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  • Immunometabolism in CVD

    Immunometabolism in CVD

    Giuseppina Caligiuri (Team 1) and Danilo Norata (University of Milan) present the content of a Cardiovascular Research spotlight issue focusing …

    Jul 9, 2019

    enabled
  • ISTH honors Martine Jandrot-Perrus amongst four other members with Esteemed Career Awards

    ISTH honors Martine Jandrot-Perrus amongst four other members with Esteemed Career Awards

    The ISTH honored Martine Jandrot-Perrus (Team 6) amongst four other members with the Esteemed Career Award at the ISTH 2019 …

    Jul 7, 2019

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  • Thierry Lhermitte and FRM representatives at the LVTS

    Thierry Lhermitte and FRM representatives at the LVTS

    Jun 12, 2019

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  • Tridek‐One raises € 3 million from Advent France Biotechnology and Advent Life Science

    Tridek‐One raises € 3 million from Advent France Biotechnology and Advent Life Science

    Jun 4, 2019

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  • Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Apr 27, 2019

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  • Création de l’Université de Paris

    Création de l’Université de Paris

    Le décret, en date du 20 mars 2019, portant création de l’Université de Paris est paru au Journal officiel de …

    Apr 5, 2019

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  • Prof. PG Steg: appointed “Vice President for Research” of the Executive Board of AP-HP

    Prof. PG Steg: appointed “Vice President for Research” of the Executive Board  of AP-HP

    Prof. Philippe Gabriel Steg (head of Team 5) has been appointed “Vice President for Research” of the Executive Board of the …

    Mar 5, 2019

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  • Discover the portrait of Catherine Boileau, leader of Team 2

    Discover the portrait of Catherine Boileau, leader of Team 2

    In the last issue of the Magazine Science&Santé of INSERM,  there is a portrait of Catherine Boileau (co-head of Team 2) …

    Dec 14, 2018

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  • A new award for Jean-Baptiste Michel

    A new award for Jean-Baptiste Michel

    Jean-Baptiste Michel (Team 2) received the MATMUT prize for Medical Innovation 2018.

    Read more on the Fondation de l’Avenir web

    Dec 14, 2018

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  • Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and …

    Jun 10, 2018

    enabled
  • MOOC: Tissue and Organ Bioengineering

    MOOC: Tissue and Organ Bioengineering

    Marie-Noëlle Labour (Team 3) is actively involved in the MOOC “Tissue and Organ Bioengineering”. You can freely attend and register to …

    Feb 28, 2018

    enabled
  • Ethique et intégrité scientifiques

    Ethique et intégrité scientifiques

    Jan 17, 2018

    enabled
  • Improved prognosis in NSTEMI patients

    Improved prognosis in NSTEMI patients

    A recent publication from Team 5 has been released in Circulation demonstrates that patients with high risk non–ST-segment–elevation myocardial infarction (NSTEMI) that undergo …

    Jan 1, 2018

    enabled
  • Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec, Professor of Biophysics and Nuclear Medicine at the UFR of Medicine at Paris Diderot University, Director of …

    Dec 13, 2017

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  • ACTICOR biotech first-in-human clinical trial in healthy volunteers

    ACTICOR biotech first-in-human clinical trial in healthy volunteers

    Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) …

    Oct 18, 2017

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  • Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Dr. Catherine Boileau (Team 2) talks with Dr. Niels Voigt for Cardiovascular Research Onlife at the 2017 William Harvey Lecture …

    Sep 25, 2017

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  • TF1 talks about Fucoidans

    TF1 talks about Fucoidans

    Cedric Chauvierre (Team 3) has given an interview on the use of fucoidans to trace early atherothrombotic lesions for the …

    Aug 16, 2017

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  • D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award.

    APA …

    May 8, 2017

    enabled
  • Prof G Jondeau, coordinator of VASCERN

    Prof G Jondeau, coordinator of VASCERN

    Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases.

