Team 4: Cardiovascular Imaging

Group leaders: Dominique Le Guludec & François Rouzet

ImagingThe new team 4 is originated from the very large previous team 3 of U698. Members involved in preclinical and clinical imaging are now gathered in this new team. They are all from Paris 7 University and are affiliated to X. Bichat hospital. The new team is constituted by 3 PU-PH, 4 MCU-PH (one under recruitment), 2 PH (one with contrat d’interface), 3 physicians in nuclear medicine, 2 CCA. Team 4 aims the development of imaging technologies as diagnostic surrogate markers in health and disease. The purpose is to provide early detection and location of the biological process involved in tissue degeneration, and to follow in situ the therapeutic activity of new compounds targeting localized tissue specific diseases. After moving from morphological to functional approaches, the new challenge is to shift to molecular imaging, providing evidence of specific molecular, cellular and tissue localization targeting. Molecular imaging is a high standard tool for translating biological molecular knowledge into clinical applications for all fields of human tissue pathologies. Specific molecular imaging requires developing innovative ligands identified through biological and/or chemical approaches, and transversal multidisciplinary competencies and know-how: chemistry, pathophysiology, animal experimental model validation, pharmacology, imaging, biophysics, radiopharmacology, software. Imaging specialists must be closely associated to the research of such imaging ligands because the development of clinical applications is the final goal. The Unit is offering such a multidisciplinary collaboration, and national or international collaborations help us in some fields were some competencies are lacking, such as signal quantification or PET chemistry.

Since several years, we have developed a translational research going from chemistry to clinical applications of new ligands. We have built an imaging platform in both sides: at the research level, with all imaging modalities dedicated for small animal imaging (7T MRI, SPECT-CT and PET, ultrasound), as well as at the clinical level (1.5 and 3T MRI, 64 time of flight PET-CT, CZT gamma-camera), and all requirements for gamma-emitters and 68Gallium labelling. This platform is now integrated in a national network (FLI), which should help us acquiring soon a SPECT-MRI for multimodality imaging. Our group have also very close collaboration with: 1/ a highly innovative group in the field of functional MRI (R Synkus and B Van Beers, U773), with elaboration of a joint program on multimodality imaging (SPECT-MRI) in the context of the FLI network; this project is not described here but in the SFR project; 2/ IMNC laboratory, CNRS UMR 8165, Irène Buvat), which has a strong expertise on signal quantification in clinical and pre-clinical PET images.

Our project is to develop new ligands targeting biological activities within diseased cardiovascular tissues, such as inflammation, thrombus, ischemia, cell necrosis and apoptosis, fibrosis. Some non-specific agents, such as 18FDG have been evaluated, but there is still room for specific agents. Several targets have been identified; among them three represent complementary approaches: selectins (inflammation), collagen (fibrosis), and serine proteases (neoangiogenesis). We also evaluate new imaging ligands developed by industry in original cardiovascular applications and animal models. Our research includes pre-clinical evaluation on animal models developed by several teams of the unit, human ex-vivo evaluation using the large tissue collection, and clinical evaluation from early clinical stages of proof of concept to large multicentric trials.

Family name
First name
Position
Tel
Email
AIDRachidaIE01.40.25.75.40rachida.aid@inserm.fr
ANIZANNadegeIRnadege.anizan@univ-paris-diderot.fr
ANNIOGiacomoPOST-DOCanniogiacomo@gmail.com
BEN ALIKhadijaDoctorantbenali_kh@yahoo.fr
BEN AYEDFatmaM2fatma.bayed@gmail.com
CHASSAINGCarolineM2carolinechassaing@gmail.com
DARWISHOmarDoctorantomar.darwish@kcl.ac.uk
DOYEUXKayaPhysicien
GLATZMarliesPOST-DOCmarlies.glatz@gmail.com
HYAFILFabienPH01.40.25.64.75fabien.hyafil@aphp.fr
JOURNEClementAIclement.journe@inserm.fr
LAISSYJean-PierrePUPH1jean-pierre.laissy@aphp.fr
LE GULUDECDominiquePUPH101.40.25.84.13dominique.leguludec@aphp.fr
LEYGNACSébastienPhysiciensebastien.leygnac@aphp.fr
MIKAILNidaaPHUnidaa.mikail@gmail.com
OUPhallaPUPHphalla.ou@aphp.fr
PIEKARSKIEveDoctorant
ROUZETFrançoisPUPH01.40.25.64.11francois.rouzet@aphp.fr
RUCHERGuillaumeIRguillaume.rucher@u-paris.fr
SINKUSRalphDR2ralph.sinkus@inserm.fr
1.
Sinigaglia M, Mahida B, Piekarski E, Chequer R, Mikail N, Benali K, Hyafil F, Le Guludec D, Rouzet F. 2019. FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation. European Journal of Nuclear Medicine and Molecular Imaging 46:1268–1275.
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Soussan M, Hyafil F. 2019. Can FDG-PET imaging play a role in guiding indications to endovascular treatments in patients presenting acute aortic syndromes? Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology 26:642–644.
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Hyafil F, Rouzet F, Le Guludec D. 2019. Imaging cardiac sarcoidosis with FDG-PET: Take a look at the right side! Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology.
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Vigne J, Thackeray J, Essers J, Makowski M, Varasteh Z, Curaj A, Karlas A, Canet-Soulas E, Mulder W, Kiessling F, Schäfers M, Botnar R, Wildgruber M, Hyafil F, Imaging C study group of the ES of M. 2018. Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis. Molecular imaging and biology: MIB: the official publication of the Academy of Molecular Imaging 20:869–887.
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Vigne J, Emery S, Lemarie N, Chavent B, Hallouard F, Le Guludec D, Rouzet F, Fraysse M, De Mil R. 2018. Fractionated elution of 99Mo/99mTc generators using calibrated vials. Nuclear Medicine Communications 39:865–869.
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Slart RHJA, Glaudemans AWJM, Lancellotti P, Hyafil F, Blankstein R, Schwartz RG, Jaber WA, Russell R, Gimelli A, Rouzet F, Hacker M, Gheysens O, Plein S, Miller EJ, Dorbala S, Donal E, Group DR. 2018. A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology. Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology 25:298–319.
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Piekarski E, Chequer R, Algalarrondo V, Eliahou L, Mahida B, Vigne J, Adams D, Slama MS, Le Guludec D, Rouzet F. 2018. Cardiac denervation evidenced by MIBG occurs earlier than amyloid deposits detection by diphosphonate scintigraphy in TTR mutation carriers. European Journal of Nuclear Medicine and Molecular Imaging 45:1108–1118.
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Piekarski E, Benali K, Rouzet F. 2018. Nuclear Imaging in Sarcoidosis. Seminars in Nuclear Medicine 48:246–260.
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Potier L, Chequer R, Roussel R, Mohammedi K, Sismail S, Hartemann A, Amouyal C, Marre M, Le Guludec D, Hyafil F. 2018. Relationship between cardiac microvascular dysfunction measured with 82Rubidium-PET and albuminuria in patients with diabetes mellitus. Cardiovascular Diabetology 17:11.
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Mikail N, Sinigaglia M, Hyafil F. 2018. Could FDG-PET imaging play a role in the detection of progressing atherosclerosis in HIV-infected patients? Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology.
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Mikail N, Benali K, Mahida B, Vigne J, Hyafil F, Rouzet F, Le Guludec D. 2018. 18F-FDG-PET/CT Imaging to Diagnose Septic Emboli and Mycotic Aneurysms in Patients with Endocarditis and Cardiac Device Infections. Current Cardiology Reports 20:14.
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Mikail N, Benali K, Dossier A, Bouleti C, Hyafil F, Le Guludec D, Rouzet F, Ou P. 2018. Additional Diagnostic Value of Combined Angio-Computed Tomography and 18F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis. JACC Cardiovascular imaging 11:361–364.
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Joner M, Koppara T, Byrne RA, Castellanos MI, Lewerich J, Novotny J, Guagliumi G, Xhepa E, Adriaenssens T, Godschalk TC, Malik N, Alfonso F, Tada T, Neumann F-J, Desmet W, Ten Berg JM, Gershlick AH, Feldman LJ, Massberg S, Kastrati A, Investigators P of P. 2018. Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium). JACC Cardiovascular interventions 11:1340–1350.
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Hyafil F, Rouzet F, Le Guludec D. 2018. Quantification of FDG uptake in patients with a suspicion of prosthetic valve endocarditis: Part of the problem or part of the solution? Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology 25:2092–2095.
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Hyafil F, Rouzet F, Le Guludec D. 2018. Quantification of myocardial blood flow with dynamic SPECT acquisitions: ready for prime time? European Journal of Nuclear Medicine and Molecular Imaging 45:2170–2172.
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Hyafil F, Ferrag W, Kefti C, Le Guludec D. 2018. Fluoride imaging of atherosclerotic plaques: Moving from macro to microcalcifications? Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology.
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Hyafil F, Vigne J. 2018. Imaging inflammation in atherosclerotic plaques: Just make it easy! Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology.
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Hyafil F, Chequer R, Sorbets E, Estellat C, Ducrocq G, Rouzet F, Alfaiate T, Regaieg H, Abtan J, Leygnac S, Milliner M, Imbert L, Burg S, Ben Azzouna R, Potier L, Laouénan C, Quintin C, Roussel R, Hartemann A, Montalescot G, Marie P-Y, Steg G, Le Guludec D. 2018. Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals. Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology.
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Gimelli A, Achenbach S, Buechel RR, Edvardsen T, Francone M, Gaemperli O, Hacker M, Hyafil F, Kaufmann PA, Lancellotti P, Nieman K, Pontone G, Pugliese F, Verberne HJ, Gutberlet M, Bax JJ, Neglia D, Committee ESD. 2018. Strategies for radiation dose reduction in nuclear cardiology and cardiac computed tomography imaging: a report from the European Association of Cardiovascular Imaging (EACVI), the Cardiovascular Committee of European Association of Nuclear Medicine (EANM), and the European Society of Cardiovascular Radiology (ESCR). European Heart Journal 39:286–296.
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Erba PA, Lancellotti P, Vilacosta I, Gaemperli O, Rouzet F, Hacker M, Signore A, Slart RHJA, Habib G. 2018. Recommendations on nuclear and multimodality imaging in IE and CIED infections. European Journal of Nuclear Medicine and Molecular Imaging 45:1795–1815.
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Emsen B, Benali K, Mahida B, Larivière D, Le Guludec D, Papo T, Sacre K, Hyafil F. 2018. Comparison between visual and numerical metrics for the evaluation of patients with Takayasu arteritis with 18F-FDG-PET. Nuclear Medicine Communications 39:779–788.
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Collignon A-M, Lesieur J, Anizan N, Azzouna RB, Poliard A, Gorin C, Letourneur D, Chaussain C, Rouzet F, Rochefort GY. 2018. Early angiogenesis detected by PET imaging with 64Cu-NODAGA-RGD is predictive of bone critical defect repair. Acta Biomaterialia 82:111–121.
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Heuzé C, Lepage L, Loubet P, Duval X, Cimadevilla C, Verdonk C, Hyafil F, Rouzet F, Ou P, Nataf P, Vahanian A, Messika-Zeitoun D. 2018. Infective Endocarditis After Bentall Surgery: Usefulness of New Imaging Modalities and Outcomes. JACC Cardiovascular imaging 11:1535–1537.
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Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J, Dézsi L, Alexiou C, Rouzet F, Storm G, Stroes E, Bruce D, MacRitchie N, Maffia P, Letourneur D. 2018. From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research 114:1714–1727.
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Algalarrondo V, Piekarski E, Eliahou L, Le Guludec D, Slama MS, Rouzet F. 2018. Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis? Current Cardiology Reports 20:33.
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Algalarrondo V, Antonini T, Théaudin M, Chemla D, Benmalek A, Castaing D, Cauquil C, Rouzet F, Mika D, Duong E, Dinanian S, Eliahou L, Le Guludec D, Samuel D, Adams D, Slama MS. 2018. Cause of death analysis and temporal trends in survival after liver transplantation for transthyretin familial amyloid polyneuropathy. Amyloid: The International Journal of Experimental and Clinical Investigation: The Official Journal of the International Society of Amyloidosis 25:253–260.
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Trägårdh E, Tan SS, Bucerius J, Gimelli A, Gaemperli O, Lindner O, Agostini D, Übleis C, Sciagrà R, Slart RH, Underwood SR, Hyafil F, Hacker M, Verberne HJ. 2017. Systematic review of cost-effectiveness of myocardial perfusion scintigraphy in patients with ischaemic heart disease: A report from the cardiovascular committee of the European Association of Nuclear Medicine. Endorsed by the European Association of Cardiovascular Imaging. European Heart Journal Cardiovascular Imaging 18:825–832.
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Terzian Z, Gasser TC, Blackwell F, Hyafil F, Louedec L, Deschildre C, Ghodbane W, Dorent R, Nicoletti A, Morvan M, Nejjari M, Feldman L, Pavon-Djavid G, Michel J-B. 2017. Peristrut microhemorrhages: a possible cause of in-stent neoatherosclerosis? Cardiovascular Pathology: The Official Journal of the Society for Cardiovascular Pathology 26:30–38.
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Varasteh Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre J-E, Döring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M. 2017. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept. EJNMMI research 7:40.
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Rouzet F, Le Guludec D. 2017. 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Cardiac Implantable Electronic Devices Infection: Ready for Routine Care! Circulation Cardiovascular Imaging 10.
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Rouzet F, Aerts J, Hyafil F, Le Guludec D. 2017. New-generation CZT cameras: the future of infection imaging? European Heart Journal 38:444–446.
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Pichon M, Mikail N, Ben Ali K, Rouzet F, Burdet C, Yazdanpanah Y, Joly V, Lepage L, Sarda-Mantel L. 2017. 18FDG-PET/CT: a useful tool for the management of patients in infectious diseases. Infectious Diseases (London, England) 49:155–157.
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Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M. 2017. Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. Platelets 28:529–539.
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Mathieu C, Mikaïl N, Benali K, Iung B, Duval X, Nataf P, Jondeau G, Hyafil F, Le Guludec D, Rouzet F. 2017. Characterization of 18F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves. Circulation Cardiovascular Imaging 10:e005585.
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Mathieu C, Mikaïl N, Benali K, Iung B, Duval X, Nataf P, Jondeau G, Hyafil F, Le Guludec D, Rouzet F. 2017. Response by Mathieu et al to Letter Regarding Article, “Characterization of 18F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves.” Circulation Cardiovascular Imaging 10.
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Iung B, Rouzet F, Brochet E, Duval X. 2017. Cardiac Imaging of Infective Endocarditis, Echo and Beyond. Current Infectious Disease Reports 19:8.
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Koutsoukis A, Halna du Fretay X, Dupouy P, Ou P, Laissy J-P, Juliard J-M, Hyafil F, Aubry P, Investigators A. 2017. Interobserver variability in the classification of congenital coronary abnormalities: A substudy of the anomalous connections of the coronary arteries registry. Congenital Heart Disease 12:726–732.
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Karlas A, Reber J, Diot G, Bozhko D, Anastasopoulou M, Ibrahim T, Schwaiger M, Hyafil F, Ntziachristos V. 2017. Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept. Biomedical Optics Express 8:3395–3403.
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Hyafil F, Rouzet F, Le Guludec D. 2017. Nuclear imaging for patients with a suspicion of infective endocarditis: Be part of the team! Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology 24:207–211.
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Hyafil F, Pelisek J, Laitinen I, Schottelius M, Mohring M, Döring Y, van der Vorst EPC, Kallmayer M, Steiger K, Poschenrieder A, Notni J, Fischer J, Baumgartner C, Rischpler C, Nekolla SG, Weber C, Eckstein H-H, Wester H-J, Schwaiger M. 2017. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68Ga-Pentixafor for PET. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 58:499–506.
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Hyafil F, Garzelli L, Touati A. 2017. What is This Image? 2017: Image 5 Result. Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology 24:360–362.
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Godschalk TC, Byrne RA, Adriaenssens T, Malik N, Feldman LJ, Guagliumi G, Alfonso F, Neumann F-J, Trenk D, Joner M, Schulz C, Steg PG, Goodall AH, Wojdyla R, Dudek D, Wykrzykowska JJ, Hlinomaz O, Zaman AG, Curzen N, Dens J, Sinnaeve P, Desmet W, Gershlick AH, Kastrati A, Massberg S, Ten Berg JM, Investigators P. 2017. Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention: Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry. JACC Cardiovascular interventions 10:2548–2556.
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Feldman L, Steg PG, Amsallem M, Puymirat E, Sorbets E, Elbaz M, Ritz B, Hueber A, Cattan S, Piot C, Ferrières J, Simon T, Danchin N, investigators F-M. 2017. Editor’s Choice-Medically managed patients with non-ST-elevation acute myocardial infarction have heterogeneous outcomes, based on performance of angiography and extent of coronary artery disease. European Heart Journal Acute Cardiovascular Care 6:262–271.
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Calais J, Pasi N, Nguyen V, Hyafil F. 2017. Mycotic aneurysm in a pulmonary artery detected with 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. European Heart Journal 38:3474.
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Ben Azzouna R, Leygnac S, Al-Shoukr F, Rouzet F, Guilloteau D, Le Guludec D. 2017. 68Ga “vacuum elution approach” for direct radiolabelling of DOTA-conjugated and NODAGA-conjugated peptides. Nuclear Medicine Communications 38:51–56.
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Ben Azzouna R, Guez A, Benali K, Al-Shoukr F, Gonzalez W, Karoyan P, Rouzet F, Le Guludec D. 2017. Synthesis, gallium labelling and characterization of P04087, a functionalized phosphatidylserine-binding peptide. EJNMMI radiopharmacy and chemistry 2:3.
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Agostini D, Marie P-Y, Ben-Haim S, Rouzet F, Songy B, Giordano A, Gimelli A, Hyafil F, Sciagrà R, Bucerius J, Verberne HJ, Slart RHJA, Lindner O, Übleis C, Hacker M, Medicine CC of the EA of N. 2017. Erratum to: Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM). European Journal of Nuclear Medicine and Molecular Imaging 44:176.
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Adriaenssens T, Joner M, Godschalk TC, Malik N, Alfonso F, Xhepa E, De Cock D, Komukai K, Tada T, Cuesta J, Sirbu V, Feldman LJ, Neumann F-J, Goodall AH, Heestermans T, Buysschaert I, Hlinomaz O, Belmans A, Desmet W, Ten Berg JM, Gershlick AH, Massberg S, Kastrati A, Guagliumi G, Byrne RA, Investigators P of LST by an IGEE. 2017. Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis: A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort). Circulation 136:1007–1021.
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Adjedj J, Ducrocq G, Bouleti C, Reinhart L, Fabbro E, Elbez Y, Fischer Q, Tesniere A, Feldman L, Varenne O. 2017. Medical Student Evaluation With a Serious Game Compared to Multiple Choice Questions Assessment. JMIR serious games 5:e11.
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Tournoux F, Chequer R, Sroussi M, Hyafil F, Algalarrondo V, Cohen-Solal A, Bodson-Clermont P, Le Guludec D, Rouzet F. 2016. Value of mechanical dyssynchrony as assessed by radionuclide ventriculography to predict the cardiac resynchronization therapy response. European Heart Journal Cardiovascular Imaging 17:1250–1258.