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  • LVTS in Eur Heart J: “a Cardiovascular Research Centre of Excellence”

    LVTS in Eur Heart J: “a Cardiovascular Research Centre of Excellence”

    Our research unit is spotlighted in the last issue of the European Heart Journal.

    Read the full paper:

    Sep 1, 2020

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  • Paris’ Claude Bernard Prize winner: Philippe-Gabriel STEG

    Paris’ Claude Bernard Prize winner: Philippe-Gabriel STEG

    As part of its policy of supporting medical research, the City of Paris annually awards two Grand Prizes to eminent …

    Feb 27, 2020

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  • Tridek-one in the INSERM journal.

    Tridek-one in the INSERM journal.

    In issue 44 of the INSERM journal, an article is devoted to the Tridek-one startup whose 2 scientific co-founders are …

    Oct 1, 2019

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  • Immunometabolism in CVD

    Immunometabolism in CVD

    Giuseppina Caligiuri (Team 1) and Danilo Norata (University of Milan) present the content of a Cardiovascular Research spotlight issue focusing …

    Jul 9, 2019

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  • ISTH honors Martine Jandrot-Perrus amongst four other members with Esteemed Career Awards

    ISTH honors Martine Jandrot-Perrus amongst four other members with Esteemed Career Awards

    The ISTH honored Martine Jandrot-Perrus (Team 6) amongst four other members with the Esteemed Career Award at the ISTH 2019 …

    Jul 7, 2019

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  • Thierry Lhermitte and FRM representatives at the LVTS

    Thierry Lhermitte and FRM representatives at the LVTS

    Jun 12, 2019

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  • Tridek‐One raises € 3 million from Advent France Biotechnology and Advent Life Science

    Tridek‐One raises € 3 million from Advent France Biotechnology and Advent Life Science

    Jun 4, 2019

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  • Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Apr 27, 2019

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  • Création de l’Université de Paris

    Création de l’Université de Paris

    Le décret, en date du 20 mars 2019, portant création de l’Université de Paris est paru au Journal officiel de …

    Apr 5, 2019

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  • Prof. PG Steg: appointed “Vice President for Research” of the Executive Board of AP-HP

    Prof. PG Steg: appointed “Vice President for Research” of the Executive Board  of AP-HP

    Prof. Philippe Gabriel Steg (head of Team 5) has been appointed “Vice President for Research” of the Executive Board of the …

    Mar 5, 2019

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  • Discover the portrait of Catherine Boileau, leader of Team 2

    Discover the portrait of Catherine Boileau, leader of Team 2

    In the last issue of the Magazine Science&Santé of INSERM,  there is a portrait of Catherine Boileau (co-head of Team 2) …

    Dec 14, 2018

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  • A new award for Jean-Baptiste Michel

    A new award for Jean-Baptiste Michel

    Jean-Baptiste Michel (Team 2) received the MATMUT prize for Medical Innovation 2018.

    Read more on the Fondation de l’Avenir web

    Dec 14, 2018

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  • Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and …

    Jun 10, 2018

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  • Nanomedicine progress in thrombolytic therapy

    Nanomedicine progress in thrombolytic therapy

    Nanomedicine progress in thrombolytic therapy
    Zenych A, Fournier L, Chauvierre C
    2020 • Biomaterials • [pdf]

    Thrombotic occlusions of blood vessels are responsible for …

    Sep 29, 2020

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  • Human and Rodent Prostaglandin Receptors & Prostacyclin Receptor

    Human and Rodent Prostaglandin Receptors & Prostacyclin Receptor

    International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and …

    Sep 28, 2020

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  • Phylogenic determinants of cardiovascular frailty

    Phylogenic determinants of cardiovascular frailty

    Phylogenic determinants of cardiovascular frailty, focus on hemodynamics and arterial smooth muscle cells
    Michel JB
    2020 • Physiol Rev • [pdf] The evolution of …

    Aug 30, 2020

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  • CD31 as a Therapeutic Target in Atherosclerosis

    CD31 as a Therapeutic Target in Atherosclerosis

    CD31 as a Therapeutic Target in Atherosclerosis
    Caligiuri G
    2020 • Circulation Res • [pdf]

    The potential of CD31 as a therapeutic target in …

    Apr 23, 2020

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  • Cleaved CD31 as a target for in vivo molecular imaging of inflammation

