Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Edelberg JM, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Lecorps G, Mahaffey KW, Moryusef A, Pordy R, Quintero K, Roe MT, Sasiela WJ, Tamby JF, Tricoci P, White HD, Zeiher AM, Committees OO, Investigators 2018 • N Engl J… Read more »

Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women Ozen G, Boumiza S, Deschildre C, Topal G, Longrois D, Jakobsson PJ, Michel JB, Jacob MP, Chahed K, Norel X 2018 • Int J Obes (Lond) • [pdf] BACKGROUND AND OBJECTIVES: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft… Read more »

Platelets and vascular integrity: how platelets prevent bleeding in inflammation Ho-Tin-Noe B, Boulaftali Y, Camerer E 2018 • Blood • [pdf] Platelets play a central role in primary hemostasis by forming aggregates that plug holes in injured vessels. Half a century ago, detailed studies of the microvasculature by electron microscopy revealed that under inflammatory conditions that do not induce major disruption… Read more »

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel JB, Piotin M, Salomon L, Mazighi M, Ho-Tin-Noe B, Desilles JP 2018 • Stroke • [pdf] BACKGROUND AND PURPOSE: Neutrophil Extracellular Traps… Read more »

Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noe B 2018 • J Am Heart Assoc • [pdf] BACKGROUND: Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute… Read more »

Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, Assadi M, Montravers P, Longrois D, Corcos O, Caligiuri G, Nicoletti A, Michel JB, Tran-Dinh A 2018 • Intensive Care Med Exp • [pdf] BACKGROUND: CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a… Read more »

Macrophage CD31 Signaling in Dissecting Aortic Aneurysm Andreata F, Syvannarath V, Clement M, Delbosc S, Guedj K, Fornasa G, Khallou-Laschet J, Morvan M, Even G, Procopio E, Gaston AT, Le Borgne M, Deschamps, L, Nicoletti A, Caligiuri G 2018 • JACC • [pdf] + Editorial from P Libby: Biologically-Based Therapies for Aortic Diseases • Link Background The authors recently found that a CD31… Read more »

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine Simon-Yarza T, Mielcarek A, Couvreur P, Serre C 2018 • Adv Mater. • [pdf] In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based… Read more »

Abiotic sequence-coded oligomers as efficient in vivo taggants for identification of implanted materials Karamessini D, Simon-Yarza T, Poyer S, Konishcheva E, Charles L, Letourneur D, Lutz JF. 2018 • Angew Chem Int Ed Engl • [pdf] Sequence-defined oligourethanes were tested as in vivo taggants for implants identification. The oligomers were prepared via an orthogonal solid-phase iterative approach and thus contained a… Read more »

External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry Darmon A, Bhatt DL, Elbez Y, Aboyans V, Anand S, Bosch J, Branch KR, Connolly SJ, Dyal L, Eikelboom JW, Fox KAA, Keltai K, Probstfield J, Yusuf S, Abtan J, Sorbets E, Eagle KA, Ducrocq G, Steg PG 2017 • Eur Heart… Read more »

Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease Hoshino T, Sissani L, Labreuche J, Ducrocq G, Lavallee PC, Meseguer E, Guidoux C, Cabrejo L, Hobeanu C, Gongora-Rivera F, Touboul PJ, Steg PG, Amarenco P, Investigators A 2017 • JAMA Neurol • [pdf] Importance: Patients who have experienced… Read more »

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters Tardy A, Honore JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D, Perrier J, Nicoletti C, Maresca M, Lefay C, Gigmes D, Nicolas J, Guillaneuf Y 2017 • Angew Chem Int Ed Engl • [pdf] For the first time, the free-radical copolymerization… Read more »

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition Ozen G, Gomez I, Daci A, Deschildre C, Boubaya L, Teskin O, Uydes-Dogan BS, Jakobsson PJ, Longrois D, Topal G, Norel X 2017 • Br J Pharmacol • [pdf] BACKGROUND AND PURPOSE: The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular… Read more »

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice – Implications for Superficial Erosion Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P 2017 • Circ Res • [pdf] Rationale:… Read more »

Free DNA precipitates calcium phosphate apatite crystals in the arterial wall in vivo Coscas R, Bensussan M, Jacob MP, Louedec L, Massy Z, Sadoine J, Daudon M, Chaussain C, Bazin D, Michel JB 2017 • Atherosclerosis • [pdf] BACKGROUND AND AIMS: The arterial wall calcium score and circulating free DNA levels are now used in clinical practice as biomarkers of cardiovascular… Read more »

Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials Costa F, van Klaveren D, James S, Heg D, Raber L, Feres F, Pilgrim T, Hong MK, Kim HS, Colombo A, Steg PG, Zanchin T, Palmerini T, Wallentin L, Bhatt DL,… Read more »

Tertiary lymphoid organs in Takayasu Arteritis Clement M, Galy A, Bruneval P, Morvan M, Hyafil F, Benali K, Pasi N, Deschamps L, Pellenc Q, Papo T, Nicoletti A, Sacre K 2016 • Frontiers Immunol • [pdf] Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs… Read more »

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections Guo D, Regalado ES, Gong L, Duan X, Santos-Cortez RL, Arnaud P, Ren Z, Cai B, Hostetler EM, Moran R, Liang D, Estrera AL, Safi HJ, Leal SM, Bamshad MJ, Shendure J, Nickerson DA, Jondeau G, Boileau C, Milewicz DM 2016 • Circ Res • [pdf] RATIONALE: Mutations in several genes have been… Read more »

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M 2015 • Stroke • [pdf] BACKGROUND AND PURPOSE: Downstream microvascular thrombosis (DMT) is known to be a contributing factor to… Read more »

Effect of chemical heterogeneity of biodegradable polymers on surface energy: A static contact angle analysis of polyester model films Belibel R, Avramoglou T, Garcia A, Barbaud C, Moras L 2015 • Mater. Sci. Eng C • [pdf] Biodegradable and bioassimilable poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) derivatives were synthesized and characterized in order to develop a new coating for coronary endoprosthesis enabling the… Read more »

The Cellular and Molecular Basis of Translational Immunometabolism Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM 2015 • Immunity • [pdf] The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions…. Read more »

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M 2015 • Blood • [pdf] Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets…. Read more »

Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noe B 2015 • Blood • [pdf] Platelets protect vascular integrity during inflammation. Recent evidence suggests that this action is independent of thrombus formation and requires the engagement of glycoprotein VI (GPVI),… Read more »

Nanomedicine as a strategy to fight thrombotic diseases Varna M, Juenet M, Bayles R, Mazighi M, Chauvierre C, Letourneur D 2015 • Future Sci OA • [pdf] This review highlights the preclinical and clinical research based on the use of nano- and micro-carriers in thrombolytic drug delivery. Ischemic heart and stroke caused by thrombosis are the main causes of death in… Read more »

Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis Le VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B 2014 • Am J Respir Crit Care Med • [pdf] RATIONALE: The hallmark of severe influenza virus infection is excessive… Read more »

Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles Meddahi-Pelle A, Legrand A, Marcellan A, Louedec L, Letourneur D, Leibler L 2014 • Angew Chem Int Ed Engl • [pdf] • Video Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization… Read more »

CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G 2014 • Proc Natl Acad Sci USA • [pdf] CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes…. Read more »

Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noe B 2014 • PLoS One • [pdf] Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these “non classical” functions… Read more »

Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression Francois D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC 2014 • Lab Invest • [pdf] Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1… Read more »

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M 2014 • Blood • [pdf] Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as… Read more »

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G 2014 •… Read more »

MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau… Read more »

Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A 2015 • Circulation • [pdf] • Editorial… Read more »

Clinical evidence for oral antiplatelet therapy in acute coronary syndromes Wiviott SD, Steg PG 2015 • Lancet • [pdf] Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the treatment and prevention of recurrence of these syndromes. Nearly 30 years ago, aspirin was the first agent to show a benefit for acute… Read more »

Thrombi and neutrophils Michel JB, Ho-Tin-Noé B 2015 • Circ Res • [pdf] (Editorial to this paper) More than a century ago, in 1881, Bizzozero discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization. […]… Read more »