Team 4: Cardiovascular Imaging

Group leader: Dominique Le Guludec


Staff of the team

Name
Position
Phone
Email
AERTS JoëlPU Associé j.aerts@ulg.ac.be
ANIZAN NadegeIR nadege.anizan@univ-paris-diderot.fr
BEN ALI KhadijaIE benali_kh@yahoo.fr
BEN AZZOUNA RanaDoctorant01.40.25.80.17rana.ben-azzouna@bch.aphp.fr
BEN ZEMZEM AichaMaster 2
BURG SamuelPH samuel.burg@yahoo.fr
DIEUDONNE ArnaudDoctorant arnaud.dieudonne@bjn.aphp.fr
FELDMAN LaurentPU-PH01.40.25.66.01laurent.feldman@bch.ap-hop-paris.fr
FISCHER QuentinMaster 2
FUIN NiccoloIR
HYAFIL Fabien 01.40.25.64.75 / 06.50.99.42.51fabien.hyafil@bch.aphp.fr
JOURNE ClementAI clement.journe@inserm.fr
LAISSY Jean-PierrePU-PH jean-pierre.laissy@bch.aphp.fr
LE GULUDEC DominiquePU-PH01.40.25.84.13dominique.leguludec@bch.aphp.fr
LEYGNAC Sébastien MED sebastien.leygnac@aphp.fr
MAHIDA Besma Master 2
OU PhallaMCUPH phalla.ou@bch.aphp.fr
ROUZET FrançoisMCUPH01.40.25.64.11francois.rouzet@bch.aphp.fr
SLAMA JérômeDoctorant jslams@hotmail.com
SORBETS EmmanuelDoctorant emmanuel.sorbets@aphp.fr
VIGNE Jonathan Doctorant jonathan.vigne.fr@gmail.com

Project outlines

ImagingThe new team 4 is originated from the very large previous team 3 of U698. Members involved in preclinical and clinical imaging are now gathered in this new team. They are all from Paris 7 University and are affiliated to X. Bichat hospital. The new team is constituted by 3 PU-PH, 4 MCU-PH (one under recruitment), 2 PH (one with contrat d’interface), 3 physicians in nuclear medicine, 2 CCA. Team 4 aims the development of imaging technologies as diagnostic surrogate markers in health and disease. The purpose is to provide early detection and location of the biological process involved in tissue degeneration, and to follow in situ the therapeutic activity of new compounds targeting localized tissue specific diseases. After moving from morphological to functional approaches, the new challenge is to shift to molecular imaging, providing evidence of specific molecular, cellular and tissue localization targeting. Molecular imaging is a high standard tool for translating biological molecular knowledge into clinical applications for all fields of human tissue pathologies. Specific molecular imaging requires developing innovative ligands identified through biological and/or chemical approaches, and transversal multidisciplinary competencies and know-how: chemistry, pathophysiology, animal experimental model validation, pharmacology, imaging, biophysics, radiopharmacology, software. Imaging specialists must be closely associated to the research of such imaging ligands because the development of clinical applications is the final goal. The Unit is offering such a multidisciplinary collaboration, and national or international collaborations help us in some fields were some competencies are lacking, such as signal quantification or PET chemistry.

Since several years, we have developed a translational research going from chemistry to clinical applications of new ligands. We have built an imaging platform in both sides: at the research level, with all imaging modalities dedicated for small animal imaging (7T MRI, SPECT-CT and PET, ultrasound), as well as at the clinical level (1.5 and 3T MRI, 64 time of flight PET-CT, CZT gamma-camera), and all requirements for gamma-emitters and 68Gallium labelling. This platform is now integrated in a national network (FLI), which should help us acquiring soon a SPECT-MRI for multimodality imaging. Our group have also very close collaboration with: 1/ a highly innovative group in the field of functional MRI (R Synkus and B Van Beers, U773), with elaboration of a joint program on multimodality imaging (SPECT-MRI) in the context of the FLI network; this project is not described here but in the SFR project; 2/ IMNC laboratory, CNRS UMR 8165, Irène Buvat), which has a strong expertise on signal quantification in clinical and pre-clinical PET images.