    Cleaved CD31 as a target for in vivo molecular imaging of inflammation

    Cleaved CD31 as a target for in vivo molecular imaging of inflammation
    Vigne J, Bay S, Aid-Launais R, Pariscoat G, Rucher …

    Dec 20, 2019

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  • A Comparison of 2 LDL Cholesterol Targets after Ischemic Stroke

    A Comparison of 2 LDL Cholesterol Targets after Ischemic Stroke

    A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke
    Amarenco P, Kim JS, Labreuche J, Charles H, Abtan J, Bejot …

    Nov 22, 2019

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  • Targeting PN-1 to control bleeding in hemophilia

    Targeting PN-1 to control bleeding in hemophilia

    Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia
    Aymonnier K, Kawecki C, Venisse L, …

    Nov 19, 2019

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  • Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension

    Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension

    Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension
    Ozen G, Benyahia C, Mani S, Boukais K, Silverstein AM, Bayles …

    Oct 2, 2019

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  • Ticagrelor in Patients with Stable Coronary Disease and Diabetes

    Ticagrelor in Patients with Stable Coronary Disease and Diabetes

    Ticagrelor in Patients with Stable Coronary Disease and Diabetes
    Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, …

    Sep 3, 2019

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  • Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by polyurethane coatings

    Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by  polyurethane coatings

    Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings
    Gossart …

    Jul 10, 2019

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  • Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD

    Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD

    Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology
    Caligiuri G
    2019 • Cardiovasc Res • [pdf] Biomechanical changes in the heart and …

    Jul 9, 2019

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  • Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab

    Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab

    Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab
    Voors-Pette C, Lebozec K, Dogterom P, Jullien …

    Jun 19, 2019

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  • Functionalized polymer microbubbles to target thrombus

    Functionalized polymer microbubbles to target thrombus

    Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus
    Li B, Aid-Launais R, Labour MN, Zenych …

    May 29, 2019

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  • Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets
    Morvan M, Arangalage D, Franck G, Perez F, Cattan-Levy …

    May 2, 2019

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  • Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis
    Franck G, Even G, Gautier A, Salinas M, Loste …

    May 2, 2019

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  • Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
    Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg …

    Nov 26, 2018

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  • Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women
    Ozen G, Boumiza S, Deschildre C, …

    Oct 29, 2018

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  • Platelets and vascular integrity

    Platelets and vascular integrity

    Platelets and vascular integrity: how platelets prevent bleeding in inflammation
    Ho-Tin-Noe B, Boulaftali Y, Camerer E
    2018 • Blood • [pdf] Platelets play a …

    Sep 3, 2018

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  • Thombus NETs impairs thrombolysis in stroke

    Thombus NETs impairs thrombolysis in stroke

    Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke
    Ducroux C, Di Meglio L, Loyau S, Delbosc S, …

    Sep 3, 2018

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  • Microvascular thombosis is an early response to cerebral arterial occlusion

    Microvascular thombosis is an early response to cerebral arterial occlusion

    Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion
    Desilles JP, Syvannarath V, Di Meglio …

    Sep 3, 2018

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The LVTS is an attractive center:

  • For Excellence in Research
  • For Education
  • For Industrial and clinical transfers

The LVTS UMRS1148 is organised to understand the physiological mechanisms by basic science approaches but also through large clinical trials, development of new diagnostic (markers and imaging) and new therapeutic/biomaterial strategies : identification of new targets, development of new molecules, validated by clinical trials.

The unit is organised into 6 collaborative teams affiliated to 3 different ITMO (National Institutes) PMN, Technologies for Health, Genetics, and to 2 Inserm scientific sections (CSS3 and CSS6).

More than 240 collaborators working together among which 119 have permanent positions.

  • 15 full time researchers
  • 77 university-hospital affiliated faculty
  • 24 permanent technical assistants and 8 non-permanent technical assistants
  • 36 PhD students
  • 14 postdoctoral fellows
  • 25 undergraduates

Our translational human and technological skills include clinical databases and assays, translational clinical investigations (carotid stenosis, aneurysms and dissections of the ascending aorta, Biocore), human tissue and cell biobanks, numerous experimental models of disease (transgenic mice, rats, rabbits), new methods in molecular and cell biology (proteomics, genetics & epigenetics, protein engineering, flow cytometry), chemistry of biopolymers, elaboration of biomaterials and nanosystems, and imaging technologies in small animals and in humans (Nuclear Imaging, Ultrasound and MRI).

Our Teams are hosted in 3 locations in the North of Paris: