Team 4: Cardiovascular Imaging

Group leader: François Rouzet

ImagingThe new team 4 is originated from the very large previous team 3 of U698. Members involved in preclinical and clinical imaging are now gathered in this new team. They are all from Paris 7 University and are affiliated to X. Bichat hospital. The new team is constituted by 3 PU-PH, 4 MCU-PH (one under recruitment), 2 PH (one with contrat d’interface), 3 physicians in nuclear medicine, 2 CCA. Team 4 aims the development of imaging technologies as diagnostic surrogate markers in health and disease. The purpose is to provide early detection and location of the biological process involved in tissue degeneration, and to follow in situ the therapeutic activity of new compounds targeting localized tissue specific diseases. After moving from morphological to functional approaches, the new challenge is to shift to molecular imaging, providing evidence of specific molecular, cellular and tissue localization targeting. Molecular imaging is a high standard tool for translating biological molecular knowledge into clinical applications for all fields of human tissue pathologies. Specific molecular imaging requires developing innovative ligands identified through biological and/or chemical approaches, and transversal multidisciplinary competencies and know-how: chemistry, pathophysiology, animal experimental model validation, pharmacology, imaging, biophysics, radiopharmacology, software. Imaging specialists must be closely associated to the research of such imaging ligands because the development of clinical applications is the final goal. The Unit is offering such a multidisciplinary collaboration, and national or international collaborations help us in some fields were some competencies are lacking, such as signal quantification or PET chemistry.

Since several years, we have developed a translational research going from chemistry to clinical applications of new ligands. We have built an imaging platform in both sides: at the research level, with all imaging modalities dedicated for small animal imaging (7T MRI, SPECT-CT and PET, ultrasound), as well as at the clinical level (1.5 and 3T MRI, 64 time of flight PET-CT, CZT gamma-camera), and all requirements for gamma-emitters and 68Gallium labelling. This platform is now integrated in a national network (FLI), which should help us acquiring soon a SPECT-MRI for multimodality imaging. Our group have also very close collaboration with: 1/ a highly innovative group in the field of functional MRI (R Synkus and B Van Beers, U773), with elaboration of a joint program on multimodality imaging (SPECT-MRI) in the context of the FLI network; this project is not described here but in the SFR project; 2/ IMNC laboratory, CNRS UMR 8165, Irène Buvat), which has a strong expertise on signal quantification in clinical and pre-clinical PET images.

Our project is to develop new ligands targeting biological activities within diseased cardiovascular tissues, such as inflammation, thrombus, ischemia, cell necrosis and apoptosis, fibrosis. Some non-specific agents, such as 18FDG have been evaluated, but there is still room for specific agents. Several targets have been identified; among them three represent complementary approaches: selectins (inflammation), collagen (fibrosis), and serine proteases (neoangiogenesis). We also evaluate new imaging ligands developed by industry in original cardiovascular applications and animal models. Our research includes pre-clinical evaluation on animal models developed by several teams of the unit, human ex-vivo evaluation using the large tissue collection, and clinical evaluation from early clinical stages of proof of concept to large multicentric trials.

Family name
First name
Position
Tel
Email
AIDRachidaIE01.40.25.75.40rachida.aid@inserm.fr
ANNIOGiacomoPOST-DOCanniogiacomo@gmail.com
BACQUETRaphaelM2
BEN ALIKhadijaDoctorantbenali_kh@yahoo.fr
DARWISHOmarDoctorantomar.darwish@kcl.ac.uk
DELETTREMarionStagiaire
DOYEUXKayaPhysicien
JOURNEClementAIclement.journe@inserm.fr
LAISSYJean-PierrePUPH1jean-pierre.laissy@aphp.fr
LE GULUDECDominiquePUPH101.40.25.84.13dominique.leguludec@aphp.fr
LEYGNACSébastienPhysiciensebastien.leygnac@aphp.fr
MESSAOUDENELamiaM2
MIKAILNidaaPHUnidaa.mikail@gmail.com
OUPhallaPUPHphalla.ou@aphp.fr
PIEKARSKIEveDoctoranteve.piekarski@aphp.fr
ROUZETFrançoisPUPH01.40.25.64.11francois.rouzet@aphp.fr
RUCHERGuillaumeIRguillaume.rucher@u-paris.fr
SINKUSRalphDR2ralph.sinkus@inserm.fr
1.
Tardieu M, Salameh N, Souris L, Rousseau D, Jourdain L, Skeif H, Prévot F, de Rochefort L, Ducreux D, Louis B, Garteiser P, Sinkus R, Darrasse L, Poirier-Quinot M, Maître X. 2022. Magnetic resonance elastography with guided pressure waves. NMR Biomed e4701.
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Régis C, Rouzet F. 2022. A new perspective for phase analysis of radionuclide angiocardiography. J Nucl Cardiol https://doi.org/10.1007/s12350-022-02912-x.
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Hyafil F, Mirabel M, Tavitian B. 2022. Molecular imaging of free radicals for anthracycline-induced cardiotoxicity: See the burn? J Nucl Cardiol 29:226–229.
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Gautier A, Ducrocq G, Elbez Y, Fox KM, Ferrari R, Ford I, Tardif JC, Tendera M, Feldman LJ, Steg PG. 2022. Cardiovascular risk of chronic coronary syndrome patients according to vascular phenotype, diabetes, and smoking. Eur J Prev Cardiol 29:e35–e37.
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Fløgstad Svensson S, Fuster-Garcia E, Latysheva A, Fraser-Green J, Nordhøy W, Isam Darwish O, Thokle Hovden I, Holm S, Vik-Mo EO, Sinkus R, Eeg Emblem K. 2022. Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow. Eur J Radiol 147:110136.
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Chaligne C, Mageau A, Ducrocq G, Ou P, Alexandra JF, Mutuon P, Papo T, Sacre K. 2022. Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome. Int J Cardiol 351:84–88.
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Vigne J, Peyronnet D, Leenhardt J, Dubegny C, Ardisson V, Pariscoat G, Bolot C, Rauscher A, Hallouard F, Clave-Darcissac C, Clotagatide A, Odouard E, Faivre-Chauvet A, Diehl J, Houdu B, Agostini D, Morello R. 2021. Quantitative impact of the first COVID-19 lockdown on nuclear medicine in France: the CORALINE study. Eur J Nucl Med Mol Imaging 48:4331–4338.
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Troelstra MA, Runge JH, Burnhope E, Polcaro A, Guenthner C, Schneider T, Razavi R, Ismail TF, Martorell J, Sinkus R. 2021. Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity. Sci Rep 11:1403.
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Tabibzadeh N, Faucon AL, Vidal-Petiot E, Serrano F, Males L, Fernandez P, Khalil A, Rouzet F, Tardivon C, Mazer N, Dubertret C, Delavest M, Marlinge E, Etain B, Bellivier F, Vrtovsnik F, Flamant M. 2021. Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder. Front Pharmacol 12:784298.
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Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE. 2021. Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods. J Magn Reson Imaging 53:1510–1521.
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Vidal-Petiot E, Courbebaisse M, Livrozet M, Corrégé G, Rusu T, Montravers F, Baron S, Dupont L, Balouzet C, Smadja C, Leygnac S, Pariscoat G, Rose J, Rouzet F, Houillier P, Haymann JP, Flamant M. 2021. Comparison of (51)Cr-EDTA and (99m)Tc-DTPA for glomerular filtration rate measurement. J Nephrol 34:729–737.
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Valensi P, Henry P, Boccara F, Cosson E, Prevost G, Emmerich J, Ernande L, Marcadet D, Mousseaux E, Rouzet F, Sultan A, Ferrières J, Vergès B, Van Belle E. 2021. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus: Position paper of the French Society of Cardiology and the French-speaking Society of Diabetology. Diabetes Metab 47:101185.
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Troelstra MA, Witjes JJ, van Dijk AM, Mak AL, Gurney-Champion O, Runge JH, Zwirs D, Stols-Gonçalves D, Zwinderman AH, Ten Wolde M, Monajemi H, Ramsoekh S, Sinkus R, van Delden OM, Beuers UH, Verheij J, Nieuwdorp M, Nederveen AJ, Holleboom AG. 2021. Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD-NASH Cohort. J Magn Reson Imaging 54:1937–1949.
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Slart R, Williams MC, Juarez-Orozco LE, Rischpler C, Dweck MR, Glaudemans A, Gimelli A, Georgoulias P, Gheysens O, Gaemperli O, Habib G, Hustinx R, Cosyns B, Verberne HJ, Hyafil F, Erba PA, Lubberink M, Slomka P, Išgum I, Visvikis D, Kolossváry M, Saraste A. 2021. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT. Eur J Nucl Med Mol Imaging 48:1399–1413.
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Slart R, Glaudemans A, Gheysens O, Lubberink M, Kero T, Dweck MR, Habib G, Gaemperli O, Saraste A, Gimelli A, Georgoulias P, Verberne HJ, Bucerius J, Rischpler C, Hyafil F, Erba PA. 2021. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM. Eur J Nucl Med Mol Imaging 48:1016–1039.
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Sciagrà R, Lubberink M, Hyafil F, Saraste A, Slart R, Agostini D, Nappi C, Georgoulias P, Bucerius J, Rischpler C, Verberne HJ. 2021. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 48:1040–1069.
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Schregel K, Baufeld C, Palotai M, Meroni R, Fiorina P, Wuerfel J, Sinkus R, Zhang YZ, McDannold N, White PJ, Guttmann CRG. 2021. Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis. Front Neurosci 15:665722.
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Nordsletten D, Capilnasiu A, Zhang W, Wittgenstein A, Hadjicharalambous M, Sommer G, Sinkus R, Holzapfel GA. 2021. A viscoelastic model for human myocardium. Acta Biomater 135:441–457.
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Mikail N, Meseguer E, Lavallée P, Klein I, Hobeanu C, Guidoux C, Cabrejo L, Lesèche G, Amarenco P, Hyafil F. 2021. Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin. J Nucl Cardiol https://doi.org/10.1007/s12350-020-02511-8.
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Milleron O, Masi P, Eliahou L, Paul JF, Arnoult F, Ouali NO, Lansac E, Raffoul R, Pellenc Q, Ou P, Jondeau G. 2021. Aortic Root Anatomy Is Related to the Bicuspid Aortic Valve Phenotype. J Am Soc Echocardiogr https://doi.org/10.1016/j.echo.2021.11.012.
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Mikail N, Pisani A, El Hatimi S, Hentic O, Lebtahi R, Poitier B, Braham W, Deschamps L, Ehmer C, Ben Driss A, Alkhoder S, Ou P. 2021. Early Diagnosis and Treatment of Myocardial Neuroendocrine Tumor Metastasis: The Cornerstone Role of Multimodality Imaging. Circ Cardiovasc Imaging 14:e011857.
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Mikail N, Khalil A, Rouzet F. 2021. Mediastinal Masses: (18)F-FDG-PET/CT Features Based on the International Thymic Malignancy Interest Group Classification. Semin Nucl Med 51:79–97.
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Mikail N, Hyafil F. 2021. Nuclear Imaging in Infective Endocarditis. Pharmaceuticals (Basel) 15.
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Manduca A, Bayly PJ, Ehman RL, Kolipaka A, Royston TJ, Sack I, Sinkus R, Van Beers BE. 2021. MR elastography: Principles, guidelines, and terminology. Magn Reson Med 85:2377–2390.
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Kooshki N, Grambow-Velilla J, Mahida B, Benali K, Nguyen C, Cimadevilla C, Braham W, Pisani A, Iung B, Raffoul R, Rouzet F, Hyafil F. 2021. Diagnostic performance of White Blood Cell SPECT imaging against intra-operative findings in patients with a suspicion of prosthetic valve endocarditis. J Nucl Cardiol https://doi.org/10.1007/s12350-021-02674-y.
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Karlas A, Kallmayer M, Bariotakis M, Fasoula NA, Liapis E, Hyafil F, Pelisek J, Wildgruber M, Eckstein HH, Ntziachristos V. 2021. Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis. Photoacoustics 23:100283.
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Gimelli A, Liga R, Agostini D, Bengel FM, Ernst S, Hyafil F, Saraste A, Scholte A, Verberne HJ, Verschure DO, Slart R. 2021. The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine. Eur Heart J Cardiovasc Imaging 22:480–490.
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Garteiser P, Pagé G, d’Assignies G, Leitao HS, Vilgrain V, Sinkus R, Van Beers BE. 2021. Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography. Sci Rep 11:19386.
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Fiorito M, Fovargue D, Capilnasiu A, Hadjicharalambous M, Nordsletten D, Sinkus R, Lee J. 2021. Impact of axisymmetric deformation on MR elastography of a nonlinear tissue-mimicking material and implications in peri-tumour stiffness quantification. PLoS One 16:e0253804.
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Ferrag W, Scalbert F, Adjedj J, Dupouy P, Ou P, Juliard JM, Farnoud R, Benadji AA, Du Fretay XH, Wijns W, Aubry P, Hyafil F. 2021. Role of FFR-CT for the Evaluation of Patients With Anomalous Aortic Origin of Coronary Artery. JACC Cardiovasc Imaging 14:1074–1076.
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Delabie P, Hyafil F. 2021. Increased lung signal as a hint of COVID-19 infection on Tc-99m-sestamibi myocardial perfusion scintigraphy. J Nucl Cardiol 28:2384–2385.
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Darmon A, Ducrocq G, Jasilek A, Feldman L, Sorbets E, Ferrari R, Ford I, Tardif JC, Tendera M, Fox KM, Steg PG. 2021. Use of risk scores to identify lower and higher risk subsets among COMPASS-eligible patients with chronic coronary syndromes. Insights from the CLARIFY registry. Clin Cardiol 44:58–65.
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Duval X, Le Moing V, Tubiana S, Esposito-Farèse M, Ilic-Habensus E, Leclercq F, Bourdon A, Goehringer F, Selton-Suty C, Chevalier E, Boutoille D, Piriou N, Le Tourneau T, Chirouze C, Seronde MF, Morel O, Piroth L, Eicher JC, Humbert O, Revest M, Thébault E, Devillers A, Delahaye F, Boibieux A, Grégoire B, Hoen B, Laouenan C, Iung B, Rouzet F. 2021. Impact of Systematic Whole-body 18F-Fluorodeoxyglucose PET/CT on the Management of Patients Suspected of Infective Endocarditis: The Prospective Multicenter TEPvENDO Study. Clin Infect Dis 73:393–403.
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Diaz-Rodriguez S, Rasser C, Mesnier J, Chevallier P, Gallet R, Choqueux C, Even G, Sayah N, Chaubet F, Nicoletti A, Ghaleh B, Feldman LJ, Mantovani D, Caligiuri G. 2021. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J 42:1760–1769.
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Delabie P, Evrard D, Zouhry I, Ou P, Rouzet F, Benali K, Piekarski E. 2021. Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT: A case report and literature review. Medicine (Baltimore) 100:e25529.
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Boursier C, Duval X, Mahida B, Hoen B, Goehringer F, Selton-Suty C, Chevalier E, Roch V, Lamiral Z, Bourdon A, Piriou N, Pallardy A, Morel O, Rouzet F, Marie PY. 2021. Hypermetabolism of the spleen or bone marrow is an additional albeit indirect sign of infective endocarditis at FDG-PET. J Nucl Cardiol 28:2533–2542.
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Bourrienne MC, Loyau S, Benichi S, Gay J, Solo-Nomenjanahary M, Journé C, Di Meglio L, Freiherr von Seckendorff A, Desilles JP, Ho-Tin-Noé B, Ajzenberg N, Mazighi M. 2021. A Novel Mouse Model for Cerebral Venous Sinus Thrombosis. Transl Stroke Res 12:1055–1066.
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Babaei B, Fovargue D, Lloyd RA, Miller R, Jugé L, Kaplan M, Sinkus R, Nordsletten DA, Bilston LE. 2021. Magnetic Resonance Elastography Reconstruction for Anisotropic Tissues. Med Image Anal 74:102212.
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Adjedj J, Hyafil F, Halna du Fretay X, Dupouy P, Juliard JM, Ou P, Laissy JP, Muller O, Wijns W, Aubry P. 2021. Physiological Evaluation of Anomalous Aortic Origin of a Coronary Artery Using Computed Tomography-Derived Fractional Flow Reserve. J Am Heart Assoc 10:e018593.
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Adjedj J, Hyafil F, Aminfar F, Halna du Fretay X, Picard F, Dupouy P, Juliard JM, Muller O, Wijns W, Aubry P. 2021. Feasibility of Quantitative Flow Ratio in Adult Patients With Anomalous Aortic Origin of the Coronary Artery With 5 Years of Clinical Follow-up. J Invasive Cardiol 33:E269-e274.
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Vigne J, Hyafil F. 2020. Inflammation imaging to define vulnerable plaque or vulnerable patient. Q J Nucl Med Mol Imaging 64:21–34.
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Vigne J, Cognet T, Guedj K, Morvan M, Merceron O, Louedec L, Choqueux C, Nicoletti A, Escoubet B, Chaubet F, Michel JB, Rouzet F. 2020. Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [(99m)Tc]Fucoidan SPECT. Mol Imaging Biol 22:643–652.
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Vigne J, Cabella C, Dézsi L, Rustique E, Couffin AC, Aid R, Anizan N, Chauvierre C, Letourneur D, Le Guludec D, Rouzet F, Hyafil F, Mészáros T, Fülöp T, Szebeni J, Cordaro A, Oliva P, Mourier V, Texier I. 2020. Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE(-/-) mice. Nanomedicine 25:102157.
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Slart R, Glaudemans A, Gheysens O, Lubberink M, Kero T, Dweck MR, Habib G, Gaemperli O, Saraste A, Gimelli A, Georgoulias P, Verberne HJ, Bucerius J, Rischpler C, Hyafil F, Erba PA. 2020. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary. Eur Heart J Cardiovasc Imaging 21:1320–1330.
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Sheth T, Pinilla-Echeverri N, Moreno R, Wang J, Wood DA, Storey RF, Mehran R, Bainey KR, Bossard M, Bangalore S, Schwalm JD, Velianou JL, Valettas N, Sibbald M, Rodés-Cabau J, Ducas J, Cohen EA, Bagai A, Rinfret S, Newby DE, Feldman L, Laster SB, Lang IM, Mills JD, Cairns JA, Mehta SR. 2020. Nonculprit Lesion Severity and Outcome of Revascularization in Patients With STEMI and Multivessel Coronary Disease. J Am Coll Cardiol 76:1277–1286.
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Schregel K, Nowicki MO, Palotai M, Nazari N, Zane R, Sinkus R, Lawler SE, Patz S. 2020. Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model. Cancer Imaging 20:35.
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Nielsen JC, Kautzner J, Casado-Arroyo R, Burri H, Callens S, Cowie MR, Dickstein K, Drossart I, Geneste G, Erkin Z, Hyafil F, Kraus A, Kutyifa V, Marin E, Schulze C, Slotwiner D, Stein K, Zanero S, Heidbuchel H, Fraser AG. 2020. Remote monitoring of cardiac implanted electronic devices: legal requirements and ethical principles - ESC Regulatory Affairs Committee/EHRA joint task force report. Europace 22:1742–1758.
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Piekarski E, Manrique A, Rouzet F, Le Guludec D. 2020. Current Status of Myocardial Perfusion Imaging With New SPECT/CT Cameras. Semin Nucl Med 50:219–226.
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Piekarski E, Mahida B, Rouzet F, Le Guludec D. 2020. FDG PET/CT in CIEDs infection: Don’t wait any longer! J Nucl Cardiol https://doi.org/10.1007/s12350-020-02377-w.
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Lairez O, Hyafil F. 2020. A Clinical Role of PET in Atherosclerosis and Vulnerable Plaques? Semin Nucl Med 50:311–318.