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The general objectives of the LVTS UMRS1148 are the understanding of the physiological mechanisms by basic science approaches but also through large clinical trials, development of new diagnostic (markers and imaging) and new therapeutic/biomaterial strategies : identification of new targets, development of new molecules, validated by clinical trials. To carry out these projects, translational human and technological skills include clinical databases and assays, translational clinical investigations (carotid stenosis, aneurysms and dissections of the ascending aorta, Biocore), human tissue and cell biobanks, numerous experimental models of disease (transgenic mice, rats, rabbits), new methods in molecular and cell biology (proteomics, genetics & epigenetics, protein engineering, flow cytometry), chemistry of biopolymers, elaboration of biomaterials and nanosystems, and imaging technologies in small animals and in humans (Nuclear Imaging, Ultrasound and MRI).

The unit is organised into 6 collaborative teams affiliated to 3 different ITMO (National Institutes) PMN, Technologies for Health, Genetics, and to 2 Inserm scientific sections (CSS3 and CSS6). The Teams are hosted in 3 locations in the North of Paris:

-in the INSERM building at the Xavier Bichat Hospital (UFR de Médecine; Paris 7 University)

-at the UFR Santé Médecine et Biologie humaine (Bobigny; Paris 13 University)

-at the Institut Galilée (Villetaneuse, Paris 13 University)

  • Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and Nabil Seidah (Institut de recherches cliniques de Montréal – Canada), the Grand Prix de la Fondation Lefoulon Delalande during a …

    Jun 10, 2018

  • MOOC: Tissue and Organ Bioengineering

    MOOC: Tissue and Organ Bioengineering

    Marie-Noëlle Labour (Team 3) is actively involved in the MOOC “Tissue and Organ Bioengineering”. You can freely attend and register to this MOOC until 8th June 2018. It will be broadcasted between the 14 May and 17 June 2018.

    Link to

    Feb 28, 2018

  • Ethique et intégrité scientifiques

    Ethique et intégrité scientifiques

    Jan 17, 2018

  • Improved prognosis in NSTEMI patients

    Improved prognosis in NSTEMI patients

    A recent publication from Team 5 has been released in Circulation demonstrates that patients with high risk non–ST-segment–elevation myocardial infarction (NSTEMI) that undergo coronary angiography within the initial 12 hours after admission had a lower risk of ischemic outcomes at 180 days.

    Timing of …

    Jan 1, 2018

  • Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec, Professor of Biophysics and Nuclear Medicine at the UFR of Medicine at Paris Diderot University, Director of the Department of Nuclear Medicine and Biophysics at Bichat Hospital – Claude Bernard, APHP and Head of the Imaging Team …

    Dec 13, 2017

  • ACTICOR biotech first-in-human clinical trial in healthy volunteers

    ACTICOR biotech first-in-human clinical trial in healthy volunteers

    Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) involved in the acute phase of thrombotic diseases, including stroke and myocardial infarction, today announced the agreement of Dutch Authorities …

    Oct 18, 2017

  • Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Dr. Catherine Boileau (Team 2) talks with Dr. Niels Voigt for Cardiovascular Research Onlife at the 2017 William Harvey Lecture of the European Society of Cardiology.

    Watch the interview:

    Sep 25, 2017

  • TF1 talks about Fucoidans

    TF1 talks about Fucoidans

    Cedric Chauvierre (Team 3) has given an interview on the use of fucoidans to trace early atherothrombotic lesions for the TV news on the first French channel (TF1) on the 14th August 2017. You can see it here:

    Aug 16, 2017

  • D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award.

    APA was founded in 2007 at the premises of Indian Institute of Technology, New Delhi, India, www.asianpolymer.org. The society involves academicians, …

    May 8, 2017

  • Prof G Jondeau, coordinator of VASCERN

    Prof G Jondeau, coordinator of VASCERN

    Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases.

    “The VASCERN project aims to facilitate and improve diagnosis, treatment and care for ALL patients suffering from Rare Multisystemic Vascular Diseases, thus enhancing …

    Apr 21, 2017

  • Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président du CA de MSD-Avenir), M Hirsch (Directeur Général de l’AP-HP), the Prof Y Levy (Président Directeur Général de l’INSERM), in the …

    Apr 19, 2017

  • RHU call results: LVTS involved in 5 granted projects!

    RHU call results: LVTS involved in 5 granted projects!

    The ‘RHU’ (Recherche Hospital Universitaire) action is to support translational research projects in health or clinical research, which are to be based on fundamental research in biology, epidemiology, social science or health economics and extend for a benefit for the care of …

    Jul 1, 2016

  • Early detection of strokes

    Early detection of strokes

    Télématin broadcasted on the 13rd May 2016 an interview from Prof Pierre Amarenco (Team 5) where it is explained why we should detect stroke as soon as possible.

