A report published in Nature demonstrate that up to 50% of the platelet production derives form megacaryocytes circulating through the lungs!
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué & Mark R. Looney