Our project is to develop new ligands targeting biological activities within diseased cardiovascular tissues, such as inflammation, thrombus, ischemia, cell necrosis and apoptosis, fibrosis. Some non-specific agents, such as 18FDG have been evaluated, but there is still room for specific agents. Several targets have been identified; among them three represent complementary approaches: selectins (inflammation), collagen (fibrosis), and serine proteases (neoangiogenesis). We also evaluate new imaging ligands developed by industry in original cardiovascular applications and animal models. Our research includes pre-clinical evaluation on animal models developed by several teams of the unit, human ex-vivo evaluation using the large tissue collection, and clinical evaluation from early clinical stages of proof of concept to large multicentric trials.


Publications (2012->Today)

2017

1.
Azzouna RB, Guez A, Benali K, Al-Shoukr F, Gonzalez W, Karoyan P, Rouzet F, Guludec DL. 2017. Synthesis, gallium labelling and characterization of P04087, a functionalized phosphatidylserine-binding peptide. EJNMMI Radiopharmacy and Chemistry 2.
1.
Ben Azzouna R, Leygnac S, Al-Shoukr F, Rouzet F, Guilloteau D, Le Guludec D. 2017. 68Ga “vacuum elution approach” for direct radiolabelling of DOTA-conjugated and NODAGA-conjugated peptides. Nuclear Medicine Communications 38:51–56.
1.
Calais J, Pasi N, Nguyen V, Hyafil F. 2017. Mycotic aneurysm in a pulmonary artery detected with 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. European Heart Journal.
1.
Hyafil F, Pelisek J, Laitinen I, Schottelius M, Mohring M, Döring Y, van der Vorst EPC, Kallmayer M, Steiger K, Poschenrieder A, Notni J, Fischer J, Baumgartner C, Rischpler C, Nekolla SG, Weber C, Eckstein H-H, Wester H-J, Schwaiger M. 2017. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer (68)Ga-Pentixafor for PET. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 58:499–506.
1.
Iung B, Rouzet F, Brochet E, Duval X. 2017. Cardiac Imaging of Infective Endocarditis, Echo and Beyond. Current Infectious Disease Reports 19:8.
1.
Mathieu C, Mikaïl N, Benali K, Iung B, Duval X, Nataf P, Jondeau G, Hyafil F, Guludec DL, Rouzet F. 2017. Characterization of 18 F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart ValvesCLINICAL PERSPECTIVE. Circulation: Cardiovascular Imaging 10:e005585.
1.
Pichon M, Mikail N, Ben Ali K, Rouzet F, Burdet C, Yazdanpanah Y, Joly V, Lepage L, Sarda-Mantel L. 2017. 18FDG-PET/CT: a useful tool for the management of patients in infectious diseases. Infectious Diseases (London, England) 49:155–157.
1.
Rouzet F, Aerts J, Hyafil F, Guludec DL. 2017. New-generation CZT cameras: the future of infection imaging? European Heart Journal 38:444–446.
1.
Rouzet F, Guludec DL. 2017. 18 F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Cardiac Implantable Electronic Devices Infection. Circulation: Cardiovascular Imaging 10:e006321.
1.
Rouzet F, Le Guludec D. 2017. (18)F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Cardiac Implantable Electronic Devices Infection: Ready for Routine Care! Circulation Cardiovascular Imaging 10.
1.
Varasteh Z, Hyafil F, Anizan N, Diallo D, Aid-Launais R, Mohanta S, Li Y, Braeuer M, Steiger K, Vigne J, Qin Z, Nekolla SG, Fabre J-E, Döring Y, Le Guludec D, Habenicht A, Vera DR, Schwaiger M. 2017. Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (111)In-tilmanocept. EJNMMI research 7:40.

2016

1.
Agostini D, Marie P-Y, Ben-Haim S, Rouzet F, Songy B, Giordano A, Gimelli A, Hyafil F, Sciagrà R, Bucerius J, Verberne HJ, Slart RHJA, Lindner O, Cardiovascular Committee of the European Association of Nuclear M. 2016. Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM). European Journal of Nuclear Medicine and Molecular Imaging 43:2423–2432.
1.
Agoston-Coldea L, Kouaho S, Sacre K, Dossier A, Escoubet B, Chillon S, Laissy J-P, Rouzet F, Kutty S, Extramiana F, Leenhardt A, Borie R, Crestani B, Ou P. 2016. High mass (>18g) of late gadolinium enhancement on CMR imaging is associated with major cardiac events on long-term outcome in patients with biopsy-proven extracardiac sarcoidosis. International Journal of Cardiology 222:950–956.
1.
Algalarrondo V, Antonini T, Théaudin M, Chemla D, Benmalek A, Lacroix C, Castaing D, Cauquil C, Dinanian S, Eliahou L, Samuel D, Adams D, Le Guludec D, Slama MS, Rouzet F. 2016. Cardiac Dysautonomia Predicts Long-Term Survival in Hereditary Transthyretin Amyloidosis After Liver Transplantation. JACC Cardiovascular imaging 9:1432–1441.
1.
Berti V, Sciagrà R, Neglia D, Pietilä M, Scholte AJ, Nekolla S, Rouzet F, Pupi A, Knuuti J. 2016. Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina. European Journal of Nuclear Medicine and Molecular Imaging 43:1522–1529.
1.
Bucerius J, Hyafil F, Verberne HJ, Slart RHJA, Lindner O, Sciagra R, Agostini D, Übleis C, Gimelli A, Hacker M, Cardiovascular Committee of the European Association of Nuclear M. 2016. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis. European Journal of Nuclear Medicine and Molecular Imaging 43:780–792.
1.
Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K. 2016. Tertiary Lymphoid Organs in Takayasu Arteritis. Frontiers in Immunology 7:158.
1.
Dweck MR, Hyafil F. 2016. Can Imaging Improve Our Understanding of Cardiovascular Pathophysiology? Circulation Cardiovascular Imaging 9:e004805.
1.
Guludec DL, Aigueperse J. 2016. Dose optimization: a major challenge for acceptability of nuclear medicine. Clinical and Translational Imaging 4:73–74.
1.
Hendel RC, Friedrich MG, Schulz-Menger J, Zemmrich C, Bengel F, Berman DS, Camici PG, Flamm SD, Guludec DL, Kim R, Lombardi M, Mahmarian J, Sechtem U, Nagel E. 2016. CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia. JACC: Cardiovascular Imaging 9:1338–1348.
1.
Hyafil F, Rischpler C, Nekolla S, Guludec DL, Schwaiger M. 2016. Emerging clinical applications for PET/MR in the field of cardiovascular imaging. Medecine Nucleaire 40:11–19.
1.
Hyafil F, Schindler A, Sepp D, Obenhuber T, Bayer-Karpinska A, Boeckh-Behrens T, Höhn S, Hacker M, Nekolla SG, Rominger A, Dichgans M, Schwaiger M, Saam T, Poppert H. 2016. High-risk plaque features can be detected in non-stenotic carotid plaques of patients with ischaemic stroke classified as cryptogenic using combined (18)F-FDG PET/MR imaging. European Journal of Nuclear Medicine and Molecular Imaging 43:270–279.
1.
Lariviere D, Benali K, Coustet B, Pasi N, Hyafil F, Klein I, Chauchard M, Alexandra J-F, Goulenok T, Dossier A, Dieude P, Papo T, Sacre K. 2016. Positron emission tomography and computed tomography angiography for the diagnosis of giant cell arteritis: A real-life prospective study. Medicine 95:e4146.
1.
Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguade-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Guludec DL, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernandez-Golfın C, Rincon LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJHA, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, Gaemperli O. 2016. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population. European Heart Journal – Cardiovascular Imaging 17:951–960.
1.
Lucas C, Pierre S, Fran�ois R, Murielle M, Jo�l A, Liliane L, Faisal A-S, Rachida A, Guy P, Dominique LG, C�dric C, Didier L, Fr�d�ric C. 2016. Fucoidan: a marine polysaccharide for SPECT diagnosis of thrombosis. Frontiers in Bioengineering and Biotechnology 4.
1.
Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M. 2016. Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. Platelets 1–11.
1.
Pitocco F, Serhal A, Abtan J, Henry-Feugeas M-C, Laissy J-P, Juliard J-M, Feldman L, Ou P. 2016. Multimodality imaging for the definitive diagnosis of spontaneous coronary artery dissection in the setting of acute coronary syndrome. International Journal of Cardiology 214:72–74.
1.
Riegger J, Byrne RA, Joner M, Chandraratne S, Gershlick AH, Ten Berg JM, Adriaenssens T, Guagliumi G, Godschalk TC, Neumann F-J, Trenk D, Feldman LJ, Steg PG, Desmet W, Alfonso F, Goodall AH, Wojdyla R, Dudek D, Philippi V, Opinaldo S, Titova A, Malik N, Cotton J, Jhagroe DA, Heestermans AACM, Sinnaeve P, Vermeersch P, Valina C, Schulz C, Kastrati A, Massberg S, Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort I. 2016. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. European Heart Journal 37:1538–1549.
1.
Sciagrà R, Passeri A, Bucerius J, Verberne HJ, Slart RHJA, Lindner O, Gimelli A, Hyafil F, Agostini D, Übleis C, Hacker M, Cardiovascular Committee of the European Association of Nuclear M. 2016. Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM). European Journal of Nuclear Medicine and Molecular Imaging 43:1530–1545.
1.
Selvaraj S, Steg PG, Elbez Y, Sorbets E, Feldman LJ, Eagle KA, Ohman EM, Blacher J, Bhatt DL, Investigators RR. 2016. Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry. Journal of the American College of Cardiology 67:392–403.

2015

1.
Algalarrondo V, Antonini T, Theaudin M, Ducot B, Lozeron P, Chemla D, Benmalek A, Lacroix C, Azoulay D, Castaing D, Cauquil C, Rouzet F, Dinanian S, Eliahou L, Guludec DL, Samuel D, Slama MS, Adams D. 2015. Prediction of Long-Term Survival After Liver Transplantation for Familial Transthyretin Amyloidosis. Journal of the American College of Cardiology 66:2154–2156.
1.
Azzouna RB, Alshoukr F, Leygnac S, Guez A, Gonzalez W, Rousseaux O, Guilloteau D, Guludec DL. 2015. A new68Ga anionic concentration and purification method for automated synthesis of [68Ga]-DOTA or NODAGA conjugated peptides in high radiochemical purity. Journal of Labelled Compounds and Radiopharmaceuticals 58:403–410.
1.
Belhatem N, Mohammedi K, Rouzet F, Matallah N, Baloshi AA, Travert F, Velho G, Roussel R, Guludec DL, Marre M, Hansel B. 2015. Impact of morbid obesity on the kidney function of patients with type 2 diabetes. Diabetes Research and Clinical Practice 108:143–149.
1.
Caselli C, Rovai D, Lorenzoni V, Carpeggiani C, Teresinska A, Aguade S, Todiere G, Gimelli A, Schroeder S, Casolo G, Poddighe R, Pugliese F, Le Guludec D, Valente S, Sambuceti G, Perrone-Filardi P, Del Ry S, Marinelli M, Nekolla S, Pietila M, Lombardi M, Sicari R, Scholte A, Zamorano J, Kaufmann PA, Underwood SR, Knuuti J, Giannessi D, Neglia D, Investigators ES. 2015. A New Integrated Clinical-Biohumoral Model to Predict Functionally Significant Coronary Artery Disease in Patients With Chronic Chest Pain. The Canadian Journal of Cardiology 31:709–716.
1.
Chatal J-F, Rouzet F, Haddad F, Bourdeau C, Mathieu C, Guludec DL. 2015. Story of Rubidium-82 and Advantages for Myocardial Perfusion PET Imaging. Frontiers in Medicine 2.
1.
Chequer R, Eliahou L, Regaieg H, Algalarrondo V, Dinanian S, Guludec DL, Slama MS, Rouzet F. 2015. Comparison of MIBG and Diphosphonate scintigraphy in cardiac involvement of aTTR-FAP. Orphanet Journal of Rare Diseases 10:P43.
1.
Degrell P, Sorbets E, Feldman LJ, Steg PG, Ducrocq G. 2015. Screening for coronary artery disease in asymptomatic individuals: Why and how? Archives of Cardiovascular Diseases 108:675–682.
1.
Dupont A-C, Guilloteau D, Ben-Azzouna R, Bidault R, Algalarrondo V, Slama M, Arlicot N, Guludec DL. 2015. [18F]FDDNP performed better than [18F] Florbetapir to distinguish transthyretin cardiac amyloidosis (TTR-CA) patients from healthy controls: an ex vivo study. Orphanet Journal of Rare Diseases 10:P38.
1.
Eliahou L, Chequer R, Ou P, Algalarrondo V, Antonini T, Slama M, Guludec DL, Rouzet F. 2015. Multi-modality imaging in cardiac ATTR amyloidosis: agreement between echocardiography, MRI and DPD-scintigraphy. Orphanet Journal of Rare Diseases 10:O17.
1.
Huet P, Burg S, Guludec DL, Hyafil F, Buvat I. 2015. Variability and Uncertainty of 18F-FDG PET Imaging Protocols for Assessing Inflammation in Atherosclerosis: Suggestions for Improvement. Journal of Nuclear Medicine 56:552–559.
1.
Hyafil F, Rouzet F, Guludec DL. 2015. Nuclear imaging for patients with a suspicion of infective endocarditis: Be part of the team! Journal of Nuclear Cardiology 24:207–211.
1.
Hyafil F, Tran-Dinh A, Burg S, Leygnac S, Louedec L, Milliner M, Ben Azzouna R, Reshef A, Ben Ami M, Meilhac O, Le Guludec D. 2015. Detection of Apoptotic Cells in a Rabbit Model with Atherosclerosis-Like Lesions Using the Positron Emission Tomography Radiotracer [18F]ML-10. Molecular Imaging 14:433–442.
1.
Mikail N, Benali K, Ou P, Slama J, Hyafil F, Le Guludec D, Rouzet F. 2015. Detection of Mycotic Aneurysms of Lower Limbs by Whole-Body (18)F-FDG-PET. JACC Cardiovascular imaging 8:859–862.
1.
Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, Aguade-Bruix S, Pizzi MN, Todiere G, Gimelli A, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Guludec DL, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernandez-Golfin C, Rincon LM, Graner FP, de Graaf MA, Fiechter M, Stehli J, Gaemperli O, Reyes E, Nkomo S, Maki M, Lorenzoni V, Turchetti G, Carpeggiani C, Marinelli M, Puzzuoli S, Mangione M, Marcheschi P, Mariani F, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJHA, Zamorano JL, Kaufmann PA, Underwood SR, and JK. 2015. Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging. Circulation: Cardiovascular Imaging 8:e002179–e002179.
1.
Regaieg H, Chequer RDP, Azzouna R, Algalarrondo V, Mahida B, Slama M, Guludec DL, Rouzet F. 2015. Disphosphonates cardiac uptake in familial amyloid neuropathy: Comparison between DPD and HMDP. Orphanet Journal of Rare Diseases 10:P41.
1.
Rouzet F, Hyafil F, Guludec DL. 2015. FDG PET/CT in cardiac electronic devices infection: Now is the time to target guidelines implementation. Journal of Nuclear Cardiology 22:800–803.
1.
Signore A, Glaudemans AWJM, Galli F, Rouzet F. 2015. Imaging infection and inflammation. BioMed Research International 2015:615150.
1.
Suzuki M, Bachelet-Violette L, Rouzet F, Beilvert A, Autret G, Maire M, Menager C, Louedec L, Choqueux C, Saboural P, Haddad O, Chauvierre C, Chaubet F, Michel J-B, Serfaty J-M, Letourneur D. 2015. Ultrasmall superparamagnetic iron oxide nanoparticles coated with fucoidan for molecular MRI of intraluminal thrombus. Nanomedicine (London, England) 10:73–87.
1.
Tournoux F, Chequer R, Sroussi M, Hyafil F, Algalarrondo V, Cohen-Solal A, Bodson-Clermont P, Guludec DL, Rouzet F. 2015. Value of mechanical dyssynchrony as assessed by radionuclide ventriculography to predict the cardiac resynchronization therapy response. European Heart Journal – Cardiovascular Imaging 17:1250–1258.
1.
Vidal-Petiot E, Bens M, Choudat L, Fernandez P, Rouzet F, Hermieu J-F, Bruneval P, Goujon J-M, Flamant M, Vandewalle A. 2015. A case report of reninoma: radiological and pathological features of the tumour and characterization of tumour-derived juxtaglomerular cells in culture. Journal of Hypertension 33:1709–1715.