    This is related to a paper published this year by P Amarenco et …

    May 13, 2016

  • FACT: French Alliance for Cardiovascular Trials

    FACT: French Alliance for Cardiovascular Trials

    The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as an « Investigative Network Initiative » and will receive a 5-year financial support from the F-CRIN (French part of ECRIN …

    May 1, 2015

  • Didier Letourneur at the French Parliament

    Didier Letourneur at the French Parliament

    Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many pharmaceutical companies develop and put on the drug market “Biosimilars” on the same pattern as for the generic chemical drugs. …

    May 1, 2015

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  • Platelets and vascular integrity

    Platelets and vascular integrity

    Platelets and vascular integrity: how platelets prevent bleeding in inflammation
    Ho-Tin-Noe B, Boulaftali Y, Camerer E
    2018 • Blood • [pdf] Platelets play a central role in primary hemostasis by forming aggregates that plug holes in injured vessels. Half a century ago, detailed studies …

    Sep 3, 2018

  • Thombus NETs impairs thrombolysis in stroke

    Thombus NETs impairs thrombolysis in stroke

    Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke
    Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel JB, Piotin …

    Sep 3, 2018

  • Microvascular thombosis is an early response to cerebral arterial occlusion

    Microvascular thombosis is an early response to cerebral arterial occlusion

    Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion
    Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noe B
    2018 • J Am Heart Assoc • …

    Sep 3, 2018

  • P8RI dampens IR-induced intestinal injury

    P8RI dampens IR-induced intestinal injury

    Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury
    Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, Assadi M, Montravers P, Longrois D, Corcos O, Caligiuri G, Nicoletti A, Michel JB, Tran-Dinh A
    2018 • Intensive Care Med …

    Aug 22, 2018

  • Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm
    Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, Morvan M, Even G, Procopio E, Gaston AT, Le Borgne M, Deschamps, L, Nicoletti A, Caligiuri G
    2018 • JACC • [pdf] + …

    Jul 16, 2018

  • Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine
    Simon-Yarza T, Mielcarek A, Couvreur P, Serre C
    2018 • Adv Mater. • [pdf]

    In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic …

    Jun 11, 2018

  • Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials
    Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, Charles L, Letourneur D, Lutz JF.
    2018 • Angew Chem Int Ed Engl • [pdf] Sequence-defined oligourethanes were tested as in vivo taggants …

    Jun 10, 2018

  • External applicability of the COMPASS trial

    External applicability of the COMPASS trial

    External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry
    Darmon A, Bhatt DL, Elbez Y, Aboyans V, Anand S, Bosch J, Branch KR, Connolly SJ, Dyal L, Eikelboom JW, Fox KAA, Keltai …

    Jan 1, 2018

  • Systemic Atherosclerosis and Stroke Etiologies

    Systemic Atherosclerosis and Stroke Etiologies

    Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease
    Hoshino T, Sissani L, Labreuche J, Ducrocq G, Lavallee PC, Meseguer E, Guidoux C, Cabrejo L, Hobeanu C, Gongora-Rivera …

    Jan 1, 2018

  • Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters
    Tardy A, Honore JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D, Perrier J, Nicoletti C, Maresca M, Lefay C, Gigmes D, …

    Nov 10, 2017

  • Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition
    Ozen G, Gomez I, Daci A, Deschildre C, Boubaya L, Teskin O, Uydes-Dogan BS, Jakobsson PJ, Longrois D, Topal G, Norel X
    2017 …

    Sep 11, 2017

  • Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice

    Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice

    Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion
    Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz …

    Jun 23, 2017

  • Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

    Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

    Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo
    Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB
    2017 • Atherosclerosis • [pdf]

    BACKGROUND AND AIMS: The arterial wall …

    Mar 26, 2017

  • One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

    One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

    Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials
    Costa F, van Klaveren D, James S, Heg D, Raber L, Feres …

    Mar 22, 2017

  • TLOs in Takayasu Arteritis

    TLOs in Takayasu Arteritis

    Tertiary lymphoid organs in Takayasu Arteritis
    Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K
    2016 • Frontiers Immunol • [pdf] Objective: The role of B cells in the …

    Apr 22, 2016

  • LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections

    LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections

    LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections
    Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, Ren Z, Cai B, Hostetler EM, Moran R, Liang D, Estrera AL, Safi HJ, Leal SM, Bamshad MJ, Shendure J, …

    Feb 4, 2016

  • Beneficial effect of reducing microvascular thrombosis

    Beneficial effect of reducing microvascular thrombosis

    Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke
    Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M
    2015 …

    Dec 2, 2015

  • Chemical heterogeneity of biodegradable polymers & surface energy

    Chemical heterogeneity of biodegradable polymers & surface energy

    Effect of chemical heterogeneity of biodegradable polymers on surface energy: A static contact angle analysis of polyester model films
    Belibel R, Avramoglou T, Garcia A, Barbaud C, Moras L
    2015 • Mater. Sci. Eng C • [pdf]

    Biodegradable and bioassimilable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) …

    Nov 18, 2015

  • Translational Immunometabolism

    Translational Immunometabolism

    The Cellular and Molecular Basis of Translational Immunometabolism
    Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM
    2015 • Immunity • [pdf]

    The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are …

    Sep 28, 2015

  • Platelets GPVI binds to fibrin

    Platelets GPVI binds to fibrin

    Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
    Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M
    2015 • Blood • [pdf]

    Fibrin, the coagulation end …

    Sep 18, 2015

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