The general objectives of the LVTS UMRS1148 are the understanding of the physiological mechanisms by basic science approaches but also through large clinical trials, development of new diagnostic (markers and imaging) and new therapeutic/biomaterial strategies : identification of new targets, development of new molecules, validated by clinical trials. To carry out these projects, translational human and technological skills include clinical databases and assays, translational clinical investigations (carotid stenosis, aneurysms and dissections of the ascending aorta, Biocore), human tissue and cell biobanks, numerous experimental models of disease (transgenic mice, rats, rabbits), new methods in molecular and cell biology (proteomics, genetics & epigenetics, protein engineering, flow cytometry), chemistry of biopolymers, elaboration of biomaterials and nanosystems, and imaging technologies in small animals and in humans (Nuclear Imaging, Ultrasound and MRI).
The unit is organised into 6 collaborative teams affiliated to 3 different ITMO (National Institutes) PMN, Technologies for Health, Genetics, and to 2 Inserm scientific sections (CSS3 and CSS6). The Teams are hosted in 3 locations in the North of Paris:
-in the INSERM building at the Xavier Bichat Hospital (UFR de Médecine; Paris 7 University)
-at the UFR Santé Médecine et Biologie humaine (Bobigny; Paris 13 University)
-at the Institut Galilée (Villetaneuse, Paris 13 University)