Team 4: Cardiovascular Imaging

Group leader: François Rouzet

ImagingThe new team 4 is originated from the very large previous team 3 of U698. Members involved in preclinical and clinical imaging are now gathered in this new team. They are all from Paris 7 University and are affiliated to X. Bichat hospital. The new team is constituted by 3 PU-PH, 4 MCU-PH (one under recruitment), 2 PH (one with contrat d’interface), 3 physicians in nuclear medicine, 2 CCA. Team 4 aims the development of imaging technologies as diagnostic surrogate markers in health and disease. The purpose is to provide early detection and location of the biological process involved in tissue degeneration, and to follow in situ the therapeutic activity of new compounds targeting localized tissue specific diseases. After moving from morphological to functional approaches, the new challenge is to shift to molecular imaging, providing evidence of specific molecular, cellular and tissue localization targeting. Molecular imaging is a high standard tool for translating biological molecular knowledge into clinical applications for all fields of human tissue pathologies. Specific molecular imaging requires developing innovative ligands identified through biological and/or chemical approaches, and transversal multidisciplinary competencies and know-how: chemistry, pathophysiology, animal experimental model validation, pharmacology, imaging, biophysics, radiopharmacology, software. Imaging specialists must be closely associated to the research of such imaging ligands because the development of clinical applications is the final goal. The Unit is offering such a multidisciplinary collaboration, and national or international collaborations help us in some fields were some competencies are lacking, such as signal quantification or PET chemistry.

Since several years, we have developed a translational research going from chemistry to clinical applications of new ligands. We have built an imaging platform in both sides: at the research level, with all imaging modalities dedicated for small animal imaging (7T MRI, SPECT-CT and PET, ultrasound), as well as at the clinical level (1.5 and 3T MRI, 64 time of flight PET-CT, CZT gamma-camera), and all requirements for gamma-emitters and 68Gallium labelling. This platform is now integrated in a national network (FLI), which should help us acquiring soon a SPECT-MRI for multimodality imaging. Our group have also very close collaboration with: 1/ a highly innovative group in the field of functional MRI (R Synkus and B Van Beers, U773), with elaboration of a joint program on multimodality imaging (SPECT-MRI) in the context of the FLI network; this project is not described here but in the SFR project; 2/ IMNC laboratory, CNRS UMR 8165, Irène Buvat), which has a strong expertise on signal quantification in clinical and pre-clinical PET images.

Our project is to develop new ligands targeting biological activities within diseased cardiovascular tissues, such as inflammation, thrombus, ischemia, cell necrosis and apoptosis, fibrosis. Some non-specific agents, such as 18FDG have been evaluated, but there is still room for specific agents. Several targets have been identified; among them three represent complementary approaches: selectins (inflammation), collagen (fibrosis), and serine proteases (neoangiogenesis). We also evaluate new imaging ligands developed by industry in original cardiovascular applications and animal models. Our research includes pre-clinical evaluation on animal models developed by several teams of the unit, human ex-vivo evaluation using the large tissue collection, and clinical evaluation from early clinical stages of proof of concept to large multicentric trials.

Family name
First name
Position
Tel
Email
AIDRachidaIE01.40.25.75.40rachida.aid@inserm.fr
ANNIOGiacomoPost-docanniogiacomo@gmail.com
DARWISHOmarDoctorantomar.darwish@kcl.ac.uk
DELETTREMarionStag Apprentimarion.delettre@edu.esiee.fr
DOYEUXKayaPhysicienkaya.doyeux@aphp.fr
JOURNEClementAI15.72.77.67.8clement.journe@inserm.fr
LAISSYJean-PierrePUPHjean-pierre.laissy@aphp.fr
LEYGNACSébastienPhysiciensebastien.leygnac@aphp.fr
MANGINGabriellePost-doc63.38.59.78.3gabrielle.mangin@inserm.fr
MESSAOUDENELamiaStag M2messaoudenelamia1997@gmail.com
OUPhallaPUPHphalla.ou@aphp.fr
PIEKARSKIEveDoctoranteve.piekarski@aphp.fr
ROUZETFrançoisPUPH01.40.25.64.11francois.rouzet@aphp.fr
RUCHERGuillaumeIRguillaume.rucher@u-paris.fr
SINKUSRalphDRralph.sinkus@inserm.fr

Publications

1.
Grenier J, David B, Journé C, Cicha I, Letourneur D, Duval H. 2023. Perfusion of MC3T3E1 Preosteoblast Spheroids within Polysaccharide-Based Hydrogel Scaffolds: An Experimental and Numerical Study at the Bioreactor Scale. Bioengineering (Basel) 10.
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Mimouni M, Bulsei J, Darlington M, Estellat C, Rouzet F, Hyafil F, Durand-Zaleski I. 2023. Cost-effectiveness of 82-Rubidium PET myocardial perfusion imaging for the diagnosis of myocardial ischemia depending on the prevalence of coronary artery  disease. EJNMMI Res 13:9.
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Sitbon S, Ou P, Nguyen C, Ehmer C, Garbarz E, Brochet E, Fuchs A, Aubry P, Abtan J. 2023. Four-Dimensional Flow Magnetic Resonance Imaging Features of a Platypnea-Orthodeoxia Syndrome Caused by a Patent Foramen Ovale. Circ Cardiovasc Imaging 16:601–603.
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Pellenc Q, Benali K, Milleron O, Leimgruber A, Jondeau G, Rouzet F. 2023. Red Blood Cell Scintigraphy and the Controversy of Endotension After Aortic Aneurysm Endovascular Repair. Eur J Vasc Endovasc Surg S1078-5884(23)00824–9.
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Popovic B, Ducrocq G, Elbez Y, Bode C, Mehta SR, Pollack CV, Sabate M, Rao SV, Parkhomenko A, Feldman LJ, Sayah N, Sabatine MS, Steg PG. 2023. Clinical Significance of Culprit Vessel Occlusion in Patients With Non-ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary  Intervention. Am J Cardiol 188:95–101.
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Joo B, Won SY, Sinkus R, Lee S-K. 2023. Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals. Korean J Radiol 24:564–573.
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Totzeck M, Aide N, Bauersachs J, Bucerius J, Georgoulias P, Herrmann K, Hyafil F, Kunikowska J, Lubberink M, Nappi C, Rassaf T, Saraste A, Sciagra R, Slart RHJA, Verberne H, Rischpler C. 2023. Correction to: Nuclear medicine in the assessment and prevention of cancer therapy‑related cardiotoxicity: prospects and proposal of use by the European  Association of Nuclear Medicine (EANM). Eur J Nucl Med Mol Imaging 50:970.
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Darwish OI, Gharib AM, Jeljeli S, Metwalli NS, Feeley J, Rotman Y, Brown RJ, Ouwerkerk R, Kleiner DE, Stäb D, Speier P, Sinkus R, Neji R. 2023. Single Breath-Hold 3-Dimensional Magnetic Resonance Elastography Depicts Liver Fibrosis and Inflammation in Obese Patients. Invest Radiol 58:413–419.
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Svensson SF, Halldórsson S, Latysheva A, Fuster-Garcia E, Hjørnevik T, Fraser-Green J, Birkeland Bugge RA, Grinband J, Holm S, Sinkus R, Vik-Mo EO, Emblem KE. 2023. MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients. Neurooncol Adv 5:vdad021.
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Goudot G, Jimenez A, Mohamedi N, Sitruk J, Khider L, Mortelette H, Papadacci C, Hyafil F, Tanter M, Messas E, Pernot M, Mirault T. 2023. Assessment of Takayasu’s arteritis activity by ultrasound localization microscopy. EBioMedicine 90:104502.
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Socie P, Benmalek A, Cauquil C, Piekarski E, Kounis I, Eliahou L, Rousseau A, Rouzet F, Echaniz-Laguna A, Samuel D, Adams D, Slama MS, Algalarrondo V. 2023. Comparison between tafamidis and liver transplantation as first-line therapy for hereditary transthyretin amyloidosis. Amyloid 30:303–312.
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Wochner P, Schneider T, Stockmann J, Lee J, Sinkus R. 2023. Diffusion phase-imaging in anisotropic media using non-linear gradients for diffusion encoding. PLoS One 18:e0281332.
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Hyafil F. 2023. Quantification of myocardial blood flow with cadmium-zinc-telluride SPECT: Is it worth the effort? Diagn Interv Imaging 104:309–310.
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Reeves EL, Li J, Zormpas-Petridis K, Boult JKR, Sullivan J, Cummings C, Blouw B, Kang D, Sinkus R, Bamber JC, Jamin Y, Robinson SP. 2023. Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography. Mol Oncol 17:1076–1092.
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Régis C, Thy M, Mahida B, Deconinck L, Tubiana S, Iung B, Duval X, Rouzet F. 2023. Absence of infective endocarditis relapse when end-of-treatment fluorodeoxyglucose positron emission tomography/computed tomography is negative. Eur Heart J Cardiovasc Imaging 24:1480–1488.
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Beauvais D, Labeyrie C, Cauquil C, Francou B, Eliahou L, Not A, Echaniz-Laguna A, Adam C, Slama MS, Benmalek A, Leonardi L, Rouzet F, Adams D, Algalarrondo V, Beaudonnet G. 2023. Detailed clinical, physiological and pathological phenotyping can impact access to disease-modifying treatments in ATTR carriers. J Neurol Neurosurg Psychiatry jnnp-2023-332180.
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Rucher G, Prigent K, Simard C, Frelin A-M, Coquemont-Guyot M, Elie N, Delcroix N, Perzo N, Guinamard R, Berger L, Manrique A, Investigators OBOTS-A. 2023. Targeted Radiation Exposure Induces Accelerated Aortic Valve Remodeling in ApoE(-/-) Mice. J Clin Med 12.
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van Schelt A-S, Gottwald LM, Wassenaar NPM, Runge JH, Sinkus R, Stoker J, Nederveen AJ, Schrauben EM. 2023. Single Breath-Hold MR Elastography for Fast Biomechanical Probing of Pancreatic Stiffness. J Magn Reson Imaging https://doi.org/10.1002/jmri.28773.
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Sperry BW, Bateman TM, Akin EA, Bravo PE, Chen W, Dilsizian V, Hyafil F, Khor YM, Miller RJH, Slart RHJA, Slomka P, Verberne H, Miller EJ, Liu C. 2023. Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM. J Nucl Cardiol 30:626–652.
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Régis C, Benali K, Rouzet F. 2023. FDG PET/CT Imaging of Sarcoidosis. Semin Nucl Med 53:258–272.
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Suc G, Cachier A, Hentic O, Bazire B, Sannier A, Delhomme C, Nataf P, Laschet J, Deschamps L, Garbarz E, Ou P, Caligiuri G, Iung B, Ruszniewski P, de Mestier L, Arangalage D. 2023. Management and outcomes of carcinoid heart disease with liver metastases of midgut neuroendocrine tumours. Heart heartjnl-2023-322945.
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Grambow-Velilla J, Mahida B, Benali K, Deconinck L, Chong-Nguyen C, Cimadevilla C, Duval X, Iung B, Rouzet F, Hyafil F. 2023. Prognosis and follow-up of patients with prosthetic valve endocarditis treated conservatively in relation to WBC-SPECT imaging. J Nucl Cardiol https://doi.org/10.1007/s12350-023-03335-y.
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Lugat A, Frampas É, Touchefeu Y, Mirallié É, Bras ML, Senellart H, Rauscher A, Fleury V, Campion L, Rohmer V, Couturier O-F, Lebtahi R, Rouzet F, Ruszniewski P, Kraeber-Bodéré F, Bourgeois M, Ansquer C. 2023. Prospective Multicentric Assessment of (68)Ga-DOTANOC PET/CT in Grade 1-2 GEP-NET. Cancers (Basel) 15.
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Hyafil F, Gropler RJ. 2023. In This Issue of the Journal. Circ Cardiovasc Imaging 16:e015178.
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Totzeck M, Aide N, Bauersachs J, Bucerius J, Georgoulias P, Herrmann K, Hyafil F, Kunikowska J, Lubberink M, Nappi C, Rassaf T, Saraste A, Sciagra R, Slart RHJA, Verberne H, Rischpler C. 2023. Nuclear medicine in the assessment and prevention of cancer therapy-related cardiotoxicity: prospects and proposal of use by the European Association of  Nuclear Medicine (EANM). Eur J Nucl Med Mol Imaging 50:792–812.
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Popovic B, Ducrocq G, Elbez Y, Bode C, Mehta SR, Pollack CV, Sabate M, Rao SV, Parkhomenko A, Feldman LJ, Sayah N, Sabatine MS, Steg PG. 2023. Clinical Significance of Culprit Vessel Occlusion in Patients With Non-ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary Intervention. Am J Cardiol 188:95–101.
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van Leeuwen FWB, Schottelius M, Mottaghy FM, Hyafil F, Lubberink M, Kramer-Marek G, Oyen WJG. 2022. Perspectives on translational molecular imaging and therapy: an overview of key questions to be addressed. EJNMMI Res 12:31.
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Vergès B, Aboyans V, Angoulvant D, Boutouyrie P, Cariou B, Hyafil F, Mohammedi K, Amarenco P. 2022. Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms. Cardiovasc Diabetol 21:242.
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Totzeck M, Aide N, Bauersachs J, Bucerius J, Georgoulias P, Herrmann K, Hyafil F, Kunikowska J, Lubberink M, Nappi C, Rassaf T, Saraste A, Sciagra R, Slart R, Verberne H, Rischpler C. 2022. Nuclear medicine in the assessment and prevention of cancer therapy-related cardiotoxicity: prospects and proposal of use by the European Association of Nuclear Medicine (EANM). Eur J Nucl Med Mol Imaging https://doi.org/10.1007/s00259-022-05991-7.
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Sperry BW, Bateman TM, Akin EA, Bravo PE, Chen W, Dilsizian V, Hyafil F, Khor YM, Miller RJH, Slart R, Slomka P, Verberne H, Miller EJ, Liu C. 2022. Hot Spot Imaging in Cardiovascular Diseases: An Information Statement from SNMMI, ASNC, and EANM. J Nucl Med https://doi.org/10.2967/jnumed.122.264311.
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Sperry BW, Bateman TM, Akin EA, Bravo PE, Chen W, Dilsizian V, Hyafil F, Khor YM, Miller RJH, Slart R, Slomka P, Verberne H, Miller EJ, Liu C. 2022. Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM. J Nucl Cardiol https://doi.org/10.1007/s12350-022-02985-8.
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Totzeck M, Aide N, Bauersachs J, Bucerius J, Georgoulias P, Herrmann K, Hyafil F, Kunikowska J, Lubberink M, Nappi C, Rassaf T, Saraste A, Sciagra R, Slart R, Verberne H, Rischpler C. 2022. Correction to: Nuclear medicine in the assessment and prevention of cancer therapy‑related cardiotoxicity: prospects and proposal of use by the European Association of Nuclear Medicine (EANM). Eur J Nucl Med Mol Imaging https://doi.org/10.1007/s00259-022-06039-6.
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Tardieu M, Salameh N, Souris L, Rousseau D, Jourdain L, Skeif H, Prévot F, de Rochefort L, Ducreux D, Louis B, Garteiser P, Sinkus R, Darrasse L, Poirier-Quinot M, Maître X. 2022. Magnetic resonance elastography with guided pressure waves. NMR Biomed 35:e4701.
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Sénémaud JN, Skarbek C, Vigne J, Rouzet F, Castier Y, Caligiuri G. 2022. Molecular Imaging of Experimental Abdominal Aortic Aneurysms Targeting Vascular Homeostasis Disruption via CD31 Shedding. Eur J Vasc Endovasc Surg https://doi.org/10.1016/j.ejvs.2022.10.004.
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Régis C, Rouzet F. 2022. A new perspective for phase analysis of radionuclide angiocardiography. J Nucl Cardiol https://doi.org/10.1007/s12350-022-02912-x.
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Piekarski E, Mahida B, Rouzet F, Le Guludec D. 2022. FDG PET/CT in CIEDs infection: Don’t wait any longer! J Nucl Cardiol 29:609–611.
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Pham V, Bonnet M, Varenne O, Lafont A, Darmon A, Feldman L, Rioufol G, Derimay F, Harbaoui B, Picard F. 2022. In-Stent Use of Intravascular Coronary Lithotripsy for Restenosis and Stent Underexpansion: A Multicentre Experience. Can J Cardiol 38:1474–1475.
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Palotai M, Schregel K, Nazari N, Merchant JP, Taylor WM, Guttmann CRG, Sinkus R, Young-Pearse TL, Patz S. 2022. Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model. J Neuroimaging 32:617–628.
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Milleron O, Masi P, Eliahou L, Paul JF, Arnoult F, Ouali NO, Lansac E, Raffoul R, Pellenc Q, Ou P, Jondeau G. 2022. Aortic Root Anatomy Is Related to the Bicuspid Aortic Valve Phenotype. J Am Soc Echocardiogr 35:278–286.
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Nedvetsky PI, Cornelissen I, Mathivet T, Bouleti C, Ou P, Baatsen P, Zhao X, Schuit F, Stanchi F, Mostov KE, Gerhardt H. 2022. Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A. Int J Mol Sci 23.
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Mikail N, Males L, Hyafil F, Benali K, Deschamps L, Brochet E, Ehmer C, Driss AB, Saker L, Rossi A, Alkhoder S, Raffoul R, Rouzet F, Ou P. 2022. Diagnosis and staging of cardiac masses: additional value of CMR with (18)F-FDG-PET compared to CMR with CECT. Eur J Nucl Med Mol Imaging 49:2232–2241.
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Mikail N, Hyafil F. 2022. Turning the heart off: give it a second try? J Nucl Cardiol https://doi.org/10.1007/s12350-022-03013-5.
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Mikail N, Meseguer E, Lavallée P, Klein I, Hobeanu C, Guidoux C, Cabrejo L, Lesèche G, Amarenco P, Hyafil F. 2022. Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin. J Nucl Cardiol 29:1329–1336.
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Mehta SR, Wang J, Wood DA, Spertus JA, Cohen DJ, Mehran R, Storey RF, Steg PG, Pinilla-Echeverri N, Sheth T, Bainey KR, Bangalore S, Cantor WJ, Faxon DP, Feldman LJ, Jolly SS, Kunadian V, Lavi S, Lopez-Sendon J, Madan M, Moreno R, Rao SV, Rodés-Cabau J, Stankovic G, Bangdiwala SI, Cairns JA. 2022. Complete Revascularization vs Culprit Lesion-Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial. JAMA Cardiol 7:1091–1099.
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Le Guludec D, Czernin J, Calais J. 2022. Health Care and Nuclear Medicine in France: A Conversation Between Dominique Le Guludec, Johannes Czernin, and Jérémie Calais. J Nucl Med 63:327–330.
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Le Guludec D. 2022. Marie Curie, PhD (1867-1934). J Nucl Cardiol https://doi.org/10.1007/s12350-022-03101-6.
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Kooshki N, Grambow-Velilla J, Mahida B, Benali K, Nguyen C, Cimadevilla C, Braham W, Pisani A, Iung B, Raffoul R, Rouzet F, Hyafil F. 2022. Diagnostic performance of White Blood Cell SPECT imaging against intra-operative findings in patients with a suspicion of prosthetic valve endocarditis. J Nucl Cardiol 29:528–534.
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Hyafil F, Mirabel M, Tavitian B. 2022. Molecular imaging of free radicals for anthracycline-induced cardiotoxicity: See the burn? J Nucl Cardiol 29:226–229.
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Hyafil F. 2022. Myocardial perfusion imaging with PET-CT: let’s think global! Eur Heart J Cardiovasc Imaging 23:1434–1435.
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Fløgstad Svensson S, Fuster-Garcia E, Latysheva A, Fraser-Green J, Nordhøy W, Isam Darwish O, Thokle Hovden I, Holm S, Vik-Mo EO, Sinkus R, Eeg Emblem K. 2022. Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow. Eur J Radiol 147:110136.
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Gautier A, Ducrocq G, Elbez Y, Fox KM, Ferrari R, Ford I, Tardif JC, Tendera M, Feldman LJ, Steg PG. 2022. Cardiovascular risk of chronic coronary syndrome patients according to vascular phenotype, diabetes, and smoking. Eur J Prev Cardiol 29:e35–e37.
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Chaligne C, Mageau A, Ducrocq G, Ou P, Alexandra JF, Mutuon P, Papo T, Sacre K. 2022. Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome. Int J Cardiol 351:84–88.
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Burnhope E, Polcaro A, Runge JH, Granlund I, Bosio F, Troelstra MA, Villa ADM, Chiribiri A, Carr-White G, Webb J, Razavi R, Martorell J, Sinkus R, Ismail TF. 2022. Assessment of Myocardial Stiffness in Patients With Left Ventricular Hypertrophy: CMR Elastography Using Intrinsic Actuation. JACC Cardiovasc Imaging 15:1163–1165.
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Vigne J, Peyronnet D, Leenhardt J, Dubegny C, Ardisson V, Pariscoat G, Bolot C, Rauscher A, Hallouard F, Clave-Darcissac C, Clotagatide A, Odouard E, Faivre-Chauvet A, Diehl J, Houdu B, Agostini D, Morello R. 2021. Quantitative impact of the first COVID-19 lockdown on nuclear medicine in France: the CORALINE study. Eur J Nucl Med Mol Imaging 48:4331–4338.
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Vidal-Petiot E, Courbebaisse M, Livrozet M, Corrégé G, Rusu T, Montravers F, Baron S, Dupont L, Balouzet C, Smadja C, Leygnac S, Pariscoat G, Rose J, Rouzet F, Houillier P, Haymann JP, Flamant M. 2021. Comparison of (51)Cr-EDTA and (99m)Tc-DTPA for glomerular filtration rate measurement. J Nephrol 34:729–737.
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Valensi P, Henry P, Boccara F, Cosson E, Prevost G, Emmerich J, Ernande L, Marcadet D, Mousseaux E, Rouzet F, Sultan A, Ferrières J, Vergès B, Van Belle E. 2021. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus: Position paper of the French Society of Cardiology and the French-speaking Society of Diabetology. Diabetes Metab 47:101185.
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Troelstra MA, Witjes JJ, van Dijk AM, Mak AL, Gurney-Champion O, Runge JH, Zwirs D, Stols-Gonçalves D, Zwinderman AH, Ten Wolde M, Monajemi H, Ramsoekh S, Sinkus R, van Delden OM, Beuers UH, Verheij J, Nieuwdorp M, Nederveen AJ, Holleboom AG. 2021. Assessment of Imaging Modalities Against Liver Biopsy in Nonalcoholic Fatty Liver Disease: The Amsterdam NAFLD-NASH Cohort. J Magn Reson Imaging 54:1937–1949.
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Troelstra MA, Runge JH, Burnhope E, Polcaro A, Guenthner C, Schneider T, Razavi R, Ismail TF, Martorell J, Sinkus R. 2021. Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity. Sci Rep 11:1403.
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Slart R, Williams MC, Juarez-Orozco LE, Rischpler C, Dweck MR, Glaudemans A, Gimelli A, Georgoulias P, Gheysens O, Gaemperli O, Habib G, Hustinx R, Cosyns B, Verberne HJ, Hyafil F, Erba PA, Lubberink M, Slomka P, Išgum I, Visvikis D, Kolossváry M, Saraste A. 2021. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT. Eur J Nucl Med Mol Imaging 48:1399–1413.
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Tabibzadeh N, Faucon AL, Vidal-Petiot E, Serrano F, Males L, Fernandez P, Khalil A, Rouzet F, Tardivon C, Mazer N, Dubertret C, Delavest M, Marlinge E, Etain B, Bellivier F, Vrtovsnik F, Flamant M. 2021. Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder. Front Pharmacol 12:784298.
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Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE. 2021. Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods. J Magn Reson Imaging 53:1510–1521.
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Slart R, Glaudemans A, Gheysens O, Lubberink M, Kero T, Dweck MR, Habib G, Gaemperli O, Saraste A, Gimelli A, Georgoulias P, Verberne HJ, Bucerius J, Rischpler C, Hyafil F, Erba PA. 2021. Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM. Eur J Nucl Med Mol Imaging 48:1016–1039.
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Sciagrà R, Lubberink M, Hyafil F, Saraste A, Slart R, Agostini D, Nappi C, Georgoulias P, Bucerius J, Rischpler C, Verberne HJ. 2021. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 48:1040–1069.
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Schregel K, Baufeld C, Palotai M, Meroni R, Fiorina P, Wuerfel J, Sinkus R, Zhang YZ, McDannold N, White PJ, Guttmann CRG. 2021. Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis. Front Neurosci 15:665722.
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Nordsletten D, Capilnasiu A, Zhang W, Wittgenstein A, Hadjicharalambous M, Sommer G, Sinkus R, Holzapfel GA. 2021. A viscoelastic model for human myocardium. Acta Biomater 135:441–457.
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Mikail N, Pisani A, El Hatimi S, Hentic O, Lebtahi R, Poitier B, Braham W, Deschamps L, Ehmer C, Ben Driss A, Alkhoder S, Ou P. 2021. Early Diagnosis and Treatment of Myocardial Neuroendocrine Tumor Metastasis: The Cornerstone Role of Multimodality Imaging. Circ Cardiovasc Imaging 14:e011857.
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Mikail N, Khalil A, Rouzet F. 2021. Mediastinal Masses: (18)F-FDG-PET/CT Features Based on the International Thymic Malignancy Interest Group Classification. Semin Nucl Med 51:79–97.
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Milleron O, Masi P, Eliahou L, Paul JF, Arnoult F, Ouali NO, Lansac E, Raffoul R, Pellenc Q, Ou P, Jondeau G. 2021. Aortic Root Anatomy Is Related to the Bicuspid Aortic Valve Phenotype. J Am Soc Echocardiogr https://doi.org/10.1016/j.echo.2021.11.012.
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Mikail N, Meseguer E, Lavallée P, Klein I, Hobeanu C, Guidoux C, Cabrejo L, Lesèche G, Amarenco P, Hyafil F. 2021. Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin. J Nucl Cardiol https://doi.org/10.1007/s12350-020-02511-8.
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Mikail N, Hyafil F. 2021. Nuclear Imaging in Infective Endocarditis. Pharmaceuticals (Basel) 15.
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Manduca A, Bayly PJ, Ehman RL, Kolipaka A, Royston TJ, Sack I, Sinkus R, Van Beers BE. 2021. MR elastography: Principles, guidelines, and terminology. Magn Reson Med 85:2377–2390.
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Kooshki N, Grambow-Velilla J, Mahida B, Benali K, Nguyen C, Cimadevilla C, Braham W, Pisani A, Iung B, Raffoul R, Rouzet F, Hyafil F. 2021. Diagnostic performance of White Blood Cell SPECT imaging against intra-operative findings in patients with a suspicion of prosthetic valve endocarditis. J Nucl Cardiol https://doi.org/10.1007/s12350-021-02674-y.
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Mikail N, Benali K, Mahida B, Vigne J, Hyafil F, Rouzet F, Le Guludec D. 2018. (18)F-FDG-PET/CT Imaging to Diagnose Septic Emboli and Mycotic Aneurysms in Patients with Endocarditis and Cardiac Device Infections. Curr Cardiol Rep 20:14.
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Mikail N, Benali K, Dossier A, Bouleti C, Hyafil F, Le Guludec D, Rouzet F, Ou P. 2018. Additional Diagnostic Value of Combined Angio-Computed Tomography and (18)F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis. JACC Cardiovasc Imaging 11:361–364.
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Legendre A, Khraiche D, Ou P, Mauvais FX, Madrange M, Guemann AS, Jais JP, Bonnet D, Hamel Y, de Lonlay P. 2018. Cardiac function and exercise adaptation in 8 children with LPIN1 mutations. Mol Genet Metab 123:375–381.
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Kerneis C, Pasi N, Arangalage D, Nguyen V, Mathieu T, Verdonk C, Codogno I, Ou P, Duval X, Tubiana S, Cimadevilla C, Vahanian A, Messika-Zeitoun D. 2018. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study. Eur Heart J Cardiovasc Imaging 19:792–799.
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Joner M, Koppara T, Byrne RA, Castellanos MI, Lewerich J, Novotny J, Guagliumi G, Xhepa E, Adriaenssens T, Godschalk TC, Malik N, Alfonso F, Tada T, Neumann FJ, Desmet W, Ten Berg JM, Gershlick AH, Feldman LJ, Massberg S, Kastrati A. 2018. Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium). JACC Cardiovasc Interv 11:1340–1350.
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Hyafil F, Rouzet F, Le Guludec D. 2018. Quantification of myocardial blood flow with dynamic SPECT acquisitions: ready for prime time? Eur J Nucl Med Mol Imaging 45:2170–2172.
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Hyafil F, Rouzet F, Le Guludec D. 2018. Quantification of FDG uptake in patients with a suspicion of prosthetic valve endocarditis: Part of the problem or part of the solution? J Nucl Cardiol 25:2092–2095.
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Heuzé C, Lepage L, Loubet P, Duval X, Cimadevilla C, Verdonk C, Hyafil F, Rouzet F, Ou P, Nataf P, Vahanian A, Messika-Zeitoun D. 2018. Infective Endocarditis After Bentall Surgery: Usefulness of New Imaging Modalities and Outcomes. JACC Cardiovasc Imaging 11:1535–1537.
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Guenthner C, Runge JH, Sinkus R, Kozerke S. 2018. Analysis and improvement of motion encoding in magnetic resonance elastography. NMR Biomed 31:e3908.
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Gimelli A, Achenbach S, Buechel RR, Edvardsen T, Francone M, Gaemperli O, Hacker M, Hyafil F, Kaufmann PA, Lancellotti P, Nieman K, Pontone G, Pugliese F, Verberne HJ, Gutberlet M, Bax JJ, Neglia D. 2018. Strategies for radiation dose reduction in nuclear cardiology and cardiac computed tomography imaging: a report from the European Association of Cardiovascular Imaging (EACVI), the Cardiovascular Committee of European Association of Nuclear Medicine (EANM), and the European Society of Cardiovascular Radiology (ESCR). Eur Heart J 39:286–296.
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Fovargue D, Nordsletten D, Sinkus R. 2018. Stiffness reconstruction methods for MR elastography. NMR Biomed 31:e3935.
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Fovargue D, Kozerke S, Sinkus R, Nordsletten D. 2018. Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction. Med Image Anal 44:126–142.
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Emsen B, Benali K, Mahida B, Larivière D, Le Guludec D, Papo T, Sacre K, Hyafil F. 2018. Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET. Nucl Med Commun 39:779–788.
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Dubreil C, Sainte Catherine O, Lalatonne Y, Journé C, Ou P, van Endert P, Motte L. 2018. Tolerogenic Iron Oxide Nanoparticles in Type 1 Diabetes: Biodistribution and Pharmacokinetics Studies in Nonobese Diabetic Mice. Small 14:e1802053.
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Erba PA, Lancellotti P, Vilacosta I, Gaemperli O, Rouzet F, Hacker M, Signore A, Slart R, Habib G. 2018. Recommendations on nuclear and multimodality imaging in IE and CIED infections. Eur J Nucl Med Mol Imaging 45:1795–1815.
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Dorent R, Gandjbakhch E, Goéminne C, Ivanes F, Sebbag L, Bauer F, Epailly E, Boissonnat P, Nubret K, Amour J, Vermes E, Ou P, Guendouz S, Chevalier P, Lebreton G, Flecher E, Obadia JF, Logeart D, de Groote P. 2018. Assessment of potential heart donors: A statement from the French heart transplant community. Arch Cardiovasc Dis 111:126–139.
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Collignon AM, Lesieur J, Anizan N, Azzouna RB, Poliard A, Gorin C, Letourneur D, Chaussain C, Rouzet F, Rochefort GY. 2018. Early angiogenesis detected by PET imaging with (64)Cu-NODAGA-RGD is predictive of bone critical defect repair. Acta Biomater 82:111–121.
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Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J, Dézsi L, Alexiou C, Rouzet F, Storm G, Stroes E, Bruce D, MacRitchie N, Maffia P, Letourneur D. 2018. From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovasc Res 114:1714–1727.
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Algalarrondo V, Piekarski E, Eliahou L, Le Guludec D, Slama MS, Rouzet F. 2018. Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis? Curr Cardiol Rep 20:33.
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Algalarrondo V, Antonini T, Théaudin M, Chemla D, Benmalek A, Castaing D, Cauquil C, Rouzet F, Mika D, Duong E, Dinanian S, Eliahou L, Le Guludec D, Samuel D, Adams D, Slama MS. 2018. Cause of death analysis and temporal trends in survival after liver transplantation for transthyretin familial amyloid polyneuropathy. Amyloid 25:253–260.
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Balleyguier C, Lakhdar AB, Dunant A, Mathieu MC, Delaloge S, Sinkus R. 2018. Value of whole breast magnetic resonance elastography added to MRI for lesion characterization. NMR Biomed 31.
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Yue JL, Tardieu M, Julea F, Boucneau T, Sinkus R, Pellot-Barakat C, Maître X. 2017. Acquisition and reconstruction conditions in silico for accurate and precise magnetic resonance elastography. Phys Med Biol 62:8655–8670.
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Varasteh Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre JE, Döring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M. 2017. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept. EJNMMI Res 7:40.
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Trägårdh E, Tan SS, Bucerius J, Gimelli A, Gaemperli O, Lindner O, Agostini D, Übleis C, Sciagrà R, Slart RH, Underwood SR, Hyafil F, Hacker M, Verberne HJ. 2017. Systematic review of cost-effectiveness of myocardial perfusion scintigraphy in patients with ischaemic heart disease: A report from the cardiovascular committee of the European Association of Nuclear Medicine. Endorsed by the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 18:825–832.
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Unterweger H, Janko C, Schwarz M, Dézsi L, Urbanics R, Matuszak J, Őrfi E, Fülöp T, Bäuerle T, Szebeni J, Journé C, Boccaccini AR, Alexiou C, Lyer S, Cicha I. 2017. Non-immunogenic dextran-coated superparamagnetic iron oxide nanoparticles: a biocompatible, size-tunable contrast agent for magnetic resonance imaging. Int J Nanomedicine 12:5223–5238.
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Terzian Z, Gasser TC, Blackwell F, Hyafil F, Louedec L, Deschildre C, Ghodbane W, Dorent R, Nicoletti A, Morvan M, Nejjari M, Feldman L, Pavon-Djavid G, Michel JB. 2017. Peristrut microhemorrhages: a possible cause of in-stent neoatherosclerosis? Cardiovasc Pathol 26:30–38.
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Shang Q, Sarikouch S, Patel S, Schuster A, Steinmetz M, Ou P, Danford DA, Beerbaum P, Kutty S. 2017. Assessment of ventriculo-vascular properties in repaired coarctation using cardiac magnetic resonance-derived aortic, left atrial and left ventricular strain. Eur Radiol 27:167–177.
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Rouzet F, Le Guludec D. 2017. (18)F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Cardiac Implantable Electronic Devices Infection: Ready for Routine Care! Circ Cardiovasc Imaging 10.
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Rouzet F, Aerts J, Hyafil F, Le Guludec D. 2017. New-generation CZT cameras: the future of infection imaging? Eur Heart J 38:444–446.
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Pichon M, Mikail N, Ben Ali K, Rouzet F, Burdet C, Yazdanpanah Y, Joly V, Lepage L, Sarda-Mantel L. 2017. 18FDG-PET/CT: a useful tool for the management of patients in infectious diseases. Infect Dis (Lond) 49:155–157.
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Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M. 2017. Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. Platelets 28:529–539.
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Nghia N, Tinet E, Ettori D, Beilvert A, Pavon-Djavid G, Maire M, Ou P, Tualle JM, Chaubet F. 2017. Gadolinium/terbium hybrid macromolecular complexes for bimodal imaging of atherothrombosis. J Biomed Opt 22:76004.
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Nelissen JL, de Graaf L, Traa WA, Schreurs TJ, Moerman KM, Nederveen AJ, Sinkus R, Oomens CW, Nicolay K, Strijkers GJ. 2017. A MRI-Compatible Combined Mechanical Loading and MR Elastography Setup to Study Deformation-Induced Skeletal Muscle Damage in Rats. PLoS One 12:e0169864.
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Mathieu C, Mikaïl N, Benali K, Iung B, Duval X, Nataf P, Jondeau G, Hyafil F, Le Guludec D, Rouzet F. 2017. Response by Mathieu et al to Letter Regarding Article, “Characterization of (18)F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves.” Circ Cardiovasc Imaging 10.
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Mathieu C, Mikaïl N, Benali K, Iung B, Duval X, Nataf P, Jondeau G, Hyafil F, Le Guludec D, Rouzet F. 2017. Characterization of (18)F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves. Circ Cardiovasc Imaging 10:e005585.
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Malinge J, Géraudie B, Savel P, Nataf V, Prignon A, Provost C, Zhang Y, Ou P, Kerrou K, Talbot JN, Siaugue JM, Sollogoub M, Ménager C. 2017. Liposomes for PET and MR Imaging and for Dual Targeting (Magnetic Field/Glucose Moiety): Synthesis, Properties, and in Vivo Studies. Mol Pharm 14:406–414.
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Koutsoukis A, Halna du Fretay X, Dupouy P, Ou P, Laissy JP, Juliard JM, Hyafil F, Aubry P. 2017. Interobserver variability in the classification of congenital coronary abnormalities: A substudy of the anomalous connections of the coronary arteries registry. Congenit Heart Dis 12:726–732.
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Koskas P, Henry-Feugeas MC, Feugeas JP, Ou P, Drunat O. 2017. Factors of Rapid Cognitive Decline in Late Onset Alzheimer’s Disease. Curr Aging Sci 10:129–135.
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Karlas A, Reber J, Diot G, Bozhko D, Anastasopoulou M, Ibrahim T, Schwaiger M, Hyafil F, Ntziachristos V. 2017. Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept. Biomed Opt Express 8:3395–3403.