Category Archives: Recent Articles

Myelo-Megakaryopoiesis Fuels Thromboinflammation in Chronic Renal Injury


Thrombopoietin-Dependent Myelo-Megakaryopoiesis Fuels Thromboinflammation and Worsens Antibody-Mediated Chronic Renal Microvascular Injury Douté M, Sannier A, Even G, Tran T, Gaston AT, Delbosc S, Loyau S; Bruneval P, Witko-Sarsat V, Mouthon L, Nicoletti A, Caligiuri G, Clement M 2023 • JASN • [pdf] Background Chronic thromboinflammation provokes microvascular alterations and rarefaction, promoting organ dysfunction in individuals with various life-threatening diseases. Hematopoietic… Read more »

Fibroblasts mediate angiogenic endothelial response in a new 3D model

Fibroblasts mediate endothelium response to angiogenic cues in a newly developed 3D stroma engineered model Dellaquila A, Dujardin C, Le Bao C, Chaumeton C, Carré A, Le Guilcher C, Lam F, Simon-Yarza T 2023 • Biomaterials Advances • [pdf] Three-dimensional stroma engineered models would enable fundamental and applicative studies of human tis- sues interaction and remodeling in both physiological and... Read more »

Recent advances in Fe-based bioresorbable stents


Recent advances in Fe-based bioresorbable stents: Materials design and biosafety Zhang Y, Roux C, Rouchaud A, Meddahi-Pellé A, Guguen V, Mangeney C, Sun F, Pavon-Djavid G, Luo Y 2023 • Bioactive Materials • [pdf] Fe-based materials have received more and more interests in recent years as candidates to fabricate bioresorbable stents due to their appropriate mechanical properties and biocompatibility. However, the… Read more »

Engineering of the outer blood-retina barrier


Advances in the engineering of the outer blood-retina barrier: From in-vitro modelling to cellular therapy Dujardin C, Habeler W, Monville C, Letourneur D, Simon-Yarza T 2023 • Bioactive Materials • [pdf] The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to the loss… Read more »

A new clot-adhesive coating for thrombectomy devices


Development of a clot-adhesive coating to improve the performance of thrombectomy devices Skarbek C, Anagnostakou V, Procopio E, Epshtein M, Raskett CM, Romagnoli R, Iviglia G, Morra M, Antonucci M, Nicoletti A, Caligiuri G, Gounis MJ. Development of a clot-adhesive coating to improve the performance of thrombectomy devices 2023 • J Neurointerv Surg • [pdf] BACKGROUND: The first-pass complete recanalization by mechanical… Read more »

Engineered human liver


Engineered human liver based on pullulan-dextran hydrogel promotes mice survival after liver failure C Le Guilchera, G Merlenb, A Dellaquila, MN Labour, A Aid, T Tordjmann, D Letourneur, T Simon-Yarza 2023 • Materials Today Bio • [pdf] Liver tissue engineering approaches aim to support drug testing, assistance devices, or transplantation. However, their suitability for clinical application remains unsatisfactory. Herein, we demonstrate the beneficial… Read more »

miRNA Delivery by Nanosystems


miRNA Delivery by Nanosystems: State of the Art and Perspectives Moraes FC, Pichon C, Letourneur D, Chaubet F 2021 •Pharmaceutics • [pdf] MicroRNAs (miRNAs) are short (~21–23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various… Read more »

In vitro strategies to vascularize 3D physiologically relevant models


In vitro strategies to vascularize 3D physiologically relevant models Dellaquila A, Le Bao C, Letourneur D, Simon-Yarza T 2021 •Adv Sci (Weigh) • [pdf] Vascularization of 3D models represents a major challenge of tissue engineering and a key prerequisite for their clinical and industrial application. The use of prevascularized models built from dedicated materials could solve some of the actual limitations,… Read more »

Coronary stent CD31-mimetic coating


Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo Diaz-Rodriguez S, Rasser C, Mesnier J, Chevallier P, Gallet R, Choqueux C, Even G, Sayah N, Chaubet F, Nicoletti A, Ghaleh B, Feldman LJ, Mantovani D, Caligiuri G 2021 • Eur Heart J• [pdf] AIMS: The rapid endothelialization of bare metal stents (BMS) is counterbalanced… Read more »

CD31 Mimetic Coating Enhances Flow Diverting Stent Integration


CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing †Cortese J, †Rasser C, Even G, Bardet SM, Choqueux C, Mesnier J, Perrin ML, Janot K, Caroff J, Nicoletti A, Michel JB, Spelle L, §Caligiuri G, §Rouchaud A 2021 • Stroke • [pdf] BACKGROUND AND PURPOSE: Beyond aneurysmal occlusion, metallic flow diverters (FDs) can induce an… Read more »

Chicken egg white a new ‘old biomaterial’


Chicken egg white: Hatching of a new old biomaterial Jalili-Firoozinezhad S, Filippi M, Mohabatpour F, Letourneur D, Scherberich A 2020 • Materials Today • [pdf] Chicken egg white is an abundant, inexpensive and natural source of important proteins such as ovalbumin and lysozyme. Thanks to its bioactivity, easy handling, anti-bacterial activity and biodegradability, egg white is being used since centuries… Read more »

Membranes for Guided Bone Regeneration


Membranes for Guided Bone Regeneration: A Road from Bench to Bedside Aprile P, Letourneur D, Simon-Yarza T 2020 • Adv Healthc Mater• [pdf] Bone resorption can negatively influence the osseointegration of dental implants. Barrier membranes for guided bone regeneration (GBR) are used to exclude nonosteogenic tissues from influencing the bone healing process. In addition to the existing barrier membranes available… Read more »

MedTech Translation in Academia


Enabling MedTech Translation in Academia: Redefining Value Proposition with Updated Regulations Letourneur D, Joyce K, Chauvierre C, Bayon Y, Pandit A 2020 • Adv Healthc Mater• [pdf] Academic institutions are becoming more focused on translating new technologies for clinical applications. A transition from “bench to bedside” is often described to take basic research concepts and methods to develop a therapeutic… Read more »

Nanomedicine progress in thrombolytic therapy


Nanomedicine progress in thrombolytic therapy Zenych A, Fournier L, Chauvierre C 2020 • Biomaterials • [pdf] Thrombotic occlusions of blood vessels are responsible for life-threatening cardiovascular disorders such as myocardial infarction, ischemic stroke, and venous thromboembolism. Current thrombolytic therapy, the injection of Plasminogen Activators (PA), is yet limited by a narrow therapeutic window, rapid drug elimination, and risks of hemorrhagic complications…. Read more »

Human and Rodent Prostaglandin Receptors & Prostacyclin Receptor


International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH 2020 •… Read more »

Phylogenic determinants of cardiovascular frailty


Phylogenic determinants of cardiovascular frailty, focus on hemodynamics and arterial smooth muscle cells Michel JB 2020 • Physiol Rev • [pdf] The evolution of the circulatory system from invertebrates to mammals has involved the passage from an open system to a closed in-parallel system via a closed in-series system, accompanying the increasing complexity and efficiency of life’s biological functions. The archaic… Read more »

CD31 as a Therapeutic Target in Atherosclerosis


CD31 as a Therapeutic Target in Atherosclerosis Caligiuri G 2020 • Circulation Res • [pdf] The potential of CD31 as a therapeutic target in atherosclerosis has been considered ever since its cloning in the 1990s, but the exact role played by this molecule in the biologic events underlying atherosclerosis has remained controversial, resulting in the stalling of any therapeutic perspective. Due… Read more »

Targeting PN-1 to control bleeding in hemophilia


Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia Aymonnier K, Kawecki C, Venisse L, Boulaftali Y, Christophe OD, Lenting PJ, Arocas V, de Raucourt E, Denis CV, Bouton MC 2019 • Blood • [pdf] Hemophilia A and B, diseases caused by the lack of factor VIII (FVIII) and factor IX (FIX) respectively, lead to… Read more »

Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension


Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension Ozen G, Benyahia C, Mani S, Boukais K, Silverstein AM, Bayles R, Nelsen AC, Castier Y, Danel C, Mal H, Clapp LH, Longrois D, Norel X 2019 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), a reduction… Read more »

Ticagrelor in Patients with Stable Coronary Disease and Diabetes


Ticagrelor in Patients with Stable Coronary Disease and Diabetes Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, Held C, Andersson M, Himmelmann A, Ridderstrale W, Leonsson-Zachrisson M, Liu Y, Opolski G, Zateyshchikov D, Ge J, Nicolau JC, Corbalan R, Cornel JH, Widimsky P, Leiter LA, Committee TS, Investigators 2019 • N Engl J Med • [pdf] BACKGROUND:… Read more »

Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by polyurethane coatings


Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings Gossart A, Letourneur D, Gand A, Regnault V, Ben Mlouka MA, Cosette P, Pauthe E, Ollivier V, Santerre JP 2019 • Biomaterials • [pdf] Monocytes are active at the crossroads between inflammation and coagulation processes since they can secrete pro-inflammatory cytokines… Read more »

Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD


Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology Caligiuri G 2019 • Cardiovasc Res • [pdf] Biomechanical changes in the heart and vessels drive rapid and dynamic regulation of blood flow, a vital process for meeting the changing metabolic needs of the peripheral tissues at any given point in time. The fluid movement of the blood exerts haemodynamic stress… Read more »

Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab


Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab Voors-Pette C, Lebozec K, Dogterom P, Jullien L, Billiald P, Ferlan P, Renaud L, Favre-Bulle O, Avenard G, Machacek M, Pletan Y, Jandrot-Perrus M 2019 • Arterioscler Thromb Vasc Biol • [pdf]  • [Editorial] Objective– ACT017 is a novel, first in class, therapeutic antibody to platelet GPVI… Read more »

Functionalized polymer microbubbles to target thrombus


Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus Li B, Aid-Launais R, Labour MN, Zenych A, Juenet M, Choqueux C, Ollivier V, Couture O, Letourneur D, Chauvierre C 2019 • Biomaterials • [pdf] Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus, early detection of thrombus by a widely spread imaging modality… Read more »

Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets


Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets Morvan M, Arangalage D, Franck G, Perez F, Cattan-Levy L, Codogno I, Jacob-Lenet MP, Deschildre C, Choqueux C, Even G, Michel JB, Back M, Messika-Zeitoun D, Nicoletti A, Caligiuri G, Laschet J 2019 • J Am Coll Cardiol • [pdf] BACKGROUND: Intraleaflet hematomas are associated with advanced stages of… Read more »

Haemodynamic stress-induced breaches of the arterial intima


Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis Franck G, Even G, Gautier A, Salinas M, Loste A, Procopio E, Gaston AT, Morvan M, Dupont S, Deschildre C, Berissi S, Laschet J, Nataf P, Nicoletti A, Michel JB, Caligiuri G 2018 • Eur Heart J • [pdf] Aims: Inflammatory mediators, including blood cells and their products, contribute… Read more »

Anti-PCSK9 and CV outcomes after acute coronary syndrome


Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM, Committees OO, Investigators 2018 • N Engl J… Read more »

Inflammation,MMP, and PGE2 in human vascular wall


Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women Ozen G, Boumiza S, Deschildre C, Topal G, Longrois D, Jakobsson PJ, Michel JB, Jacob MP, Chahed K, Norel X 2018 • Int J Obes (Lond) • [pdf] BACKGROUND AND OBJECTIVES: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft… Read more »

Platelets and vascular integrity


Platelets and vascular integrity: how platelets prevent bleeding in inflammation Ho-Tin-Noe B, Boulaftali Y, Camerer E 2018 • Blood • [pdf] Platelets play a central role in primary hemostasis by forming aggregates that plug holes in injured vessels. Half a century ago, detailed studies of the microvasculature by electron microscopy revealed that under inflammatory conditions that do not induce major disruption… Read more »

Thombus NETs impairs thrombolysis in stroke


Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel JB, Piotin M, Salomon L, Mazighi M, Ho-Tin-Noe B, Desilles JP 2018 • Stroke • [pdf] BACKGROUND AND PURPOSE: Neutrophil Extracellular Traps… Read more »

Microvascular thombosis is an early response to cerebral arterial occlusion


Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noe B 2018 • J Am Heart Assoc • [pdf] BACKGROUND: Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute… Read more »

P8RI dampens IR-induced intestinal injury


Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, Assadi M, Montravers P, Longrois D, Corcos O, Caligiuri G, Nicoletti A, Michel JB, Tran-Dinh A 2018 • Intensive Care Med Exp • [pdf] BACKGROUND: CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a… Read more »

Macrophage CD31 Signaling in Dissecting Aortic Aneurysm


Macrophage CD31 Signaling in Dissecting Aortic Aneurysm Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, Morvan M, Even G, Procopio E, Gaston AT, Le Borgne M, Deschamps, L, Nicoletti A, Caligiuri G 2018 • JACC • [pdf] + Editorial from P Libby: Biologically-Based Therapies for Aortic Diseases • Link Background The authors recently found that a CD31… Read more »

Nanoparticles of Metal-Organic Frameworks


Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine Simon-Yarza T, Mielcarek A, Couvreur P, Serre C 2018 • Adv Mater. • [pdf] In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based… Read more »

Abiotic sequence-coded oligomers as taggants


Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, Charles L, Letourneur D, Lutz JF. 2018 • Angew Chem Int Ed Engl • [pdf] Sequence-defined oligourethanes were tested as in vivo taggants for implants identification. The oligomers were prepared via an orthogonal solid-phase iterative approach and thus contained a… Read more »

External applicability of the COMPASS trial


External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry Darmon A, Bhatt DL, Elbez Y, Aboyans V, Anand S, Bosch J, Branch KR, Connolly SJ, Dyal L, Eikelboom JW, Fox KAA, Keltai K, Probstfield J, Yusuf S, Abtan J, Sorbets E, Eagle KA, Ducrocq G, Steg PG 2017 • Eur Heart… Read more »

Systemic Atherosclerosis and Stroke Etiologies


Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease Hoshino T, Sissani L, Labreuche J, Ducrocq G, Lavallee PC, Meseguer E, Guidoux C, Cabrejo L, Hobeanu C, Gongora-Rivera F, Touboul PJ, Steg PG, Amarenco P, Investigators A 2017 • JAMA Neurol • [pdf] Importance: Patients who have experienced… Read more »

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters


Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters Tardy A, Honore JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D, Perrier J, Nicoletti C, Maresca M, Lefay C, Gigmes D, Nicolas J, Guillaneuf Y 2017 • Angew Chem Int Ed Engl • [pdf] For the first time, the free-radical copolymerization… Read more »

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2


Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition Ozen G, Gomez I, Daci A, Deschildre C, Boubaya L, Teskin O, Uydes-Dogan BS, Jakobsson PJ, Longrois D, Topal G, Norel X 2017 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular… Read more »

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice


Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P 2017 • Circ Res • [pdf] Rationale:… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo


Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke


Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials Costa F, van Klaveren D, James S, Heg D, Raber L, Feres F, Pilgrim T, Hong MK, Kim HS, Colombo A, Steg PG, Zanchin T, Palmerini T, Wallentin L, Bhatt DL,… Read more »

TLOs in Takayasu Arteritis


Tertiary lymphoid organs in Takayasu Arteritis Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K 2016 • Frontiers Immunol • [pdf] Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs… Read more »

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections


LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, Ren Z, Cai B, Hostetler EM, Moran R, Liang D, Estrera AL, Safi HJ, Leal SM, Bamshad MJ, Shendure J, Nickerson DA, Jondeau G, Boileau C, Milewicz DM 2016 • Circ Res • [pdf] RATIONALE: Mutations in several genes have been… Read more »

Beneficial effect of reducing microvascular thrombosis


Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M 2015 • Stroke • [pdf] BACKGROUND AND PURPOSE: Downstream microvascular thrombosis (DMT) is known to be a contributing factor to… Read more »

Chemical heterogeneity of biodegradable polymers & surface energy


Effect of chemical heterogeneity of biodegradable polymers on surface energy: A static contact angle analysis of polyester model films Belibel R, Avramoglou T, Garcia A, Barbaud C, Moras L 2015 • Mater. Sci. Eng C • [pdf] Biodegradable and bioassimilable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) derivatives were synthesized and characterized in order to develop a new coating for coronary endoprosthesis enabling the… Read more »

Translational Immunometabolism


The Cellular and Molecular Basis of Translational Immunometabolism Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM 2015 • Immunity • [pdf] The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions…. Read more »

Platelets GPVI binds to fibrin


Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M 2015 • Blood • [pdf] Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets…. Read more »

Platelets seal neutrophil-induced vascular breaches


Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noe B 2015 • Blood • [pdf] Platelets protect vascular integrity during inflammation. Recent evidence suggests that this action is independent of thrombus formation and requires the engagement of glycoprotein VI (GPVI),… Read more »

Nanomedicine as a strategy to fight thrombotic diseases


Nanomedicine as a strategy to fight thrombotic diseases Varna M, Juenet M, Bayles R, Mazighi M, Chauvierre C, Letourneur D 2015 • Future Sci OA • [pdf] This review highlights the preclinical and clinical research based on the use of nano- and micro-carriers in thrombolytic drug delivery. Ischemic heart and stroke caused by thrombosis are the main causes of death in… Read more »

Role of platelets in the pathogenesis of Influenza virus


Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis Le VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B 2014 • Am J Respir Crit Care Med • [pdf] RATIONALE: The hallmark of severe influenza virus infection is excessive… Read more »

Organ repair & Nanoparticles


Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles Meddahi-Pelle A, Legrand A, Marcellan A, Louedec L, Letourneur D, Leibler L 2014 • Angew Chem Int Ed Engl • [pdf] • Video Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization… Read more »

CD31 & immunogenic DCs


CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G 2014 • Proc Natl Acad Sci USA • [pdf] CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes…. Read more »

Collagen & Platelet secretory phenotype


Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noe B 2014 • PLoS One • [pdf] Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these “non classical” functions… Read more »

PN-1 & Pulmonary Fibrosis


Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression Francois D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC 2014 • Lab Invest • [pdf] Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1… Read more »

Hemostatic disorders in JAK2(V617F) Tg mice


Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M 2014 • Blood • [pdf] Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as… Read more »

CD31 in the immunological synapse


Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G 2014 •… Read more »

Mutations in an ECM gene in TAAD


MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau… Read more »

Control of B cells in atherosclerosis


Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A 2015 • Circulation • [pdf] • Editorial… Read more »

Antiplatelet therapy in ACS


Clinical evidence for oral antiplatelet therapy in acute coronary syndromes Wiviott SD, Steg PG 2015 • Lancet • [pdf] Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the treatment and prevention of recurrence of these syndromes. Nearly 30 years ago, aspirin was the first agent to show a benefit for acute… Read more »

Thrombi and neutrophils


Thrombi and neutrophils Michel JB, Ho-Tin-Noé B 2015 • Circ Res • [pdf] (Editorial to this paper) More than a century ago, in 1881, Bizzozero discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization. […]… Read more »