2014

1.
Belhatem N, Mohammedi K, Rouzet F, Matallah N, Travert F, Roussel R, Marre M, Guludec DL, Hansel B. 2014. P263 Impact de l’obesite morbide sur la fonction renale chez les patients diabetiques de type 2. Diabetes & Metabolism 40:A90.
1.
Benali K, Louedec L, Azzouna RB, Merceron O, Nassar P, Al Shoukr F, Petiet A, Barbato D, Michel J-B, Sarda-Mantel L, Le Guludec D, Rouzet F. 2014. Preclinical validation of 99mTc-annexin A5-128 in experimental autoimmune myocarditis and infective endocarditis: comparison with 99mTc-HYNIC-annexin A5. Molecular Imaging 13.
1.
Guludec DL, Delforge J, Dolle F. 2014. Imaging the Parasympathetic Cardiac Innervation with PET, p. 111–135. In Autonomic Innervation of the Heart. Springer Berlin Heidelberg.
1.
Hyafil F, Klein I, Desilles J-P, Mazighi M, Guludec DL, Amarenco P. 2014. Rupture of Nonstenotic Carotid Plaque as a Cause of Ischemic Stroke Evidenced by Multimodality Imaging. Circulation 129:130–131.
1.
Larivière D, Sacre K, Klein I, Hyafil F, Choudat L, Chauveheid M-P, Papo T. 2014. Extra- and intracranial cerebral vasculitis in giant cell arteritis: an observational study. Medicine 93:e265.
1.
Rouzet F, Chequer R, Benali K, Lepage L, Ghodbane W, Duval X, Iung B, Vahanian A, Guludec DL, Hyafil F. 2014. Respective Performance of 18F-FDG PET and Radiolabeled Leukocyte Scintigraphy for the Diagnosis of Prosthetic Valve Endocarditis. Journal of Nuclear Medicine 55:1980–1985.
1.
Rouzet F, de Labriolle-Vaylet C, Trouillet J-L, Hitzel A, Benali K, Lebtahi R, Guludec DL. 2014. Diagnostic value of 99mTc-HMPAO-labeled leukocytes scintigraphy in suspicion of post-sternotomy mediastinitis relapse. Journal of Nuclear Cardiology 22:123–129.
1.
Saboural P, Chaubet F, Rouzet F, Al-Shoukr F, Azzouna R, Bouchemal N, Picton L, Louedec L, Maire M, Rolland L, Potier G, Guludec D, Letourneur D, Chauvierre C. 2014. Purification of a Low Molecular Weight Fucoidan for SPECT Molecular Imaging of Myocardial Infarction. Marine Drugs 12:4851–4867.
1.
Souron J-B, Petiet A, Decup F, Tran XV, Lesieur J, Poliard A, Guludec DL, Letourneur D, Chaussain C, Rouzet F, Vital SO. 2014. Pulp Cell Tracking by Radionuclide Imaging for Dental Tissue Engineering. Tissue Engineering Part C: Methods 20:188–197.
1.
von Olshausen G, Hyafil F, Langwieser N, Laugwitz K-L, Schwaiger M, Ibrahim T. 2014. Detection of acute inflammatory myocarditis in Epstein Barr virus infection using hybrid 18F-fluoro-deoxyglucose-positron emission tomography/magnetic resonance imaging. Circulation 130:925–926.

2013

1.
Amarenco P, Lavallée PC, Labreuche J, Ducrocq G, Juliard J-M, Feldman L, Cabrejo L, Meseguer E, Guidoux C, Adraï V, Ratani S, Kusmierek J, Lapergue B, Klein IF, Gongora-Rivera F, Jaramillo A, Abboud H, Olivot J-M, Mazighi M, Touboul P-J, Steg PG. 2013. Coronary artery disease and risk of major vascular events after cerebral infarction. Stroke 44:1505–1511.
1.
Burg S, Dupas A, Stute S, Dieudonne A, Huet P, Guludec DL, Buvat I. 2013. Partial volume effect estimation and correction in the aortic vascular wall in PET imaging. Physics in Medicine and Biology 58:7527–7542.
1.
Hyafil F, Rouzet F, Lepage L, Benali K, Raffoul R, Duval X, Hvass U, Iung B, Nataf P, Lebtahi R, Vahanian A, Guludec DL. 2013. Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. European Heart Journal - Cardiovascular Imaging 14:586–594.
1.
Juliard J-M, Golmard JL, Himbert D, Feldman LJ, Delorme L, Ducrocq G, Descoutures F, Sorbets E, Garbarz E, Boudvillain O, Aubry P, Vahanian A, Steg PG. 2013. Comparison of hospital mortality during ST-segment elevation myocardial infarction in the era of reperfusion therapy in women versus men and in older versus younger patients. The American Journal of Cardiology 111:1708–1713.
1.
Knuuti J, Bengel F, Bax JJ, Kaufmann PA, Guludec DL, Filardi PP, Marcassa C, Marsan NA, Achenbach S, Kitsiou A, Flotats A, Eeckhout E, Minn H, Hesse B. 2013. Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease. European Heart Journal 35:633–638.
1.
Senior R, Moreo A, Gaibazzi N, Agati L, Tiemann K, Shivalkar B, von Bardeleben S, Galiuto L, Lardoux H, Trocino G, Carrió I, Le Guludec D, Sambuceti G, Becher H, Colonna P, Ten Cate F, Bramucci E, Cohen A, Bezante G, Aggeli C, Kasprzak JD. 2013. Comparison of sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial contrast echocardiography with gated single-photon emission computed tomography for detection of significant coronary artery disease: a large European multicenter study. Journal of the American College of Cardiology 62:1353–1361.
1.
Srour A, Gardin I, Maurel F, Burg S, Guludec DL, Lebtahi R, Dieudonne A. 2013. Influence of lung/soft-tissue interfaces in targeted radionuclide therapy (TRT) dosimetry: Implication for the voxel-s-values (VSV) fast convolution. Physica Medica 29:e26.
1.
Steff M, Joly V, Di Lucca J, Feldman J, Burg S, Sarda-Mantel L, Peytavin G, Marinho E, Crickx B, Raymond E, Lariven S, Maubec E. 2013. Clinical activity of lenalidomide in visceral human immunodeficiency virus-related Kaposi sarcoma. JAMA dermatology 149:1319–1322.
1.
Verger A, Djaballah W, Fourquet N, Rouzet F, Koehl G, Imbert L, Poussier S, Fay R, Roch V, Le Guludec D, Karcher G, Marie P-Y. 2013. Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols. European Journal of Nuclear Medicine and Molecular Imaging 40:331–340.
1.
Verger A, Imbert L, Yagdigul Y, Fay R, Djaballah W, Rouzet F, Fourquet N, Poussier S, Roch V, Guludec DL, Karcher G, Marie P-Y. 2013. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera. European Journal of Nuclear Medicine and Molecular Imaging 41:522–528.

