Author Archives: Antonino NICOLETTI

Coronary stent CD31-mimetic coating


Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo Diaz-Rodriguez S, Rasser C, Mesnier J, Chevallier P, Gallet R, Choqueux C, Even G, Sayah N, Chaubet F, Nicoletti A, Ghaleh B, Feldman LJ, Mantovani D, Caligiuri G 2021 • Eur Heart J• [pdf] AIMS: The rapid endothelialization of bare metal stents (BMS) is counterbalanced… Read more »

CD31 Mimetic Coating Enhances Flow Diverting Stent Integration


CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing †Cortese J, †Rasser C, Even G, Bardet SM, Choqueux C, Mesnier J, Perrin ML, Janot K, Caroff J, Nicoletti A, Michel JB, Spelle L, §Caligiuri G, §Rouchaud A 2021 • Stroke • [pdf] BACKGROUND AND PURPOSE: Beyond aneurysmal occlusion, metallic flow diverters (FDs) can induce an… Read more »

Appel à candidatures spontanées pour le financement de post-doctorats par le China Scholarship Council


Le sénat académique d’Université de Paris a validé en décembre dernier un accord avec le China Scolarship Council (CSC) qui prend la suite de l’accord qui avait cours entre USPC et le CSC. Cet accord permet en premier lieu de proposer des sujets de thèses à des étudiants chinois (appel en cours porté par les Écoles Doctorales, cf document joint)…. Read more »

Acticor Biotech Announces the Recruitment of the First Patient in its Phase 2 GARDEN Study in COVID-19-related ARDS


– Approval of phase 2 GARDEN study in France and Brazil – GARDEN will enroll 60 patients hospitalized for COVID19 – First Patient included at University Hospital of Strasbourg Acticor Biotech is a clinical stage biotechnology spin-off of INSERM (built upon the expertise and the results of research conducted by the founders: Dr. Martine Jandrot-Perrus from U1148 Team 6 and Pr…. Read more »

Chicken egg white a new ‘old biomaterial’


Chicken egg white: Hatching of a new old biomaterial Jalili-Firoozinezhad S, Filippi M, Mohabatpour F, Letourneur D, Scherberich A 2020 • Materials Today • [pdf] Chicken egg white is an abundant, inexpensive and natural source of important proteins such as ovalbumin and lysozyme. Thanks to its bioactivity, easy handling, anti-bacterial activity and biodegradability, egg white is being used since centuries… Read more »

Karen Aymonnier, laureate of the Bettencourt prize for young investigators


Each year,the Fondation Bettencourt awards prizes for Postdoc training to young investigators. Among the 14 laureates of the 2020 edition, Karen Aymonnier (ex-Team 6 PhD student) received one of the prizes for a project that will be conducted in the Denisa Wagner lab. She will continue to work on the interaction of neutrophils and platelets during thrombosis.  



On nous signale qu’il est désormais possible de se connecter à Eduroam en WIFI en utilisant 3 types d’identifiants : – Compte informatique ex Descartes – Compte informatique ex Diderot – Compte informatique UP Liens utiles:

Membranes for Guided Bone Regeneration


Membranes for Guided Bone Regeneration: A Road from Bench to Bedside Aprile P, Letourneur D, Simon-Yarza T 2020 • Adv Healthc Mater• [pdf] Bone resorption can negatively influence the osseointegration of dental implants. Barrier membranes for guided bone regeneration (GBR) are used to exclude nonosteogenic tissues from influencing the bone healing process. In addition to the existing barrier membranes available… Read more »

MedTech Translation in Academia


Enabling MedTech Translation in Academia: Redefining Value Proposition with Updated Regulations Letourneur D, Joyce K, Chauvierre C, Bayon Y, Pandit A 2020 • Adv Healthc Mater• [pdf] Academic institutions are becoming more focused on translating new technologies for clinical applications. A transition from “bench to bedside” is often described to take basic research concepts and methods to develop a therapeutic… Read more »

1 Post-doc & 1 technician/Ingénieur d’études positions (Immuno/microbio) available at U1152


Ci-joint une annonce concernant 2 postes ouverts dans l’équipe ‘‘Immunité Innée et défenses pulmonaires anti-infectieuses” dirigée par le Prof Jean-Michel Sallenave dans l’UMR1152 Inserm ‘Physiopathologie et Epidémiologie des Maladies Respiratoires’. Postdoctoral and technician positions JM Sallenave Carb-X Septembre 2020

Nanomedicine progress in thrombolytic therapy


Nanomedicine progress in thrombolytic therapy Zenych A, Fournier L, Chauvierre C 2020 • Biomaterials • [pdf] Thrombotic occlusions of blood vessels are responsible for life-threatening cardiovascular disorders such as myocardial infarction, ischemic stroke, and venous thromboembolism. Current thrombolytic therapy, the injection of Plasminogen Activators (PA), is yet limited by a narrow therapeutic window, rapid drug elimination, and risks of hemorrhagic complications…. Read more »

Human and Rodent Prostaglandin Receptors & Prostacyclin Receptor


International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH 2020 •… Read more »

[Mise à jour] Université de Paris : signature scientifique et logos


Mise à jour (14 sept 2020): nous venons de recevoir une nouvelle charte des signatures des publications Université de Paris: charte_publication_UP_2020 L’Université de Paris (UP) est née ce qui peut considérablement augmenter notre visibilité internationale. Il convient désormais de pérenniser l’IDEX et sa dotation de plusieurs centaines de millions d’euros dont l’UP ne perçois actuellement que les intérêts au cours… Read more »

Phylogenic determinants of cardiovascular frailty


Phylogenic determinants of cardiovascular frailty, focus on hemodynamics and arterial smooth muscle cells Michel JB 2020 • Physiol Rev • [pdf] The evolution of the circulatory system from invertebrates to mammals has involved the passage from an open system to a closed in-parallel system via a closed in-series system, accompanying the increasing complexity and efficiency of life’s biological functions. The archaic… Read more »

CD31 as a Therapeutic Target in Atherosclerosis


CD31 as a Therapeutic Target in Atherosclerosis Caligiuri G 2020 • Circulation Res • [pdf] The potential of CD31 as a therapeutic target in atherosclerosis has been considered ever since its cloning in the 1990s, but the exact role played by this molecule in the biologic events underlying atherosclerosis has remained controversial, resulting in the stalling of any therapeutic perspective. Due… Read more »

Paris’ Claude Bernard Prize winner: Philippe-Gabriel STEG


As part of its policy of supporting medical research, the City of Paris annually awards two Grand Prizes to eminent personalities from the Parisian scientific community. Meeting on January 28, 2020, the jury for the Grands Prix de Médecine chose its winners: Philippe-Gabriel Steg (Team 5) and Nicolas Manel. The Grand Prix of Medicine and Medical Research of the City… Read more »

Volet universitaire du CHUGPN labellisé “projet immobilier de l’État”


