Category Archives: Hot Stuff Archives

Our research unit is spotlighted in the last issue of the European Heart Journal. Read the full paper: pdf

As part of its policy of supporting medical research, the City of Paris annually awards two Grand Prizes to eminent personalities from the Parisian scientific community. Meeting on January 28, 2020, the jury for the Grands Prix de Médecine chose its winners: Philippe-Gabriel Steg (Team 5) and Nicolas Manel. The Grand Prix of Medicine and Medical Research of the City… Read more »

In issue 44 of the INSERM journal, an article is devoted to the Tridek-one startup whose 2 scientific co-founders are Giuseppina CALIGIURI and Antonino NICOLETTI who lead Team 1. Read the Article.

Giuseppina Caligiuri (Team 1) and Danilo Norata (University of Milan) present the content of a Cardiovascular Research spotlight issue focusing on immunometabolism. Link to issue. Aim of this Spotlight Issue is to present an overview of how changes in metabolic pathways of immune cells impact their function in the context of cardiovascular and metabolic diseases. Moreover, classical risk factors affect… Read more »

The ISTH honored Martine Jandrot-Perrus (Team 6) amongst four other members with the Esteemed Career Award at the ISTH 2019 Congress Opening Ceremony. These awards are presented annually to individuals whose career contributions have significantly advanced the scientific community’s understanding of diseases and disorders that affect hemostasis. Their accomplishments are internationally regarded as exemplary models of research and mentoring excellence…. Read more »

In the context of the FRM grant obtained by Fredéric Chaubet following the tender “Pionnier de la Recherche, Chimie pour la Médecine", Thierry Lhermitte, supporter of the FRM, and several foundation's members visited the laboratory. The project focuses on the treatment of intracranial aneuryms with novel bioactive devices and involves, in addition to the LVTS, two research teams from the... Read more »

Tridek One, Paris, June 4, 2019 ‐ Tridek One, a biotech company specialized in the development of products for the treatment of immune disorders, is pleased to announce a first round of funding of 3 million euros with leading investors Advent France Biotechnology and Advent Life Sciences. Tridek One was founded in 2018 by Dr. Giuseppina Caligiuri and Professor Antonino Nicoletti, researchers in... Read more »

Thursday, April 25th 2019: Prof. Catherine Boileau, co-leader of Team 2 and Head of Genetics Department of Bichat Hospital was awarded the grand prize of scientific recognition by the Queen of Belgium. Professor Boileau and her team have made significant and multiple contributions  in understanding the mechanisms responsible for the appearance of aortic aneurysms. With the hope that — as for... Read more »

Le décret, en date du 20 mars 2019, portant création de l’Université de Paris est paru au Journal officiel de la République française. En savoir plus

Prof. Philippe Gabriel Steg (head of Team 5) has been appointed “Vice President for Research” of the Executive Board of the AP-HP on joint proposal of deans, university presidents and Inserm. The Management Board is chaired by the Director General and has two other vice presidents: the president of the medical commission of establishment of the AP-HP, Prof. Christmas Garabedian, is… Read more »

In the last issue of the Magazine Science&Santé of INSERM,  there is a portrait of Catherine Boileau (co-head of Team 2) where her career is called to mind. Read the dossier

Jean-Baptiste Michel (Team 2) received the MATMUT prize for Medical Innovation 2018. Read more on the Fondation de l’Avenir web site

Catherine BOILEAU (Team 2) was awarded, together with Helen Hobbs (University of Texas Southwestern Medical School, Dallas – Etats-Unis) and Nabil Seidah (Institut de recherches cliniques de Montréal – Canada), the Grand Prix de la Fondation Lefoulon Delalande during a ceremony held on Wednesday, May 30 2018 under the Dome of the Institut de France. The ceremony was chaired by Mr…. Read more »

Marie-Noëlle Labour (Team 3) is actively involved in the MOOC “Tissue and Organ Bioengineering”. You can freely attend and register to this MOOC until 8th June 2018. It will be broadcasted between the 14 May and 17 June 2018. Link to subscribe

Il y a plusieurs mois de cela, Pierre Corvol remettait un rapport portant sur le "Bilan et des proposition de mise en oeuvre de la charte nationale d'intégrité scientifique" à Thierry Mandon, alors secrétaire d'Etat chargé de l'Enseignement Supérieur et de la Recherche. Ce rapport débute ainsi: La recherche est un superbe métier, pratiqué avec rigueur et honnêteté par l’immense... Read more »

A recent publication from Team 5 has been released in Circulation demonstrates that patients with high risk non–ST-segment–elevation myocardial infarction (NSTEMI) that undergo coronary angiography within the initial 12 hours after admission had a lower risk of ischemic outcomes at 180 days. Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment– Elevation Myocardial Infarction Managed Invasively Insights From the TAO Trial (Treatment… Read more »

Dominique Le Guludec, Professor of Biophysics and Nuclear Medicine at the UFR of Medicine at Paris Diderot University, Director of the Department of Nuclear Medicine and Biophysics at Bichat Hospital – Claude Bernard, APHP and Head of the Imaging Team Cardiovascular in the Translational Vascular Research Laboratory, has just been appointed head of the Haute Autorité de Santé (HAS). Dominique… Read more »

Acticor Biotech, a clinical stage biotechnology company (raised on the basis of a work initiated in Team 6 of U1148) involved in the acute phase of thrombotic diseases, including stroke and myocardial infarction, today announced the agreement of Dutch Authorities for the initiation of a phase I clinical trial in healthy volunteers with its drug candidate, ACT017. ACT017 is a… Read more »

Cedric Chauvierre (Team 3) has given an interview on the use of fucoidans to trace early atherothrombotic lesions for the TV news on the first French channel (TF1) on the 14th August 2017. You can see it here: LINK.

Didier Letourneur (Director of LVTS, head of Team 3) has been awarded the 2017 Asian Polymer Association (APA)’s Jubilee Award. APA was founded in 2007 at the premises of Indian Institute of Technology, New Delhi, India, www.asianpolymer.org. The society involves academicians, scientists and technologists from all over the Asian countries providing a well knitted structure of the society. Vision of… Read more »

Prof Guillaume JONDEAU (Team 2) is the corrdinator of VASCERN, the European Reference Network on Rare Multisystemic Vascular Diseases. “The VASCERN project aims to facilitate and improve diagnosis, treatment and care for ALL patients suffering from Rare Multisystemic Vascular Diseases, thus enhancing access to care, and improving quantity and quality of life of these patients. Networking, sharing and spreading our expertise,… Read more »

On the 18th April 2017, D Blazy (Président du Conseil Scientifique de MSD-Avenir) on the behalf of C Schiever (Président du CA de MSD-Avenir), M Hirsch (Directeur Général de l’AP-HP), the Prof Y Levy (Président Directeur Général de l’INSERM), in the presence of the Prof P Ruszniewski (Doyen de l’UFR de médecine de l’Université Denis Diderot) and of F Crémieux (Directeur… Read more »

We invite you to visit the website of the medical team from the Bichat hospital working on obesity  and metabolic diseases: http://hupnvs.aphp.fr/nutritionbichat/  

You are invited to visit the brand new web site of the iVASC RHU. Spread the voice around you! Our unit is critically involved in this clinical research program and several U1148’s PI are WP leader of the RHU iVASC. Visit the iVASC web site.

Cedric Chauvière (U1148 Team 3) was invited by Alain Ducardonnet on BFM Business TV on the 4th Oct 2016 to talk about ‘new diagnostic methods to anticipate artery disease’. See the video

The Grant and Prizes form the Société Française de Cardiologie are now listed. Download the announces for Prizes and Grants.

The ‘RHU‘ (Recherche Hospital Universitaire) action is to support translational research projects in health or clinical research, which are to be based on fundamental research in biology, epidemiology, social science or health economics and extend for a benefit for the care of patients, improving the understanding of diseases, more effective and better tolerated treatments, or a performance improvement of care systems. The… Read more »

We are proud that one of our PhD student, Charlotte Rasser (Team 1), is one of the final candidates of the “My thesis in 180 sec” contest. Link. Update: Charlotte was amongst the very finalists (16 students selected out of 560 candidates from all over France) of the contest which was organized in Bordeaux on the 31st May 2016

A paper in the Eur Heart Journal from Nail Seidah that recapitulates the discovery of the PCSK9 mutations in familial hypercholesterolemia made by Marianne Abifadel and Catherine Boileau (Team 2) in 2003. Read the paper..

Siltiss, a subsidiary of Silab group based near Brive-la-Gaillarde (Corrèze), has acquired the exclusive rights to use four patents regarding tissue engineering technology developed by Inserm. This technology was developed in two laboratories of Inserm in Paris (U1148; LVTS) and Bordeaux (U1026). Siltiss, founded in January, aims the development, production and marketing of natural biomaterials that promote or induce tissue… Read more »

Didier Letourneur, the Director of LVTS and leader of Team 3, is the 2016 laureate for the George Winter Award from the European Society for Biomaterials (ESB). “This award is established to recognise, encourage and stimulate outstanding research contributions to the field of biomaterials. It will be presented annually during the Annual Biomaterials Meeting of the Society.[…].The nominee must have contributed significantly to… Read more »

The ‘Magazine de la Santé’ on France 5 has taken the example of Acticor, a startup based in U1148, for the emerging supports of Biotech development through crowdfunding. You can watch the program here (broadcasted on the 27/01/2016).

