Author Archives: Antonino NICOLETTI

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters Tardy A, Honore JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D, Perrier J, Nicoletti C, Maresca M, Lefay C, Gigmes D, Nicolas J, Guillaneuf Y 2017 • Angew Chem Int Ed Engl • [pdf] For the first time, the free-radical copolymerization… Read more »

ACTICOR biotech first-in-human clinical trial in healthy volunteers

Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) involved in the acute phase of thrombotic diseases, including stroke and myocardial infarction, today announced the agreement of Dutch Authorities for the initiation of a phase I clinical trial in healthy volunteers with its drug candidate, ACT017. ACT017 is a… Read more »

Post-doctoral position in UMR Inserm 1011 – Institut Pasteur de Lille – University of Lille (headed Bart Staels)

A post-doctoral position is available in the « nuclear receptors, cardiovascular diseases and diabetes” laboratory, team 1 (Nuclear receptor and metabolic disease). The successful applicant will be involved in the development of metabolic disorders in mouse models (obesity, insulin-resistance, T2D, NASH/NAFLD…). That will include the characterization of the metabolic phenotype, the determination of the underlying molecular mechanisms, as well as the… Read more »

Un nouvel outil web à Paris Diderot pour chercher des financements

Après une phase test lancée en 2016 par la Direction d’aide à la recherche et à l’innovation (DARI), en lien avec USPC, l’université P7 s’est récemment dotée d’un moteur de veille web sur les appels à projets de recherche, RESEARCHconnect. Cet outil permet d’élargir le spectre des fonds auxquels vous pourrez candidater, tout en retrouvant de manière centralisée les fonds… Read more »

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition Ozen G, Gomez I, Daci A, Deschildre C, Boubaya L, Teskin O, Uydes-Dogan BS, Jakobsson PJ, Longrois D, Topal G, Norel X 2017 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular… Read more »

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P 2017 • Circ Res • [pdf] Rationale:… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

D Letourneur granted the 2017 Asian Polymer Association (APA)’s Jubilee Award

Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award. APA was founded in 2007 at the premises of Indian Institute of Technology, New Delhi, India, www.asianpolymer.org. The society involves academicians, scientists and technologists from all over the Asian countries providing a well knitted structure of the society. Vision of… Read more »

Prix de thèse de la Chancellerie

La Chancellerie des Universités de Paris vient de lancer son appel à candidatures pour la campagne 2017 des Prix Solennels de La Chancellerie. Les dossiers de candidatures seront étudiés par la Commission d’évaluation  de l’université  le lundi 15 mai 2017. La date limite de dépôt des dossiers à la DARI a été fixée au 12 mai  2017. (Mme Meneceur, Bureau… Read more »

Prof G Jondeau, coordinator of VASCERN

Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases. “The VASCERN project aims to facilitate and improve diagnosis, treatment and care for ALL patients suffering from Rare Multisystemic Vascular Diseases, thus enhancing access to care, and improving quantity and quality of life of these patients. Networking, sharing and spreading our expertise,… Read more »

Signature of the SAVE-BRAIN and SURVI MSD-Avenir projects

On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président du CA de MSD-Avenir), M Hirsch (Directeur Général de l’AP-HP), the Prof Y Levy (Président Directeur Général de l’INSERM), in the presence of the Prof P Ruszniewski (Doyen de l’UFR de médecine de l’Université Denis Diderot) and of F Crémieux (Directeur… Read more »

The lung, a major site of platelet biogenesis!!

A report published in Nature demonstrate that up to 50% of the platelet production derives form megacaryocytes circulating through the lungs! The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew… Read more »

Appel à candidature 2017 pour Prix de thèse du GERLI en lipidomique

Le Groupe d’Etude et de Recherche en Lipidomique fait appel à candidatures pour son prix de thèse. Ce prix récompense un travail dans le domaine des lipides, réalisé dans un laboratoire français ; la thèse aura été soutenue en 2016. Le montant du prix est de 1500€. Le prix de thèse décerné par le conseil scientifique du GERLI sera remis… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials Costa F, van Klaveren D, James S, Heg D, Raber L, Feres F, Pilgrim T, Hong MK, Kim HS, Colombo A, Steg PG, Zanchin T, Palmerini T, Wallentin L, Bhatt DL,… Read more »

Plusieurs propositions de postdoc pour les US

Cellular Mechanobiology Lab at the University at Buffalo Postdoctoral candidate Téléchargez l’annonce…   Research Positions Cardiac Physiology Postdoctoral Fellow/Instructor Téléchargez l’annonce… An NIH-sponsored postdoctoral fellowship  Available on human genome editing for blood disease modeling and treatment Téléchargez l’annonce…   Postdoctoral Fellow Harvard Medical School, Beth Israel Deaconess Medical Center (BIDMC) Téléchargez l’annonce…

Guide pour ‘Pratiquer une recherche intègre et responsable’

Ce guide est destiné à tous les acteurs de la recherche, quels que soient leur appartenance disciplinaire, leur niveau de responsabilité et leur statut. Il vise aussi à répondre aux questions que peuvent se poser les étudiants de master et doctorants sur de nombreux aspects de leur activité et à leur donner quelques pistes pour la pratiquer de manière responsable…. Read more »

Postdoctoral Research Fellow position in Nantes

Postdoctoral Research Fellow position available at INSERM UMR1064 Center for Research in Transplantation and Immunology, France Title: Antigen-specific Tregs in transplantation The laboratory: The Center for Research in Transplantation and Immunology (CRTI) is a research unit (UMR 1064) dedicated to transplantation science and immunology since 1993 in Nantes. The CRTI (3,000 m2 of laboratory surface area and two animal facilities) currently… Read more »

3 appels à projets USPC en cours

Trois appels à projets ont été publiés pour 2017 dans le cadre des bureaux de USPC à l’international: AAP USPC-NUS (Singapour), http://www.sorbonne-paris-cite.fr/fr/singapour-uspc-et-nus-lancent-3-appels-projets-conjoints La date limite de candidature est le 30 janvier 2017. Le contact est : mariana.losada@sciencespo.fr AAP USPC-CIN(Argentine) ; http://www.sorbonne-paris-cite.fr/fr/argentine-2e-appel-projets-conjoint-de-formation La date limite de candidature est le 15/02/2017. Le contact est flopezsastre@yahoo.fr AAP USPC-USP (Brésil) : http://www.sorbonne-paris-cite.fr/fr/uspc-au-bresil-appels-projets-recherche-et-formation-uspc-sao-paulo La date limite de candidature est le 1er mars 2017 ; le… Read more »

Assistant/Associate Professor – Vascular Biology in Geneva

Posted on 19 Dec 2016 University of Geneva · The Faculty of Medicine Switzerland, Genève Job description The Faculty of Medicine of the University of Geneva is seeking to fill a position of: Assistant or Associate Professor in vascular biology in the context of inflammation and immunology. Charge: This full-time position will involve undergraduate and postgraduate teaching in vascular biology and immunology , as… Read more »

Concours chercheurs session 2017

Le service RH de l’INSERM nous informe de l’ouverture de la campagne des concours chercheurs session 2017 (CR et DR). Vous trouverez ci-joint la lettre d’information relative à cette campagne, le tableau de répartition des postes ainsi que l’affiche de communication. Modalités de candidature : https://www.eva2.inserm.fr Concours CR : Date limite de Dépôt des dossiers (CR1 & CR2) : le 12 Janvier 2017 –… Read more »

Fiches produits chimiques

Le Bureau de coordination de la prévention de l’Inserm (BCPR) a élaboré en collaboration avec le Service prévention des risques de l’Institut Pasteur des fiches synthétiques destinées à tous ceux qui manipulent des produits chimiques dangereux. Elles permettront d’identifier rapidement les risques et de manipuler les produits en toute sécurité. Télécharger les version électroniques des fiches

Lancement du programme d’accueil d’étudiants Chinois

L’Université Sorbonne Paris Cité (UPSC) a signé en juin 2014 un accord avec le China Scholarship Council1 (CSC), un organisme gouvernemental chinois, pour permettre l’accueil dans les établissements et les ED de USPC de doctorants chinois. La procédure est lancée, attention, les délais sont courts!! Procedure csc_modele-sujet_2016-2017

Calendrier: qualification des enseignants-chercheurs 2017

Ouverture du serveur Antares : jeudi 08 septembre 2016, 10h (heure de Paris) Clôture des inscriptions : Mardi 25 octobre 2016, 16h (heure de Paris) Mise en ligne des rapporteurs sur GALAXIE : à partir du vendredi 25 novembre 2016 Date à laquelle la thèse ou l’habilitation doit avoir été soutenue : mercredi 14 décembre 2016 inclus Date limite d’envoi… Read more »

RHU call results: LVTS involved in 5 granted projects!

The ‘RHU‘ (Recherche Hospital Universitaire) action is to support translational research projects in health or clinical research, which are to be based on fundamental research in biology, epidemiology, social science or health economics and extend for a benefit for the care of patients, improving the understanding of diseases, more effective and better tolerated treatments, or a performance improvement of care systems. The… Read more »

3 postes INSERM ouverts à la mobilité interne vers le LVTS

3 postes INSERM sont ouverts à la mobilité au sein de notre unité INSERM U1148 LVTS: • Un poste d‘ingénieur(e) d’étude en expérimentation et instrumentation biologiques —> Voir le profil du poste • Un poste d’Animalier  —> Voir le profil du poste • Un poste de Technicien biologiste —> Voir le profil du poste Pour toute information, veuillez contacter notre secrétariat ou la DR Paris 7.

Early detection of strokes

Télématin broadcasted on the 13rd May 2016 an interview from Prof Pierre Amarenco (Team 5) where it is explained why we should detect stroke as soon as possible. This is related to a paper published this year by P Amarenco et al (N Engl J Med 2016. 374:1533) describing the results obtained from the ‘TIAregistry.org’ project that was designed to establish the contemporary profile, etiologic… Read more »

2 PhD programs in Rouen

The INSERM U1096 located in Rouen is looking for 2 PhD candidates which are already granted: – The first will assess the role of the phosphatase activity of the soluble epoxide hydrolase in a model of genetically modified rats subjected to a heart failure model (Supervisor: Jeremy Bellien) – The second will evaluate mechanisms involved in aortic stenosis in a mouse model… Read more »

TLOs in Takayasu Arteritis

Tertiary lymphoid organs in Takayasu Arteritis Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K 2016 • Frontiers Immunol • [pdf] Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs… Read more »

Silab and Inserm for tissue regeneration

Siltiss, a subsidiary of Silab group based near Brive-la-Gaillarde (Corrèze), has acquired the exclusive rights to use four patents regarding tissue engineering technology developed by Inserm. This technology was developed in two laboratories of Inserm in Paris (U1148; LVTS) and Bordeaux (U1026). Siltiss, founded in January, aims the development, production and marketing of natural biomaterials that promote or induce tissue… Read more »

MSDAVENIR & INSERM: a strategic framework agreement to support French medical research

Cyril Schiever, Chairman of the Board of MSDAVENIR, Professor Yves Lévy, Chairman and CEO of Inserm, and Pasca le Augé, President of the Management Board of Inserm Transfer, today signed a strategic framework agreement to support the French medical research. The event was held under the patronage and in the presence of Marisol Touraine, Minister of Social Affairs and Health,… Read more »

Prix “Le Monde” pour la recherche universitaire

Depuis deux décennies, « Le Monde », associé à divers partenaires, a choisi de distinguer les meilleures thèses françaises en organisant un prix destiné à récompenser des travaux remarquables « pour leur impact sur notre environnement scientifique, économique et social ». Cette année marquera la 19e édition de ce prix, ouvert tant aux sciences humaines et sociales qu’aux sciences dites « dures ». Le jury est présidé par Edgar Morin pour la première catégorie, et par Cédric Villani… Read more »

D Letourneur awarded the George Winter Prize

Didier Letourneur, the Director of LVTS and leader of Team 3, is the 2016 laureate for the George Winter Award from the European Society for Biomaterials (ESB). “This award is established to recognise, encourage and stimulate outstanding research contributions to the field of biomaterials. It will be presented annually during the Annual Biomaterials Meeting of the Society.[…].The nominee must have contributed significantly to… Read more »

Stroke: locate, react, restore

Nowadays, the management procedures of strokes are well codified. Nevertheless, the detection of clinical signs is still problematic. How can we deal with a transient ischemic attack? Follow the answers of Prpf Pierre Amarenco (Neurology Department of Bichat Hospital & Team 5 U1148) in an interview (in French) broadcasted on ‘Fréquency Médicale‘.–> Link to the video

Important!!! New section on our website!!!

Antonino NICOLETTI   March 10, 2016   Comments Off on Important!!! New section on our website!!!

Please note that there is a new INTRANET section on our website: “General Interest documents“. The first document that we have dropped there has been elaborated by Catherine Deschildre and explains how to proper cite our Biobanks in your articles.

Attention, Emails en berne les 18 et 19 mars

Antonino NICOLETTI   March 7, 2016   Comments Off on Attention, Emails en berne les 18 et 19 mars

La maintenance électrique annuelle sur le site informatique de Villejuif (site d’hébergement du DSI pour les applications nationales) va avoir lieu le 18/03 et 19/03. Cette intervention nécessite une coupure électrique totale sur le site.La messagerie électronique nationale qui dessert les domaines @inserm.fr, @anrs.fr et @aviesan.fr et les services associés seront interrompus le vendredi 18 mars à partir de 18h00. Durant cette interruption vous… Read more »

Campagne d’appréciation et concours internes ITA 2016

Campagne d’appréciation ITA 2016 Début de la campagne : 7 mars 2016. La campagne d’appréciation des ingénieurs et techniciens de l’Inserm démarre cette semaine. Pensez à préparer votre entretien annuel grâce au guide ci-dessous ! Envie d’évoluer dans votre carrière ou votre orientation professionnelle ? Une fiche d’évolution des compétences est disponible dans votre espace. Validation des dossiers et bordereaux d’avancement… Read more »

Loi Numérique : quel intérêt pour les chercheurs ?

Avec le projet de loi pour une République numérique, la France veut s’équiper d’un cadre juridique favorable à l’accès et à la circulation des données. Une démarche en cohérence avec les préconisations de la Commission européenne. Quelles conséquences auraient l’adoption de ce projet ? Quel intérêt pour les chercheurs ? En dehors de quelques journaux en Open access, la majeure… Read more »

Blood vessels from algae

Antonino NICOLETTI   February 24, 2016   Comments Off on Blood vessels from algae

To replace defective arteries, researchers from Team 3 are inspired by the long polysaccharide molecule that gives seaweed its flexibility and strength. Cedric Chauvierre from Team 3 explains in this video from Universcience and ‘Le Monde Médecine‘ that these artificial vessels must withstand high pressure variations and be biocompatible. Several tests in rats have shown that these artificial vessels are promising future vascular… Read more »

Stroke: from the clinics to the pathophysiology

This health training session organised by the ’Institut thématique multi-organismes “Neurosciences, sciences cognitives, neurologie, psychiatrie”, the ‘Bureau des formations scientifiques et de soutien à la recherche du Département des ressources humaines de l’Inserm’ has taken place the 24th Nov 2015 at the ‘Institut du cerveau et de la moelle épinière’ (ICM), GH de la Pitié Salpêtrière, Paris 13e. You can watch the lectures… Read more »

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, Ren Z, Cai B, Hostetler EM, Moran R, Liang D, Estrera AL, Safi HJ, Leal SM, Bamshad MJ, Shendure J, Nickerson DA, Jondeau G, Boileau C, Milewicz DM 2016 • Circ Res • [pdf] RATIONALE: Mutations in several genes have been… Read more »

Dispositif Emergence de la Mairie de Paris

La Mairie de Paris lance de l’édition 2016 du dispositif « Emergence(s) » destiné à aider les jeunes équipes des laboratoires publics parisiens. Les candidats pourront déposer leur dossier jusqu’au mardi 15 mars 2016 à 16 h. Vous pouvez, dès à présent, vous connecter sur le site Internet de la ville de Paris à l’adresse suivante : https://teleservices.paris.fr/k10/jsp/site/Portal.jsp?page=form&id_form=18

Beneficial effect of reducing microvascular thrombosis

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M 2015 • Stroke • [pdf] BACKGROUND AND PURPOSE: Downstream microvascular thrombosis (DMT) is known to be a contributing factor to… Read more »

Marc Clement: prize of the Chancellerie of Paris

On the 1st December 2015, Marc Clement (Team 1 LVTS) received one of the Prizes (Prix Aguirre-Basualdo/Robin) of the Chancellerie des Universités de Paris, in the Medecine section. Each year, these prizes award the best theses defended in Paris’ universities. Watch a short video of the ceremony. Marc did his thesis in our unit under the supervision of Dr Giuseppina… Read more »

Chemical heterogeneity of biodegradable polymers & surface energy

Effect of chemical heterogeneity of biodegradable polymers on surface energy: A static contact angle analysis of polyester model films Belibel R, Avramoglou T, Garcia A, Barbaud C, Moras L 2015 • Mater. Sci. Eng C • [pdf] Biodegradable and bioassimilable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) derivatives were synthesized and characterized in order to develop a new coating for coronary endoprosthesis enabling the… Read more »

A post-doc/PhD position in the Geneva Platelet Group

The Geneva Platelet Group Is recruiting a post-doc / PhD student for projects related to miRNAs and modulation of platelet reactivity using a cell-based and an animal model. Contact for application: Prof P. Fontana Division of Angiology and Hemostasis Geneva Platelet Group Geneva University Hospitals and Faculty of Medicine Pierre.fontana@hcuge.ch http://www.unige.ch/GenevaPlateletGroup/home/

Postdoc in INSERM U1138 Team 1 (Cordeliers Research Centre)

Post doctoral position in the INSERM U1138 Team 1 « Mineralocorticoid Receptor : Pathophysiology and Therapeutic Innovation » at INSERM/ Cordeliers Research Centre (Paris, France) The Cordeliers Research Centre (19 independent teams, Paris, France) (http://www.crcjussieu.fr) is a research centre of excellence for multidisciplinary research on the regulation of the different functions and the impact of their deregulation in the genesis and progression of… Read more »

GREMI: Vascular Inflammation, Pasteur Institute, November 13th, 2015

“Vascular Inflammation: Blood vessels under attack” meeting, November 13th 2015. Organised by GREMI. Institut Pasteur, Paris. The One Day GREMI Meeting untitled “Vascular Inflammation: Blood vessels under attack” meeting will be held at the Pasteur Institute (Paris) on November 13th, 2015. This one day meeting is organized by GREMI, the French society on Inflammation http://www.gremi.asso.fr, member of IAIS (International Association… Read more »

Translational Immunometabolism

The Cellular and Molecular Basis of Translational Immunometabolism Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM 2015 • Immunity • [pdf] The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions…. Read more »

Postdoctoral position in tissue repair and inflammation

An ERC-funded postdoctoral position is available in the Stroma Group within the Microenvironment & Immunity Unit, Department of Immunology at the Institut Pasteur (Paris), to study the mechanism(s) that regulate inflammation and tissue repair, more specifically the role of the stromal microenvironment in this process. Under the supervision of Lucie PEDUTO. Download the full proposal

Mails malveillants

La lettre SSI du Haut Fonctionnaire de Défense et de sécurité concernant une recrudescence de courriels véhiculant des logiciels malveillants depuis plusieurs semaines. Ce bulletin de rentrée est l’occasion de rappeler l’importance de se montrer extrêmement prudent avec les messageries électroniques, particulièrement avec les messages « inattendus ». Il reviendra sur trois catégories de bonnes pratiques informatiques avant de parcourir l’actualité… Read more »

Poste de technicien (12 mois renouvelables) à pourvoir à l’Institut Pasteur dans l’Unité de lymphopoïèse

Unité  de    lymphopoièse    dirigée    par    Pr.    Ana    Cumano Inserm  U668,    Institut    Pasteur,    25    rue    du    Docteur    Roux    75015    Paris Groupe:    Développement    des    cellules    lymphoïdes    innées direction  Pr.    Rachel    Golub Un  poste    de    technicien    est    à    pourvoir    dans    l’unité    de    lymphopoïèse    de    l’Institut    Pasteur     dans   le   cadre   d’un     projet   «  Caractérisation     et      … Read more »

Platelets GPVI binds to fibrin

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M 2015 • Blood • [pdf] Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets…. Read more »

Accident vasculaire cérébral : de la clinique à la physiopathologie

Les Journées Recherche et Santé sont des séminaires de formation organisés en collaboration avec les Instituts thématiques multi-organismes à l’initiative du Bureau des formations scientifiques et de soutien à la recherche (BFSSR) du Département des ressources humaines de l’Inserm. Mardi 24 novembre 2015, Jean-Baptiste Michel et Martine Jandrot-Perrus participeront comme orateur à cet ensemble de conférence. Auditorium de l’Institut du… Read more »

[Important] Info pour les utilisateurs Apple

Apple modifie la politique de sécurité de ses logiciels pour iPhone, iPad et Macintosh OS X. Cette politique inclut le durcissement du chiffrement utilisé pour les transactions Web et de courrier électronique ; elle affecte également la procédure d’accès aux réseaux WiFi dont EDUROAM. Elle sera appliquée avec la version IOS 9 (iPad, iPhone) disponible cette semaine ainsi que la nouvelle… Read more »

Platelets seal neutrophil-induced vascular breaches

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noe B 2015 • Blood • [pdf] Platelets protect vascular integrity during inflammation. Recent evidence suggests that this action is independent of thrombus formation and requires the engagement of glycoprotein VI (GPVI),… Read more »

CVD & Obesity: Surprising links

An international team of researchers coordinated by Professor Gabriel Steg  and Dr. Boris Hansel (Departments of ‘Cardiology’ and of ‘Endocrinology, Diabetes and Nutrition’ from the Bichat Claude Bernard Hospital: AP-HP and the University Paris-Diderot) has demonstrated that in people who have heart or arterial diseases, obesity does not appear to increase cardiovascular risk, whereas leanness is a very poor prognosis. These results… Read more »

Research Technician position at U1152 (Bichat Hospital)

Un poste de technicien est à pourvoir dans l’équipe du Pr J-M Sallenave (‘Equipe 4 : Immunité innée et défenses pulmonaires anti-infectieuses’ ; UMR INSERM 1152 , Hôpital Bichat) pour une durée initiale de 12 mois. Pour tout renseignement, veuillez contacter Jean-Michel Sallenave aux coordonnées ci-dessous: Jean-Michel Sallenave Professeur d’Immunologie , Université Paris Diderot Equipe 4 : ‘Immunité Innée et défenses pulmonaires… Read more »

Postdoc position at ELVEFLOW

ELVEFLOW est en phase de recrutement d’un post-doctorant à Paris pour le développement de kits de PCRq ultra-rapide pour sa plateforme FASTGEN. Vous trouverez le descriptif complet de l’offre ici. Ce projet vise à finaliser une plateforme de PCRq permettant de détecter simultanément une centaine de cible en moins de 10 minutes. Les candidats intéressés peuvent envoyer leur lettre de motivation et… Read more »

Nanomedicine as a strategy to fight thrombotic diseases

Nanomedicine as a strategy to fight thrombotic diseases Varna M, Juenet M, Bayles R, Mazighi M, Chauvierre C, Letourneur D 2015 • Future Sci OA • [pdf] This review highlights the preclinical and clinical research based on the use of nano- and micro-carriers in thrombolytic drug delivery. Ischemic heart and stroke caused by thrombosis are the main causes of death in… Read more »

Role of platelets in the pathogenesis of Influenza virus

Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis Le VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B 2014 • Am J Respir Crit Care Med • [pdf] RATIONALE: The hallmark of severe influenza virus infection is excessive… Read more »

Laroumanie F et al. 2014. CD4+ T Cells Promote the Transition from Hypertrophy to Heart Failure During Chronic Pressure Overload. Circulation.

This paper shows for the first time a crucial role of CD4+ T cells and specific antigen recognition in the progression from compensated cardiac hypertrophy to HF. CIRCULATIONAHA.113.007101.full

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors (Nature)

A fate-mapping experiments that identifies, in the fetal liver, a sequence of yolk sac erythromyeloid progenitor-derived and hematopoietic stem cell-derived haematopoiesis, and identifies yolk sac erythromyeloid progenitors as a common origin for tissue macrophages. nature13989

LVTS Videos

2017 B Hansel -Reversion Diabète - Télématin 3Nov2917Interview of Dr. Catherine Boileau at the European Society of Cardiology - Sept 2017Le yoyo pondéral et ses effets expliqué par Boris HANSEL à télématin (Sept 2017)TF1_14Aout2017_CChauvierre_FucoFredric Chaubet_PresentationLVTS_P13 {"type":"video","tracklist":true,"tracknumbers":true,"images":true,"artists":true,"tracks":[{"src":"https:\/\/lvts.fr\/wp-content\/uploads\/2015\/05\/B-Hansel-Reversion-Diab\u00e8te-T\u00e9l\u00e9matin-3Nov2917.mp4","type":"video\/mp4","title":"B Hansel -Reversion Diab\u00e8te - T\u00e9l\u00e9matin 3Nov2917","caption":"","description":"","meta":{"length_formatted":"4:45"},"dimensions":{"original":{"width":850,"height":480},"resized":{"width":603,"height":341}},"image":{"src":"https:\/\/lvts.fr\/wp-includes\/images\/media\/video.png","width":48,"height":64},"thumb":{"src":"https:\/\/lvts.fr\/wp-includes\/images\/media\/video.png","width":48,"height":64}},{"src":"https:\/\/lvts.fr\/wp-content\/uploads\/2015\/05\/Dr.-Niels-Voigt-talks-with-Dr.-Catherine-Boileau.mp4","type":"video\/mp4","title":"Interview of Dr. Catherine Boileau at the European Society of Cardiology - Sept 2017","caption":"","description":"","meta":{"length_formatted":"5:46"},"dimensions":{"original":{"width":1280,"height":720},"resized":{"width":603,"height":339}},"image":{"src":"https:\/\/lvts.fr\/wp-includes\/images\/media\/video.png","width":48,"height":64},"thumb":{"src":"https:\/\/lvts.fr\/wp-includes\/images\/media\/video.png","width":48,"height":64}},{"src":"https:\/\/lvts.fr\/wp-content\/uploads\/2015\/05\/TelematinYOYOsept2017.mp4","type":"video\/mp4","title":"Le yoyo pond\u00e9ral et ses effets... Read more »

Organ repair & Nanoparticles

Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles Meddahi-Pelle A, Legrand A, Marcellan A, Louedec L, Letourneur D, Leibler L 2014 • Angew Chem Int Ed Engl • [pdf] • Video Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization… Read more »

CD31 & immunogenic DCs

CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G 2014 • Proc Natl Acad Sci USA • [pdf] CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes…. Read more »

Collagen & Platelet secretory phenotype

Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noe B 2014 • PLoS One • [pdf] Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these “non classical” functions… Read more »

PN-1 & Pulmonary Fibrosis

Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression Francois D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC 2014 • Lab Invest • [pdf] Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1… Read more »

Hemostatic disorders in JAK2(V617F) Tg mice

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M 2014 • Blood • [pdf] Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as… Read more »

CD31 in the immunological synapse

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G 2014 •… Read more »

Mutations in an ECM gene in TAAD

MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau… Read more »

Control of B cells in atherosclerosis

Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A 2015 • Circulation • [pdf] • Editorial… Read more »

Antiplatelet therapy in ACS

Clinical evidence for oral antiplatelet therapy in acute coronary syndromes Wiviott SD, Steg PG 2015 • Lancet • [pdf] Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the treatment and prevention of recurrence of these syndromes. Nearly 30 years ago, aspirin was the first agent to show a benefit for acute… Read more »

IMMATIS project leaded by D Letourneur supported by OSEO

For the 15th edition of the National competition for the ‘’aide à la création d’entreprises de technologies innovantes’, the minister of ‘Enseignement supérieur et de la Recherche’ in association with OSEO has granted 55 projects in the “création-développement” and 120 projects in “Emergence”. The project IMMATIS coordinated by D Letourneur (Team 3) was selected in the “création-développement” category. It was… Read more »

NANOATHERO – A new FP7 Large Scale program coordinated by U1148

Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility NanoAthero is a Large Scale European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. Coordination : Didier Letourneur (Team 3; Inserm U1148, CHU… Read more »

‘FUCO-CHEM’ coordinated by C Chauvierre selected as a LABCOM

The ‘Agence nationale de la recherche’ has selected the first 7 common laboratories between research organisms and private companies as part of the « Labcom » program. The project FucoChem has been selected for its research on marine polysaccharides to be used as cardiovascular biotherapies. This project is coordinated by Cédric Chauvierre (Team 3 Inserm U1148). It involves the laboratory of polymer bioengineering… Read more »

Prof. D Le Guludec appointed chairperson of the board of Directors of IRSN

PhD in Biophysics, Dominique Le Guludec is Professor of Biophysics and Nuclear Medicine at University Paris 7. She is head of the Department of Nuclear Medicine, Hôpital Bichat, AP-HP, Paris, since 1994. She is also head of a research team of our Inserm Unit 1148, member of the Executive Committee of the EANM, and member of the National Council of… Read more »

D Letourneur: Innovative strategy to facilitate organ repair

A significant breakthrough could revolutionize surgical practice and regenerative medicine. The team led by Ludwik Leibler (Laboratoire Matière Molle et Chimie CNRS/ESPCI Paris Tech) and the Team headed by Didier Letourneur from the LVTS (INSERM U1148/Universités Paris Diderot and Paris 13), has just demonstrated that the principle of adhesion by aqueous solutions of nanoparticles can be used in vivo to… Read more »

Charte Publis INSERM P7 P13

Recommandations pour l’INSERM Toutes les unités Inserm sont mixtes avec l’université et/ou d’autres institutions. Chacune des ces institutions (Université, EPST, EPIC,…) doit être identifiée, dans les publications par une adresse séparée. Le séparateur toujours reconnu par les systèmes informatiques est le nom du pays.Institution 1, nom ou numéro du laboratoire ou du service…,ville, code postal, pays Institution 2, nom ou… Read more »

Partage (LinShare)->FileSender

Fin de vie de l’application Partage (LinShare) qui permettait d’échanger des fichiers volumineux: 1 avril. Partage est remplacée par l’application FileSender que nous mutualisons avec nos partenaires de la recherche et de l’enseignement supérieur. Cette application gérée par Renater, est accessible à l’adresse “https://filesender.renater.fr/­” . Une documentation complète est à votre disposition sur notre site “https://si-pratique.inserm.fr/­index.php/­File_Sender” .

Thrombi and neutrophils

Thrombi and neutrophils Michel JB, Ho-Tin-Noé B 2015 • Circ Res • [pdf] (Editorial to this paper) More than a century ago, in 1881, Bizzozero discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization. […]… Read more »

FACT: French Alliance for Cardiovascular Trials

The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as an « Investigative Network Initiative » and will receive a 5-year financial support from the F-CRIN (French part of ECRIN – European Clinical Research Infrastructures Network). FACT is an academic research network that federates more than 20 sites throughout France… Read more »

G Caligiuri spotted in the ‘International Innovation’ journal

The last issue of ‘International Innovation’, a journal for the global dissemination resource for the wider scientific, technology and research communities, focuses on the Women in Healthcare. Giuseppina (Team 1) has been invited to expose her research and to give her opinion on gender issues in medicine. Learn more

Didier Letourneur at the French Parliament

Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many pharmaceutical companies develop and put on the drug market “Biosimilars” on the same pattern as for the generic chemical drugs. Because substantial savings are expected with this interchangeability, a public audition was held at the French Parliament on 29 January… Read more »

Platelets & Influenza: INRA press release

Platelets play a role in severe pulmonary infections associated with influenza viruses. This has been revealed for the first time by researchers from Team 1 of LVTS in collaboration with researchers from INRA and the Université Claude Bernard Lyon 1. This work has been published on April 1, 2015 in the American Journal of Respiratory and Critical Care Medicine. Their… Read more »