C’est une étape importante pour la réalisation du volet universitaire du Campus hospitalo universitaire Grand Paris Nord qui vient d’être franchie. En effet, après une présentation de l’opération le 17 décembre dernier lors de la Conférence Nationale de l’Immobilier Public (CNIP) le projet a obtenu la labellisation de la Direction de l’Immobilier de l’État (DIE ) qui a émis un… Read more »

Postdoctoral Researcher or Project Researcher in Neurosciences


The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,500 students and 2,500 members of staff. We operate in Joensuu and Kuopio. In international rankings, we are ranked among the leading universities in the world. The Faculty of Health Sciences… Read more »

Targeting PN-1 to control bleeding in hemophilia


Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia Aymonnier K, Kawecki C, Venisse L, Boulaftali Y, Christophe OD, Lenting PJ, Arocas V, de Raucourt E, Denis CV, Bouton MC 2019 • Blood • [pdf] Hemophilia A and B, diseases caused by the lack of factor VIII (FVIII) and factor IX (FIX) respectively, lead to… Read more »

A postdoc position in U1152 (Bichat Hospital)


A post-doctoral position is available for one year, in the first instance, in Pr. Jean-Michel Sallenave’s laboratory (see address below) in the INSERM Unit 1152 (Physiopathologie et Epidémiologie des maladies respiratoires). Starting date as early as February 2020. The successful candidate will have recently obtained a PhD in Immunology, and will have expertise in FACS technology and cell biology/molecular biology techniques. The project aims at… Read more »

Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension


Bronchodilation induced by PGE2 is impaired in Group-III pulmonary hypertension Ozen G, Benyahia C, Mani S, Boukais K, Silverstein AM, Bayles R, Nelsen AC, Castier Y, Danel C, Mal H, Clapp LH, Longrois D, Norel X 2019 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), a reduction… Read more »

Société AMBIOTIS recherche un TR supérieur de laboratoire à Toulouse


 La société AMBIOTIS basée à Toulouse est reconnue par la communauté scientifique internationale, pour sa capacité unique à travailler sur la résolution de la réponse inflammatoire de manière innovante. La société travaille avec les industries Pharmaceutiques, Biotechnologiques, Cosmétiques et d’Aliments Santé. Nous vous proposons de travailler dans un environnement innovant, à la pointe de la technologie et en lien avec… Read more »

Tridek-one in the INSERM journal.


In issue 44 of the INSERM journal, an article is devoted to the Tridek-one startup whose 2 scientific co-founders are Giuseppina CALIGIURI and Antonino NICOLETTI who lead Team 1. Read the Article.

Ticagrelor in Patients with Stable Coronary Disease and Diabetes


Ticagrelor in Patients with Stable Coronary Disease and Diabetes Steg PG, Bhatt DL, Simon T, Fox K, Mehta SR, Harrington RA, Held C, Andersson M, Himmelmann A, Ridderstrale W, Leonsson-Zachrisson M, Liu Y, Opolski G, Zateyshchikov D, Ge J, Nicolau JC, Corbalan R, Cornel JH, Widimsky P, Leiter LA, Committee TS, Investigators 2019 • N Engl J Med • [pdf] BACKGROUND:… Read more »

Mitigation of monocyte driven thrombosis on cobalt chrome surfaces by polyurethane coatings


Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings Gossart A, Letourneur D, Gand A, Regnault V, Ben Mlouka MA, Cosette P, Pauthe E, Ollivier V, Santerre JP 2019 • Biomaterials • [pdf] Monocytes are active at the crossroads between inflammation and coagulation processes since they can secrete pro-inflammatory cytokines… Read more »

Immunometabolism in CVD


Giuseppina Caligiuri (Team 1) and Danilo Norata (University of Milan) present the content of a Cardiovascular Research spotlight issue focusing on immunometabolism. Link to issue. Aim of this Spotlight Issue is to present an overview of how changes in metabolic pathways of immune cells impact their function in the context of cardiovascular and metabolic diseases. Moreover, classical risk factors affect… Read more »

Mechanotransduction, immunoregulation, and metabolic functions of CD31 in CVD


Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology Caligiuri G 2019 • Cardiovasc Res • [pdf] Biomechanical changes in the heart and vessels drive rapid and dynamic regulation of blood flow, a vital process for meeting the changing metabolic needs of the peripheral tissues at any given point in time. The fluid movement of the blood exerts haemodynamic stress… Read more »

ISTH honors Martine Jandrot-Perrus amongst four other members with Esteemed Career Awards


The ISTH honored Martine Jandrot-Perrus (Team 6) amongst four other members with the Esteemed Career Award at the ISTH 2019 Congress Opening Ceremony. These awards are presented annually to individuals whose career contributions have significantly advanced the scientific community’s understanding of diseases and disorders that affect hemostasis. Their accomplishments are internationally regarded as exemplary models of research and mentoring excellence…. Read more »

Safety and Tolerability, PK, and PD of an Antiplatelet GPVI Fab


Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab Voors-Pette C, Lebozec K, Dogterom P, Jullien L, Billiald P, Ferlan P, Renaud L, Favre-Bulle O, Avenard G, Machacek M, Pletan Y, Jandrot-Perrus M 2019 • Arterioscler Thromb Vasc Biol • [pdf]  • [Editorial] Objective– ACT017 is a novel, first in class, therapeutic antibody to platelet GPVI… Read more »

Thierry Lhermitte and FRM representatives at the LVTS

In the context of the FRM grant obtained by Fredéric Chaubet following the tender “Pionnier de la Recherche, Chimie pour la Médecine", Thierry Lhermitte, supporter of the FRM, and several foundation's members visited the laboratory. The project focuses on the treatment of intracranial aneuryms with novel bioactive devices and involves, in addition to the LVTS, two research teams from the... Read more »

Tridek‐One raises € 3 million from Advent France Biotechnology and Advent Life Science

Tridek One, Paris, June 4, 2019 ‐ Tridek One, a biotech company specialized in the development of products for the treatment of immune disorders, is pleased to announce a first round of funding of 3 million euros with leading investors Advent France Biotechnology and Advent Life Sciences. Tridek One was founded in 2018 by Dr. Giuseppina Caligiuri and Professor Antonino Nicoletti, researchers in... Read more »

Functionalized polymer microbubbles to target thrombus


Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus Li B, Aid-Launais R, Labour MN, Zenych A, Juenet M, Choqueux C, Ollivier V, Couture O, Letourneur D, Chauvierre C 2019 • Biomaterials • [pdf] Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus, early detection of thrombus by a widely spread imaging modality… Read more »

Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets


Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets Morvan M, Arangalage D, Franck G, Perez F, Cattan-Levy L, Codogno I, Jacob-Lenet MP, Deschildre C, Choqueux C, Even G, Michel JB, Back M, Messika-Zeitoun D, Nicoletti A, Caligiuri G, Laschet J 2019 • J Am Coll Cardiol • [pdf] BACKGROUND: Intraleaflet hematomas are associated with advanced stages of… Read more »

Haemodynamic stress-induced breaches of the arterial intima


Haemodynamic stress-induced breaches of the arterial intima trigger inflammation and drive atherogenesis Franck G, Even G, Gautier A, Salinas M, Loste A, Procopio E, Gaston AT, Morvan M, Dupont S, Deschildre C, Berissi S, Laschet J, Nataf P, Nicoletti A, Michel JB, Caligiuri G 2018 • Eur Heart J • [pdf] Aims: Inflammatory mediators, including blood cells and their products, contribute… Read more »

Catherine Boileau awarded the grand prize of scientific recognition by the Queen of Belgium

Thursday, April 25th 2019: Prof. Catherine Boileau, co-leader of Team 2 and Head of Genetics Department of Bichat Hospital was awarded the grand prize of scientific recognition by the Queen of Belgium. Professor Boileau and her team have made significant and multiple contributions  in understanding the mechanisms responsible for the appearance of aortic aneurysms. With the hope that — as for... Read more »

Prof. PG Steg: appointed “Vice President for Research” of the Executive Board of AP-HP


Prof. Philippe Gabriel Steg (head of Team 5) has been appointed “Vice President for Research” of the Executive Board of the AP-HP on joint proposal of deans, university presidents and Inserm. The Management Board is chaired by the Director General and has two other vice presidents: the president of the medical commission of establishment of the AP-HP, Prof. Christmas Garabedian, is… Read more »

Campagne nationale « doctorat handicap » pour 2019


Le MESRI lance la campagne nationale « doctorat handicap » pour 2019. Voici les information pour l’ED BioSPC: LES DOSSIERS DEVRONT ETRE RETOURNES A L’ED AU PLUS TARD LE MERCREDI 27 MARS 2019. Dossier de candidature en format Word, Pièces annexes réunies en un seul PDF. Pour les équipes Paris Descartes ; Pour les équipes Paris Diderot ; Comme les… Read more »

Webconf du LVTS


Dans la mesure du possible, les séminaires du LVTS du vendredi seront désormais diffusés en direct en webconf. Pour vous connecter: 1/ utiliser GOOGLE CHROME (il est possible que Firefox fonctionne aussi…) 2/ aller à cette adresse : (à partir de 11h55).

Anti-PCSK9 and CV outcomes after acute coronary syndrome


Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM, Committees OO, Investigators 2018 • N Engl J… Read more »

Post-doctoral positions in vascular ECM, development and disease


Post-doctoral positions in vascular ECM, development and disease Cleveland Clinic Lerner Research Institute Post-doctoral fellowships are available in Suneel Apte’s laboratory at the Cleveland Clinic Lerner Research Institute (LRI), Cleveland, USA. The project area will be extracellular matrix in vascular development and disease, specifically aortic aneurysm. The positions will suit recent PhDs, MD/PhDs or MDs with an interest in proteases,… Read more »

Inflammation,MMP, and PGE2 in human vascular wall


Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women Ozen G, Boumiza S, Deschildre C, Topal G, Longrois D, Jakobsson PJ, Michel JB, Jacob MP, Chahed K, Norel X 2018 • Int J Obes (Lond) • [pdf] BACKGROUND AND OBJECTIVES: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft… Read more »

Apprentis chercheurs rentrée 2018


Le temps est à nouveau venu pour participer au programme national ‘Apprentis chercheurs’. Votre mission: accueillir un binôme constitue de un eleve de 3e et un eleve de 1ere au sein de votre laboratoire La fréquence: une demi journée par mois (8 au total) Leur objectif: suivre un projet de recherche sur l’année, qu’ils présenteront en quelques minutes dans le… Read more »

Endothelium, from development to pathology


L’ITMO Physiopathologie Métabolisme Nutrition organise un symposium ayant pour thématique l’Endothelium. Il se tiendra le 4 octobre 2018 à Paris (Amphithéâtre Buffon, 15 rue Hélène Brion, Paris 13). Le programme abordera différents aspects de recherche sur l’endothelium, du développement à la pathologie, et étendue à différents organes. Il inclura une conférence générale donnée par le Professeur Eli Keshet, de l’Université… Read more »

Platelets and vascular integrity


Platelets and vascular integrity: how platelets prevent bleeding in inflammation Ho-Tin-Noe B, Boulaftali Y, Camerer E 2018 • Blood • [pdf] Platelets play a central role in primary hemostasis by forming aggregates that plug holes in injured vessels. Half a century ago, detailed studies of the microvasculature by electron microscopy revealed that under inflammatory conditions that do not induce major disruption… Read more »

Thombus NETs impairs thrombolysis in stroke


Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel JB, Piotin M, Salomon L, Mazighi M, Ho-Tin-Noe B, Desilles JP 2018 • Stroke • [pdf] BACKGROUND AND PURPOSE: Neutrophil Extracellular Traps… Read more »

Microvascular thombosis is an early response to cerebral arterial occlusion


Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noe B 2018 • J Am Heart Assoc • [pdf] BACKGROUND: Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute… Read more »

P8RI dampens IR-induced intestinal injury


Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, Assadi M, Montravers P, Longrois D, Corcos O, Caligiuri G, Nicoletti A, Michel JB, Tran-Dinh A 2018 • Intensive Care Med Exp • [pdf] BACKGROUND: CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a… Read more »

Poll to choose the conference/seminar day


Some members have requested to change the day (currently the Fridays) of the weekly conference/seminar of the LVTS for next year (from Sept 2018 onward). The Conseil de Laboratoire (13th July 2018) has decided that all LVTS members should vote to choose the conference/seminar. You have until the 31st of August to vote (upper part of the sidebar of our… Read more »

Macrophage CD31 Signaling in Dissecting Aortic Aneurysm


Macrophage CD31 Signaling in Dissecting Aortic Aneurysm Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, Morvan M, Even G, Procopio E, Gaston AT, Le Borgne M, Deschamps, L, Nicoletti A, Caligiuri G 2018 • JACC • [pdf] + Editorial from P Libby: Biologically-Based Therapies for Aortic Diseases • Link Background The authors recently found that a CD31… Read more »

Nanoparticles of Metal-Organic Frameworks


Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine Simon-Yarza T, Mielcarek A, Couvreur P, Serre C 2018 • Adv Mater. • [pdf] In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based… Read more »

Abiotic sequence-coded oligomers as taggants


Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, Charles L, Letourneur D, Lutz JF. 2018 • Angew Chem Int Ed Engl • [pdf] Sequence-defined oligourethanes were tested as in vivo taggants for implants identification. The oligomers were prepared via an orthogonal solid-phase iterative approach and thus contained a… Read more »

Catherine Boileau awarded the “Grand Prix Lefoulon-Delalande 2018”


Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and Nabil Seidah (Institut de recherches cliniques de Montréal – Canada), the Grand Prix de la Fondation Lefoulon Delalande during a ceremony held on Wednesday, May 30 2018 under the Dome of the Institut de France. The ceremony was chaired by Mr…. Read more »

Journée microscopie Univ. Paris Diderot – le 31 mai 2018


Le 31 mai, une demi-journée dédiée à la microscopie photonique est organisée à Paris Diderot. Une journée avec des présentations de plateformes, des presentations scientifiques mais aussi avec de tables rondes, afin de créer un réseau de competences. A l’amphi Turing. Inscription libre, mais obligatoire: Journée microscopie Paris Diderot

Prix de thèse de la Chancellerie des Universités de Paris


La chancellerie vient de lancer son Appel à candidature pour les prix solennels 2018  qui récompense l’excellence de 50 thèses ( soutenues en 2017) dans les différents domaines LSH, Médecine ,Sciences… Lire  le document (à télécharger ici)  pour  la constitution du dossier de candidature ( nouvelle procédure cette année). Les candidatures sont transmises à la chancellerie par l’université, aucune candidature… Read more »

MOOC: Tissue and Organ Bioengineering


Marie-Noëlle Labour (Team 3) is actively involved in the MOOC “Tissue and Organ Bioengineering”. You can freely attend and register to this MOOC until 8th June 2018. It will be broadcasted between the 14 May and 17 June 2018. Link to subscribe

Campagne d’appréciation ITA 2018


Début de la campagne : 27 février 2018 La campagne d’appréciation des personnels ingénieurs, techniciens et administratifs de l’Inserm débute ce mardi dans Gaia. Vous êtes invités à préparer vos entretiens annuels d’appréciation dès à présent. Validation des dossiers jusqu’au : 3 avril 2018 En savoir plus…

Ethique et intégrité scientifiques

Il y a plusieurs mois de cela, Pierre Corvol remettait un rapport portant sur le "Bilan et des proposition de mise en oeuvre de la charte nationale d'intégrité scientifique" à Thierry Mandon, alors secrétaire d'Etat chargé de l'Enseignement Supérieur et de la Recherche. Ce rapport débute ainsi: La recherche est un superbe métier, pratiqué avec rigueur et honnêteté par l’immense... Read more »

Improved prognosis in NSTEMI patients


A recent publication from Team 5 has been released in Circulation demonstrates that patients with high risk non–ST-segment–elevation myocardial infarction (NSTEMI) that undergo coronary angiography within the initial 12 hours after admission had a lower risk of ischemic outcomes at 180 days. Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment– Elevation Myocardial Infarction Managed Invasively Insights From the TAO Trial (Treatment… Read more »

External applicability of the COMPASS trial


External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry Darmon A, Bhatt DL, Elbez Y, Aboyans V, Anand S, Bosch J, Branch KR, Connolly SJ, Dyal L, Eikelboom JW, Fox KAA, Keltai K, Probstfield J, Yusuf S, Abtan J, Sorbets E, Eagle KA, Ducrocq G, Steg PG 2017 • Eur Heart… Read more »

Systemic Atherosclerosis and Stroke Etiologies


Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease Hoshino T, Sissani L, Labreuche J, Ducrocq G, Lavallee PC, Meseguer E, Guidoux C, Cabrejo L, Hobeanu C, Gongora-Rivera F, Touboul PJ, Steg PG, Amarenco P, Investigators A 2017 • JAMA Neurol • [pdf] Importance: Patients who have experienced… Read more »

Dominique Le Guludec appointed head of the Haute Autorité de Santé


Dominique Le Guludec, Professor of Biophysics and Nuclear Medicine at the UFR of Medicine at Paris Diderot University, Director of the Department of Nuclear Medicine and Biophysics at Bichat Hospital – Claude Bernard, APHP and Head of the Imaging Team Cardiovascular in the Translational Vascular Research Laboratory, has just been appointed head of the Haute Autorité de Santé (HAS). Dominique… Read more »

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters


Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters Tardy A, Honore JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D, Perrier J, Nicoletti C, Maresca M, Lefay C, Gigmes D, Nicolas J, Guillaneuf Y 2017 • Angew Chem Int Ed Engl • [pdf] For the first time, the free-radical copolymerization… Read more »

ACTICOR biotech first-in-human clinical trial in healthy volunteers


Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) involved in the acute phase of thrombotic diseases, including stroke and myocardial infarction, today announced the agreement of Dutch Authorities for the initiation of a phase I clinical trial in healthy volunteers with its drug candidate, ACT017. ACT017 is a… Read more »

Post-doctoral position in UMR Inserm 1011 – Institut Pasteur de Lille – University of Lille (headed Bart Staels)


A post-doctoral position is available in the « nuclear receptors, cardiovascular diseases and diabetes” laboratory, team 1 (Nuclear receptor and metabolic disease). The successful applicant will be involved in the development of metabolic disorders in mouse models (obesity, insulin-resistance, T2D, NASH/NAFLD…). That will include the characterization of the metabolic phenotype, the determination of the underlying molecular mechanisms, as well as the… Read more »

Un nouvel outil web à Paris Diderot pour chercher des financements


Après une phase test lancée en 2016 par la Direction d’aide à la recherche et à l’innovation (DARI), en lien avec USPC, l’université P7 s’est récemment dotée d’un moteur de veille web sur les appels à projets de recherche, RESEARCHconnect. Cet outil permet d’élargir le spectre des fonds auxquels vous pourrez candidater, tout en retrouvant de manière centralisée les fonds… Read more »

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2


Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition Ozen G, Gomez I, Daci A, Deschildre C, Boubaya L, Teskin O, Uydes-Dogan BS, Jakobsson PJ, Longrois D, Topal G, Norel X 2017 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular… Read more »

Offre de thèse à Bordeaux


Veuillez trouver ci-joint une offre d’allocation doctorale, à diffuser aux étudiants en Master ou ayant déjà obtenu un Master, afin de réaliser une thèse dans l’équipe UMR-Inserm U1034 à Bordeaux. PhD fellowship_Inserm U1034

TF1 talks about Fucoidans


Cedric Chauvierre (Team 3) has given an interview on the use of fucoidans to trace early atherothrombotic lesions for the TV news on the first French channel (TF1) on the 14th August 2017. You can see it here: LINK.

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice


Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P 2017 • Circ Res • [pdf] Rationale:… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo


Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award


Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award. APA was founded in 2007 at the premises of Indian Institute of Technology, New Delhi, India, The society involves academicians, scientists and technologists from all over the Asian countries providing a well knitted structure of the society. Vision of… Read more »

Prix de thèse de la Chancellerie


La Chancellerie des Universités de Paris vient de lancer son appel à candidatures pour la campagne 2017 des Prix Solennels de La Chancellerie. Les dossiers de candidatures seront étudiés par la Commission d’évaluation  de l’université  le lundi 15 mai 2017. La date limite de dépôt des dossiers à la DARI a été fixée au 12 mai  2017. (Mme Meneceur, Bureau… Read more »

Prof G Jondeau, coordinator of VASCERN


Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases. “The VASCERN project aims to facilitate and improve diagnosis, treatment and care for ALL patients suffering from Rare Multisystemic Vascular Diseases, thus enhancing access to care, and improving quantity and quality of life of these patients. Networking, sharing and spreading our expertise,… Read more »

Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects


On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président du CA de MSD-Avenir), M Hirsch (Directeur Général de l’AP-HP), the Prof Y Levy (Président Directeur Général de l’INSERM), in the presence of the Prof P Ruszniewski (Doyen de l’UFR de médecine de l’Université Denis Diderot) and of F Crémieux (Directeur… Read more »

The lung, a major site of platelet biogenesis!!


A report published in Nature demonstrate that up to 50% of the platelet production derives form megacaryocytes circulating through the lungs! The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew… Read more »

Appel à candidature 2017 pour Prix de thèse du GERLI en lipidomique


Le Groupe d’Etude et de Recherche en Lipidomique fait appel à candidatures pour son prix de thèse. Ce prix récompense un travail dans le domaine des lipides, réalisé dans un laboratoire français ; la thèse aura été soutenue en 2016. Le montant du prix est de 1500€. Le prix de thèse décerné par le conseil scientifique du GERLI sera remis… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo


Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke


Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials Costa F, van Klaveren D, James S, Heg D, Raber L, Feres F, Pilgrim T, Hong MK, Kim HS, Colombo A, Steg PG, Zanchin T, Palmerini T, Wallentin L, Bhatt DL,… Read more »

Plusieurs propositions de postdoc pour les US


Cellular Mechanobiology Lab at the University at Buffalo Postdoctoral candidate Téléchargez l’annonce…   Research Positions Cardiac Physiology Postdoctoral Fellow/Instructor Téléchargez l’annonce… An NIH-sponsored postdoctoral fellowship  Available on human genome editing for blood disease modeling and treatment Téléchargez l’annonce…   Postdoctoral Fellow Harvard Medical School, Beth Israel Deaconess Medical Center (BIDMC) Téléchargez l’annonce…

Guide pour ‘Pratiquer une recherche intègre et responsable’


Ce guide est destiné à tous les acteurs de la recherche, quels que soient leur appartenance disciplinaire, leur niveau de responsabilité et leur statut. Il vise aussi à répondre aux questions que peuvent se poser les étudiants de master et doctorants sur de nombreux aspects de leur activité et à leur donner quelques pistes pour la pratiquer de manière responsable…. Read more »

Postdoctoral Research Fellow position in Nantes


Postdoctoral Research Fellow position available at INSERM UMR1064 Center for Research in Transplantation and Immunology, France Title: Antigen-specific Tregs in transplantation The laboratory: The Center for Research in Transplantation and Immunology (CRTI) is a research unit (UMR 1064) dedicated to transplantation science and immunology since 1993 in Nantes. The CRTI (3,000 m2 of laboratory surface area and two animal facilities) currently… Read more »

3 appels à projets USPC en cours


Trois appels à projets ont été publiés pour 2017 dans le cadre des bureaux de USPC à l’international: AAP USPC-NUS (Singapour), La date limite de candidature est le 30 janvier 2017. Le contact est : AAP USPC-CIN(Argentine) ; La date limite de candidature est le 15/02/2017. Le contact est AAP USPC-USP (Brésil) : La date limite de candidature est le 1er mars 2017 ; le… Read more »

Assistant/Associate Professor – Vascular Biology in Geneva


Posted on 19 Dec 2016 University of Geneva · The Faculty of Medicine Switzerland, Genève Job description The Faculty of Medicine of the University of Geneva is seeking to fill a position of: Assistant or Associate Professor in vascular biology in the context of inflammation and immunology. Charge: This full-time position will involve undergraduate and postgraduate teaching in vascular biology and immunology , as… Read more »

Concours chercheurs session 2017


Le service RH de l’INSERM nous informe de l’ouverture de la campagne des concours chercheurs session 2017 (CR et DR). Vous trouverez ci-joint la lettre d’information relative à cette campagne, le tableau de répartition des postes ainsi que l’affiche de communication. Modalités de candidature : Concours CR : Date limite de Dépôt des dossiers (CR1 & CR2) : le 12 Janvier 2017 –… Read more »

Fiches produits chimiques


Le Bureau de coordination de la prévention de l’Inserm (BCPR) a élaboré en collaboration avec le Service prévention des risques de l’Institut Pasteur des fiches synthétiques destinées à tous ceux qui manipulent des produits chimiques dangereux. Elles permettront d’identifier rapidement les risques et de manipuler les produits en toute sécurité. Télécharger les version électroniques des fiches

FRM : appel à projets


La Fondation pour la recherche médicale finance des projets dans le cadre de son programme “Espoir de la recherche : amorçage de jeunes équipes”. Montant : 2 000 000 € Date limite de candidature : 24 octobre 2016 Lien vers le site

Lancement du programme d’accueil d’étudiants Chinois


L’Université Sorbonne Paris Cité (UPSC) a signé en juin 2014 un accord avec le China Scholarship Council1 (CSC), un organisme gouvernemental chinois, pour permettre l’accueil dans les établissements et les ED de USPC de doctorants chinois. La procédure est lancée, attention, les délais sont courts!! Procedure csc_modele-sujet_2016-2017

Calendrier: qualification des enseignants-chercheurs 2017


Ouverture du serveur Antares : jeudi 08 septembre 2016, 10h (heure de Paris) Clôture des inscriptions : Mardi 25 octobre 2016, 16h (heure de Paris) Mise en ligne des rapporteurs sur GALAXIE : à partir du vendredi 25 novembre 2016 Date à laquelle la thèse ou l’habilitation doit avoir été soutenue : mercredi 14 décembre 2016 inclus Date limite d’envoi… Read more »

RHU call results: LVTS involved in 5 granted projects!


The ‘RHU‘ (Recherche Hospital Universitaire) action is to support translational research projects in health or clinical research, which are to be based on fundamental research in biology, epidemiology, social science or health economics and extend for a benefit for the care of patients, improving the understanding of diseases, more effective and better tolerated treatments, or a performance improvement of care systems. The… Read more »

3 postes INSERM ouverts à la mobilité interne vers le LVTS


3 postes INSERM sont ouverts à la mobilité au sein de notre unité INSERM U1148 LVTS: • Un poste d‘ingénieur(e) d’étude en expérimentation et instrumentation biologiques —> Voir le profil du poste • Un poste d’Animalier  —> Voir le profil du poste • Un poste de Technicien biologiste —> Voir le profil du poste Pour toute information, veuillez contacter notre secrétariat ou la DR Paris 7.

[Update] My thesis in 180s


We are proud that one of our PhD student, Charlotte Rasser (Team 1), is one of the final candidates of the “My thesis in 180 sec” contest. Link. Update: Charlotte was amongst the very finalists (16 students selected out of 560 candidates from all over France) of the contest which was organized in Bordeaux on the 31st May 2016

The PCSK9 story


A paper in the Eur Heart Journal from Nail Seidah that recapitulates the discovery of the PCSK9 mutations in familial hypercholesterolemia made by Marianne Abifadel and Catherine Boileau (Team 2) in 2003. Read the paper..

Early detection of strokes


Télématin broadcasted on the 13rd May 2016 an interview from Prof Pierre Amarenco (Team 5) where it is explained why we should detect stroke as soon as possible. This is related to a paper published this year by P Amarenco et al (N Engl J Med 2016. 374:1533) describing the results obtained from the ‘’ project that was designed to establish the contemporary profile, etiologic… Read more »

2 PhD programs in Rouen


The INSERM U1096 located in Rouen is looking for 2 PhD candidates which are already granted: – The first will assess the role of the phosphatase activity of the soluble epoxide hydrolase in a model of genetically modified rats subjected to a heart failure model (Supervisor: Jeremy Bellien) – The second will evaluate mechanisms involved in aortic stenosis in a mouse model… Read more »

TLOs in Takayasu Arteritis


Tertiary lymphoid organs in Takayasu Arteritis Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K 2016 • Frontiers Immunol • [pdf] Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs… Read more »

Silab and Inserm for tissue regeneration


Siltiss, a subsidiary of Silab group based near Brive-la-Gaillarde (Corrèze), has acquired the exclusive rights to use four patents regarding tissue engineering technology developed by Inserm. This technology was developed in two laboratories of Inserm in Paris (U1148; LVTS) and Bordeaux (U1026). Siltiss, founded in January, aims the development, production and marketing of natural biomaterials that promote or induce tissue… Read more »

MSDAVENIR & INSERM: a strategic framework agreement to support French medical research


Cyril Schiever, Chairman of the Board of MSDAVENIR, Professor Yves Lévy, Chairman and CEO of Inserm, and Pasca le Augé, President of the Management Board of Inserm Transfer, today signed a strategic framework agreement to support the French medical research. The event was held under the patronage and in the presence of Marisol Touraine, Minister of Social Affairs and Health,… Read more »

Prix “Le Monde” pour la recherche universitaire


Depuis deux décennies, « Le Monde », associé à divers partenaires, a choisi de distinguer les meilleures thèses françaises en organisant un prix destiné à récompenser des travaux remarquables « pour leur impact sur notre environnement scientifique, économique et social ». Cette année marquera la 19e édition de ce prix, ouvert tant aux sciences humaines et sociales qu’aux sciences dites « dures ». Le jury est présidé par Edgar Morin pour la première catégorie, et par Cédric Villani… Read more »

D Letourneur awarded the George Winter Prize


Didier Letourneur, the Director of LVTS and leader of Team 3, is the 2016 laureate for the George Winter Award from the European Society for Biomaterials (ESB). “This award is established to recognise, encourage and stimulate outstanding research contributions to the field of biomaterials. It will be presented annually during the Annual Biomaterials Meeting of the Society.[…].The nominee must have contributed significantly to… Read more »

Stroke: locate, react, restore


Nowadays, the management procedures of strokes are well codified. Nevertheless, the detection of clinical signs is still problematic. How can we deal with a transient ischemic attack? Follow the answers of Prpf Pierre Amarenco (Neurology Department of Bichat Hospital & Team 5 U1148) in an interview (in French) broadcasted on ‘Fréquency Médicale‘.–> Link to the video

Attention, Emails en berne les 18 et 19 mars


La maintenance électrique annuelle sur le site informatique de Villejuif (site d’hébergement du DSI pour les applications nationales) va avoir lieu le 18/03 et 19/03. Cette intervention nécessite une coupure électrique totale sur le site.La messagerie électronique nationale qui dessert les domaines, et et les services associés seront interrompus le vendredi 18 mars à partir de 18h00. Durant cette interruption vous… Read more »

Campagne d’appréciation et concours internes ITA 2016


Campagne d’appréciation ITA 2016 Début de la campagne : 7 mars 2016. La campagne d’appréciation des ingénieurs et techniciens de l’Inserm démarre cette semaine. Pensez à préparer votre entretien annuel grâce au guide ci-dessous ! Envie d’évoluer dans votre carrière ou votre orientation professionnelle ? Une fiche d’évolution des compétences est disponible dans votre espace. Validation des dossiers et bordereaux d’avancement… Read more »

Loi Numérique : quel intérêt pour les chercheurs ?


Avec le projet de loi pour une République numérique, la France veut s’équiper d’un cadre juridique favorable à l’accès et à la circulation des données. Une démarche en cohérence avec les préconisations de la Commission européenne. Quelles conséquences auraient l’adoption de ce projet ? Quel intérêt pour les chercheurs ? En dehors de quelques journaux en Open access, la majeure… Read more »

Blood vessels from algae


To replace defective arteries, researchers from Team 3 are inspired by the long polysaccharide molecule that gives seaweed its flexibility and strength. Cedric Chauvierre from Team 3 explains in this video from Universcience and ‘Le Monde Médecine‘ that these artificial vessels must withstand high pressure variations and be biocompatible. Several tests in rats have shown that these artificial vessels are promising future vascular… Read more »

Stroke: from the clinics to the pathophysiology


This health training session organised by the ’Institut thématique multi-organismes “Neurosciences, sciences cognitives, neurologie, psychiatrie”, the ‘Bureau des formations scientifiques et de soutien à la recherche du Département des ressources humaines de l’Inserm’ has taken place the 24th Nov 2015 at the ‘Institut du cerveau et de la moelle épinière’ (ICM), GH de la Pitié Salpêtrière, Paris 13e. You can watch the lectures… Read more »

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections


LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, Ren Z, Cai B, Hostetler EM, Moran R, Liang D, Estrera AL, Safi HJ, Leal SM, Bamshad MJ, Shendure J, Nickerson DA, Jondeau G, Boileau C, Milewicz DM 2016 • Circ Res • [pdf] RATIONALE: Mutations in several genes have been… Read more »

Dispositif Emergence de la Mairie de Paris


La Mairie de Paris lance de l’édition 2016 du dispositif « Emergence(s) » destiné à aider les jeunes équipes des laboratoires publics parisiens. Les candidats pourront déposer leur dossier jusqu’au mardi 15 mars 2016 à 16 h. Vous pouvez, dès à présent, vous connecter sur le site Internet de la ville de Paris à l’adresse suivante :

Beneficial effect of reducing microvascular thrombosis


Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M 2015 • Stroke • [pdf] BACKGROUND AND PURPOSE: Downstream microvascular thrombosis (DMT) is known to be a contributing factor to… Read more »

Marc Clement: prize of the Chancellerie of Paris


On the 1st December 2015, Marc Clement (Team 1 LVTS) received one of the Prizes (Prix Aguirre-Basualdo/Robin) of the Chancellerie des Universités de Paris, in the Medecine section. Each year, these prizes award the best theses defended in Paris’ universities. Watch a short video of the ceremony. Marc did his thesis in our unit under the supervision of Dr Giuseppina… Read more »

Chemical heterogeneity of biodegradable polymers & surface energy


Effect of chemical heterogeneity of biodegradable polymers on surface energy: A static contact angle analysis of polyester model films Belibel R, Avramoglou T, Garcia A, Barbaud C, Moras L 2015 • Mater. Sci. Eng C • [pdf] Biodegradable and bioassimilable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) derivatives were synthesized and characterized in order to develop a new coating for coronary endoprosthesis enabling the… Read more »

A post-doc/PhD position in the Geneva Platelet Group


The Geneva Platelet Group Is recruiting a post-doc / PhD student for projects related to miRNAs and modulation of platelet reactivity using a cell-based and an animal model. Contact for application: Prof P. Fontana Division of Angiology and Hemostasis Geneva Platelet Group Geneva University Hospitals and Faculty of Medicine

Postdoc in INSERM U1138 Team 1 (Cordeliers Research Centre)


Post doctoral position in the INSERM U1138 Team 1 « Mineralocorticoid Receptor : Pathophysiology and Therapeutic Innovation » at INSERM/ Cordeliers Research Centre (Paris, France) The Cordeliers Research Centre (19 independent teams, Paris, France) ( is a research centre of excellence for multidisciplinary research on the regulation of the different functions and the impact of their deregulation in the genesis and progression of… Read more »

GREMI: Vascular Inflammation, Pasteur Institute, November 13th, 2015


“Vascular Inflammation: Blood vessels under attack” meeting, November 13th 2015. Organised by GREMI. Institut Pasteur, Paris. The One Day GREMI Meeting untitled “Vascular Inflammation: Blood vessels under attack” meeting will be held at the Pasteur Institute (Paris) on November 13th, 2015. This one day meeting is organized by GREMI, the French society on Inflammation, member of IAIS (International Association… Read more »

Translational Immunometabolism


The Cellular and Molecular Basis of Translational Immunometabolism Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM 2015 • Immunity • [pdf] The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions…. Read more »

Mails malveillants


La lettre SSI du Haut Fonctionnaire de Défense et de sécurité concernant une recrudescence de courriels véhiculant des logiciels malveillants depuis plusieurs semaines. Ce bulletin de rentrée est l’occasion de rappeler l’importance de se montrer extrêmement prudent avec les messageries électroniques, particulièrement avec les messages « inattendus ». Il reviendra sur trois catégories de bonnes pratiques informatiques avant de parcourir l’actualité… Read more »

Poste de technicien (12 mois renouvelables) à pourvoir à l’Institut Pasteur dans l’Unité de lymphopoïèse


Unité  de    lymphopoièse    dirigée    par    Pr.    Ana    Cumano Inserm  U668,    Institut    Pasteur,    25    rue    du    Docteur    Roux    75015    Paris Groupe:    Développement    des    cellules    lymphoïdes    innées direction  Pr.    Rachel    Golub Un  poste    de    technicien    est    à    pourvoir    dans    l’unité    de    lymphopoïèse    de    l’Institut    Pasteur     dans   le   cadre   d’un     projet   «  Caractérisation     et      … Read more »

Platelets GPVI binds to fibrin


Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M 2015 • Blood • [pdf] Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets…. Read more »

Accident vasculaire cérébral : de la clinique à la physiopathologie


Les Journées Recherche et Santé sont des séminaires de formation organisés en collaboration avec les Instituts thématiques multi-organismes à l’initiative du Bureau des formations scientifiques et de soutien à la recherche (BFSSR) du Département des ressources humaines de l’Inserm. Mardi 24 novembre 2015, Jean-Baptiste Michel et Martine Jandrot-Perrus participeront comme orateur à cet ensemble de conférence. Auditorium de l’Institut du… Read more »

Postdoc à Pasteur Paris


Post-doctoral position in immunology at the Institut Pasteur “Innate lymphoid cells differentiation in homeostatic conditions and pathological conditions.” Unité de lymphopoièse, Inserm U668, Institut Pasteur, 25 rue du Docteur Roux 75015 Paris led by Pr. Ana Cumano Group: Innate lymphoid cell differentiation led by Pr. Rachel Golub Download Full Proposal

[Important] Info pour les utilisateurs Apple


Apple modifie la politique de sécurité de ses logiciels pour iPhone, iPad et Macintosh OS X. Cette politique inclut le durcissement du chiffrement utilisé pour les transactions Web et de courrier électronique ; elle affecte également la procédure d’accès aux réseaux WiFi dont EDUROAM. Elle sera appliquée avec la version IOS 9 (iPad, iPhone) disponible cette semaine ainsi que la nouvelle… Read more »

Platelets seal neutrophil-induced vascular breaches


Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noe B 2015 • Blood • [pdf] Platelets protect vascular integrity during inflammation. Recent evidence suggests that this action is independent of thrombus formation and requires the engagement of glycoprotein VI (GPVI),… Read more »

CVD & Obesity: Surprising links


An international team of researchers coordinated by Professor Gabriel Steg  and Dr. Boris Hansel (Departments of ‘Cardiology’ and of ‘Endocrinology, Diabetes and Nutrition’ from the Bichat Claude Bernard Hospital: AP-HP and the University Paris-Diderot) has demonstrated that in people who have heart or arterial diseases, obesity does not appear to increase cardiovascular risk, whereas leanness is a very poor prognosis. These results… Read more »

Research Technician position at U1152 (Bichat Hospital)


Un poste de technicien est à pourvoir dans l’équipe du Pr J-M Sallenave (‘Equipe 4 : Immunité innée et défenses pulmonaires anti-infectieuses’ ; UMR INSERM 1152 , Hôpital Bichat) pour une durée initiale de 12 mois. Pour tout renseignement, veuillez contacter Jean-Michel Sallenave aux coordonnées ci-dessous: Jean-Michel Sallenave Professeur d’Immunologie , Université Paris Diderot Equipe 4 : ‘Immunité Innée et défenses pulmonaires… Read more »

Postdoc position at ELVEFLOW


ELVEFLOW est en phase de recrutement d’un post-doctorant à Paris pour le développement de kits de PCRq ultra-rapide pour sa plateforme FASTGEN. Vous trouverez le descriptif complet de l’offre ici. Ce projet vise à finaliser une plateforme de PCRq permettant de détecter simultanément une centaine de cible en moins de 10 minutes. Les candidats intéressés peuvent envoyer leur lettre de motivation et… Read more »

Nanomedicine as a strategy to fight thrombotic diseases


Nanomedicine as a strategy to fight thrombotic diseases Varna M, Juenet M, Bayles R, Mazighi M, Chauvierre C, Letourneur D 2015 • Future Sci OA • [pdf] This review highlights the preclinical and clinical research based on the use of nano- and micro-carriers in thrombolytic drug delivery. Ischemic heart and stroke caused by thrombosis are the main causes of death in… Read more »

Role of platelets in the pathogenesis of Influenza virus


Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis Le VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B 2014 • Am J Respir Crit Care Med • [pdf] RATIONALE: The hallmark of severe influenza virus infection is excessive… Read more »

LVTS Videos

2017 B Hansel -Reversion Diabète - Télématin 3Nov2917Interview of Dr. Catherine Boileau at the European Society of Cardiology - Sept 2017Le yoyo pondéral et ses effets expliqué par Boris HANSEL à télématin (Sept 2017)TF1_14Aout2017_CChauvierre_FucoFredric Chaubet_PresentationLVTS_P13 2015-2016 C Chauvierre Univers Le Monde 24_02_16P Amarenco 13 mai 2016 - Telematin - SOS AITJB Michel Telematin 24 Feb 2016 - Maladies parodontales et... Read more »

Organ repair & Nanoparticles


Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles Meddahi-Pelle A, Legrand A, Marcellan A, Louedec L, Letourneur D, Leibler L 2014 • Angew Chem Int Ed Engl • [pdf] • Video Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization… Read more »

CD31 & immunogenic DCs


CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G 2014 • Proc Natl Acad Sci USA • [pdf] CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes…. Read more »

Collagen & Platelet secretory phenotype


Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noe B 2014 • PLoS One • [pdf] Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these “non classical” functions… Read more »

PN-1 & Pulmonary Fibrosis


Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression Francois D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC 2014 • Lab Invest • [pdf] Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1… Read more »

Hemostatic disorders in JAK2(V617F) Tg mice


Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M 2014 • Blood • [pdf] Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as… Read more »

CD31 in the immunological synapse


Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G 2014 •… Read more »

Mutations in an ECM gene in TAAD


MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau… Read more »

Control of B cells in atherosclerosis


Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A 2015 • Circulation • [pdf] • Editorial… Read more »

Antiplatelet therapy in ACS


Clinical evidence for oral antiplatelet therapy in acute coronary syndromes Wiviott SD, Steg PG 2015 • Lancet • [pdf] Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the treatment and prevention of recurrence of these syndromes. Nearly 30 years ago, aspirin was the first agent to show a benefit for acute… Read more »

IMMATIS project leaded by D Letourneur supported by OSEO


For the 15th edition of the National competition for the ‘’aide à la création d’entreprises de technologies innovantes’, the minister of ‘Enseignement supérieur et de la Recherche’ in association with OSEO has granted 55 projects in the “création-développement” and 120 projects in “Emergence”. The project IMMATIS coordinated by D Letourneur (Team 3) was selected in the “création-développement” category. It was… Read more »

NANOATHERO – A new FP7 Large Scale program coordinated by U1148


Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility NanoAthero is a Large Scale European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. Coordination : Didier Letourneur (Team 3; Inserm U1148, CHU… Read more »

‘FUCO-CHEM’ coordinated by C Chauvierre selected as a LABCOM


The ‘Agence nationale de la recherche’ has selected the first 7 common laboratories between research organisms and private companies as part of the « Labcom » program. The project FucoChem has been selected for its research on marine polysaccharides to be used as cardiovascular biotherapies. This project is coordinated by Cédric Chauvierre (Team 3 Inserm U1148). It involves the laboratory of polymer bioengineering… Read more »

Prof. D Le Guludec appointed chairperson of the board of Directors of IRSN


PhD in Biophysics, Dominique Le Guludec is Professor of Biophysics and Nuclear Medicine at University Paris 7. She is head of the Department of Nuclear Medicine, Hôpital Bichat, AP-HP, Paris, since 1994. She is also head of a research team of our Inserm Unit 1148, member of the Executive Committee of the EANM, and member of the National Council of… Read more »

D Letourneur: Innovative strategy to facilitate organ repair


A significant breakthrough could revolutionize surgical practice and regenerative medicine. The team led by Ludwik Leibler (Laboratoire Matière Molle et Chimie CNRS/ESPCI Paris Tech) and the Team headed by Didier Letourneur from the LVTS (INSERM U1148/Universités Paris Diderot and Paris 13), has just demonstrated that the principle of adhesion by aqueous solutions of nanoparticles can be used in vivo to… Read more »

ACTICOR spotted in BiotechFinances


The agreement between ACTICOR, a biotech hosted within the LVTS and created on the basis of the work from Martine Jandrot-Perrus (Team 1), Christian Gachet (U949) and Philippe Billiad (Institut Paris Sud d’Innovation Thérapeutique) is highlighted in the April issue of the BiotechFinances journal.

D Letourneur on BFM TV


Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Votre Santé m’intéresse” on BFM TV (3 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).

D Letourneur on France 5


Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Le Magazine de la Santé” on France 5 (27 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).

Charte Publis INSERM P7 P13


Recommandations pour l’INSERM Toutes les unités Inserm sont mixtes avec l’université et/ou d’autres institutions. Chacune des ces institutions (Université, EPST, EPIC,…) doit être identifiée, dans les publications par une adresse séparée. Le séparateur toujours reconnu par les systèmes informatiques est le nom du pays.Institution 1, nom ou numéro du laboratoire ou du service…,ville, code postal, pays Institution 2, nom ou… Read more »

Partage (LinShare)->FileSender


Fin de vie de l’application Partage (LinShare) qui permettait d’échanger des fichiers volumineux: 1 avril. Partage est remplacée par l’application FileSender que nous mutualisons avec nos partenaires de la recherche et de l’enseignement supérieur.Cette application gérée par Renater, est accessible à l’adresse “­” .Une documentation complète est à votre disposition sur notre site “­index.php/­File_Sender” .

Thrombi and neutrophils


Thrombi and neutrophils Michel JB, Ho-Tin-Noé B 2015 • Circ Res • [pdf] (Editorial to this paper) More than a century ago, in 1881, Bizzozero discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization. […]… Read more »

FACT: French Alliance for Cardiovascular Trials


The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as an « Investigative Network Initiative » and will receive a 5-year financial support from the F-CRIN (French part of ECRIN – European Clinical Research Infrastructures Network). FACT is an academic research network that federates more than 20 sites throughout France… Read more »

Meet ACTICOR Biotech team in Paris on July 1st, 2014


Some recent news on the Acticor Biotech team, a company dedicated to the development of an innovative, safe and effective treatment of ischemic stroke:<br> • Acticor is currently selecting its main lead to enter the development phase.<br> • Dr Gilles Avenard is the new President of the company. Acticor Website

Didier Letourneur at the French Parliament


Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many pharmaceutical companies develop and put on the drug market “Biosimilars” on the same pattern as for the generic chemical drugs. Because substantial savings are expected with this interchangeability, a public audition was held at the French Parliament on 29 January… Read more »

Platelets & Influenza: INRA press release


Platelets play a role in severe pulmonary infections associated with influenza viruses. This has been revealed for the first time by researchers from Team 1 of LVTS in collaboration with researchers from INRA and the Université Claude Bernard Lyon 1. This work has been published on April 1, 2015 in the American Journal of Respiratory and Critical Care Medicine. Their… Read more »