On the 1st December 2015, Marc Clement (Team 1 LVTS) received one of the Prizes (Prix Aguirre-Basualdo/Robin) of the Chancellerie des Universités de Paris, in the Medecine section. Each year, these prizes award the best theses defended in Paris’ universities. Watch a short video of the ceremony. Marc did his thesis in our unit under the supervision of Dr Giuseppina… Read more »

On the 24th November 2015, Jean-Baptiste Michel received the ‘Grand Prix Lamonica’ from the ‘Académie des Sciences’. You can watch an extract of the ceremony HERE, or the full ceremony HERE.

“Vascular Inflammation: Blood vessels under attack” meeting, November 13th 2015. Organised by GREMI. Institut Pasteur, Paris. The One Day GREMI Meeting untitled “Vascular Inflammation: Blood vessels under attack” meeting will be held at the Pasteur Institute (Paris) on November 13th, 2015. This one day meeting is organized by GREMI, the French society on Inflammation http://www.gremi.asso.fr, member of IAIS (International Association… Read more »

The ‘Académie des Sciences’ grants 5 main prizes and 4 thematic ones to INSERM researchers. This year, Jean-Baptiste Michel, a researcher of LVTS Team 1, has been granted the ‘Grand Prix Lamonica de Cardiologie. Download the full listing

An international team of researchers coordinated by Professor Gabriel Steg  and Dr. Boris Hansel (Departments of ‘Cardiology’ and of ‘Endocrinology, Diabetes and Nutrition’ from the Bichat Claude Bernard Hospital: AP-HP and the University Paris-Diderot) has demonstrated that in people who have heart or arterial diseases, obesity does not appear to increase cardiovascular risk, whereas leanness is a very poor prognosis. These results… Read more »

For the 15th edition of the National competition for the ‘’aide à la création d’entreprises de technologies innovantes’, the minister of ‘Enseignement supérieur et de la Recherche’ in association with OSEO has granted 55 projects in the “création-développement” and 120 projects in “Emergence”. The project IMMATIS coordinated by D Letourneur (Team 3) was selected in the “création-développement” category. It was… Read more »

Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility NanoAthero is a Large Scale European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. Coordination : Didier Letourneur (Team 3; Inserm U1148, CHU… Read more »

The ‘Agence nationale de la recherche’ has selected the first 7 common laboratories between research organisms and private companies as part of the « Labcom » program. The project FucoChem has been selected for its research on marine polysaccharides to be used as cardiovascular biotherapies. This project is coordinated by Cédric Chauvierre (Team 3 Inserm U1148). It involves the laboratory of polymer bioengineering… Read more »

PhD in Biophysics, Dominique Le Guludec is Professor of Biophysics and Nuclear Medicine at University Paris 7. She is head of the Department of Nuclear Medicine, Hôpital Bichat, AP-HP, Paris, since 1994. She is also head of a research team of our Inserm Unit 1148, member of the Executive Committee of the EANM, and member of the National Council of… Read more »

A significant breakthrough could revolutionize surgical practice and regenerative medicine. The team led by Ludwik Leibler (Laboratoire Matière Molle et Chimie CNRS/ESPCI Paris Tech) and the Team headed by Didier Letourneur from the LVTS (INSERM U1148/Universités Paris Diderot and Paris 13), has just demonstrated that the principle of adhesion by aqueous solutions of nanoparticles can be used in vivo to… Read more »

The agreement between ACTICOR, a biotech hosted within the LVTS and created on the basis of the work from Martine Jandrot-Perrus (Team 1), Christian Gachet (U949) and Philippe Billiad (Institut Paris Sud d’Innovation Thérapeutique) is highlighted in the April issue of the BiotechFinances journal.

Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Votre Santé m’intéresse” on BFM TV (3 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).

Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Le Magazine de la Santé” on France 5 (27 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).

The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as an « Investigative Network Initiative » and will receive a 5-year financial support from the F-CRIN (French part of ECRIN – European Clinical Research Infrastructures Network). FACT is an academic research network that federates more than 20 sites throughout France… Read more »

The last issue of ‘International Innovation’, a journal for the global dissemination resource for the wider scientific, technology and research communities, focuses on the Women in Healthcare. Giuseppina (Team 1) has been invited to expose her research and to give her opinion on gender issues in medicine. Learn more

Some recent news on the Acticor Biotech team, a company dedicated to the development of an innovative, safe and effective treatment of ischemic stroke:<br> • Acticor is currently selecting its main lead to enter the development phase.<br> • Dr Gilles Avenard is the new President of the company. Acticor Website

Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many pharmaceutical companies develop and put on the drug market “Biosimilars” on the same pattern as for the generic chemical drugs. Because substantial savings are expected with this interchangeability, a public audition was held at the French Parliament on 29 January… Read more »

Platelets play a role in severe pulmonary infections associated with influenza viruses. This has been revealed for the first time by researchers from Team 1 of LVTS in collaboration with researchers from INRA and the Université Claude Bernard Lyon 1. This work has been published on April 1, 2015 in the American Journal of Respiratory and Critical Care Medicine. Their… Read more »