Team 6: Serpins and hemostasis in health and diseases

Team leaders: Marie-Christine BOUTON & Yacine BOULAFTALI

Pastille-Team1

TEAM 1

Pastille-Team2

TEAM 2

Pastille-Team3

TEAM 3

Pastille-Team4

TEAM 4

Pastille-Team5

TEAM 5

Pastille-Team6

TEAM 6

Pastille-HUB

Innovation & Industrial partnerships Hub

Pastille-Team0

Secretary

Pastille-COMMUN

Common services

Project Outlines

The Team 6 projects are focused and will focus on hemostasis, bleeding, and thrombo-inflammation. More specifically, the team investigates the contribution of platelets and their numerous activation pathways as well as the impact of the balance between serpins and their protease targets to vascular and inflammatory diseases. We combine multidisciplinary approaches ranging from biochemistry and cell biology to in vivo experimental models and clinical research for translational application.

Recently, we have demonstrated that:

  • Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
  • GPVI is a platelet receptor with a central role in the repairing functions of platelets
  • There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
  • Immunomodulation and cell therapy might help to improve post-stroke functional recovery
  • Neutrophil extracellular traps interfere with thrombolysis

We have also established:

  • The platelet platform
  • The “fibrino/thrombolytic event” platform

Our major common research themes are:

  •  Coagulation disorders (haemophilia, thrombophilia…)
  •  Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation) in various contexts:
    • Myeloproliferative disorders-associated thrombosis
    • Liver and kidney diseases
    • Lung fibrosis
    • Acute mesenteric ischemia

Publications

2024

1.
Reintam Blaser A, Mändul M, Björck M, Acosta S, Bala M, Bodnar Z, Casian D, Demetrashvili Z, D’Oria M, Durán Muñoz-Cruzado V, Forbes A, Fuglseth H, Hellerman Itzhaki M, Hess B, Kase K, Kirov M, Lein K, Lindner M, Loudet CI, Mole DJ, Murruste M, Nuzzo A, Saar S, Scheiterle M, Starkopf J, Talving P, Voomets A-L, Voon KKT, Yunus MA, Tamme K, AMESI Investigators (Collaborators), Corcos O, Castier Y, Ronot M, Biloslavo A, Paiano L, Elke G, Nagel D, Radke DI, Vilca Becerra J, Abeleyra ME, Cahenzli M, Semenkova T, Nikonov A, Smetkin A, Nedredal GI, Irtun Ø, Cohen-Arazi O, Keda A, Rojnoveanu G, Ursu A, Ciuró FP, García-Leon A, García-Sánchez CJ, Hui LJ, Ling LY, Kagan I, Singer P, Lipping E, Tvaladze A, Damaskos D, Clinch D, Qing TX, Vetrhus M, Martellucci J, Cerino G, Hong D, Liu J, Ong E, Kundogan K, Talih T, Bains L, Visconti D, Gibello L, Jailani RF, Ashra MA, Dzulkarnaen Zakaria A, Najmuddin Mohd Ghazi AF, Abd Ghani NS, Ab Rahim MF, Augustin G, Halužan D, Gurjar M, Rahul R, Hayati F, Mah J-J. 2024. Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study). Crit Care 28:32.
1.
Bourrienne M-C, Le Cam Duchez V, Faille D, Farkh C, Solo Nomenjanahary M, Gay J, Loyau S, Journé C, Dupont S, Ollivier V, Villeval J-LJ-L, Plo I, Edmond V, Jandrot-Perrus M, Labrouche-Colomer S, Cassinat B, Verger E, Desilles J-P, Ho Tin Noé BH, Triquenot Bagan A, Mazighi M, Ajzenberg N. 2024. Exacerbation of thrombo-inflammation by JAK2 V617F mutation worsens the prognosis of cerebral venous sinus thrombosis. Blood Advances bloodadvances.2023011692.
1.
Maïer B, Di Meglio L, Desilles J-P, Solo Nomenjanahary M, Delvoye F, Kyheng M, Boursin P, Ollivier V, Dupont S, Rambaud T, Hamdani M, Labreuche J, Blanc R, Piotin M, Halimi J-M, Mazighi M, Ho-Tin-Noe B. 2024. Neutrophil activation in patients treated with endovascular therapy is associated with unfavorable outcomes and mitigated by intravenous thrombolysis. J NeuroIntervent Surg 16:131–137.
1.
Uzzan M, Nachury M, Nuzzo A, Amiot A, Caron B, Benezech A, Buisson A, Bouguen G, Le Berre C, Reenaers C, Le Cosquer G, Savoye G, Charkaoui M, Vidon M, Guillo L, Fumery M, Peyrin-Biroulet L, Kirchgesner J, Bouhnik Y, GETAID TOFA-PRO study group, Fumery M, Yzet C, Brazier F, Billiauws L, Bouhnik Y, Nuzzo A, Amiot A, Carbonnel F, Bresteau C, Meyer A, Bellanger C, Nachury M, Wils P, Desreumaux P, Branche J, Gérard R, Assaraf J, Gagnière C, Uzzan M, Beaugerie L, Sokol H, Seksik P, Bourrier A, Kirchgesner J, McLellan P, Le Cosquer G, Gilletta C, Caron B, Peyrin-Biroulet L, Guilmoteau T, Dodel M, Coban D, Bouhnik Y, Cohen M, Treton X, Guillo L, Serrero M. 2024. Tofacitinib for Patients with Anti-TNF Refractory Ulcerative Proctitis: A Multicentre Cohort Study from the GETAID. Journal of Crohn’s and Colitis 18:424–430.
1.
Freiherr Von Seckendorff A, Nomenjanahary MS, Labreuche J, Ollivier V, Di Meglio L, Dupont S, Hamdani M, Brikci-Nigassa N, Brun A, Boursin P, Piotin M, Mazighi M, Ho-Tin-Noé B, Desilles J-P, Delbosc S. 2024. Periodontitis in ischemic stroke: impact of Porphyromonas gingivalis on thrombus composition and ischemic stroke outcomes. Research and Practice in Thrombosis and Haemostasis 8:102313.
1.
Guy A, Garcia G, Gourdou-Latyszenok V, Wolff-Trombini L, Josserand L, Kimmerlin Q, Favre S, Kilani B, Marty C, Boulaftali Y, Labrouche-Colomer S, Mansier O, James C. 2024. Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms. Journal of Thrombosis and Haemostasis 22:172–187.

2023

1.
Andreata F, Clément M, Benson RA, Hadchouel J, Procopio E, Even G, Vorbe J, Benadda S, Ollivier V, Ho-Tin-Noe B, Le Borgne M, Maffia P, Nicoletti A, Caligiuri G. 2023. CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation. eLife 12:e84752.
1.
De Dreuille B, Nuzzo A, Bataille J, Mailhat C, Billiauws L, Le Gall M, Joly F. 2023. Post-Marketing Use of Teduglutide in a Large Cohort of Adults with Short Bowel Syndrome-Associated Chronic Intestinal Failure: Evolution and Outcomes. Nutrients 15:2448.
1.
Wauters L, Dermine S, De Dreuille B, Bettolo J, Hutinet C, Mohamed A, Lecoq E, Billiauws L, Nuzzo A, Corcos O, Joly F. 2023. Malnutrition with Low Muscle Mass Is Common after Weaning off Home Parenteral Nutrition for Chronic Intestinal Failure. Nutrients 15:338.
1.
Chapelain OL, Jadoui S, Gros A, Barbaria S, Benmeziane K, Ollivier V, Dupont S, Nomenjanahary MS, Mavouna S, Mawhin M-A, Caligiuri G, Delbosc S, Porteu F, Nieswandt B, Mangin PH, Boulaftali Y, Ho-Tin-Noé B. 2023. The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent. preprint. In Review.
1.
Douté M, Sannier A, Even G, Tran T-T, Gaston A-T, Delbosc S, Loyau S, Bruneval P, Witko-Sarsat V, Mouthon L, Nicoletti A, Caligiuri G, Clement M. 2023. Thrombopoietin-Dependent Myelo-Megakaryopoiesis Fuels Thromboinflammation and Worsens Antibody-Mediated Chronic Renal Microvascular Injury. JASN 34:1207–1221.
1.
Bouton M, Geiger M, Sheffield WP, Irving JA, Lomas DA, Song S, Satyanarayanan RS, Zhang L, McFadden G, Lucas AR. 2023. The under‐appreciated world of the serpin family of serine proteinase inhibitors. EMBO Mol Med 15:e17144.
1.
Ouldali N, Le Roux E, Faye A, Leblanc C, Angoulvant F, Korb D, Delcour C, Caula C, Wohrer D, Rybak A, Delafoy M, Carrié C, Strullu M, Oualha M, Levy R, Mimoun C, Griffon L, Nuzzo A, Eyraud C, Levy M, Ellul P. 2023. Early formative objective structured clinical examinations for students in the pre-clinical years of medical education: A non-randomized controlled prospective pilot study. PLoS ONE 18:e0294022.
1.
Nuzzo A, Peoc’h K, Vaittinada Ayar P, Tran-Dinh A, Weiss E, Panis Y, Ronot M, Garzelli L, Eloy P, Ben Abdallah I, Castier Y, Corcos O. 2023. Improving clinical suspicion of acute mesenteric ischemia among patients with acute abdomen: a cross-sectional study from an intestinal stroke center. World J Emerg Surg 18:37.
1.
Billiald P, Slater A, Welin M, Clark JC, Loyau S, Pugnière M, Jiacomini IG, Rose N, Lebozec K, Toledano E, François D, Watson SP, Jandrot-Perrus M. 2023. Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances 7:1258–1268.
1.
Lebas H, Boutigny A, Maupu C, Salfati J, Orset C, Mazighi M, Bonnin P, Boulaftali Y. 2023. Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models. SVIN 3:e000476.
1.
Le Joncour A, Saadoun D, Boulaftali Y. 2023. Response to: ‘Correspondence on “Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease”’ by Chen et al. Ann Rheum Dis 82:e49–e49.
1.
Loyau S, Bauters A, Trillot N, Garcia C, Cougoul P, Pol H, Paris C, Robin G, Rubod C, Payrastre B, Jandrot-Perrus M, Voisin S, Dupont A. 2023. Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients. Platelets 34:2226756.
1.
Nguyen Y, Nuzzo A, Gross A, Minka O, Lilamand M, Rossi G, Sanchez M, Legué C, Pourbaix A, Tran Dinh A, Rozencwajg S, Khider L, Peiffer-Smadja N, Bouzid D, Faye A, Mirault T, De Lastours V. 2023. Prior participation as a standardized patient improves OSCE scores of third-year medical students: A pilot comparative study at Université Paris Cité Medical School. Medical Teacher 45:1177–1182.
1.
Ben Abdallah I, Craiem D, Casciaro M, Deza D, Garzelli L, Nuzzo A, Corcos O, Ronot M, Castier Y, El Batti S. 2023. Volumetric Analysis of Progressive Remodeling of Isolated Mesenteric Artery Dissection Treated by Conservative Therapy. Journal of Vascular and Interventional Radiology 34:445–453.
1.
Deltenre P, Payancé A, Elkrief L, Mura VL, Artru F, Baiges A, Cervoni J-P, China L, Colle I, Lemaitre E, Procopet B, Schiller D, Bureau C, Goria O, Ollivier I, Nuzzo A, Rautou P-E, Plessier A. 2023. Splanchnic vein thrombosis associated with SARS-CoV-2 infection: A VALDIG case–control study. JHEP Reports 5:100894.
1.
Tual A, Garzelli L, Nuzzo A, Corcos O, Castier Y, Ben Abdallah I, Ronot M. 2023. Strengthening the Description of Superior Mesenteric Artery Occlusions in Acute Mesenteric Ischaemia: Proposition for an Anatomical Classification. European Journal of Vascular and Endovascular Surgery 65:802–808.
1.
Joly F, Nuzzo A, Bozzetti F, Cuerda C, Jeppesen PB, Lal S, Lamprecht G, Mundi M, Szczepanek K, Van Gossum A, Wanten G, Pironi L. 2023. A multi-national survey of experience and attitudes towards managing catheter related blood stream infections for home parenteral nutrition. Clinical Nutrition ESPEN 57:126–130.
1.
Le Joncour A, Cacoub P, Boulaftali Y, Saadoun D. 2023. Neutrophil, NETs and Behçet’s disease: A review. Clinical Immunology 250:109318.
1.
Garzelli L, Felli E, Al‐Taher M, Barberio M, Agnus V, Plaforet V, Bonvalet F, Baiocchini A, Nuzzo A, Paulatto L, Vilgrain V, Gallix B, Diana M, Ronot M. 2023. MRI for the Detection of Small Bowel Ischemic Injury in Arterial Acute Mesenteric Ischemia: Preclinical Study in a Porcine Model. Magnetic Resonance Imaging 57:918–927.

2022

1.
Houdeville C, Leenhardt R, Souchaud M, Velut G, Carbonell N, Nion-Larmurier I, Nuzzo A, Histace A, Marteau P, Dray X. 2022. Evaluation by a Machine Learning System of Two Preparations for Small Bowel Capsule Endoscopy: The BUBS (Burst Unpleasant Bubbles with Simethicone) Study. JCM 11:2822.
1.
De Simone I, Baaten CCFMJ, Jandrot-Perrus M, Gibbins JM, Ten Cate H, Heemskerk JWM, Jones CI, Van Der Meijden PEJ. 2022. Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1. IJMS 23:10203.
1.
Freiherr Von Seckendorff A, Delvoye F, Levant P, Solo Nomenjanahary M, Ollivier V, Bourrienne M-C, Di Meglio L, Piotin M, Escalard S, Maier B, Hebert S, Smajda S, Redjem H, Mazighi M, Blanc R, Ho-Tin-Noé B, Désilles J-P. 2022. Modeling Large Vessel Occlusion Stroke for the Evaluation of Endovascular Therapy According to Thrombus Composition. Front Neurol 12:815814.
1.
Zalghout S, Vo S, Arocas V, Jadoui S, Hamade E, Badran B, Oudar O, Charnaux N, Longrois D, Boulaftali Y, Bouton M-C, Richard B. 2022. Syndecan-1 Is Overexpressed in Human Thoracic Aneurysm but Is Dispensable for the Disease Progression in a Mouse Model. Front Cardiovasc Med 9:839743.
1.
Maupu C, Lebas H, Boulaftali Y. 2022. Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye. Front Cardiovasc Med 9:793072.
1.
Bouton M-C, Corral J, Lucas AR. 2022. Editorial: The Serpin Family in the Cardiovascular System. Front Cardiovasc Med 8:821490.
1.
Slater A, Jandrot-Perrus M. 2022. GPVI and collagen: the final word? Blood 139:3005–3007.
1.
Desilles J, Solo Nomenjanahary M, Consoli A, Ollivier V, Faille D, Bourrienne M, Hamdani M, Dupont S, Di Meglio L, Escalard S, Maier B, Blanc R, Piotin M, Lapergue B, Ajzenberg N, Vasse M, Mazighi M, Ho‐Tin‐Noé B, Désilles J, Mazighi M, Piotin M, Blanc R, Redjem H, Smajda S, Seners P, Escalard S, Delvoye F, Maier B, Hebert S, Ben Maacha M, Hamdani M, Sabben C, Obadia M, Deschildre C, Lapergue B, Consoli A, Rodesch G, Maria F, Coskun O, Lopez D, Bourcier R, Detraz L, Desal H, Roy M, Clavier D, Marnat G, Gariel F, Lucas L, Sibon I, Eugene F, Vannier S, Ferre J, LeBras A, Raoult H, Paya C, Gauvrit J, Richard S, Gory B, Barbier C, Vivien D, Touze E, Gauberti M, Blaizot G, Ifergan H, Herbreteau D, Bibi R, Janot K, Charron V, Boulouis G. 2022. Impact of COVID‐19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID‐19 patients with acute ischemic stroke. Journal of Thrombosis and Haemostasis 20:919–928.
1.
Nuzzo A, Camus M, Corcos O. 2022. Duodenal fistula of an aorto-mesenteric vascular bypass graft. British Journal of Surgery 109:889–889.
1.
Delvoye F, Loyau S, Labreuche J, Taylor G, Maier B, Piotin M, Blanc R, Escalard S, Di Meglio L, Ben Maacha M, Redjem H, Smajda S, Ciccio G, Hébert S, Sabben C, Jandrot-Perrus M, Maertens De Noordhout A, Mazighi M, Ho-Tin-Noé B, Desilles J-P. 2022. Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients. Platelets 33:285–290.
1.
Jiacomini IG, Beltramino M, Boursin F, Minozzo JC, De Moura JF, Billiald P, Alvarenga LM, Aubrey N. 2022. An effective strategy for the humanization of antibody fragments under an accelerated timeline. International Journal of Biological Macromolecules 216:465–474.
1.
Ben Abdallah I, Huguet A, Nuzzo A, Mirault T, Roussel A, El Batti S, Ronot M, Castier Y, Corcos O. 2022. Acute Isolated Mesenteric Artery Dissection: Four Year Experience From a French Intestinal Stroke Centre. European Journal of Vascular and Endovascular Surgery 64:656–664.
1.
Garzelli L, Ben Abdallah I, Nuzzo A, Corcos O, Castier Y, Ronot M. 2022. Endovascular Thrombectomy for Acute Arterial Mesenteric Ischaemia: No Benefit of Mechanical Over Manual Thrombus Aspiration. European Journal of Vascular and Endovascular Surgery 64:128–129.
1.
Becq A, Chandnani M, Bartley A, Nuzzo A, Bilal M, Bharadwaj S, Cohen J, Gabr M, Berzin TM, Pleskow DK, Sawhney MS. 2022. ERCP within 6 or 12 h for acute cholangitis: a propensity score-matched analysis. Surg Endosc 36:2418–2429.
1.
Najdawi M, Garzelli L, Nuzzo A, Huguet A, Raynaud L, Paulatto L, Panis Y, Ben Abdallah I, Castier Y, Sibert A, Vilgrain V, Corcos O, Ronot M. 2022. Endovascular revascularization of acute arterial mesenteric ischemia: report of a 3-year experience from an intestinal stroke center unit. Eur Radiol 32:5606–5615.
1.
Ksouri A, Copin P, Bonvalet F, Bozi L, Cazals-Hatem D, Garzelli L, Panis Y, Weiss E, Castier Y, Bouhnik Y, Corcos O, Vilgrain V, Ronot M, Nuzzo A. 2022. Colonic involvement in acute mesenteric ischemia: prevalence, risk factors, and outcomes. Eur Radiol 32:2813–2823.
1.
Rodríguez‐Lago I, Hollenbach M, Archibugi L, Ciocan D, Libânio D, Nuzzo A, Pawlak KM, Zanetto A, Melchior C. 2022. Young GI angle: Challenges and opportunities as a trainee editor: The United European Gastroenterology journal experience. UEG Journal 10:348–353.
1.
Melchior C, Nuzzo A, Keszthelyi D. 2022. Raising interest for neurogastroenterology: Bottom‐up from the undergraduate medical curriculum? UEG Journal 10:128–129.
1.
Venisse L, François D, Madjène C, Brouwers E, De Raucourt E, Boulaftali Y, Declerck P, Arocas V, Bouton M. 2022. Novel ELISA for the specific detection of protease NEXIN‐1 in human biological samples. Research and Practice in Thrombosis and Haemostasis 6:e12756.

2021

1.
Madjene C, Boutigny A, Bouton M-C, Arocas V, Richard B. 2021. Protease Nexin-1 in the Cardiovascular System: Wherefore Art Thou? Front Cardiovasc Med 8:652852.
1.
Guedj K, Uzzan M, Soudan D, Trichet C, Nicoletti A, Weiss E, Manceau H, Nuzzo A, Corcos O, Treton X, Peoc’h K. 2021. I-FABP is decreased in COVID-19 patients, independently of the prognosis. PLoS ONE 16:e0249799.
1.
Matet A, Fournel L, Gaillard F, Amar L, Arlet J-B, Baron S, Bats A-S, Buffel Du Vaure C, Charlier C, De Lastours V, Faye A, Jablon E, Kadlub N, Leguen J, Lebeaux D, Malmartel A, Mirault T, Planquette B, Régent A, Thebault J-L, Dinh AT, Nuzzo A, Turc G, Friedlander G, Ruszniewski P, Badoual C, Ranque B, Oualha M, Courbebaisse M. 2021. Impact of integrating objective structured clinical examination into academic student assessment: Large-scale experience in a French medical school. PLoS ONE 16:e0245439.
1.
Perrella G, Huang J, Provenzale I, Swieringa F, Heubel-Moenen FCJI, Farndale RW, Roest M, Van Der Meijden PEJ, Thomas M, Ariëns RAS, Jandrot-Perrus M, Watson SP, Heemskerk JWM. 2021. Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation. ATVB 41.
1.
Brun A, Nuzzo A, Prouvost B, Diallo D, Hamdan S, Meseguer E, Guidoux C, Lavallée P, Amarenco P, Lesèche G, Bouchard P, Michel J, Rangé H. 2021. Oral microbiota and atherothrombotic carotid plaque vulnerability in periodontitis patients. A cross‐sectional study. J of Periodontal Research 56:339–350.
1.
Martin A, Boehm V, Zappa M, Billiauws L, Bonvalet F, Nuzzo A, Vilgrain V, Joly F, Ronot M. 2021. Imaging as predictor of clinical response to teduglutide in adult patients with short bowel syndrome with chronic intestinal failure. The American Journal of Clinical Nutrition 113:1343–1350.
1.
Loyau Inserm S, Faille D, Gautier P, Nurden P, Jandrot-Perrus M, Ajzenberg N. 2021. Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency. Platelets 32:705–709.
1.
Lakshmanan HHS, Melrose AR, Sepp A-LI, Mitrugno A, Ngo ATP, Khader A, Thompson R, Sallee D, Pang J, Mangin PH, Jandrot-Perrus M, Aslan JE, McCarty OJT. 2021. The basement membrane protein nidogen-1 supports platelet adhesion and activation. Platelets 32:424–428.
1.
Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH. 2021. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability. Thromb Haemost 121:543–546.
1.
Aymonnier K, Kawecki C, Arocas V, Boulaftali Y, Bouton MC. 2021. Serpins, New Therapeutic Targets for Hemophilia. Thromb Haemost 121:261–269.
1.
Nuzzo A, Guedj K, Curac S, Hercend C, Bendavid C, Gault N, Tran-Dinh A, Ronot M, Nicoletti A, Bouhnik Y, Castier Y, Corcos O, Peoc’h K, The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center), Huguet A, Stefanescu C, Treton X, Joly F, Billiauws L, Hamon A, Boitet A, Lekhal C, Deutsch D, Oiknin E, Cohen L, Marcellier G, Senemaud J, Corre F, Soudan D, Voican C, Leclère J-B, Iquilles J, Raynaud L, Paulatto L, Haas M, Uzzan M, Cohen M, Tadbiri S, Prevot S, Panis Y, Frontali A, Msika S, Ribeiro L, Rebibo L, Arapis K, Orville M, Sibert A, Copin P, Zappa M, Dioguardi Burgio M, Vilgrain V, Bertin C, Kerbaol A, Allaham W, Pellenc Q, Roussel A, Cerceau P, Ben Abdallah I, Girault A, Mordant P, De Blic R, Paugam C, Weiss E, Abback P-S, Enriquez I, Janny S, Bout H, Giabicani M, Achouf M, Grigoresco B, Ear LK, Curac S, Cachier A, Plessier A, Rautou P-E, Valla D, Payancé A, Sauvanet A, Dokmak S, Dondero F, Sepulveda A, Farges O, Aussilhou B, Jais B, Cazals-Hatem D, De Raucourt E, Boudaoud L, Trichet C, Puy H, Pons-Kerjean N, Stocco J, Bataille J, Bouton V, Montravers P, Augustin P, Lortat Jacob B, Michel J-B, Gauguier D, Dumas M-E, Brial F, Myridakis A, Martinez-Gili L, Olanipekun M, Marcault E, Nilusmas C, Barnier A, Souare A. 2021. Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia. Sci Rep 11:18929.
1.
Selbonne S, Madjene C, Salmon B, Boulaftali Y, Bouton M-C, Arocas V. 2021. Protease nexin-1 deficiency increases mouse hindlimb neovascularisation following ischemia and accelerates femoral artery perfusion. Sci Rep 11:13412.
1.
Nuzzo A, Czernichow S, Hertig A, Ledoux S, Poghosyan T, Quilliot D, Le Gall M, Bado A, Joly F. 2021. Prevention and treatment of nutritional complications after bariatric surgery. The Lancet Gastroenterology & Hepatology 6:238–251.
1.
Bourrienne M-C, Loyau S, Benichi S, Gay J, Solo-Nomenjanahary M, Journé C, Di Meglio L, Freiherr Von Seckendorff A, Desilles J-P, Ho-Tin-Noé B, Ajzenberg N, Mazighi M. 2021. A Novel Mouse Model for Cerebral Venous Sinus Thrombosis. Transl Stroke Res 12:1055–1066.
1.
Calame P, Nuzzo A, Ronot M. 2021. Local Intra-Arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia: Dealing with One Consequence Hoping to Affect the Cause? Cardiovasc Intervent Radiol 44:507–508.
1.
Melchior C, Nuzzo A, Keszthelyi D. 2021. How to raise the interest for neurogastroenterology among young gastroenterologists? UEG Journal 9:1193–1196.
1.
Magro F, Nuzzo A, Abreu C, Libânio D, Rodriguez‐Lago I, Pawlak K, Hollenbach M, Brouwer WP, Siau K. 2021. COVID‐19 in gastroenterology: Where are we now? Current evidence on the impact of COVID‐19 in gastroenterology. UEG Journal 9:750–765.
1.
Nuzzo A, Salem S, Malissin I, Diallo A, Deye N, Goury A, Gourlain H, Péron N, Vicaut E, Voicu S, Mégarbane B. 2021. Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study. UEG Journal 9:571–580.
1.
Ahmed MU, Receveur N, Janus‐Bell E, Mouriaux C, Gachet C, Jandrot‐Perrus M, Hechler B, Gardiner EE, Mangin PH. 2021. Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability. Research and Practice in Thrombosis and Haemostasis 5:e12551.

2020

1.
Karim-Silva S, Becker-Finco A, Jiacomini IG, Boursin F, Leroy A, Noiray M, De Moura J, Aubrey N, Billiald P, Alvarenga LM. 2020. Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential. Toxins 12:256.
1.
Faille D, Lamrani L, Loyau S, Huisse M-G, Bourrienne M-C, Alkhaier S, Cassinat B, Boulaftali Y, Debus J, Jandrot-Perrus M, Chomienne C, Dosquet C, Ajzenberg N. 2020. Interferon Alpha Therapy Increases Pro-Thrombotic Biomarkers in Patients with Myeloproliferative Neoplasms. Cancers 12:992.
1.
Jadoui S, Le Chapelain O, Ollivier V, Mostefa-Kara A, Di Meglio L, Dupont S, Gros A, Nomenjanahary MS, Desilles J-P, Mazighi M, Nieswandt B, Loyau S, Jandrot-Perrus M, Mangin PH, Ho-Tin-Noé B. 2020. Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis. haematol 106:2000–2003.
1.
Nuzzo A, Corcos O, Ronot M. 2020. Small-Bowel Dilatation Is the Most Consistent Feature of Transmural Intestinal Necrosis. American Journal of Roentgenology 215:W42–W42.
1.
Garzelli L, Nuzzo A, Copin P, Calame P, Corcos O, Vilgrain V, Ronot M. 2020. Contrast-Enhanced CT for the Diagnosis of Acute Mesenteric Ischemia. American Journal of Roentgenology 215:29–38.
1.
Nuzzo A, Joly F, Ronot M, Castier Y, Huguet A, Paugam-Burtz C, Cazals-Hatem D, Tran-Dinh A, Becq A, Panis Y, Bouhnik Y, Maggiori L, Corcos O, on behalf of the SURVI group. 2020. Normal Lactate and Unenhanced CT-Scan Result in Delayed Diagnosis of Acute Mesenteric Ischemia. Am J Gastroenterol 115:1902–1905.
1.
Nuzzo A, Tran-Dinh A, Courbebaisse M, Peyre H, Plaisance P, Matet A, Ranque B, Faye A, De Lastours V, on behalf of the University of Paris OSCE and SBT groups. 2020. Improved clinical communication OSCE scores after simulation-based training: Results of a comparative study. PLoS ONE 15:e0238542.
1.
Terlouw LG, Moelker A, Abrahamsen J, Acosta S, Bakker OJ, Baumgartner I, Boyer L, Corcos O, Van Dijk LJ, Duran M, Geelkerken RH, Illuminati G, Jackson RW, Kärkkäinen JM, Kolkman JJ, Lönn L, Mazzei MA, Nuzzo A, Pecoraro F, Raupach J, Verhagen HJ, Zech CJ, Van Noord D, Bruno MJ. 2020. European guidelines on chronic mesenteric ischaemia – joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia. UEG Journal 8:371–395.
1.
Di Meglio L, Desilles J-P, Solonomenjanahary M, Labreuche J, Ollivier V, Dupont S, Deschildre C, Maacha MB, Consoli A, Lapergue B, Piotin M, Blanc R, Ho-Tin-Noe B, Mazighi M, Désilles J-P, Redjem H, Smajda S, Ciccio G, Escalard S, Delvoye F, Maier B, Hebert S, Hamdani M, Sabben C, Obadia M, Rodesch G, Di Maria F, Coskun O, Lopez D, Bourcier R, Detraz L, Desal H, Roy M, Clavier D, Marnat G, Gariel F, Lucas L, Sibon I, Eugene F, Vannier S, Ferre J-C, Le Bras A, Raoult H, Paya C, Gauvrit J-Y, Richard S, Gory B, Barbier C, Vivien D, Touzé E, Gauberti M, Blaizot G. 2020. DNA Content in Ischemic Stroke Thrombi Can Help Identify Cardioembolic Strokes Among Strokes of Undetermined Cause. Stroke 51:2810–2816.
1.
Ducroux C, Desilles J-P, Mawhin M-A, Delbosc S, Ho-Tin-Noé B, Ollivier V, Di Meglio L, Lapergue B, Michel J-B, Amarenco P. 2020. Protective Effect of ApoA1 (Apolipoprotein A1)-Milano in a Rat Model of Large Vessel Occlusion Stroke. Stroke 51:1886–1890.
1.
Ahmed MU, Kaneva V, Loyau S, Nechipurenko D, Receveur N, Le Bris M, Janus-Bell E, Didelot M, Rauch A, Susen S, Chakfé N, Lanza F, Gardiner EE, Andrews RK, Panteleev M, Gachet C, Jandrot-Perrus M, Mangin PH. 2020. Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin. ATVB 40:2127–2142.
1.
Karhausen J, Choi HW, Maddipati KR, Mathew JP, Ma Q, Boulaftali Y, Lee RH, Bergmeier W, Abraham SN. 2020. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. Sci Adv 6:eaay6314.
1.
Mertens JC, Boisseau W, Leenaerts D, Di Meglio L, Loyau S, Lambeir A, Ducroux C, Jandrot‐Perrus M, Michel J, Mazighi M, Hendriks D, Desilles J. 2020. Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke. Journal of Thrombosis and Haemostasis 18:3325–3335.
1.
Kulkarni K, Chiasakul T, Riva N, Eslick R, Casari C, Pabinger I, Blondon M, Boulaftali Y, Campbell R, Las Casas P, Lauw M, Muia J, Skeith L. 2020. Exciting times for the ISTH early career professionals. Journal of Thrombosis and Haemostasis 18:2437–2438.
1.
Kawecki C, Aymonnier K, Ferrière S, Venisse L, Arocas V, Boulaftali Y, Christophe OD, Lenting PJ, Bouton M, Denis CV. 2020. Development and characterization of single‐domain antibodies neutralizing protease nexin‐1 as tools to increase thrombin generation. Journal of Thrombosis and Haemostasis 18:2155–2168.
1.
Gresele P, Orsini S, Noris P, Falcinelli E, Alessi MC, Bury L, Borhany M, Santoro C, Glembotsky AC, Cid AR, Tosetto A, De Candia E, Fontana P, Guglielmini G, Pecci A, Heller PG, Rodorigo G, Lammle B, Trinchero A, Paolo R, Ferrari S, Rancitelli D, Stolinski A, Arulselvan A, Lassandro G, Luceros AS, Jandrot‐Perrus M, Kunishima S, Rivera Pozo J, Lordkipanidzé M, Melazzini F, Falaise C, Casonato A, Podda G, Kannan M, Jurk K, Sevivas T, Castaman G, Grandone E, Fiore M, Zuniga P, Henskens Y, Miyazaki K, Dupuis A, Hayward C, Zaninetti C, Abid M, Ferrara G, Mazzucconi MG, Tagariello G, James P, Fabris F, Russo A, Bermejo N, Napolitano M, Curnow J, Vasiliki G, Zieger B, Fedor M, Chitlur M, Lambert M, Barcella L, Cosmi B, Giordano P, Porri C, Eker I, Morel‐Kopp M, Deckmyn H, Frelinger AL, Harrison P, Mezzano D, Mumford AD. 2020. Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC. Journal of Thrombosis and Haemostasis 18:732–739.
1.
Le Joncour A, Biard L, Vautier M, Bugaut H, Mekinian A, Maalouf G, Vieira M, Marcelin A-G, Rosenzwajg M, Klatzmann D, Corvol J-C, Paccoud O, Carillion A, Salem J-E, Cacoub P, Boulaftali Y, Saadoun D. 2020. Neutrophil–Platelet and Monocyte–Platelet Aggregates in COVID-19 Patients. Thromb Haemost 120:1733–1735.
1.
Bourrienne M-C, Loyau S, Faille D, De Raucourt E, De Mazancourt P, Ho-Tin-Noé B, Gabison E, Ajzenberg N. 2020. Functional Fibrinolysis Assays Reveal Different Mechanisms underlying Plasminogen Dysfunction in Ligneous Conjunctivitis. Thromb Haemost 120:758–767.
1.
Belkahla H, Antunes JC, Lalatonne Y, Sainte Catherine O, Illoul C, Journé C, Jandrot-Perrus M, Coradin T, Gigoux V, Guenin E, Motte L, Helary C. 2020. USPIO–PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis. J Mater Chem B 8:5515–5528.
1.
Weber-Lima MM, Prado-Costa B, Becker-Finco A, Costa AO, Billilad P, Furst C, De Moura JF, Alvarenga LM. 2020. Acanthamoeba spp. monoclonal antibody against a CPA2 transporter: a promising molecular tool for acanthamoebiasis diagnosis and encystment study. Parasitology 147:1678–1688.
1.
Joly F, Seguy D, Nuzzo A, Chambrier C, Beau P, Poullenot F, Thibault R, Armengol Debeir L, Layec S, Boehm V, Lallemand J, Quilliot D, Schneider SM. 2020. Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: A real-world French observational cohort study. Clinical Nutrition 39:2856–2862.
1.
Renaud L, Lebozec K, Voors‐Pette C, Dogterom P, Billiald P, Jandrot Perrus M, Pletan Y, Machacek M. 2020. Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation. The Journal of Clinical Pharma 60:1198–1208.

2019

1.
Lebas H, Yahiaoui K, Martos R, Boulaftali Y. 2019. Platelets Are at the Nexus of Vascular Diseases. Front Cardiovasc Med 6:132.
1.
Guy A, Gourdou-Latyszenok V, Le Lay N, Peghaire C, Kilani B, Dias JV, Duplaa C, Renault M-A, Denis C, Villeval JL, Boulaftali Y, Jandrot-Perrus M, Couffinhal T, James C. 2019. Vascular endothelial cell expression of JAK2 V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression. Haematologica 104:70–81.
1.
Fogaça RL, Alvarenga LM, Woiski TD, Becker-Finco A, Teixeira KN, Silva SK, De Moraes RN, Noronha LD, Noiray M, De Figueiredo BC, Billiald P, Moura JD. 2019. Biomolecular engineering of antidehydroepiandrosterone antibodies: a new perspective in cancer diagnosis and treatment using single-chain antibody variable fragment. Nanomedicine 14:689–705.
1.
Di Meglio L, Desilles J-P, Ollivier V, Nomenjanahary MS, Di Meglio S, Deschildre C, Loyau S, Olivot J-M, Blanc R, Piotin M, Bouton M-C, Michel J-B, Jandrot-Perrus M, Ho-Tin-Noé B, Mazighi M. 2019. Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis. Neurology 93.
1.
Party H, Dujarrier C, Hébert M, Lenoir S, Martinez De Lizarrondo S, Delépée R, Fauchon C, Bouton M-C, Obiang P, Godefroy O, Save E, Lecardeur L, Chabry J, Vivien D, Agin V. 2019. Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments. acta neuropathol commun 7:153.
1.
Kizlik-Masson C, Deveuve Q, Zhou Y, Vayne C, Thibault G, McKenzie SE, Pouplard C, Loyau S, Gruel Y, Rollin J. 2019. Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia. Blood 133:2427–2435.
1.
Aymonnier K, Kawecki C, Venisse L, Boulaftali Y, Christophe OD, Lenting PJ, Arocas V, De Raucourt E, Denis CV, Bouton M-C. 2019. Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia. Blood 134:1632–1644.
1.
Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Härdtner C, Koentges C, Kienle K, Ollivier V, Schell M, Dorner L, Wippel C, Stallmann D, Normann C, Bugger H, Walther P, Wolf D, Ahrens I, Lämmermann T, Ho-Tin-Noé B, Ley K, Bode C, Hilgendorf I, Duerschmied D. 2019. Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Circulation 139:918–931.
1.
Voors-Pette C, Lebozec K, Dogterom P, Jullien L, Billiald P, Ferlan P, Renaud L, Favre-Bulle O, Avenard G, Machacek M, Plétan Y, Jandrot-Perrus M. 2019. Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial. ATVB 39:956–964.
1.
Le Joncour A, Martos R, Loyau S, Lelay N, Dossier A, Cazes A, Fouret P, Domont F, Papo T, Jandrot-Perrus M, Bouton M-C, Cacoub P, Ajzenberg N, Saadoun D, Boulaftali Y. 2019. Critical role of neutrophil extracellular traps (NETs) in patients with Behcet’s disease. Ann Rheum Dis 78:1274–1282.
1.
Pillois X, Guy A, Choquet É, James C, Tuffigo M, Viallard J, Garcia C, Bordet J, Jandrot‐Perrus M, Payrastre B, Fiore M. 2019. First description of an IgM monoclonal antibody causing αIIbβ3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia. Journal of Thrombosis and Haemostasis 17:795–802.
1.
Nuzzo A, Ronot M, Maggiori L, Corcos O. 2019. Rather than Surgical Technique, Dedicated Stroke Centers Improve Bowel and Life Outcomes in Acute Mesenteric Ischemia. Journal of Clinical Gastroenterology 53:471–472.
1.
Nuzzo A, Shaar-Chneker C, Maillet M, Mégarbane B. 2019. Gastroduodenal injury induced by orally administered sodium polystyrene sulfonate. Clinical Toxicology 57:75–76.
1.
Jandrot-Perrus M, Hermans C, Mezzano D. 2019. Platelet glycoprotein VI genetic quantitative and qualitative defects. Platelets 30:708–713.
1.
Bohec P, Gachelin J, Ollivier V, Mutin T, Télot X, Ho-Tin-Noé B, Sanfilippo S. 2019. Acoustophoretic purification of platelets: feasibility and impact on platelet activation and function. Platelets 30:174–180.
1.
Nuzzo A, Maggiori L, Paugam-Burtz C, Cazals-Hatem D, Ronot M, Huguet A, Becq A, Castier Y, Weiss E, Plessier A, Tran-Dinh A, Joly F, Panis Y, Bouhnik Y, Gault N, Corcos O, on behalf of the SURVI group. 2019. Oral Antibiotics Reduce Intestinal Necrosis in Acute Mesenteric Ischemia: A Prospective Cohort Study. Am J Gastroenterol 114:348–351.
1.
Nuzzo A, Ronot M, Maggiori L, Joly F, Corcos O. 2019. Des douleurs abdominales de cause vasculaire. La Revue de Médecine Interne 40:129–131.
1.
Antunes JC, Benarroch L, Moraes FC, Juenet M, Gross M-S, Aubart M, Boileau C, Caligiuri G, Nicoletti A, Ollivier V, Chaubet F, Letourneur D, Chauvierre C. 2019. Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells. Molecular Therapy - Nucleic Acids 17:210–222.
1.
Mansour MB, Balti R, Yacoubi L, Ollivier V, Chaubet F, Maaroufi RM. 2019. Primary structure and anticoagulant activity of fucoidan from the sea cucumber Holothuria polii. International Journal of Biological Macromolecules 121:1145–1153.
1.
Gossart A, Gand A, Ollivier V, Boissière M, Santerre JP, Letourneur D, Pauthe E. 2019. Coating of cobalt chrome substrates with thin films of polar/hydrophobic/ionic polyurethanes: Characterization and interaction with human immunoglobulin G and fibronectin. Colloids and Surfaces B: Biointerfaces 179:114–120.
1.
Gossart A, Letourneur D, Gand A, Regnault V, Ben Mlouka MA, Cosette P, Pauthe E, Ollivier V, Santerre JP. 2019. Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings. Biomaterials 217:119306.
1.
Li B, Aid-Launais R, Labour M-N, Zenych A, Juenet M, Choqueux C, Ollivier V, Couture O, Letourneur D, Chauvierre C. 2019. Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus. Biomaterials 194:139–150.
1.
Nuzzo A, Dautry R, Francoz C, Logeart D, Mégarbane B. 2019. Hepatopulmonary syndrome-attributed extreme hypoxemia and polycythemia revealing liver cirrhosis. The American Journal of Emergency Medicine 37:175.e1-175.e2.
1.
Aubrey N, Billiald P. 2019. Antibody Fragments Humanization: Beginning with the End in Mind, p. 231–252. In Steinitz, M (ed.), Human Monoclonal Antibodies. Springer New York, New York, NY.

2018

1.
Saultier P, Szepetowski S, Canault M, Falaise C, Poggi M, Suchon P, Barlogis V, Michel G, Loyau S, Jandrot-Perrus M, Bordet J-C, Alessi M-C, Chambost H. 2018. Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation. Haematologica 103:e264–e267.
1.
Mangin PH, Onselaer M-B, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP. 2018. Immobilized fibrinogen activates human platelets through glycoprotein VI. Haematologica 103:898–907.
1.
Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B. 2018. The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. Haematologica 103:e256–e258.
1.
Nuzzo A, Peron N, Voicu S, Mégarbane B, Deye N. 2018. Targeted temperature management for non-shockable cardiac arrests: the debate must go on. J Thorac Dis 10:1304–1307.
1.
Delattre C, Velazquez D, Roques C, Pavon-Djavid G, Ollivier V, Lokajczyk A, Avramoglou T, Gueguen V, Louedec L, Caligiuri G, Jandrot-Perrus M, Boisson-Vidal C, Letourneur D, Meddahi-Pelle A. 2018. In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent. Bioimpacts 9:25–36.
1.
Peoc’h K, Nuzzo A, Guedj K, Paugam C, Corcos O. 2018. Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far. Clinical Chemistry and Laboratory Medicine (CCLM) 56:373–385.
1.
Hoang QT, Nuzzo A, Louedec L, Delbosc S, Andreata F, Khallou-Laschet J, Assadi M, Montravers P, Longrois D, Corcos O, Caligiuri G, Nicoletti A, Michel J-B, Tran-Dinh A. 2018. Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury. ICMx 6:27.
1.
François D, Arocas V, Venisse L, Aymonnier K, Idir L, Martos R, Gazit S, Couty L, Jandrot-Perrus M, Camerer E, Boulaftali Y, Bouton M-C. 2018. Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice. Blood Advances 2:2389–2399.
1.
Berrou E, Soukaseum C, Favier R, Adam F, Elaib Z, Kauskot A, Bordet J-C, Ballerini P, Loyau S, Feng M, Dias K, Muheidli A, Girault S, Nurden AT, Turro E, Ouwehand WH, Denis CV, Jandrot-Perrus M, Rosa J-P, Nurden P, Bryckaert M. 2018. A mutation of the human EPHB2 gene leads to a major platelet functional defect. Blood 132:2067–2077.
1.
Stefanini L, Lee RH, Paul DS, O’Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W. 2018. Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood 132:1951–1962.
1.
Ho-Tin-Noé B, Boulaftali Y, Camerer E. 2018. Platelets and vascular integrity: how platelets prevent bleeding in inflammation. Blood 131:277–288.
1.
Lefevre T, Nuzzo A, Mégarbane B. 2018. Poppers-induced Life-Threatening Methemoglobinemia. Am J Respir Crit Care Med 198:e137–e138.
1.
Ducroux C, Di Meglio L, Loyau S, Delbosc S, Boisseau W, Deschildre C, Ben Maacha M, Blanc R, Redjem H, Ciccio G, Smajda S, Fahed R, Michel J-B, Piotin M, Salomon L, Mazighi M, Ho-Tin-Noe B, Desilles J-P. 2018. Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke. Stroke 49:754–757.
1.
Desilles J, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot‐Perrus M, Michel J, Mazighi M, Ho‐Tin‐Noé B. 2018. Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion. JAHA 7:e007804.
1.
Loyau S, Ho-Tin-Noé B, Bourrienne M-C, Boulaftali Y, Jandrot-Perrus M. 2018. Microfluidic Modeling of Thrombolysis: Effect of Antiplatelet and Anticoagulant Agents on tPA (Tissue-Type Plasminogen Activator)-Induced Fibrinolysis. ATVB 38:2626–2637.
1.
Lehmann M, Schoeman RM, Krohl PJ, Wallbank AM, Samaniuk JR, Jandrot-Perrus M, Neeves KB. 2018. Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI–Dependent Manner in an In Vitro Venous Thrombosis Model. ATVB 38:1052–1062.
1.
Ghebouli R, Loyau S, Maire M, Saboural P, Collet J-P, Jandrot-Perrus M, Letourneur D, Chaubet F, Michel J-B. 2018. Amino-Fucoidan as a Vector for rtPA-Induced Fibrinolysis in Experimental Thrombotic Events. Thromb Haemost 118:042–053.
1.
Leenaerts D, Loyau S, Mertens JC, Boisseau W, Michel JB, Lambeir AM, Jandrot‐Perrus M, Hendriks D. 2018. Carboxypeptidase U (CPU, carboxypeptidase B2, activated thrombin‐activatable fibrinolysis inhibitor) inhibition stimulates the fibrinolytic rate in different in vitro models. Journal of Thrombosis and Haemostasis 16:2057–2069.
1.
Lê VB, Riteau B, Alessi M, Couture C, Jandrot‐Perrus M, Rhéaume C, Hamelin M, Boivin G. 2018. Protease‐activated receptor 1 inhibition protects mice against thrombin‐dependent respiratory syncytial virus and human metapneumovirus infections. British J Pharmacology 175:388–403.
1.
Lê BV, Jandrot-Perrus M, Couture C, Checkmahomed L, Venable M-C, Hamelin M-È, Boivin G. 2018. Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice. Journal of General Virology 99:1367–1380.
1.
Nuzzo A, Ronot M, Maggiori L, Corcos O. 2018. Early Acute Mesenteric Ischemia: Many Rivers to Cross. Annals of Surgery 268:e41.
1.
Rautou P-E, Busse J, Kheloufi M, Vion A-C, Boulaftali Y, Stark K, Boulanger C. 2018. Endothelial Autophagy Does Not Influence Venous Thrombosis in Mice. Thromb Haemost 118:1113–1115.
1.
Lebozec K, Jandrot-Perrus M, Avenard G, Favre-Bulle O, Billiald P. 2018. Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development. New Biotechnology 44:31–40.
1.
Nuzzo A, Huguet A, Corcos O. 2018. Prise en charge moderne des ischémies mésentériques. La Presse Médicale 47:519–530.
1.
Roussel A, Nuzzo A, Pellenc Q, Castier Y, De Blic R, Cerceau P, Boulitrop C, Coblence M, Aguir S, Mordant P, Maggiori L, Huguet A, Sibert A, Joly F, Corcos O. 2018. Surgical revascularization of the celiac artery for persistent intestinal ischemia in short bowel syndrome. International Journal of Surgery 49:39–44.
1.
Copin P, Ronot M, Nuzzo A, Maggiori L, Bouhnik Y, Corcos O, Vilgrain V. 2018. Inter-reader agreement of CT features of acute mesenteric ischemia. European Journal of Radiology 105:87–95.
1.
Copin P, Zins M, Nuzzo A, Purcell Y, Beranger-Gibert S, Maggiori L, Corcos O, Vilgrain V, Ronot M. 2018. Erratum to “Acute mesenteric ischemia: A critical role for the radiologist” [Diagn. Interv. Imaging 99 (2018) 123—134]. Diagnostic and Interventional Imaging 99:345–346.
1.
Boukais K, Borges LF, Venisse L, Touat Z, François D, Arocas V, Jondeau G, Declerck P, Bouton M-C, Michel J-B. 2018. Clearance of plasmin–PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta. Cardiovascular Pathology 32:15–25.
1.
Marinval N, Morenc M, Labour MN, Samotus A, Mzyk A, Ollivier V, Maire M, Jesse K, Bassand K, Niemiec-Cyganek A, Haddad O, Jacob MP, Chaubet F, Charnaux N, Wilczek P, Hlawaty H. 2018. Fucoidan/VEGF-based surface modification of decellularized pulmonary heart valve improves the antithrombotic and re-endothelialization potential of bioprostheses. Biomaterials 172:14–29.
1.
Juenet M, Aid-Launais R, Li B, Berger A, Aerts J, Ollivier V, Nicoletti A, Letourneur D, Chauvierre C. 2018. Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156:204–216.
1.
The PALUREA Study Group, Bruneel F, Tubach F, Mira J-P, Houze S, Gibot S, Huisse M-G, Megarbane B, Choquet C, Corne P, Peytel E, Villers D, Camus C, Bouchaud O, Caumes E, Girard P-M, Simon F, Kalloumeh A, Roy C, Durand R, Le Bras J, Matheron S, Wolff M. 2018. Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study. Intensive Care Med 44:141–143.
1.
Boulaftali Y, Mawhin M, Jandrot‐Perrus M, Ho‐Tin‐Noé B. 2018. Glycoprotein VI in securing vascular integrity in inflamed vessels. Research and Practice in Thrombosis and Haemostasis 2:228–239.

2017

1.
Delbosc S, Bayles RG, Laschet J, Ollivier V, Ho-Tin-Noé B, Touat Z, Deschildre C, Morvan M, Louedec L, Gouya L, Guedj K, Nicoletti A, Michel J-B. 2017. Erythrocyte Efferocytosis by the Arterial Wall Promotes Oxidation in Early-Stage Atheroma in Humans. Front Cardiovasc Med 4:43.
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Desilles J-P, Syvannarath V, Ollivier V, Journé C, Delbosc S, Ducroux C, Boisseau W, Louedec L, Di Meglio L, Loyau S, Jandrot-Perrus M, Potier L, Michel J-B, Mazighi M, Ho-Tin-Noé B. 2017. Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation. Stroke 48:1932–1940.
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Albaladejo P, Samama C-M, Sié P, Kauffmann S, Mémier V, Suchon P, Viallon A, David JS, Gruel Y, Bellamy L, De Maistre E, Romegoux P, Thoret S, Pernod G, Bosson J-L, on behalf of the GIHP-NACO Study Group. 2017. Management of Severe Bleeding in Patients Treated with Direct Oral Anticoagulants. Anesthesiology 127:111–120.
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Nuzzo A, Maggiori L, Ronot M, Becq A, Plessier A, Gault N, Joly F, Castier Y, Vilgrain V, Paugam C, Panis Y, Bouhnik Y, Cazals-Hatem D, Corcos O. 2017. Predictive Factors of Intestinal Necrosis in Acute Mesenteric Ischemia: Prospective Study from an Intestinal Stroke Center. American Journal of Gastroenterology 112:597–605.
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De Raucourt E, Kuadjovi C, Rautou PE, Ajzenberg N, Boudaoud L, Valla D, Plessier A. 2017. Thrombin generation in patients with non-cirrhotic vascular liver diseases treated or not treated with vitamin K antagonist. Thrombosis Research 155:28–30.
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Poisson J, Plessier A, Kiladjian J-J, Turon F, Cassinat B, Andreoli A, De Raucourt E, Goria O, Zekrini K, Bureau C, Lorre F, Cervantes F, Colomer D, Durand F, Garcia-Pagan J-C, Casadevall N, Valla D-C, Rautou P-E, Marzac C. 2017. Selective testing for calreticulin gene mutations in patients with splanchnic vein thrombosis: A prospective cohort study. Journal of Hepatology 67:501–507.
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Ben Mansour M, Balti R, Ollivier V, Ben Jannet H, Chaubet F, Maaroufi RM. 2017. Characterization and anticoagulant activity of a fucosylated chondroitin sulfate with unusually procoagulant effect from sea cucumber. Carbohydrate Polymers 174:760–771.
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Nuzzo A, Soudan D, Billiauws L, Bataille J, Maggiori L, Ronot M, Stocco J, Bouhnik Y, Castier Y, Corcos O, Corcos O, Bouhnik Y, Nuzzo A, Stefanescu C, Treton X, Joly F, Billiauws L, Panis Y, Maggiori L, Prost À La Denise J, Tribillon E, Laforêt A, Lakkis Z, Sibert A, Zappa M, Garcia-Alba C, Abdel-Rehim M, Vilgrain V, Bertin C, Kerbaol A, Allaham W, Lagadec M, Benzimra J, Ronot M, Paugam C, Weiss E, Abback P-S, Delefosse D, Enriquez I, Janny S, Toussaint A, Iserentant J, Bout H, Pease S, Ear LK, Castier Y, Pellenc Q, Roussel A, Cerceau P, Mordant P, Deblic R, Boulitrop C, Curac S, Cachier A, Plessier A, Rautou P-E, Valla D, Soubrane O, Sauvanet A, Dokmak S, Dondero F, Sepulveda A, Farges O, Aussilhou B, Palazzo M, Cazals-Hatem D, De Raucourt E, Boudaoud L, Peoc’h K, Puy H, Pons-Kerjean N, Stocco J, Bataille J, Bouton V, Diop A, Gault N, Montravers P, Augustin P, Jacob BL. 2017. Iloprost Use in Patients with Persistent Intestinal Ischemia Unsuitable for Revascularization. Annals of Vascular Surgery 42:128–135.
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Ho‐Tin‐Noé B, Vo S, Bayles R, Ferrière S, Ladjal H, Toumi S, Deschildre C, Ollivier V, Michel J. 2017. Cholesterol crystallization in human atherosclerosis is triggered in smooth muscle cells during the transition from fatty streak to fibroatheroma. The Journal of Pathology 241:671–682.