    “The VASCERN project …

    Apr 21, 2017

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  • Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président …

    Apr 19, 2017

    enabled

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  • Ticagrelor in Patients with Stable Coronary Disease and Diabetes

    Ticagrelor in Patients with Stable Coronary Disease and Diabetes

    Ticagrelor in Patients with Stable Coronary Disease and Diabetes
    Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, …

    Sep 3, 2019

    enabled
  • Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by polyurethane coatings

    Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by  polyurethane coatings

    Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings
    Gossart …

    Jul 10, 2019

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  • Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD

    Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD

    Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology
    Caligiuri G
    2019 • Cardiovasc Res • [pdf] Biomechanical changes in the heart and …

    Jul 9, 2019

    enabled
  • Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab

    Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab

    Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab
    Voors-Pette C, Lebozec K, Dogterom P, Jullien …

    Jun 19, 2019

    enabled
  • Functionalized polymer microbubbles to target thrombus

    Functionalized polymer microbubbles to target thrombus

    Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus
    Li B, Aid-Launais R, Labour MN, Zenych …

    May 29, 2019

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  • Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets
    Morvan M, Arangalage D, Franck G, Perez F, Cattan-Levy …

    May 2, 2019

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  • Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis
    Franck G, Even G, Gautier A, Salinas M, Loste …

    May 2, 2019

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  • Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
    Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg …

    Nov 26, 2018

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  • Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women
    Ozen G, Boumiza S, Deschildre C, …

    Oct 29, 2018

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  • Platelets and vascular integrity

    Platelets and vascular integrity

    Platelets and vascular integrity: how platelets prevent bleeding in inflammation
    Ho-Tin-Noe B, Boulaftali Y, Camerer E
    2018 • Blood • [pdf] Platelets play a …

    Sep 3, 2018

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  • Thombus NETs impairs thrombolysis in stroke

    Thombus NETs impairs thrombolysis in stroke

    Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke
    Ducroux C, Di Meglio L, Loyau S, Delbosc S, …

    Sep 3, 2018

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  • Microvascular thombosis is an early response to cerebral arterial occlusion

    Microvascular thombosis is an early response to cerebral arterial occlusion

    Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion
    Desilles JP, Syvannarath V, Di Meglio …

    Sep 3, 2018

    enabled
  • P8RI dampens IR-induced intestinal injury

    P8RI dampens IR-induced intestinal injury

    Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury
    Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, …

    Aug 22, 2018

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  • Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm
    Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, …

    Jul 16, 2018

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  • Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine
    Simon-Yarza T, Mielcarek A, Couvreur P, Serre C
    2018 …

    Jun 11, 2018

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  • Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials
    Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, …

    Jun 10, 2018

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  • External applicability of the COMPASS trial

    External applicability of the COMPASS trial

    External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry
    Darmon A, Bhatt …

    Jan 1, 2018

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  • Systemic Atherosclerosis and Stroke Etiologies

    Systemic Atherosclerosis and Stroke Etiologies

    Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial …

    Jan 1, 2018

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  • Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters
    Tardy A, Honore JC, …

    Nov 10, 2017

    enabled
  • Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition
    Ozen G, …

    Sep 11, 2017

    enabled

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The LVTS is an attractive center:

  • For Excellence in Research
  • For Education
  • For Industrial and clinical transfers

The LVTS UMRS1148 is organised to understand the physiological mechanisms by basic science approaches but also through large clinical trials, development of new diagnostic (markers and imaging) and new therapeutic/biomaterial strategies : identification of new targets, development of new molecules, validated by clinical trials.

The unit is organised into 6 collaborative teams affiliated to 3 different ITMO (National Institutes) PMN, Technologies for Health, Genetics, and to 2 Inserm scientific sections (CSS3 and CSS6).

More than 240 collaborators working together among which 119 have permanent positions.

  • 15 full time researchers
  • 77 university-hospital affiliated faculty
  • 24 permanent technical assistants and 8 non-permanent technical assistants
  • 36 PhD students
  • 14 postdoctoral fellows
  • 25 undergraduates

Our translational human and technological skills include clinical databases and assays, translational clinical investigations (carotid stenosis, aneurysms and dissections of the ascending aorta, Biocore), human tissue and cell biobanks, numerous experimental models of disease (transgenic mice, rats, rabbits), new methods in molecular and cell biology (proteomics, genetics & epigenetics, protein engineering, flow cytometry), chemistry of biopolymers, elaboration of biomaterials and nanosystems, and imaging technologies in small animals and in humans (Nuclear Imaging, Ultrasound and MRI).

Our Teams are hosted in 3 locations in the North of Paris: