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  • Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

    Apr 27, 2019

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  • Création de l’Université de Paris

    Création de l’Université de Paris

    Le décret, en date du 20 mars 2019, portant création de l’Université de Paris est paru au Journal officiel de …

    Apr 5, 2019

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  • Prof. PG Steg: appointed “Vice President for Research” of the Executive Board of AP-HP

    Prof. PG Steg: appointed “Vice President for Research” of the Executive Board  of AP-HP

    Prof. Philippe Gabriel Steg (head of Team 5) has been appointed “Vice President for Research” of the Executive Board of the …

    Mar 5, 2019

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  • Discover the portrait of Catherine Boileau, leader of Team 2

    Discover the portrait of Catherine Boileau, leader of Team 2

    In the last issue of the Magazine Science&Santé of INSERM,  there is a portrait of Catherine Boileau (co-head of Team 2) …

    Dec 14, 2018

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  • A new award for Jean-Baptiste Michel

    A new award for Jean-Baptiste Michel

    Jean-Baptiste Michel (Team 2) received the MATMUT prize for Medical Innovation 2018.

    Read more on the Fondation de l’Avenir web

    Dec 14, 2018

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  • Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”

    Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and …

    Jun 10, 2018

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  • MOOC: Tissue and Organ Bioengineering

    MOOC: Tissue and Organ Bioengineering

    Marie-Noëlle Labour (Team 3) is actively involved in the MOOC “Tissue and Organ Bioengineering”. You can freely attend and register to …

    Feb 28, 2018

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  • Ethique et intégrité scientifiques

    Ethique et intégrité scientifiques

    Jan 17, 2018

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  • Improved prognosis in NSTEMI patients

    Improved prognosis in NSTEMI patients

    A recent publication from Team 5 has been released in Circulation demonstrates that patients with high risk non–ST-segment–elevation myocardial infarction (NSTEMI) that undergo …

    Jan 1, 2018

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  • Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec appointed head of the Haute Autorité de Santé

    Dominique Le Guludec, Professor of Biophysics and Nuclear Medicine at the UFR of Medicine at Paris Diderot University, Director of …

    Dec 13, 2017

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  • ACTICOR biotech first-in-human clinical trial in healthy volunteers

    ACTICOR biotech first-in-human clinical trial in healthy volunteers

    Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) …

    Oct 18, 2017

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  • Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Interview of Dr. Catherine Boileau at the ESC 2017 after her William Harvey Lecture award

    Dr. Catherine Boileau (Team 2) talks with Dr. Niels Voigt for Cardiovascular Research Onlife at the 2017 William Harvey Lecture …

    Sep 25, 2017

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  • TF1 talks about Fucoidans

    TF1 talks about Fucoidans

    Cedric Chauvierre (Team 3) has given an interview on the use of fucoidans to trace early atherothrombotic lesions for the …

    Aug 16, 2017

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  • D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

    Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award.

    APA …

    May 8, 2017

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  • Prof G Jondeau, coordinator of VASCERN

    Prof G Jondeau, coordinator of VASCERN

    Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases.

    “The VASCERN project …

    Apr 21, 2017

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  • Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

    On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président …

    Apr 19, 2017

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  • RHU call results: LVTS involved in 5 granted projects!

    RHU call results: LVTS involved in 5 granted projects!

    The ‘RHU’ (Recherche Hospital Universitaire) action is to support translational research projects in health or clinical research, which are to be based …

    Jul 1, 2016

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  • Early detection of strokes

    Early detection of strokes

    Télématin broadcasted on the 13rd May 2016 an interview from Prof Pierre Amarenco (Team 5) where it is explained why …

    May 13, 2016

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  • FACT: French Alliance for Cardiovascular Trials

    FACT: French Alliance for Cardiovascular Trials

    The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as …

    May 1, 2015

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  • Didier Letourneur at the French Parliament

    Didier Letourneur at the French Parliament

    Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many …

    May 1, 2015

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  • Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

    Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets
    Morvan M, Arangalage D, Franck G, Perez F, Cattan-Levy …

    May 2, 2019

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  • Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima

    Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis
    Franck G, Even G, Gautier A, Salinas M, Loste …

    May 2, 2019

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  • Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Anti-PCSK9 and CV outcomes after acute coronary syndrome

    Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
    Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg …

    Nov 26, 2018

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  • Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation,MMP, and PGE2 in human vascular wall

    Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women
    Ozen G, Boumiza S, Deschildre C, …

    Oct 29, 2018

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  • Platelets and vascular integrity

    Platelets and vascular integrity

    Platelets and vascular integrity: how platelets prevent bleeding in inflammation
    Ho-Tin-Noe B, Boulaftali Y, Camerer E
    2018 • Blood • [pdf] Platelets play a …

    Sep 3, 2018

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  • Thombus NETs impairs thrombolysis in stroke

    Thombus NETs impairs thrombolysis in stroke

    Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke
    Ducroux C, Di Meglio L, Loyau S, Delbosc S, …

    Sep 3, 2018

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  • Microvascular thombosis is an early response to cerebral arterial occlusion

    Microvascular thombosis is an early response to cerebral arterial occlusion

    Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion
    Desilles JP, Syvannarath V, Di Meglio …

    Sep 3, 2018

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  • P8RI dampens IR-induced intestinal injury

    P8RI dampens IR-induced intestinal injury

    Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury
    Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, …

    Aug 22, 2018

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  • Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm

    Macrophage CD31 Signaling in Dissecting Aortic Aneurysm
    Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, …

    Jul 16, 2018

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  • Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks

    Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine
    Simon-Yarza T, Mielcarek A, Couvreur P, Serre C
    2018 …

    Jun 11, 2018

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  • Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as taggants

    Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials
    Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, …

    Jun 10, 2018

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  • External applicability of the COMPASS trial

    External applicability of the COMPASS trial

    External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry
    Darmon A, Bhatt …

    Jan 1, 2018

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  • Systemic Atherosclerosis and Stroke Etiologies

    Systemic Atherosclerosis and Stroke Etiologies

    Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial …

    Jan 1, 2018

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  • Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

    Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters
    Tardy A, Honore JC, …

    Nov 10, 2017

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  • Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

    Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition
    Ozen G, …

    Sep 11, 2017

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  • Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice

    Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice

    Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion
    Franck G, Mawson …

    Jun 23, 2017

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  • Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

    Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

    Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo
    Coscas R, Bensussan M, Jacob MP, Louedec L, …

    Mar 26, 2017

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  • One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

    One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

    Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: …

    Mar 22, 2017

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  • TLOs in Takayasu Arteritis

    TLOs in Takayasu Arteritis

    Tertiary lymphoid organs in Takayasu Arteritis
    Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps …

    Apr 22, 2016

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  • LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections

    LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections

    LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections
    Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, …

    Feb 4, 2016

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The LVTS is an attractive center:

  • For Excellence in Research
  • For Education
  • For Industrial and clinical transfers

The LVTS UMRS1148 is organised to understand the physiological mechanisms by basic science approaches but also through large clinical trials, development of new diagnostic (markers and imaging) and new therapeutic/biomaterial strategies : identification of new targets, development of new molecules, validated by clinical trials.

The unit is organised into 6 collaborative teams affiliated to 3 different ITMO (National Institutes) PMN, Technologies for Health, Genetics, and to 2 Inserm scientific sections (CSS3 and CSS6).

More than 240 collaborators working together among which 119 have permanent positions.

  • 15 full time researchers
  • 77 university-hospital affiliated faculty
  • 24 permanent technical assistants and 8 non-permanent technical assistants
  • 36 PhD students
  • 14 postdoctoral fellows
  • 25 undergraduates

Our translational human and technological skills include clinical databases and assays, translational clinical investigations (carotid stenosis, aneurysms and dissections of the ascending aorta, Biocore), human tissue and cell biobanks, numerous experimental models of disease (transgenic mice, rats, rabbits), new methods in molecular and cell biology (proteomics, genetics & epigenetics, protein engineering, flow cytometry), chemistry of biopolymers, elaboration of biomaterials and nanosystems, and imaging technologies in small animals and in humans (Nuclear Imaging, Ultrasound and MRI).

Our Teams are hosted in 3 locations in the North of Paris: