RUCHERGuillaumeIRguillaume.rucher@u-paris.fr
SINKUSRalphDR2ralph.sinkus@inserm.fr
1.
Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE. 2021. Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods. J Magn Reson Imaging https://doi.org/10.1002/jmri.27475.
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Mikail N, Khalil A, Rouzet F. 2021. Mediastinal Masses: (18)F-FDG-PET/CT Features Based on the International Thymic Malignancy Interest Group Classification. Semin Nucl Med 51:79–97.
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Vigne J, Cabella C, Dézsi L, Rustique E, Couffin AC, Aid R, Anizan N, Chauvierre C, Letourneur D, Le Guludec D, Rouzet F, Hyafil F, Mészáros T, Fülöp T, Szebeni J, Cordaro A, Oliva P, Mourier V, Texier I. 2020. Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE(-/-) mice. Nanomedicine 25:102157.
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Vigne J, Hyafil F. 2020. Inflammation imaging to define vulnerable plaque or vulnerable patient. Q J Nucl Med Mol Imaging 64:21–34.
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Vigne J, Cognet T, Guedj K, Morvan M, Merceron O, Louedec L, Choqueux C, Nicoletti A, Escoubet B, Chaubet F, Michel JB, Rouzet F. 2020. Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [(99m)Tc]Fucoidan SPECT. Mol Imaging Biol 22:643–652.
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Valensi P, Henry P, Boccara F, Cosson E, Prevost G, Emmerich J, Ernande L, Marcadet D, Mousseaux E, Rouzet F, Sultan A, Ferrières J, Vergès B, Van Belle E. 2020. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus: Position paper of the French Society of Cardiology and the French-speaking Society of Diabetology. Arch Cardiovasc Dis https://doi.org/10.1016/j.acvd.2020.07.003.
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Valensi P, Belle EV, Cosson E, Emmerich J, Prevost G, Ferrières J, Sultan A, Ernande L, Rouzet F, Marcadet D, Mousseaux E, Boccara F, Vergès B, Henry P. 2020. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus. Diabetes Metab https://doi.org/10.1016/j.diabet.2020.08.002.
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Slart R, Glaudemans A, Gheysens O, Lubberink M, Kero T, Dweck MR, Habib G, Gaemperli O, Saraste A, Gimelli A, Georgoulias P, Verberne HJ, Bucerius J, Rischpler C, Hyafil F, Erba PA. 2020. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM. Eur J Nucl Med Mol Imaging https://doi.org/10.1007/s00259-020-05066-5.
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Sheth T, Pinilla-Echeverri N, Moreno R, Wang J, Wood DA, Storey RF, Mehran R, Bainey KR, Bossard M, Bangalore S, Schwalm JD, Velianou JL, Valettas N, Sibbald M, Rodés-Cabau J, Ducas J, Cohen EA, Bagai A, Rinfret S, Newby DE, Feldman L, Laster SB, Lang IM, Mills JD, Cairns JA, Mehta SR. 2020. Nonculprit Lesion Severity and Outcome of Revascularization in Patients With STEMI and Multivessel Coronary Disease. J Am Coll Cardiol 76:1277–1286.
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Slart R, Glaudemans A, Gheysens O, Lubberink M, Kero T, Dweck MR, Habib G, Gaemperli O, Saraste A, Gimelli A, Georgoulias P, Verberne HJ, Bucerius J, Rischpler C, Hyafil F, Erba PA. 2020. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary. Eur Heart J Cardiovasc Imaging 21:1320–1330.
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Schregel K, Nowicki MO, Palotai M, Nazari N, Zane R, Sinkus R, Lawler SE, Patz S. 2020. Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model. Cancer Imaging 20:35.
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Sciagrà R, Lubberink M, Hyafil F, Saraste A, Slart R, Agostini D, Nappi C, Georgoulias P, Bucerius J, Rischpler C, Verberne HJ. 2020. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 1–30.
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Piekarski E, Mahida B, Rouzet F, Le Guludec D. 2020. FDG PET/CT in CIEDs infection: Don’t wait any longer! J Nucl Cardiol https://doi.org/10.1007/s12350-020-02377-w.
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Piekarski E, Manrique A, Rouzet F, Le Guludec D. 2020. Current Status of Myocardial Perfusion Imaging With New SPECT/CT Cameras. Semin Nucl Med 50:219–226.
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Nielsen JC, Kautzner J, Casado-Arroyo R, Burri H, Callens S, Cowie MR, Dickstein K, Drossart I, Geneste G, Erkin Z, Hyafil F, Kraus A, Kutyifa V, Marin E, Schulze C, Slotwiner D, Stein K, Zanero S, Heidbuchel H, Fraser AG. 2020. Remote monitoring of cardiac implanted electronic devices: legal requirements and ethical principles - ESC Regulatory Affairs Committee/EHRA joint task force report. Europace 22:1742–1758.
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Lairez O, Hyafil F. 2020. A Clinical Role of PET in Atherosclerosis and Vulnerable Plaques? Semin Nucl Med 50:311–318.
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Manduca A, Bayly PJ, Ehman RL, Kolipaka A, Royston TJ, Sack I, Sinkus R, Van Beers BE. 2020. MR elastography: Principles, guidelines, and terminology. Magn Reson Med https://doi.org/10.1002/mrm.28627.
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Hyafil F, Rouzet F, Le Guludec D. 2020. Imaging cardiac sarcoidosis with FDG-PET: Take a look at the right side! J Nucl Cardiol 27:2144–2148.
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Hyafil F, Mirabel M, Tavitian B. 2020. Molecular imaging of free radicals for anthracycline-induced cardiotoxicity: See the burn? J Nucl Cardiol https://doi.org/10.1007/s12350-020-02254-6.
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Hyafil F, Jaber WA, Neglia D. 2020. Highlights of the 14th International Conference on Nuclear Cardiology and Cardiac Computed Tomography. Eur Heart J Cardiovasc Imaging 21:1–9.
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Hyafil F, Chequer R, Sorbets E, Estellat C, Ducrocq G, Rouzet F, Alfaiate T, Regaieg H, Abtan J, Leygnac S, Milliner M, Imbert L, Burg S, Ben Azzouna R, Potier L, Laouénan C, Quintin C, Roussel R, Hartemann A, Montalescot G, Marie PY, Steg G, Le Guludec D. 2020. Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals. J Nucl Cardiol 27:755–768.
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Guenthner C, Sethi S, Troelstra M, van Gorkum RJH, Gastl M, Sinkus R, Kozerke S. 2020. Unipolar MR elastography: Theory, numerical analysis and implementation. NMR Biomed 33:e4138.
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Fovargue D, Fiorito M, Capilnasiu A, Nordsletten D, Lee J, Sinkus R. 2020. Towards noninvasive estimation of tumour pressure by utilising MR elastography and nonlinear biomechanical models: a simulation and phantom study. Sci Rep 10:5588.
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Fischer Q, Darmon A, Ducrocq G, Feldman L. 2020. Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019. Eur Heart J Case Rep 4:1–5.
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Forsgren MF, Nasr P, Karlsson M, Dahlström N, Norén B, Ignatova S, Sinkus R, Cedersund G, Leinhard OD, Ekstedt M, Kechagias S, Lundberg P. 2020. Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography. Scand J Gastroenterol 55:848–859.
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Ferrag W, Scalbert F, Adjedj J, Dupouy P, Ou P, Juliard JM, Farnoud R, Benadji AA, Du Fretay XH, Wijns W, Aubry P, Hyafil F. 2020. Role of FFR-CT for the Evaluation of Patients With Anomalous Aortic Origin of Coronary Artery. JACC Cardiovasc Imaging https://doi.org/10.1016/j.jcmg.2020.10.003.
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Delabie P, Hyafil F. 2020. Increased lung signal as a hint of COVID-19 infection on Tc-99m-sestamibi myocardial perfusion scintigraphy. J Nucl Cardiol 1–2.
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Duval X, Le Moing V, Tubiana S, Esposito-Farèse M, Ilic-Habensus E, Leclercq F, Bourdon A, Goehringer F, Selton-Suty C, Chevalier E, Boutoille D, Piriou N, Le Tourneau T, Chirouze C, Seronde MF, Morel O, Piroth L, Eicher JC, Humbert O, Revest M, Thébault E, Devillers A, Delahaye F, Boibieux A, Grégoire B, Hoen B, Laouenan C, Iung B, Rouzet F. 2020. Impact of systematic whole-body 18F-fluorodeoxyglucose PET/CT on the management of patients suspected of infective endocarditis: the prospective multicenter TEPvENDO study. Clin Infect Dis https://doi.org/10.1093/cid/ciaa666.
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Darmon A, Ducrocq G, Jasilek A, Feldman L, Sorbets E, Ferrari R, Ford I, Tardif JC, Tendera M, Fox KM, Steg PG. 2020. Use of risk scores to identify lower and higher risk subsets among COMPASS-eligible patients with chronic coronary syndromes. Insights from the CLARIFY registry. Clin Cardiol https://doi.org/10.1002/clc.23505.
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Chareonthaitawee P, Hyafil F. 2020. Correlation of (18)F-NaF Activity With Progression of Macrocalcification: Another Step Toward Vulnerable Plaque Detection? Circ Cardiovasc Imaging 13:e012095.
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Capilnasiu A, Bilston L, Sinkus R, Nordsletten D. 2020. Nonlinear viscoelastic constitutive model for bovine liver tissue. Biomech Model Mechanobiol 19:1641–1662.
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Bunevicius A, Schregel K, Sinkus R, Golby A, Patz S. 2020. REVIEW: MR elastography of brain tumors. Neuroimage Clin 25:102109.
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Boursier C, Duval X, Bourdon A, Imbert L, Mahida B, Chevalier E, Claudin M, Hoen B, Goehringer F, Selton-Suty C, Roch V, Lamiral Z, Humbert O, Rouzet F, Marie PY. 2020. ECG-Gated Cardiac FDG PET Acquisitions Significantly Improve Detectability of Infective Endocarditis. JACC Cardiovasc Imaging 13:2691–2693.
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Bigot M, Chauveau F, Amaz C, Sinkus R, Beuf O, Lambert SA. 2020. The apparent mechanical effect of isolated amyloid-β and α-synuclein aggregates revealed by multi-frequency MRE. NMR Biomed 33:e4174.
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Boursier C, Duval X, Mahida B, Hoen B, Goehringer F, Selton-Suty C, Chevalier E, Roch V, Lamiral Z, Bourdon A, Piriou N, Pallardy A, Morel O, Rouzet F, Marie PY. 2020. Hypermetabolism of the spleen or bone marrow is an additional albeit indirect sign of infective endocarditis at FDG-PET. J Nucl Cardiol https://doi.org/10.1007/s12350-020-02050-2.
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Al-Mallah MH, Hyafil F, Santulli G. 2020. No pleotropic effects of linagliptin on atherosclerotic plaques: Case closed. Atherosclerosis 305:61–63.
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Vigne J, Bay S, Aid-Launais R, Pariscoat G, Rucher G, Sénémaud J, Truffier A, Anizan N, Even G, Ganneau C, Andreata F, Le Borgne M, Nicoletti A, Le Guludec D, Caligiuri G, Rouzet F. 2019. Cleaved CD31 as a target for in vivo molecular imaging of inflammation. Sci Rep 9:19560.
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Strijkers GJ, Araujo ECA, Azzabou N, Bendahan D, Blamire A, Burakiewicz J, Carlier PG, Damon B, Deligianni X, Froeling M, Heerschap A, Hollingsworth KG, Hooijmans MT, Karampinos DC, Loudos G, Madelin G, Marty B, Nagel AM, Nederveen AJ, Nelissen JL, Santini F, Scheidegger O, Schick F, Sinclair C, Sinkus R, de Sousa PL, Straub V, Walter G, Kan HE. 2019. Exploration of New Contrasts, Targets, and MR Imaging and Spectroscopy Techniques for Neuromuscular Disease - A Workshop Report of Working Group 3 of the Biomedicine and Molecular Biosciences COST Action BM1304 MYO-MRI. J Neuromuscul Dis 6:1–30.
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Soussan M, Hyafil F. 2019. Can FDG-PET imaging play a role in guiding indications to endovascular treatments in patients presenting acute aortic syndromes? J Nucl Cardiol 26:642–644.
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Sinigaglia M, Mahida B, Piekarski E, Chequer R, Mikail N, Benali K, Hyafil F, Le Guludec D, Rouzet F. 2019. FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation. Eur J Nucl Med Mol Imaging 46:1268–1275.
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Runge JH, Hoelzl SH, Sudakova J, Dokumaci AS, Nelissen JL, Guenthner C, Lee J, Troelstra M, Fovargue D, Stoker J, Nederveen AJ, Nordsletten D, Sinkus R. 2019. A novel magnetic resonance elastography transducer concept based on a rotational eccentric mass: preliminary experiences with the gravitational transducer. Phys Med Biol 64:045007.
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Rouzet F, Iung B, Duval X. 2019. (18)F-FDG PET/CT in Infective Endocarditis: New Perspectives for Improving Patient Management. J Am Coll Cardiol 74:1041–1043.
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Patz S, Fovargue D, Schregel K, Nazari N, Palotai M, Barbone PE, Fabry B, Hammers A, Holm S, Kozerke S, Nordsletten D, Sinkus R. 2019. Imaging localized neuronal activity at fast time scales through biomechanics. Sci Adv 5:eaav3816.
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Nelissen JL, Sinkus R, Nicolay K, Nederveen AJ, Oomens CWJ, Strijkers GJ. 2019. Magnetic resonance elastography of skeletal muscle deep tissue injury. NMR Biomed 32:e4087.
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Pagé G, Tardieu M, Besret L, Blot L, Lopes J, Sinkus R, Van Beers BE, Garteiser P. 2019. Assessing Tumor Mechanics by MR Elastography at Different Strain Levels. J Magn Reson Imaging 50:1982–1989.
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Mikail N, Sinigaglia M, Hyafil F. 2019. Could FDG-PET imaging play a role in the detection of progressing atherosclerosis in HIV-infected patients? J Nucl Cardiol 26:1266–1268.
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Mehta SR, Wood DA, Storey RF, Mehran R, Bainey KR, Nguyen H, Meeks B, Di Pasquale G, López-Sendón J, Faxon DP, Mauri L, Rao SV, Feldman L, Steg PG, Avezum Á, Sheth T, Pinilla-Echeverri N, Moreno R, Campo G, Wrigley B, Kedev S, Sutton A, Oliver R, Rodés-Cabau J, Stanković G, Welsh R, Lavi S, Cantor WJ, Wang J, Nakamya J, Bangdiwala SI, Cairns JA. 2019. Complete Revascularization with Multivessel PCI for Myocardial Infarction. N Engl J Med 381:1411–1421.
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Li J, Zormpas-Petridis K, Boult JKR, Reeves EL, Heindl A, Vinci M, Lopes F, Cummings C, Springer CJ, Chesler L, Jones C, Bamber JC, Yuan Y, Sinkus R, Jamin Y, Robinson SP. 2019. Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography. Cancer Res 79:5874–5883.
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Hyafil F, Vigne J. 2019. Nuclear Imaging: Focus on Vascular Probes. Arterioscler Thromb Vasc Biol 39:1369–1378.
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Hyafil F, Vigne J. 2019. Imaging inflammation in atherosclerotic plaques: Just make it easy! J Nucl Cardiol 26:1705–1708.