The Team 6 projects are focused and will focus on hemostasis, bleeding, and thrombo-inflammation. More specifically, the team investigates the contribution of platelets and their numerous activation pathways as well as the impact of the balance between serpins and their protease targets to vascular and inflammatory diseases. We combine multidisciplinary approaches ranging from biochemistry and cell biology to in vivo experimental models and clinical research for translational application.

Recently, we have demonstrated that:

• Protease Nexin-1 is a serine protease inhibitor with an important protective role in tissues
• GPVI is a platelet receptor with a central role in the repairing functions of platelets
• There are tight interactions between actors of hemostasis/thrombosis and of the immune system during stroke
• Immunomodulation and cell therapy might help to improve post-stroke functional recovery
• Neutrophil extracellular traps interfere with thrombolysis

We have also established:

• The platelet platform
• The “fibrino/thrombolytic event” platform

Our major common research themes are:

•  Coagulation disorders (haemophilia, thrombophilia…)
•  Thrombo-inflammation (Platelets/ Leucocytes/ proteases & antiproteases of coagulation) in various contexts:
  • Myeloproliferative disorders-associated thrombosis
  • Liver and kidney diseases
  • Lung fibrosis
  • Acute mesenteric ischemia