Das et al demonstrate that plasminogen induces macrophage expression of CD36 via leukotriene B4 production and promotes lipid uptake. Plg-CD36-macro Edito-Plg-CD36-Macro
This paper shows for the first time a crucial role of CD4+ T cells and specific antigen recognition in the progression from compensated cardiac hypertrophy to HF. CIRCULATIONAHA.113.007101.full
A fate-mapping experiments that identifies, in the fetal liver, a sequence of yolk sac erythromyeloid progenitor-derived and hematopoietic stem cell-derived haematopoiesis, and identifies yolk sac erythromyeloid progenitors as a common origin for tissue macrophages. nature13989
Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles Meddahi-Pelle A, Legrand A, Marcellan A, Louedec L, Letourneur D, Leibler L 2014 • Angew Chem Int Ed Engl • [pdf] • Video Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization… Read more »
CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells Clement M, Fornasa G, Guedj K, Ben Mkaddem S, Gaston AT, Khallou-Laschet J, Morvan M, Nicoletti A, Caligiuri G 2014 • Proc Natl Acad Sci USA • [pdf] CD31 is a transhomophilic tyrosine-based inhibitory motif receptor and is expressed by both dendritic cells (DCs) and T lymphocytes…. Read more »
Collagen Can Selectively Trigger a Platelet Secretory Phenotype via Glycoprotein VI Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noe B 2014 • PLoS One • [pdf] Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these “non classical” functions… Read more »
Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression Francois D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC 2014 • Lab Invest • [pdf] Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse lung disease characterized by an accumulation of excess fibrous material in the lung. Protease nexin-1… Read more »
Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M 2014 • Blood • [pdf] Thrombosis is common in patients suffering from myeloproliferative neoplasm (MPN), whereas bleeding is less frequent. JAK2(V617F), the main mutation involved in MPN, is considered as… Read more »
Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G 2014 •… Read more »
MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections Barbier M, Gross MS, Aubart M, Hanna N, Kessler K, Guo DC, Tosolini L, Ho-Tin-Noe B, Regalado E, Varret M, Abifadel M, Milleron O, Odent S, Dupuis-Girod S, Faivre L, Edouard T, Dulac Y, Busa T, Gouya L, Milewicz DM, Jondeau… Read more »
Control of the Tfh-GC B Cell Axis by CD8+ Tregs Limits Atherosclerosis and Tertiary Lymphoid Organ Development Clement M, Guedj K, Andreata F, Morvan M, Bey L, Khallou-Laschet J, Gaston AT, Delbosc S, Alsac JM, Bruneval P, Deschildre C, Le Borgne M, Castier Y, Kim HJ, Cantor H, Michel JB, Caligiuri G, Nicoletti A 2015 • Circulation • [pdf] • Editorial… Read more »
Clinical evidence for oral antiplatelet therapy in acute coronary syndromes Wiviott SD, Steg PG 2015 • Lancet • [pdf] Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the treatment and prevention of recurrence of these syndromes. Nearly 30 years ago, aspirin was the first agent to show a benefit for acute… Read more »
For the 15th edition of the National competition for the ‘’aide à la création d’entreprises de technologies innovantes’, the minister of ‘Enseignement supérieur et de la Recherche’ in association with OSEO has granted 55 projects in the “création-développement” and 120 projects in “Emergence”. The project IMMATIS coordinated by D Letourneur (Team 3) was selected in the “création-développement” category. It was… Read more »
Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility NanoAthero is a Large Scale European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. Coordination : Didier Letourneur (Team 3; Inserm U1148, CHU… Read more »
The ‘Agence nationale de la recherche’ has selected the first 7 common laboratories between research organisms and private companies as part of the « Labcom » program. The project FucoChem has been selected for its research on marine polysaccharides to be used as cardiovascular biotherapies. This project is coordinated by Cédric Chauvierre (Team 3 Inserm U1148). It involves the laboratory of polymer bioengineering… Read more »
PhD in Biophysics, Dominique Le Guludec is Professor of Biophysics and Nuclear Medicine at University Paris 7. She is head of the Department of Nuclear Medicine, Hôpital Bichat, AP-HP, Paris, since 1994. She is also head of a research team of our Inserm Unit 1148, member of the Executive Committee of the EANM, and member of the National Council of… Read more »
A significant breakthrough could revolutionize surgical practice and regenerative medicine. The team led by Ludwik Leibler (Laboratoire Matière Molle et Chimie CNRS/ESPCI Paris Tech) and the Team headed by Didier Letourneur from the LVTS (INSERM U1148/Universités Paris Diderot and Paris 13), has just demonstrated that the principle of adhesion by aqueous solutions of nanoparticles can be used in vivo to… Read more »
The agreement between ACTICOR, a biotech hosted within the LVTS and created on the basis of the work from Martine Jandrot-Perrus (Team 1), Christian Gachet (U949) and Philippe Billiad (Institut Paris Sud d’Innovation Thérapeutique) is highlighted in the April issue of the BiotechFinances journal.
Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Votre Santé m’intéresse” on BFM TV (3 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).
Dr Didier Letourneur (Director of LVTS and leader of Team 3) was invited at the “Le Magazine de la Santé” on France 5 (27 May 2014) where he was interviewed on the recent publication from his group on a new strategy to facilitate tissue and organ repair (Press release).
Recommandations pour l’INSERM Toutes les unités Inserm sont mixtes avec l’université et/ou d’autres institutions. Chacune des ces institutions (Université, EPST, EPIC,…) doit être identifiée, dans les publications par une adresse séparée. Le séparateur toujours reconnu par les systèmes informatiques est le nom du pays.Institution 1, nom ou numéro du laboratoire ou du service…,ville, code postal, pays Institution 2, nom ou… Read more »
Fin de vie de l’application Partage (LinShare) qui permettait d’échanger des fichiers volumineux: 1 avril. Partage est remplacée par l’application FileSender que nous mutualisons avec nos partenaires de la recherche et de l’enseignement supérieur.Cette application gérée par Renater, est accessible à l’adresse “https://filesender.renater.fr/” .Une documentation complète est à votre disposition sur notre site “https://si-pratique.inserm.fr/index.php/File_Sender” .
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Thrombi and neutrophils Michel JB, Ho-Tin-Noé B 2015 • Circ Res • [pdf] (Editorial to this paper) More than a century ago, in 1881, Bizzozero discovered platelets and their role in primary hemostasis. Since this founding study, it has been shown that, in addition to the scaffold of platelets and fibrin, other proteins and cells play an important role in thrombus formation and stabilization. […]… Read more »
The FACT (French Alliance for Cardiovascular Trials) network, chaired by Prof PG Steg (LVTS Team 5) has been selected as an « Investigative Network Initiative » and will receive a 5-year financial support from the F-CRIN (French part of ECRIN – European Clinical Research Infrastructures Network). FACT is an academic research network that federates more than 20 sites throughout France… Read more »
The last issue of ‘International Innovation’, a journal for the global dissemination resource for the wider scientific, technology and research communities, focuses on the Women in Healthcare. Giuseppina (Team 1) has been invited to expose her research and to give her opinion on gender issues in medicine. Learn more
Some recent news on the Acticor Biotech team, a company dedicated to the development of an innovative, safe and effective treatment of ischemic stroke:<br> • Acticor is currently selecting its main lead to enter the development phase.<br> • Dr Gilles Avenard is the new President of the company. Acticor Website
Over the next five years, a large number of biological drug patents will fall into the public domain. Already, many pharmaceutical companies develop and put on the drug market “Biosimilars” on the same pattern as for the generic chemical drugs. Because substantial savings are expected with this interchangeability, a public audition was held at the French Parliament on 29 January… Read more »
Platelets play a role in severe pulmonary infections associated with influenza viruses. This has been revealed for the first time by researchers from Team 1 of LVTS in collaboration with researchers from INRA and the Université Claude Bernard Lyon 1. This work has been published on April 1, 2015 in the American Journal of Respiratory and Critical Care Medicine. Their… Read more »