2012

1.
Algalarrondo V, Dinanian S, Juin C, Chemla D, Bennani SL, Sebag C, Plante V, Guludec DL, Samuel D, Adams D, Slama MS. 2012. Prophylactic pacemaker implantation in familial amyloid polyneuropathy. Heart Rhythm 9:1069–1075.
1.
Algalarrondo V, Eliahou L, Thierry I, Bouzeman A, Dasoveanu M, Sebag C, Moubarak G, Guludec DL, Samuel D, Adams D, Dinanian S, Slama MS. 2012. Circadian rhythm of blood pressure reflects the severity of cardiac impairment in familial amyloid polyneuropathy. Archives of Cardiovascular Diseases 105:281–290.
1.
Dieudonne A, Gardin I, Reguiga MB, Sebahoun S, Legendre S, Guludec DL, Lebtahi R. 2012. Dosimetrie personnalisee en radiotherapie interne vectorisee : exemple du traitement des carcinomes hepatocellulaires par microspheres marquees a l’yttrium 90. Medecine Nucleaire 36:215–221.
1.
Dieudonne A, Hobbs RF, Lebtahi R, Maurel F, Baechler S, Wahl RL, Boubaker A, Guludec DL, Sgouros G, Gardin I. 2012. Study of the Impact of Tissue Density Heterogeneities on 3-Dimensional Abdominal Dosimetry: Comparison Between Dose Kernel Convolution and Direct Monte Carlo Methods. Journal of Nuclear Medicine 54:236–243.
1.
Flotats A, Bengel FM, Knuuti J, Guludec DL, Marcassa C. 2012. CMR versus SPECT for diagnosis of coronary heart disease. The Lancet 379:2145.
1.
Guludec DL, Rouzet F. 2012. 64 PET-CT IN CARDIO-VASCULAR DISEASES: EXPANDING THE FIELD OF NON-INVASIVE IMAGING. Radiotherapy and Oncology 102:S22–S23.
1.
Hassani H, Slama, Hayem, ali B, Sarda mantel, Burg, dominique Le G. 2012. Melorheostosis associated with peripheral form spondyloarthropathy: new image with 18-fluoride positron emission tomoscintigraphy coupled to computed tomography. Open Access Rheumatology: Research and Reviews 1.
1.
Hyafil F, Feldman L, Fayad ZA, Guludec DL. 2012. Imaging Atherosclerotic Plaques with MRI: Role of Contrast Agents. Current Cardiovascular Imaging Reports 6:76–88.
1.
Hyafil F, Feldman L, Guludec DL, Fayad ZA. 2012. Evaluating Efficacy of Pharmaceutical Interventions in Atherosclerosis: Role of Magnetic Resonance Imaging and Positron Emission Tomography. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 79:689–704.
1.
Hyafil F, Messika-Zeitoun D, Burg S, Rouzet F, Benali K, Iung B, Vahanian A, Guludec DL. 2012. Detection of 18Fluoride Sodium Accumulation by Positron Emission Tomography in Calcified Stenotic Aortic Valves. The American Journal of Cardiology 109:1194–1196.
1.
Ouimet T, Lancelot E, Hyafil F, Rienzo M, Deux F, Lemaître M, Duquesnoy S, Garot J, Roques BP, Michel J-B, Corot C, Ballet S. 2012. Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging. Molecular Pharmaceutics 9:850–861.
1.
Ramos-Mozo P, Madrigal-Matute J, Vega de Ceniga M, Blanco-Colio LM, Meilhac O, Feldman L, Michel J-B, Clancy P, Golledge J, Norman PE, Egido J, Martin-Ventura JL. 2012. Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm. Atherosclerosis 220:552–556.
1.
Rouzet F, Michel J-B, Chaubet F, Azzouna RB, Letourneur D, Guludec DL. 2012. Molecular Imaging of Selectins in Endothelial Activation. Current Cardiovascular Imaging Reports 5:199–202.
1.
Sarda-Mantel L, Alsac J-M, Boisgard R, Hervatin F, Montravers F, Tavitian B, Michel J-B, Guludec DL. 2012. Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms. Journal of Vascular Surgery 56:765–773.